JP2014533518A5 - - Google Patents
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- Publication number
- JP2014533518A5 JP2014533518A5 JP2014542951A JP2014542951A JP2014533518A5 JP 2014533518 A5 JP2014533518 A5 JP 2014533518A5 JP 2014542951 A JP2014542951 A JP 2014542951A JP 2014542951 A JP2014542951 A JP 2014542951A JP 2014533518 A5 JP2014533518 A5 JP 2014533518A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- ugt
- seq
- amino acid
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 35
- 229920001184 polypeptide Polymers 0.000 claims 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims 31
- 150000001413 amino acids Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 229930189775 mogroside Natural products 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000013592 cell lysate Substances 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 230000001279 glycosylating effect Effects 0.000 claims 4
- JLYBBRAAICDTIS-AYEHCKLZSA-N mogrol Chemical compound C([C@H]1[C@]2(C)CC[C@@H]([C@]2(C[C@@H](O)[C@]11C)C)[C@@H](CC[C@@H](O)C(C)(C)O)C)C=C2[C@H]1CC[C@H](O)C2(C)C JLYBBRAAICDTIS-AYEHCKLZSA-N 0.000 claims 4
- JLYBBRAAICDTIS-UHFFFAOYSA-N mogrol Natural products CC12C(O)CC3(C)C(C(CCC(O)C(C)(C)O)C)CCC3(C)C1CC=C1C2CCC(O)C1(C)C JLYBBRAAICDTIS-UHFFFAOYSA-N 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 101100483369 Arabidopsis thaliana UGT73C3 gene Proteins 0.000 claims 3
- 101100483372 Arabidopsis thaliana UGT73C5 gene Proteins 0.000 claims 3
- 101100483373 Arabidopsis thaliana UGT73C6 gene Proteins 0.000 claims 3
- 102000000340 Glucosyltransferases Human genes 0.000 claims 3
- 108010055629 Glucosyltransferases Proteins 0.000 claims 3
- 101100483376 Stevia rebaudiana UGT73E1 gene Proteins 0.000 claims 3
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000005090 green fluorescent protein Substances 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 108010031100 chloroplast transit peptides Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 241001515965 unidentified phage Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161563303P | 2011-11-23 | 2011-11-23 | |
| US61/563,303 | 2011-11-23 | ||
| PCT/IB2012/002857 WO2013076577A1 (en) | 2011-11-23 | 2012-11-19 | Methods and materials for enzymatic synthesis of mogroside compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533518A JP2014533518A (ja) | 2014-12-15 |
| JP2014533518A5 true JP2014533518A5 (enExample) | 2016-09-29 |
| JP6084983B2 JP6084983B2 (ja) | 2017-02-22 |
Family
ID=47624376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542951A Active JP6084983B2 (ja) | 2011-11-23 | 2012-11-19 | モグロシド化合物の酵素的合成のための方法および材料 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9920349B2 (enExample) |
| EP (1) | EP2783009B1 (enExample) |
| JP (1) | JP6084983B2 (enExample) |
| KR (1) | KR101791597B1 (enExample) |
| CN (1) | CN103958693B (enExample) |
| AU (2) | AU2012342114B2 (enExample) |
| BR (1) | BR112014012543A2 (enExample) |
| CA (1) | CA2853677C (enExample) |
| IN (1) | IN2014CN03557A (enExample) |
| MX (1) | MX342851B (enExample) |
| MY (1) | MY170686A (enExample) |
| RU (1) | RU2633644C2 (enExample) |
| SG (1) | SG11201401927PA (enExample) |
| WO (1) | WO2013076577A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY185668A (en) | 2010-06-02 | 2021-05-28 | Evolva Inc | Recombinant production of steviol glycosides |
| KR102114493B1 (ko) | 2011-08-08 | 2020-05-26 | 에볼바 에스아 | 스테비올 글리코시드의 재조합 생산 |
| IN2014CN03557A (enExample) | 2011-11-23 | 2015-10-09 | Evolva Sa | |
| TW201402599A (zh) * | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| HK1215053A1 (zh) | 2012-12-04 | 2016-08-12 | Evolva Sa | 用作生物合成罗汉果化合物的方法及材料 |
| WO2016050890A2 (en) * | 2014-10-01 | 2016-04-07 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
| CN105189771B (zh) | 2013-02-11 | 2019-11-05 | 埃沃尔瓦公司 | 在重组宿主中有效产生甜菊醇糖苷 |
| EP3179869A1 (en) | 2014-08-11 | 2017-06-21 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| JP2017528134A (ja) | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組み換え宿主におけるステビオールグリコシドの生産 |
| WO2016038617A1 (en) | 2014-09-11 | 2016-03-17 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of producing mogrosides and compositions comprising same and uses thereof |
| WO2016060276A1 (ja) | 2014-10-17 | 2016-04-21 | サントリーホールディングス株式会社 | モグロール配糖体化酵素およびそれをコードする遺伝子 |
| JP6850130B2 (ja) | 2015-01-20 | 2021-03-31 | サントリーホールディングス株式会社 | モグロシドの調製方法 |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN115851470B (zh) | 2015-03-16 | 2025-09-02 | 帝斯曼知识产权资产管理有限公司 | Udp-糖基转移酶 |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| NZ741741A (en) | 2015-10-29 | 2019-08-30 | Senomyx Inc | High intensity sweeteners |
| CN106924274B (zh) * | 2015-12-29 | 2019-01-04 | 成都普睿法药物研发有限公司 | 葫芦烷型四环三萜类化合物抗肺纤维化应用 |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458598A1 (en) * | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2018016483A1 (ja) * | 2016-07-19 | 2018-01-25 | サントリーホールディングス株式会社 | モグロールまたはモグロール配糖体の生産方法 |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| BR112019023104A2 (pt) | 2017-05-03 | 2020-11-03 | Firmenich Incorporated | métodos para fazer adoçante de alta intensidade |
| EP3624595A4 (en) | 2017-05-19 | 2021-03-03 | The Coca-Cola Company | COMPOSITIONS SWEETED WITH SIAMENOSIDE I AND USES THEREOF |
| EP3629764A1 (en) | 2017-06-02 | 2020-04-08 | Givaudan SA | Compositions |
| WO2021214008A1 (en) | 2020-04-20 | 2021-10-28 | Givaudan Sa | Compositions |
| US11248248B2 (en) | 2017-06-15 | 2022-02-15 | Evolva Sa | Production of mogroside compounds in recombinant hosts |
| CN107189976B (zh) * | 2017-07-28 | 2022-03-11 | 李华政 | 促进罗汉果ugt72b21基因表达的方法 |
| CN113286523A (zh) | 2018-11-07 | 2021-08-20 | 弗门尼舍公司 | 制备高强度甜味剂的方法 |
| WO2020096905A1 (en) | 2018-11-07 | 2020-05-14 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| US12234464B2 (en) | 2018-11-09 | 2025-02-25 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN110669094B (zh) * | 2019-10-14 | 2021-12-21 | 上海交通大学 | 罗汉果新苷及其制备方法 |
| KR102362135B1 (ko) * | 2019-10-25 | 2022-02-14 | 고려대학교 산학협력단 | 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| BR112022018627A2 (pt) * | 2020-03-17 | 2022-12-20 | Coca Cola Co | Sistemas e métodos inovadores de produção de mogrosídeo |
| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN112063647B (zh) * | 2020-09-17 | 2023-05-02 | 云南农业大学 | 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用 |
| CN116064712B (zh) * | 2022-10-08 | 2025-05-06 | 中国药科大学 | 一种罗汉果醇的生物合成方法 |
| EP4698673A1 (en) | 2023-04-20 | 2026-02-25 | DSM IP Assets B.V. | Strains and methods for the production of mogrosides |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399321B1 (en) * | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
| EP1510573A1 (en) * | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US20080148432A1 (en) * | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
| CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8257948B1 (en) * | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2455853C2 (ru) * | 2005-11-23 | 2012-07-20 | Дзе Кока-Кола Компани | Композиция интенсивного подсластителя с пищевой клетчаткой и подслащенные ею композиции |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| WO2008062165A2 (en) * | 2006-11-22 | 2008-05-29 | The University Of York | Monoterpenoid modifying enzymes |
| WO2008065370A2 (en) | 2006-12-01 | 2008-06-05 | The University Of York | Sesquiterpenoid modifying enzymes |
| GB0904639D0 (en) * | 2009-03-18 | 2009-04-29 | Univ York | Assay |
| MY185668A (en) | 2010-06-02 | 2021-05-28 | Evolva Inc | Recombinant production of steviol glycosides |
| IN2014CN03557A (enExample) | 2011-11-23 | 2015-10-09 | Evolva Sa | |
| HK1215053A1 (zh) | 2012-12-04 | 2016-08-12 | Evolva Sa | 用作生物合成罗汉果化合物的方法及材料 |
-
2012
- 2012-11-19 IN IN3557CHN2014 patent/IN2014CN03557A/en unknown
- 2012-11-19 EP EP12819015.4A patent/EP2783009B1/en active Active
- 2012-11-19 SG SG11201401927PA patent/SG11201401927PA/en unknown
- 2012-11-19 US US14/356,782 patent/US9920349B2/en active Active
- 2012-11-19 KR KR1020147016910A patent/KR101791597B1/ko active Active
- 2012-11-19 RU RU2014125216A patent/RU2633644C2/ru not_active IP Right Cessation
- 2012-11-19 JP JP2014542951A patent/JP6084983B2/ja active Active
- 2012-11-19 WO PCT/IB2012/002857 patent/WO2013076577A1/en not_active Ceased
- 2012-11-19 AU AU2012342114A patent/AU2012342114B2/en active Active
- 2012-11-19 MY MYPI2014001482A patent/MY170686A/en unknown
- 2012-11-19 MX MX2014006276A patent/MX342851B/es active IP Right Grant
- 2012-11-19 BR BR112014012543A patent/BR112014012543A2/pt unknown
- 2012-11-19 CN CN201280057518.8A patent/CN103958693B/zh active Active
- 2012-11-19 CA CA2853677A patent/CA2853677C/en active Active
-
2017
- 2017-09-26 AU AU2017235907A patent/AU2017235907A1/en not_active Withdrawn
-
2018
- 2018-02-06 US US15/889,743 patent/US10738340B2/en active Active
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