MX342851B - Metodos y materiales para sintesis enzimatica de compuestos mogrosido. - Google Patents
Metodos y materiales para sintesis enzimatica de compuestos mogrosido.Info
- Publication number
- MX342851B MX342851B MX2014006276A MX2014006276A MX342851B MX 342851 B MX342851 B MX 342851B MX 2014006276 A MX2014006276 A MX 2014006276A MX 2014006276 A MX2014006276 A MX 2014006276A MX 342851 B MX342851 B MX 342851B
- Authority
- MX
- Mexico
- Prior art keywords
- materials
- methods
- enzymatic synthesis
- mogroside compounds
- mogroside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un método para producir un compuesto mogrosido, que comprende poner en contacto y glicosilar un mogrol con un polipéptido de Uridina-5´difosfo (UDP) dependiente de glucosiltransferasa ( UGT) que es: (a) polipéptido UGT3C3 que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos expuesta en SEQ ID NO: 1; (b) polipéptido UGT73C5 que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos expuesta en SEQ ID NO: 2; (c) polipéptido UGT3C6 que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos expuesta en SEQ ID NO: 3; (d) polipéptido UGT73E1 que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos expuesta en SEQ ID NO: 4; o (e) polipéptido UGT85C2 que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos expuesta en SEQ ID NO: 5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161563303P | 2011-11-23 | 2011-11-23 | |
PCT/IB2012/002857 WO2013076577A1 (en) | 2011-11-23 | 2012-11-19 | Methods and materials for enzymatic synthesis of mogroside compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014006276A MX2014006276A (es) | 2014-10-13 |
MX342851B true MX342851B (es) | 2016-10-14 |
Family
ID=47624376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006276A MX342851B (es) | 2011-11-23 | 2012-11-19 | Metodos y materiales para sintesis enzimatica de compuestos mogrosido. |
Country Status (15)
Country | Link |
---|---|
US (2) | US9920349B2 (es) |
EP (1) | EP2783009B1 (es) |
JP (1) | JP6084983B2 (es) |
KR (1) | KR101791597B1 (es) |
CN (1) | CN103958693B (es) |
AU (2) | AU2012342114B2 (es) |
BR (1) | BR112014012543A2 (es) |
CA (1) | CA2853677C (es) |
HK (1) | HK1200494A1 (es) |
IN (1) | IN2014CN03557A (es) |
MX (1) | MX342851B (es) |
MY (1) | MY170686A (es) |
RU (1) | RU2633644C2 (es) |
SG (1) | SG11201401927PA (es) |
WO (1) | WO2013076577A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ708078A (en) | 2010-06-02 | 2017-01-27 | Evolva Nutrition Inc | Recombinant production of steviol glycosides |
BR112014003037B1 (pt) | 2011-08-08 | 2022-04-05 | Evolva Sa | Hospedeiro recombinante e método para produzir um glicosídeo de esteviol |
KR101791597B1 (ko) | 2011-11-23 | 2017-10-30 | 에볼바 에스아 | 모그로사이드 화합물을 효소에 의해 합성하기 위한 방법 및 재료 |
TW201402599A (zh) * | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
WO2014086842A1 (en) | 2012-12-04 | 2014-06-12 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
SG11201700651RA (en) | 2014-08-11 | 2017-02-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN107109358B (zh) | 2014-09-09 | 2022-08-02 | 埃沃尔瓦公司 | 在重组宿主中生产甜菊醇糖苷 |
IL287789B2 (en) * | 2014-09-11 | 2024-05-01 | The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo | Mogroside compounds, methods for their preparation, preparations including them and their uses |
CN107466320B (zh) | 2014-10-01 | 2021-11-05 | 埃沃尔瓦公司 | 用于生物合成罗汉果苷化合物的方法和材料 |
CA2968331C (en) | 2014-10-17 | 2024-02-06 | Suntory Holdings Limited | Mogrol glycosyltransferase and gene encoding same |
CA2974185A1 (en) | 2015-01-20 | 2016-07-28 | Suntory Holdings Limited | Method for preparing mogroside |
WO2016120486A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
MY190296A (en) | 2015-10-29 | 2022-04-12 | Firmenich Incorporated | High intensity sweeteners |
CN106924274B (zh) * | 2015-12-29 | 2019-01-04 | 成都普睿法药物研发有限公司 | 葫芦烷型四环三萜类化合物抗肺纤维化应用 |
WO2017178632A1 (en) | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
SG11201809483UA (en) * | 2016-05-16 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
CN109477126B (zh) * | 2016-07-19 | 2023-06-20 | 三得利控股株式会社 | 罗汉果醇或罗汉果醇糖苷的生产方法 |
US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
BR112019023104A2 (pt) | 2017-05-03 | 2020-11-03 | Firmenich Incorporated | métodos para fazer adoçante de alta intensidade |
JP7285788B2 (ja) | 2017-05-19 | 2023-06-02 | ザ コカ・コーラ カンパニー | シアメノシドi甘味料入り組成物及びその使用 |
MX2019014119A (es) | 2017-06-02 | 2020-02-07 | Givaudan Sa | Composiciones. |
WO2021214008A1 (en) | 2020-04-20 | 2021-10-28 | Givaudan Sa | Compositions |
WO2018229283A1 (en) | 2017-06-15 | 2018-12-20 | Evolva Sa | Production of mogroside compounds in recombinant hosts |
CN107189976B (zh) * | 2017-07-28 | 2022-03-11 | 李华政 | 促进罗汉果ugt72b21基因表达的方法 |
CN110669094B (zh) * | 2019-10-14 | 2021-12-21 | 上海交通大学 | 罗汉果新苷及其制备方法 |
KR102362135B1 (ko) * | 2019-10-25 | 2022-02-14 | 고려대학교 산학협력단 | 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
EP4120823A4 (en) * | 2020-03-17 | 2024-08-07 | Coca Cola Co | INNOVATIVE SYSTEM AND PROCESSES FOR PRODUCTION OF MOGROSIDE |
GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
CN112063647B (zh) * | 2020-09-17 | 2023-05-02 | 云南农业大学 | 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6399321B1 (en) * | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
EP1510573A1 (en) | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
US20080148432A1 (en) * | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
US8257948B1 (en) * | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
RU2417031C2 (ru) * | 2005-11-23 | 2011-04-27 | Дзе Кока-Кола Компани | Композиция интенсивного подсластителя с минеральным веществом и подслащенные ею композиции |
US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
US20100143975A1 (en) * | 2006-11-22 | 2010-06-10 | The University Of York | Monoterpenoid modifying enzymes |
US20100132073A1 (en) * | 2006-12-01 | 2010-05-27 | The University Of York | Sesquiterpenoid modifying enzymes |
GB0904639D0 (en) * | 2009-03-18 | 2009-04-29 | Univ York | Assay |
NZ708078A (en) | 2010-06-02 | 2017-01-27 | Evolva Nutrition Inc | Recombinant production of steviol glycosides |
KR101791597B1 (ko) | 2011-11-23 | 2017-10-30 | 에볼바 에스아 | 모그로사이드 화합물을 효소에 의해 합성하기 위한 방법 및 재료 |
WO2014086842A1 (en) | 2012-12-04 | 2014-06-12 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
-
2012
- 2012-11-19 KR KR1020147016910A patent/KR101791597B1/ko active IP Right Grant
- 2012-11-19 AU AU2012342114A patent/AU2012342114B2/en active Active
- 2012-11-19 US US14/356,782 patent/US9920349B2/en active Active
- 2012-11-19 MX MX2014006276A patent/MX342851B/es active IP Right Grant
- 2012-11-19 EP EP12819015.4A patent/EP2783009B1/en active Active
- 2012-11-19 JP JP2014542951A patent/JP6084983B2/ja active Active
- 2012-11-19 WO PCT/IB2012/002857 patent/WO2013076577A1/en active Application Filing
- 2012-11-19 SG SG11201401927PA patent/SG11201401927PA/en unknown
- 2012-11-19 CA CA2853677A patent/CA2853677C/en active Active
- 2012-11-19 BR BR112014012543A patent/BR112014012543A2/pt unknown
- 2012-11-19 IN IN3557CHN2014 patent/IN2014CN03557A/en unknown
- 2012-11-19 RU RU2014125216A patent/RU2633644C2/ru not_active IP Right Cessation
- 2012-11-19 MY MYPI2014001482A patent/MY170686A/en unknown
- 2012-11-19 CN CN201280057518.8A patent/CN103958693B/zh active Active
-
2015
- 2015-01-26 HK HK15100864.6A patent/HK1200494A1/zh not_active IP Right Cessation
-
2017
- 2017-09-26 AU AU2017235907A patent/AU2017235907A1/en not_active Withdrawn
-
2018
- 2018-02-06 US US15/889,743 patent/US10738340B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2012342114A1 (en) | 2014-05-22 |
WO2013076577A1 (en) | 2013-05-30 |
CA2853677A1 (en) | 2013-05-30 |
SG11201401927PA (en) | 2014-09-26 |
US20140308698A1 (en) | 2014-10-16 |
IN2014CN03557A (es) | 2015-10-09 |
MY170686A (en) | 2019-08-26 |
US10738340B2 (en) | 2020-08-11 |
JP2014533518A (ja) | 2014-12-15 |
AU2012342114B2 (en) | 2017-12-21 |
KR20140099281A (ko) | 2014-08-11 |
KR101791597B1 (ko) | 2017-10-30 |
RU2633644C2 (ru) | 2017-10-16 |
CN103958693B (zh) | 2016-08-24 |
BR112014012543A2 (pt) | 2017-06-13 |
US9920349B2 (en) | 2018-03-20 |
AU2017235907A1 (en) | 2017-10-12 |
CN103958693A (zh) | 2014-07-30 |
HK1200494A1 (zh) | 2015-08-07 |
JP6084983B2 (ja) | 2017-02-22 |
MX2014006276A (es) | 2014-10-13 |
RU2014125216A (ru) | 2015-12-27 |
US20180237819A1 (en) | 2018-08-23 |
EP2783009B1 (en) | 2016-04-13 |
EP2783009A1 (en) | 2014-10-01 |
CA2853677C (en) | 2019-01-29 |
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