JP2015193582A - イミダゾールジペプチドを含む剤 - Google Patents

イミダゾールジペプチドを含む剤 Download PDF

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Publication number
JP2015193582A
JP2015193582A JP2014142910A JP2014142910A JP2015193582A JP 2015193582 A JP2015193582 A JP 2015193582A JP 2014142910 A JP2014142910 A JP 2014142910A JP 2014142910 A JP2014142910 A JP 2014142910A JP 2015193582 A JP2015193582 A JP 2015193582A
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JP
Japan
Prior art keywords
group
agent
genes
aging
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014142910A
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English (en)
Japanese (ja)
Other versions
JP2015193582A5 (enExample
Inventor
辰博 久恒
Tatsuhiro Hisatsune
辰博 久恒
護 戸塚
Mamoru Totsuka
護 戸塚
薩　秀夫
Hideo Satsusui
秀夫 薩
金子　順
Jun Kaneko
順 金子
片倉　喜範
Yoshinori Katakura
喜範 片倉
三佳子 佐藤
Mikako Sato
三佳子 佐藤
貴之 松本
Takayuki Matsumoto
貴之 松本
森松　文毅
Fumitake Morimatsu
文毅 森松
悦子 今林
Etsuko Imabayashi
悦子 今林
博史 松田
Hiroshi Matsuda
博史 松田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyushu University NUC
National Center of Neurology and Psychiatry
University of Tokyo NUC
NH Foods Ltd
Original Assignee
Kyushu University NUC
Nippon Meat Packers Inc
National Center of Neurology and Psychiatry
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyushu University NUC, Nippon Meat Packers Inc, National Center of Neurology and Psychiatry, University of Tokyo NUC filed Critical Kyushu University NUC
Priority to JP2014142910A priority Critical patent/JP2015193582A/ja
Priority to SG11201608027RA priority patent/SG11201608027RA/en
Priority to SG10201808208PA priority patent/SG10201808208PA/en
Priority to CN201580017212.3A priority patent/CN106413733A/zh
Priority to US15/129,602 priority patent/US20170165314A1/en
Priority to PCT/JP2015/056412 priority patent/WO2015146522A1/ja
Priority to ES15768816T priority patent/ES2879329T3/es
Priority to EP15768816.9A priority patent/EP3124034B1/en
Priority to KR1020227041506A priority patent/KR20220164079A/ko
Priority to KR1020167030159A priority patent/KR20160146760A/ko
Publication of JP2015193582A publication Critical patent/JP2015193582A/ja
Publication of JP2015193582A5 publication Critical patent/JP2015193582A5/ja
Priority to US15/877,304 priority patent/US20180140655A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/13—Dipeptidases (3.4.13)
    • C12Y304/1302—Beta-Ala-His dipeptidase (3.4.13.20)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
JP2014142910A 2014-03-28 2014-07-11 イミダゾールジペプチドを含む剤 Pending JP2015193582A (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2014142910A JP2015193582A (ja) 2014-03-28 2014-07-11 イミダゾールジペプチドを含む剤
PCT/JP2015/056412 WO2015146522A1 (ja) 2014-03-28 2015-03-04 イミダゾールジペプチドを含む剤
SG10201808208PA SG10201808208PA (en) 2014-03-28 2015-03-04 Agent comprising imidazole dipeptide
CN201580017212.3A CN106413733A (zh) 2014-03-28 2015-03-04 包含咪唑二肽的试剂
US15/129,602 US20170165314A1 (en) 2014-03-28 2015-03-04 Agent containing imidazole dipeptide
SG11201608027RA SG11201608027RA (en) 2014-03-28 2015-03-04 Agent comprising imidazole dipeptide
ES15768816T ES2879329T3 (es) 2014-03-28 2015-03-04 Dipéptido imidazol para el tratamiento de la demencia debida al envejecimiento o la atrofia cerebral
EP15768816.9A EP3124034B1 (en) 2014-03-28 2015-03-04 Imidazole dipeptide for treating dementia due to aging or cerebral atrophy
KR1020227041506A KR20220164079A (ko) 2014-03-28 2015-03-04 이미다졸디펩티드를 포함하는 제제
KR1020167030159A KR20160146760A (ko) 2014-03-28 2015-03-04 이미다졸디펩티드를 포함하는 제제
US15/877,304 US20180140655A1 (en) 2014-03-28 2018-01-22 Agent containing imidazole dipeptide

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014069103 2014-03-28
JP2014069103 2014-03-28
JP2014142910A JP2015193582A (ja) 2014-03-28 2014-07-11 イミダゾールジペプチドを含む剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019019712A Division JP6588666B2 (ja) 2014-03-28 2019-02-06 イミダゾールジペプチドを含む剤

Publications (2)

Publication Number Publication Date
JP2015193582A true JP2015193582A (ja) 2015-11-05
JP2015193582A5 JP2015193582A5 (enExample) 2017-08-17

Family

ID=54195052

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014142910A Pending JP2015193582A (ja) 2014-03-28 2014-07-11 イミダゾールジペプチドを含む剤

Country Status (8)

Country Link
US (2) US20170165314A1 (enExample)
EP (1) EP3124034B1 (enExample)
JP (1) JP2015193582A (enExample)
KR (2) KR20160146760A (enExample)
CN (1) CN106413733A (enExample)
ES (1) ES2879329T3 (enExample)
SG (2) SG11201608027RA (enExample)
WO (1) WO2015146522A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016102068A (ja) * 2014-11-27 2016-06-02 Ｓｈｉｏｄａライフサイエンス株式会社 鯨筋肉抽出物からなる中長期記憶障害予防改善剤
JP2018030809A (ja) * 2016-08-24 2018-03-01 日本ハム株式会社 イミダゾールジペプチドを含有する、グリア細胞における神経栄養因子等の遺伝子の発現誘導剤
JP2018035143A (ja) * 2016-08-25 2018-03-08 大正製薬株式会社 錠剤
JP2018083808A (ja) * 2016-11-15 2018-05-31 日本ハム株式会社 イミダゾールジペプチドを含有するエクソソーム調節剤、およびエクソソームを含有する神経細胞活性化剤
JP2020003352A (ja) * 2018-06-28 2020-01-09 ポーラ化成工業株式会社 皮膚老化改善剤のスクリーニング方法
WO2020085459A1 (ja) * 2018-10-26 2020-04-30 国立大学法人東京大学 抗酸化剤、抗糖化剤又は抗炎症剤
JP2021017402A (ja) * 2019-07-17 2021-02-15 東海物産株式会社 軽度認知障害改善用組成物及びこの組成物を用いた軽度認知障害の改善方法

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JP2018140958A (ja) * 2017-02-28 2018-09-13 国立大学法人 東京大学 ペリサイトの変成を抑制する剤
US11148118B2 (en) * 2017-10-13 2021-10-19 W.M. Barr & Company, Inc. Encapsulated fragrance in compressed tablet
EP4081303A4 (en) * 2019-12-27 2024-01-24 Suntory Holdings Limited COMPOSITION CONTAINING A CYCLIC DIPEPTIDE, A PURINE NUCLEOSIDE AND/OR AN AMINO ACID AND A CHICKEN EXTRACT, METHOD FOR MANUFACTURING THE SAME, AND USE OF A CYCLIC DIPEPTIDE, A PURINE NUCLEOSIDE AND/OR AN AMINO ACID AND FROM CHICKEN EXTRACT
JP7523771B2 (ja) * 2020-02-26 2024-07-29 国立大学法人 東京大学 トランジスタ型センサ
EP4338267A4 (en) * 2021-05-14 2025-01-08 University of Rochester Variants of sirt6 for use in preventing and/or treating age-related diseases
KR102868976B1 (ko) * 2021-12-10 2025-11-03 (주)잇마플 생체이용율과 이미다졸 펩타이드가 증가된 수용성 닭가슴살 가수분해물 및 그 제조방법
WO2025104978A1 (ja) * 2023-11-13 2025-05-22 国立大学法人 東京大学 ネクロプトーシス制御剤

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