JP2015193582A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015193582A5 JP2015193582A5 JP2014142910A JP2014142910A JP2015193582A5 JP 2015193582 A5 JP2015193582 A5 JP 2015193582A5 JP 2014142910 A JP2014142910 A JP 2014142910A JP 2014142910 A JP2014142910 A JP 2014142910A JP 2015193582 A5 JP2015193582 A5 JP 2015193582A5
- Authority
- JP
- Japan
- Prior art keywords
- agent according
- group
- aging
- anserine
- carnosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 14
- 230000032683 aging Effects 0.000 claims 8
- 108010085443 Anserine Proteins 0.000 claims 6
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims 6
- 108010087806 Carnosine Proteins 0.000 claims 6
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 claims 6
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims 6
- 241000210053 Potentilla elegans Species 0.000 claims 6
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 claims 6
- 229940044199 carnosine Drugs 0.000 claims 6
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims 6
- 230000007979 neuropsychological functioning Effects 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 230000006999 cognitive decline Effects 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 2
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 2
- 230000018109 developmental process Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102100035352 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Human genes 0.000 claims 1
- 102100040958 Aconitate hydratase, mitochondrial Human genes 0.000 claims 1
- 102100030343 Antigen peptide transporter 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 101710098275 C-X-C motif chemokine 10 Proteins 0.000 claims 1
- 102100036293 Calcium-binding mitochondrial carrier protein SCaMC-3 Human genes 0.000 claims 1
- 102100033086 Calcium/calmodulin-dependent protein kinase type 1 Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 101000845237 Cereibacter sphaeroides Tryptophan-rich sensory protein Proteins 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108010022637 Copper-Transporting ATPases Proteins 0.000 claims 1
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100021472 Equilibrative nucleoside transporter 3 Human genes 0.000 claims 1
- 102100035226 GDP-fucose transporter 1 Human genes 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 101000597665 Homo sapiens 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Proteins 0.000 claims 1
- 101000965314 Homo sapiens Aconitate hydratase, mitochondrial Proteins 0.000 claims 1
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 1
- 101000944250 Homo sapiens Calcium/calmodulin-dependent protein kinase type 1 Proteins 0.000 claims 1
- 101000804964 Homo sapiens DNA polymerase subunit gamma-1 Proteins 0.000 claims 1
- 101000960245 Homo sapiens Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Proteins 0.000 claims 1
- 101000616738 Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Proteins 0.000 claims 1
- 101001098232 Homo sapiens P2Y purinoceptor 1 Proteins 0.000 claims 1
- 101000595929 Homo sapiens POLG alternative reading frame Proteins 0.000 claims 1
- 101000845206 Homo sapiens Putative peripheral benzodiazepine receptor-related protein Proteins 0.000 claims 1
- 101000687737 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Proteins 0.000 claims 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 101000845233 Homo sapiens Translocator protein Proteins 0.000 claims 1
- 102100023915 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000003816 Interleukin-13 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102100039906 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Human genes 0.000 claims 1
- 102100034693 Large neutral amino acids transporter small subunit 4 Human genes 0.000 claims 1
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 1
- 102100040200 Mitochondrial uncoupling protein 2 Human genes 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 102100021840 NAD-dependent protein deacetylase sirtuin-6 Human genes 0.000 claims 1
- 102100037600 P2Y purinoceptor 1 Human genes 0.000 claims 1
- 102100035196 POLG alternative reading frame Human genes 0.000 claims 1
- 102100031269 Putative peripheral benzodiazepine receptor-related protein Human genes 0.000 claims 1
- 108091006692 SLC23A2 Proteins 0.000 claims 1
- 108091006464 SLC25A23 Proteins 0.000 claims 1
- 108091006473 SLC25A33 Proteins 0.000 claims 1
- 108091006546 SLC29A3 Proteins 0.000 claims 1
- 108091006955 SLC35C1 Proteins 0.000 claims 1
- 108091006996 SLC43A2 Proteins 0.000 claims 1
- 108060007751 SLC6A12 Proteins 0.000 claims 1
- 102000005019 SLC6A12 Human genes 0.000 claims 1
- 108060007752 SLC6A13 Proteins 0.000 claims 1
- 102000005021 SLC6A13 Human genes 0.000 claims 1
- 102100024777 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Human genes 0.000 claims 1
- 102100034246 Solute carrier family 23 member 2 Human genes 0.000 claims 1
- 102100033827 Solute carrier family 25 member 33 Human genes 0.000 claims 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 1
- 101800000849 Tachykinin-associated peptide 2 Proteins 0.000 claims 1
- 108010021111 Uncoupling Protein 2 Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 229960003624 creatine Drugs 0.000 claims 1
- 239000006046 creatine Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 150000002611 lead compounds Chemical class 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014142910A JP2015193582A (ja) | 2014-03-28 | 2014-07-11 | イミダゾールジペプチドを含む剤 |
| PCT/JP2015/056412 WO2015146522A1 (ja) | 2014-03-28 | 2015-03-04 | イミダゾールジペプチドを含む剤 |
| SG10201808208PA SG10201808208PA (en) | 2014-03-28 | 2015-03-04 | Agent comprising imidazole dipeptide |
| CN201580017212.3A CN106413733A (zh) | 2014-03-28 | 2015-03-04 | 包含咪唑二肽的试剂 |
| US15/129,602 US20170165314A1 (en) | 2014-03-28 | 2015-03-04 | Agent containing imidazole dipeptide |
| SG11201608027RA SG11201608027RA (en) | 2014-03-28 | 2015-03-04 | Agent comprising imidazole dipeptide |
| ES15768816T ES2879329T3 (es) | 2014-03-28 | 2015-03-04 | Dipéptido imidazol para el tratamiento de la demencia debida al envejecimiento o la atrofia cerebral |
| EP15768816.9A EP3124034B1 (en) | 2014-03-28 | 2015-03-04 | Imidazole dipeptide for treating dementia due to aging or cerebral atrophy |
| KR1020227041506A KR20220164079A (ko) | 2014-03-28 | 2015-03-04 | 이미다졸디펩티드를 포함하는 제제 |
| KR1020167030159A KR20160146760A (ko) | 2014-03-28 | 2015-03-04 | 이미다졸디펩티드를 포함하는 제제 |
| US15/877,304 US20180140655A1 (en) | 2014-03-28 | 2018-01-22 | Agent containing imidazole dipeptide |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014069103 | 2014-03-28 | ||
| JP2014069103 | 2014-03-28 | ||
| JP2014142910A JP2015193582A (ja) | 2014-03-28 | 2014-07-11 | イミダゾールジペプチドを含む剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019019712A Division JP6588666B2 (ja) | 2014-03-28 | 2019-02-06 | イミダゾールジペプチドを含む剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015193582A JP2015193582A (ja) | 2015-11-05 |
| JP2015193582A5 true JP2015193582A5 (enExample) | 2017-08-17 |
Family
ID=54195052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142910A Pending JP2015193582A (ja) | 2014-03-28 | 2014-07-11 | イミダゾールジペプチドを含む剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20170165314A1 (enExample) |
| EP (1) | EP3124034B1 (enExample) |
| JP (1) | JP2015193582A (enExample) |
| KR (2) | KR20160146760A (enExample) |
| CN (1) | CN106413733A (enExample) |
| ES (1) | ES2879329T3 (enExample) |
| SG (2) | SG11201608027RA (enExample) |
| WO (1) | WO2015146522A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6401028B2 (ja) * | 2014-11-27 | 2018-10-03 | Ｓｈｉｏｄａライフサイエンス株式会社 | 鯨筋肉抽出物からなる中長期記憶障害予防改善剤 |
| JP6550357B2 (ja) * | 2016-08-24 | 2019-07-24 | 日本ハム株式会社 | イミダゾールジペプチドを含有する、グリア細胞における神経栄養因子等の遺伝子の発現誘導剤 |
| JP7134607B2 (ja) * | 2016-08-25 | 2022-09-12 | 大正製薬株式会社 | 錠剤 |
| JP6510004B2 (ja) * | 2016-11-15 | 2019-05-08 | 日本ハム株式会社 | イミダゾールジペプチドを含有するエクソソーム調節剤、およびエクソソームを含有する神経細胞活性化剤 |
| JP2018140958A (ja) * | 2017-02-28 | 2018-09-13 | 国立大学法人 東京大学 | ペリサイトの変成を抑制する剤 |
| US11148118B2 (en) * | 2017-10-13 | 2021-10-19 | W.M. Barr & Company, Inc. | Encapsulated fragrance in compressed tablet |
| JP7251036B2 (ja) * | 2018-06-28 | 2023-04-04 | ポーラ化成工業株式会社 | 皮膚老化改善剤のスクリーニング方法 |
| WO2020085459A1 (ja) * | 2018-10-26 | 2020-04-30 | 国立大学法人東京大学 | 抗酸化剤、抗糖化剤又は抗炎症剤 |
| JP7321017B2 (ja) * | 2019-07-17 | 2023-08-04 | 東海物産株式会社 | 機能性食品 |
| EP4081303A4 (en) * | 2019-12-27 | 2024-01-24 | Suntory Holdings Limited | COMPOSITION CONTAINING A CYCLIC DIPEPTIDE, A PURINE NUCLEOSIDE AND/OR AN AMINO ACID AND A CHICKEN EXTRACT, METHOD FOR MANUFACTURING THE SAME, AND USE OF A CYCLIC DIPEPTIDE, A PURINE NUCLEOSIDE AND/OR AN AMINO ACID AND FROM CHICKEN EXTRACT |
| JP7523771B2 (ja) * | 2020-02-26 | 2024-07-29 | 国立大学法人 東京大学 | トランジスタ型センサ |
| EP4338267A4 (en) * | 2021-05-14 | 2025-01-08 | University of Rochester | Variants of sirt6 for use in preventing and/or treating age-related diseases |
| KR102868976B1 (ko) * | 2021-12-10 | 2025-11-03 | (주)잇마플 | 생체이용율과 이미다졸 펩타이드가 증가된 수용성 닭가슴살 가수분해물 및 그 제조방법 |
| WO2025104978A1 (ja) * | 2023-11-13 | 2025-05-22 | 国立大学法人 東京大学 | ネクロプトーシス制御剤 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR960010020A (ko) * | 1994-09-09 | 1996-04-20 | 도리이 신이치로 | 조혈 기능 항진제 |
| EP2327404A1 (en) * | 1994-11-08 | 2011-06-01 | Avicena Group, Inc. | Use of creatine or creatine analogs for the treatment of diseases of the nervous system |
| JP2000116987A (ja) | 1998-10-15 | 2000-04-25 | Sanyo Electric Co Ltd | 洗剤溶かし装置およびこれを備えた洗濯機ならびに静止型溶解装置 |
| JP4023648B2 (ja) | 1999-01-13 | 2007-12-19 | 日本ハム株式会社 | 皮膚代謝促進物及び機能性食品 |
| CA2389623A1 (en) * | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
| KR20020044740A (ko) * | 2000-12-06 | 2002-06-19 | 강경선 | 카노신을 유효성분으로 하는 세포예정사 관련 질환의 예방및 치료제 |
| EP1285654B1 (en) * | 2001-03-16 | 2006-06-07 | Suntory Limited | Autonomic system controlling agents and health drinks and foods |
| US6498498B1 (en) * | 2001-06-27 | 2002-12-24 | Intel Corporation | Apparatus and method for applying reciprocity to frequency-domain noise analysis |
| WO2003013514A1 (en) * | 2001-08-08 | 2003-02-20 | Carn-Aware Llc | Improving neurological functions |
| US20060257502A1 (en) * | 2005-05-11 | 2006-11-16 | Jiankang Liu | A combination of mitochondrial nutrients for relieving stress, preventing and improving stress-related disorders |
| JP2007070316A (ja) | 2005-09-09 | 2007-03-22 | Nippon Meat Packers Inc | 経口用組成物及び栄養補助食品 |
| JPWO2007116987A1 (ja) * | 2006-03-31 | 2009-08-20 | 日本ハム株式会社 | 学習機能向上効果及び抗不安効果を有する機能性食品及び薬剤 |
-
2014
- 2014-07-11 JP JP2014142910A patent/JP2015193582A/ja active Pending
-
2015
- 2015-03-04 KR KR1020167030159A patent/KR20160146760A/ko not_active Ceased
- 2015-03-04 CN CN201580017212.3A patent/CN106413733A/zh active Pending
- 2015-03-04 KR KR1020227041506A patent/KR20220164079A/ko not_active Ceased
- 2015-03-04 SG SG11201608027RA patent/SG11201608027RA/en unknown
- 2015-03-04 ES ES15768816T patent/ES2879329T3/es active Active
- 2015-03-04 EP EP15768816.9A patent/EP3124034B1/en active Active
- 2015-03-04 US US15/129,602 patent/US20170165314A1/en not_active Abandoned
- 2015-03-04 SG SG10201808208PA patent/SG10201808208PA/en unknown
- 2015-03-04 WO PCT/JP2015/056412 patent/WO2015146522A1/ja not_active Ceased
-
2018
- 2018-01-22 US US15/877,304 patent/US20180140655A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015193582A5 (enExample) | ||
| Catena-Dell’Osso et al. | Inflammation, serotonin and major depression | |
| JP2015503593A5 (enExample) | ||
| JP2014528474A5 (enExample) | ||
| Permoda-Osip et al. | Vitamin B12 level may be related to the efficacy of single ketamine infusion in bipolar depression | |
| JP2011190199A (ja) | 関節リウマチ薬 | |
| CN110248646A (zh) | 包含吡非尼酮的缓释组合物用于治疗和逆转人脂肪性肝炎(nafld/nash)的药物用途 | |
| JP2017533220A5 (enExample) | ||
| RU2016149316A (ru) | Лечение ревматоидного артрита | |
| EP4233913A3 (en) | Improved bromocriptine formulations | |
| JP2016520114A5 (enExample) | ||
| Hamer et al. | Using stress models to evaluate immuno-modulating effects of nutritional intervention in healthy individuals | |
| Kunkulol et al. | Evaluation of efficacy and tolerability of acetaminophen (paracetamol) and mefenamic acid as antipyretic in pediatric patients with febrile illness: a comparative study | |
| BR112016029749A8 (pt) | composição para perda de peso, composição que compreende cinamaldeído e zinco, seus usos, e método para fabricação de umm produto alimentício | |
| JP6154029B2 (ja) | 睡眠改善剤、ノンレム睡眠時間増加剤及び鎮静剤 | |
| Cobos et al. | A case of exuberant candidal onychomycosis in a child with hyper IgE syndrome | |
| Tanaka et al. | Environment, the immune system, and depression: an integrative review and discussion of the infection-defense hypothesis | |
| Al Nasrallah et al. | The use of dexmedetomidine for longer than 48 hours with evaluation of its secondary outcome in patients with liver disease | |
| RU2624978C2 (ru) | Способ лечения умеренного когнитивного снижения | |
| Omran et al. | Rubinstein-Taybi Syndrome; A Case Report. | |
| Ezzati | Time-Restricted Eating on Inflammation and Oxidative Stress in Overweight, Older Adults | |
| Weiner | Valproic acid | |
| SALEHI et al. | RUBINSTEIN-TAYBI SYNDROME; A CASE REPORT (CASE REPORT) | |
| Ross | A possible epigenetic explanation for the relationship between physical activity and exceptional health among older women | |
| Sari | A case of phagophobia |