CA2853677C - Methods and materials for enzymatic synthesis of mogroside compounds - Google Patents
Methods and materials for enzymatic synthesis of mogroside compounds Download PDFInfo
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- CA2853677C CA2853677C CA2853677A CA2853677A CA2853677C CA 2853677 C CA2853677 C CA 2853677C CA 2853677 A CA2853677 A CA 2853677A CA 2853677 A CA2853677 A CA 2853677A CA 2853677 C CA2853677 C CA 2853677C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
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| PCT/IB2012/002857 WO2013076577A1 (en) | 2011-11-23 | 2012-11-19 | Methods and materials for enzymatic synthesis of mogroside compounds |
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| SG10201606567TA (en) | 2011-08-08 | 2016-10-28 | Evolva Sa | Recombinant production of steviol glycosides |
| RU2633644C2 (ru) | 2011-11-23 | 2017-10-16 | Эвольва Са | Способы ферментативного синтеза могрозидных соединений |
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| SG10201704575XA (en) | 2012-12-04 | 2017-07-28 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
| US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| EP3179869A1 (en) | 2014-08-11 | 2017-06-21 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| BR112017004712B1 (pt) | 2014-09-09 | 2021-11-03 | Evolva Sa | Hospedeiro recombinante que produz um precursor de glicosídeo de esteviol, métodos para produzir um precursor de glicosídeo de esteviol, um esteviol ou um ou mais glicosídeos de esteviol, cultura do dito hospedeiro e lisado da cultura do dito hospedeiro |
| US20170283844A1 (en) | 2014-09-11 | 2017-10-05 | The State of Israel, Ministry of Agriculture & Rural Development, Argricultural Research Organiza | Methods of producing mogrosides and compositions comprising same and uses thereof |
| EP3201315A2 (en) | 2014-10-01 | 2017-08-09 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| EP3208342A4 (en) | 2014-10-17 | 2018-07-04 | Suntory Holdings Limited | Mogrol glycosyltransferase and gene encoding same |
| US10626430B2 (en) | 2015-01-20 | 2020-04-21 | Suntory Holdings Limited | Method for preparing mogroside having no β-1,6-glucoside bond |
| BR112017016338A2 (pt) | 2015-01-30 | 2018-03-27 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| CN107567492B (zh) | 2015-03-16 | 2022-10-14 | 帝斯曼知识产权资产管理有限公司 | Udp-糖基转移酶 |
| WO2017025362A1 (en) | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| ES2925017T3 (es) | 2015-10-29 | 2022-10-13 | Firmenich Incorporated | Edulcorantes de alta intensidad |
| CN106924274B (zh) * | 2015-12-29 | 2019-01-04 | 成都普睿法药物研发有限公司 | 葫芦烷型四环三萜类化合物抗肺纤维化应用 |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| BR112018073662A2 (pt) * | 2016-05-16 | 2019-02-19 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| CN109477126B (zh) | 2016-07-19 | 2023-06-20 | 三得利控股株式会社 | 罗汉果醇或罗汉果醇糖苷的生产方法 |
| EP3535406A1 (en) | 2016-11-07 | 2019-09-11 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| US11060124B2 (en) * | 2017-05-03 | 2021-07-13 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN111246749A (zh) | 2017-05-19 | 2020-06-05 | 可口可乐公司 | 翅子罗汉果i甜味化的组合物及其用途 |
| CN116941752A (zh) | 2017-06-02 | 2023-10-27 | 奇华顿股份有限公司 | 组合物 |
| WO2018229283A1 (en) | 2017-06-15 | 2018-12-20 | Evolva Sa | Production of mogroside compounds in recombinant hosts |
| CN107189976B (zh) * | 2017-07-28 | 2022-03-11 | 李华政 | 促进罗汉果ugt72b21基因表达的方法 |
| CA3118467A1 (en) | 2018-11-07 | 2020-05-14 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| JP2022512931A (ja) | 2018-11-07 | 2022-02-07 | フィルメニッヒ インコーポレイテッド | 高甘味度甘味料の製造方法 |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| CN110669094B (zh) * | 2019-10-14 | 2021-12-21 | 上海交通大学 | 罗汉果新苷及其制备方法 |
| KR102362135B1 (ko) * | 2019-10-25 | 2022-02-14 | 고려대학교 산학협력단 | 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| WO2021188703A1 (en) * | 2020-03-17 | 2021-09-23 | The Coca-Cola Company | Novel mogroside production system and methods |
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| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN112063647B (zh) * | 2020-09-17 | 2023-05-02 | 云南农业大学 | 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用 |
| CN116064712B (zh) * | 2022-10-08 | 2025-05-06 | 中国药科大学 | 一种罗汉果醇的生物合成方法 |
| WO2024218244A1 (en) | 2023-04-20 | 2024-10-24 | Dsm Ip Assets B.V. | Strains and methods for the production of mogrosides |
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| EP1510573A1 (en) * | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US20080148432A1 (en) * | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
| EP2194140A2 (en) | 2005-03-02 | 2010-06-09 | Metanomics GmbH | Process for the production of fine chemicals |
| US8257948B1 (en) * | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2008123259A (ru) * | 2005-11-23 | 2009-12-27 | Дзе Кока-Кола Компани (US) | Композиция интенсивного подсластителя с противовоспалительным средством и подслащенные ею композиции |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
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| WO2008065370A2 (en) * | 2006-12-01 | 2008-06-05 | The University Of York | Sesquiterpenoid modifying enzymes |
| GB0904639D0 (en) * | 2009-03-18 | 2009-04-29 | Univ York | Assay |
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- 2012-11-19 MY MYPI2014001482A patent/MY170686A/en unknown
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- 2012-11-19 MX MX2014006276A patent/MX342851B/es active IP Right Grant
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Also Published As
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| MX2014006276A (es) | 2014-10-13 |
| AU2017235907A1 (en) | 2017-10-12 |
| KR101791597B1 (ko) | 2017-10-30 |
| EP2783009A1 (en) | 2014-10-01 |
| HK1200494A1 (zh) | 2015-08-07 |
| RU2633644C2 (ru) | 2017-10-16 |
| US10738340B2 (en) | 2020-08-11 |
| BR112014012543A2 (pt) | 2017-06-13 |
| AU2012342114A1 (en) | 2014-05-22 |
| JP2014533518A (ja) | 2014-12-15 |
| JP6084983B2 (ja) | 2017-02-22 |
| US20140308698A1 (en) | 2014-10-16 |
| WO2013076577A1 (en) | 2013-05-30 |
| RU2014125216A (ru) | 2015-12-27 |
| KR20140099281A (ko) | 2014-08-11 |
| SG11201401927PA (en) | 2014-09-26 |
| CA2853677A1 (en) | 2013-05-30 |
| MX342851B (es) | 2016-10-14 |
| US9920349B2 (en) | 2018-03-20 |
| EP2783009B1 (en) | 2016-04-13 |
| CN103958693B (zh) | 2016-08-24 |
| IN2014CN03557A (enExample) | 2015-10-09 |
| CN103958693A (zh) | 2014-07-30 |
| US20180237819A1 (en) | 2018-08-23 |
| MY170686A (en) | 2019-08-26 |
| AU2012342114B2 (en) | 2017-12-21 |
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