SG10201808208PA - Agent comprising imidazole dipeptide - Google Patents
Agent comprising imidazole dipeptideInfo
- Publication number
- SG10201808208PA SG10201808208PA SG10201808208PA SG10201808208PA SG10201808208PA SG 10201808208P A SG10201808208P A SG 10201808208PA SG 10201808208P A SG10201808208P A SG 10201808208PA SG 10201808208P A SG10201808208P A SG 10201808208PA SG 10201808208P A SG10201808208P A SG 10201808208PA
- Authority
- SG
- Singapore
- Prior art keywords
- agent
- imidazole dipeptide
- metabolite
- group
- neuropsychologic
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 18
- 239000003795 chemical substances by application Substances 0.000 title abstract 7
- 108010016626 Dipeptides Proteins 0.000 title abstract 6
- 239000002207 metabolite Substances 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 108091006692 SLC23A2 Proteins 0.000 abstract 1
- 102100034246 Solute carrier family 23 member 2 Human genes 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000010195 expression analysis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/13—Dipeptidases (3.4.13)
- C12Y304/1302—Beta-Ala-His dipeptidase (3.4.13.20)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
Agent containing imidazole dipeptide An anti-aging agent derived from a natural product is provided. The agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for changing expression of a transporter such as SLC23A2, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, and an agent for controlling blood concentration of a cytokine such as IP-10, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, as well as an expression analysis method for detecting improvement or degradation of a neuropsychologic function, and a kit for detecting improvement or degradation of a neuropsychologic function. Figure 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014069103 | 2014-03-28 | ||
JP2014142910A JP2015193582A (en) | 2014-03-28 | 2014-07-11 | Agent containing imidazoledipeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201808208PA true SG10201808208PA (en) | 2018-10-30 |
Family
ID=54195052
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201608027RA SG11201608027RA (en) | 2014-03-28 | 2015-03-04 | Agent comprising imidazole dipeptide |
SG10201808208PA SG10201808208PA (en) | 2014-03-28 | 2015-03-04 | Agent comprising imidazole dipeptide |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201608027RA SG11201608027RA (en) | 2014-03-28 | 2015-03-04 | Agent comprising imidazole dipeptide |
Country Status (8)
Country | Link |
---|---|
US (2) | US20170165314A1 (en) |
EP (1) | EP3124034B1 (en) |
JP (1) | JP2015193582A (en) |
KR (2) | KR20220164079A (en) |
CN (1) | CN106413733A (en) |
ES (1) | ES2879329T3 (en) |
SG (2) | SG11201608027RA (en) |
WO (1) | WO2015146522A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6401028B2 (en) * | 2014-11-27 | 2018-10-03 | Shiodaライフサイエンス株式会社 | Medium / long-term memory disorder prevention / improvement agent consisting of whale muscle extract |
JP6550357B2 (en) * | 2016-08-24 | 2019-07-24 | 日本ハム株式会社 | An agent for inducing expression of a gene such as neurotrophic factor in glial cells, comprising an imidazole dipeptide |
JP7134607B2 (en) * | 2016-08-25 | 2022-09-12 | 大正製薬株式会社 | tablet |
JP6510004B2 (en) * | 2016-11-15 | 2019-05-08 | 日本ハム株式会社 | Exosome modulator containing imidazole dipeptide, and nerve cell activator containing exosome |
US11148118B2 (en) * | 2017-10-13 | 2021-10-19 | W.M. Barr & Company, Inc. | Encapsulated fragrance in compressed tablet |
JP7251036B2 (en) * | 2018-06-28 | 2023-04-04 | ポーラ化成工業株式会社 | Screening method for skin aging improving agent |
WO2020085459A1 (en) * | 2018-10-26 | 2020-04-30 | 国立大学法人東京大学 | Antioxidation agent, antiglycation agent or anti-inflammatory agent |
JP7321017B2 (en) * | 2019-07-17 | 2023-08-04 | 東海物産株式会社 | functional food |
EP4081303A4 (en) * | 2019-12-27 | 2024-01-24 | Suntory Holdings Ltd | Composition containing cyclic dipeptide, purine nucleoside and/or amino acid, and chicken extract, production method thereof, and use of cyclic dipeptide, purine nucleoside and/or amino acid, and chicken extract |
CA3218849A1 (en) * | 2021-05-14 | 2022-11-17 | University Of Rochester | Variants of sirt6 for use in preventing and/or treating age-related diseases |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960010020A (en) * | 1994-09-09 | 1996-04-20 | 도리이 신이치로 | Hematopoietic antihypertensives |
ATE332127T1 (en) * | 1994-11-08 | 2006-07-15 | Avicena Group Inc | USE OF CREATINE OR CREATINENOLOGIST TO TREAT HUNTINGTON CHOREA, PARKINSON'S DISEASE AND AMYOTROPHIC LATERAL SCLERosis |
JP2000116987A (en) | 1998-10-15 | 2000-04-25 | Sanyo Electric Co Ltd | Detergent dissolving apparatus and washing machine with the same and static dissolver |
JP4023648B2 (en) | 1999-01-13 | 2007-12-19 | 日本ハム株式会社 | Skin metabolism promoter and functional food |
WO2001032168A1 (en) * | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
KR20020044740A (en) * | 2000-12-06 | 2002-06-19 | 강경선 | Preventive and therapeutic agents for apoptosis-related diseases which contain carnosine as a pharmaceutically active ingredient |
EP1285654B1 (en) * | 2001-03-16 | 2006-06-07 | Suntory Limited | Autonomic system controlling agents and health drinks and foods |
US6498498B1 (en) * | 2001-06-27 | 2002-12-24 | Intel Corporation | Apparatus and method for applying reciprocity to frequency-domain noise analysis |
WO2003013514A1 (en) * | 2001-08-08 | 2003-02-20 | Carn-Aware Llc | Improving neurological functions |
US20060257502A1 (en) * | 2005-05-11 | 2006-11-16 | Jiankang Liu | A combination of mitochondrial nutrients for relieving stress, preventing and improving stress-related disorders |
JP2007070316A (en) | 2005-09-09 | 2007-03-22 | Nippon Meat Packers Inc | Peroral composition and dietary supplement |
WO2007116987A1 (en) * | 2006-03-31 | 2007-10-18 | Nippon Meat Packers, Inc. | Functional food and drug having learning function-improving effect and antidepressant effect |
-
2014
- 2014-07-11 JP JP2014142910A patent/JP2015193582A/en active Pending
-
2015
- 2015-03-04 EP EP15768816.9A patent/EP3124034B1/en active Active
- 2015-03-04 ES ES15768816T patent/ES2879329T3/en active Active
- 2015-03-04 CN CN201580017212.3A patent/CN106413733A/en active Pending
- 2015-03-04 US US15/129,602 patent/US20170165314A1/en not_active Abandoned
- 2015-03-04 SG SG11201608027RA patent/SG11201608027RA/en unknown
- 2015-03-04 KR KR1020227041506A patent/KR20220164079A/en not_active Application Discontinuation
- 2015-03-04 WO PCT/JP2015/056412 patent/WO2015146522A1/en active Application Filing
- 2015-03-04 KR KR1020167030159A patent/KR20160146760A/en not_active Application Discontinuation
- 2015-03-04 SG SG10201808208PA patent/SG10201808208PA/en unknown
-
2018
- 2018-01-22 US US15/877,304 patent/US20180140655A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170165314A1 (en) | 2017-06-15 |
ES2879329T3 (en) | 2021-11-22 |
JP2015193582A (en) | 2015-11-05 |
EP3124034B1 (en) | 2021-04-21 |
EP3124034A1 (en) | 2017-02-01 |
KR20160146760A (en) | 2016-12-21 |
KR20220164079A (en) | 2022-12-12 |
EP3124034A4 (en) | 2018-03-21 |
SG11201608027RA (en) | 2016-11-29 |
US20180140655A1 (en) | 2018-05-24 |
WO2015146522A1 (en) | 2015-10-01 |
CN106413733A (en) | 2017-02-15 |
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