JP6084983B2 - モグロシド化合物の酵素的合成のための方法および材料 - Google Patents

モグロシド化合物の酵素的合成のための方法および材料 Download PDF

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JP6084983B2
JP6084983B2 JP2014542951A JP2014542951A JP6084983B2 JP 6084983 B2 JP6084983 B2 JP 6084983B2 JP 2014542951 A JP2014542951 A JP 2014542951A JP 2014542951 A JP2014542951 A JP 2014542951A JP 6084983 B2 JP6084983 B2 JP 6084983B2
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polypeptide
ugt
mogroside
amino acid
seq
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JP2014533518A (ja
JP2014533518A5 (enExample
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リウ，ヤオクァン
ヨプ イ，ジョン
ヨプ イ，ジョン
クハレ，モニカ
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Evolva Holding SA
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Evolva AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2014542951A 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料 Active JP6084983B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

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JP2014533518A JP2014533518A (ja) 2014-12-15
JP2014533518A5 JP2014533518A5 (enExample) 2016-09-29
JP6084983B2 true JP6084983B2 (ja) 2017-02-22

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JP2014542951A Active JP6084983B2 (ja) 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料

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US (2) US9920349B2 (enExample)
EP (1) EP2783009B1 (enExample)
JP (1) JP6084983B2 (enExample)
KR (1) KR101791597B1 (enExample)
CN (1) CN103958693B (enExample)
AU (2) AU2012342114B2 (enExample)
BR (1) BR112014012543A2 (enExample)
CA (1) CA2853677C (enExample)
IN (1) IN2014CN03557A (enExample)
MX (1) MX342851B (enExample)
MY (1) MY170686A (enExample)
RU (1) RU2633644C2 (enExample)
SG (1) SG11201401927PA (enExample)
WO (1) WO2013076577A1 (enExample)

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EP3009508B1 (en) 2011-08-08 2020-11-25 Evolva SA Recombinant production of steviol glycosides
JP6084983B2 (ja) 2011-11-23 2017-02-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の酵素的合成のための方法および材料
TW201402599A (zh) * 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
KR20170041209A (ko) 2014-08-11 2017-04-14 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
MY191735A (en) 2014-09-09 2022-07-13 Evolva Sa Production of steviol glycosides in recombinant hosts
US20170283844A1 (en) 2014-09-11 2017-10-05 The State of Israel, Ministry of Agriculture & Rural Development, Argricultural Research Organiza Methods of producing mogrosides and compositions comprising same and uses thereof
JP2017529860A (ja) 2014-10-01 2017-10-12 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料
CA2968331C (en) 2014-10-17 2024-02-06 Suntory Holdings Limited Mogrol glycosyltransferase and gene encoding same
EP3249044A4 (en) 2015-01-20 2018-11-07 Suntory Holdings Limited Method for preparing mogroside
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
MX2018001620A (es) 2015-08-07 2018-06-11 Evolva Sa Produccion de glucosidos de esteviol en hospedadores recombinantes.
HK1258515A1 (zh) 2015-10-29 2019-11-15 赛诺米克斯公司 高强度甜味剂
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
AU2017267214A1 (en) * 2016-05-16 2018-11-15 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3502265B1 (en) 2016-07-19 2020-12-02 Suntory Holdings Limited Method for producing mogrol or mogrol glycoside
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
MX2019012940A (es) * 2017-05-03 2019-12-16 Firmenich Incorporated Metodos para producir edulcorantes de alta intensidad.
WO2018213683A1 (en) 2017-05-19 2018-11-22 The Coca-Cola Company Siamenoside i sweetened compositions and uses of the same
CN116941752A (zh) 2017-06-02 2023-10-27 奇华顿股份有限公司 组合物
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
CA3118467A1 (en) 2018-11-07 2020-05-14 Firmenich Incorporated Methods for making high intensity sweeteners
EP3860363A1 (en) 2018-11-07 2021-08-11 Firmenich Incorporated Methods for making high intensity sweeteners
WO2020097588A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
JP2023523886A (ja) * 2020-03-17 2023-06-08 ザ コカ・コーラ カンパニー 新規モグロシド製造システム及び方法
EP4138574A1 (en) 2020-04-20 2023-03-01 Givaudan SA Compositions
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
WO2024218244A1 (en) 2023-04-20 2024-10-24 Dsm Ip Assets B.V. Strains and methods for the production of mogrosides

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US8257948B1 (en) * 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
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RU2008123259A (ru) 2005-11-23 2009-12-27 Дзе Кока-Кола Компани (US) Композиция интенсивного подсластителя с противовоспалительным средством и подслащенные ею композиции
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008062165A2 (en) * 2006-11-22 2008-05-29 The University Of York Monoterpenoid modifying enzymes
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KR101971818B1 (ko) 2010-06-02 2019-04-23 에볼바, 인크. 스테비올 글리코시드의 재조합 생산
JP6084983B2 (ja) 2011-11-23 2017-02-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の酵素的合成のための方法および材料
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015536157A (ja) * 2012-12-04 2015-12-21 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料

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Publication number Publication date
KR101791597B1 (ko) 2017-10-30
CA2853677A1 (en) 2013-05-30
US20180237819A1 (en) 2018-08-23
EP2783009A1 (en) 2014-10-01
AU2012342114A1 (en) 2014-05-22
KR20140099281A (ko) 2014-08-11
MX2014006276A (es) 2014-10-13
MY170686A (en) 2019-08-26
US20140308698A1 (en) 2014-10-16
JP2014533518A (ja) 2014-12-15
BR112014012543A2 (pt) 2017-06-13
US10738340B2 (en) 2020-08-11
IN2014CN03557A (enExample) 2015-10-09
HK1200494A1 (zh) 2015-08-07
AU2017235907A1 (en) 2017-10-12
WO2013076577A1 (en) 2013-05-30
RU2633644C2 (ru) 2017-10-16
US9920349B2 (en) 2018-03-20
SG11201401927PA (en) 2014-09-26
CN103958693A (zh) 2014-07-30
RU2014125216A (ru) 2015-12-27
AU2012342114B2 (en) 2017-12-21
CA2853677C (en) 2019-01-29
CN103958693B (zh) 2016-08-24
MX342851B (es) 2016-10-14
EP2783009B1 (en) 2016-04-13

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