JP2015157843A5 - - Google Patents
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- Publication number
- JP2015157843A5 JP2015157843A5 JP2015093417A JP2015093417A JP2015157843A5 JP 2015157843 A5 JP2015157843 A5 JP 2015157843A5 JP 2015093417 A JP2015093417 A JP 2015093417A JP 2015093417 A JP2015093417 A JP 2015093417A JP 2015157843 A5 JP2015157843 A5 JP 2015157843A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- pyrido
- dihydro
- phthalazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8668708P | 2008-08-06 | 2008-08-06 | |
| US61/086,687 | 2008-08-06 | ||
| US15103609P | 2009-02-09 | 2009-02-09 | |
| US61/151,036 | 2009-02-09 | ||
| US17308809P | 2009-04-27 | 2009-04-27 | |
| US61/173,088 | 2009-04-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522113A Division JP5984389B2 (ja) | 2008-08-06 | 2009-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017145036A Division JP2018012698A (ja) | 2008-08-06 | 2017-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015157843A JP2015157843A (ja) | 2015-09-03 |
| JP2015157843A5 true JP2015157843A5 (https=) | 2015-10-15 |
Family
ID=41129519
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522113A Active JP5984389B2 (ja) | 2008-08-06 | 2009-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
| JP2015093417A Pending JP2015157843A (ja) | 2008-08-06 | 2015-04-30 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
| JP2017145036A Pending JP2018012698A (ja) | 2008-08-06 | 2017-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522113A Active JP5984389B2 (ja) | 2008-08-06 | 2009-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017145036A Pending JP2018012698A (ja) | 2008-08-06 | 2017-07-27 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤 |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US8012976B2 (https=) |
| EP (3) | EP2767537B1 (https=) |
| JP (3) | JP5984389B2 (https=) |
| KR (1) | KR101846029B1 (https=) |
| CN (3) | CN102171214B (https=) |
| AR (1) | AR072970A1 (https=) |
| AU (1) | AU2009279944B2 (https=) |
| BR (1) | BRPI0917119B1 (https=) |
| CA (1) | CA2732797C (https=) |
| CY (3) | CY1115022T1 (https=) |
| DK (2) | DK2326650T3 (https=) |
| ES (2) | ES2625817T3 (https=) |
| FR (1) | FR19C1071I2 (https=) |
| GB (1) | GB2462361A (https=) |
| HR (1) | HRP20170982T1 (https=) |
| HU (2) | HUE035295T2 (https=) |
| IL (1) | IL211070A (https=) |
| LT (2) | LT2767537T (https=) |
| LU (1) | LUC00140I2 (https=) |
| MX (1) | MX2011001328A (https=) |
| NL (1) | NL301021I2 (https=) |
| NO (1) | NO2019042I1 (https=) |
| NZ (1) | NZ591166A (https=) |
| PL (2) | PL2326650T3 (https=) |
| PT (2) | PT2767537T (https=) |
| SG (2) | SG193842A1 (https=) |
| SI (2) | SI2767537T1 (https=) |
| SM (1) | SMT201700312T1 (https=) |
| TW (2) | TW201422617A (https=) |
| WO (1) | WO2010017055A2 (https=) |
| ZA (1) | ZA201100897B (https=) |
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| ES2663222T3 (es) | 2008-12-19 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina útiles como inhibidores de la quinasa ATR |
| CA2787844C (en) * | 2010-02-03 | 2019-08-27 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency |
| US20110190266A1 (en) * | 2010-02-04 | 2011-08-04 | Daniel Chu | 5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) |
| PT2533640T (pt) | 2010-02-08 | 2017-01-03 | Medivation Technologies Inc | Processos de síntese de derivados de di-hidropiridoftalazinona |
| WO2011130661A1 (en) * | 2010-04-16 | 2011-10-20 | Biomarin Pharmaceutical Inc. | Methods of using dihydropyridophthalazinone inhibitors of poly (adp-ribose)polymerase (parp) |
| US9630956B2 (en) | 2010-05-12 | 2017-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| NZ609490A (en) * | 2010-10-21 | 2015-06-26 | Biomarin Pharm Inc | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
| WO2012166151A1 (en) * | 2011-06-03 | 2012-12-06 | Biomarin Pharmaceutical Inc. | Use of dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) in the treatment of myelodysplastic syndrome (mds) and acute myeloid leukaemia (aml) |
| WO2013028495A1 (en) * | 2011-08-19 | 2013-02-28 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma |
| SG10201606774UA (en) * | 2011-09-30 | 2016-10-28 | Vertex Pharma | Processes for making compounds useful as inhibitors of atr kinase |
| WO2013049859A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors |
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| BR112014017833A2 (pt) | 2012-01-20 | 2021-03-23 | Dennis Brown | Uso de hexitóis substituídos incluindo dianidrogalactitol e análogos para tratar doença neoplástica e células-tronco de câncer incluindo glioblastoma multiforme e meduloblastoma |
| CA2869309C (en) | 2012-04-05 | 2021-02-09 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| WO2014073447A1 (ja) | 2012-11-08 | 2014-05-15 | 日本化薬株式会社 | カンプトテシン類と抗癌効果増強剤の結合した高分子化合物及びその用途 |
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| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| TW201605814A (zh) | 2013-11-07 | 2016-02-16 | 拜奧馬林製藥公司 | 用於合成經保護之ｎ－烷基三唑甲醛的三唑中間體 |
| CN103772395B (zh) * | 2014-01-23 | 2016-05-11 | 中国药科大学 | 一类具有parp抑制活性的化合物、其制备方法及用途 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| LT3157566T (lt) | 2014-06-17 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį |
| SG11201700734RA (en) * | 2014-07-31 | 2017-02-27 | Medivation Technologies Inc | Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and methods of preparing them |
| JP6871169B2 (ja) | 2015-03-02 | 2021-05-12 | シナイ ヘルス システム | 相同組換え因子 |
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