JP6084983B2 - モグロシド化合物の酵素的合成のための方法および材料 - Google Patents

モグロシド化合物の酵素的合成のための方法および材料 Download PDF

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JP6084983B2
JP6084983B2 JP2014542951A JP2014542951A JP6084983B2 JP 6084983 B2 JP6084983 B2 JP 6084983B2 JP 2014542951 A JP2014542951 A JP 2014542951A JP 2014542951 A JP2014542951 A JP 2014542951A JP 6084983 B2 JP6084983 B2 JP 6084983B2
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polypeptide
ugt
mogroside
amino acid
seq
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JP2014533518A (ja
JP2014533518A5 (enExample
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リウ，ヤオクァン
ヨプ イ，ジョン
ヨプ イ，ジョン
クハレ，モニカ
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Evolva Holding SA
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Evolva AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2014542951A 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料 Active JP6084983B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

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JP2014533518A JP2014533518A (ja) 2014-12-15
JP2014533518A5 JP2014533518A5 (enExample) 2016-09-29
JP6084983B2 true JP6084983B2 (ja) 2017-02-22

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JP2014542951A Active JP6084983B2 (ja) 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料

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US (2) US9920349B2 (enExample)
EP (1) EP2783009B1 (enExample)
JP (1) JP6084983B2 (enExample)
KR (1) KR101791597B1 (enExample)
CN (1) CN103958693B (enExample)
AU (2) AU2012342114B2 (enExample)
BR (1) BR112014012543A2 (enExample)
CA (1) CA2853677C (enExample)
IN (1) IN2014CN03557A (enExample)
MX (1) MX342851B (enExample)
MY (1) MY170686A (enExample)
RU (1) RU2633644C2 (enExample)
SG (1) SG11201401927PA (enExample)
WO (1) WO2013076577A1 (enExample)

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SG11201401927PA (en) 2011-11-23 2014-09-26 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
TW201402599A (zh) * 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
WO2016023844A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2972739A1 (en) 2014-09-11 2016-03-17 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of producing mogrosides and compositions comprising same and uses thereof
JP2017529860A (ja) 2014-10-01 2017-10-12 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料
JP6698028B2 (ja) * 2014-10-17 2020-05-27 サントリーホールディングス株式会社 モグロール配糖体化酵素およびそれをコードする遺伝子
CA2974185A1 (en) 2015-01-20 2016-07-28 Suntory Holdings Limited Method for preparing mogroside
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
EP3332018B1 (en) 2015-08-07 2022-07-27 Evolva SA Production of steviol glycosides in recombinant hosts
MX395362B (es) 2015-10-29 2025-03-11 Firmenich Incorporated Edulcorantes de alta intensidad
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
MY198001A (en) 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
JP2019519212A (ja) * 2016-05-16 2019-07-11 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
JP6845244B2 (ja) * 2016-07-19 2021-03-17 サントリーホールディングス株式会社 モグロールまたはモグロール配糖体の生産方法
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
EP3615679A4 (en) 2017-05-03 2021-02-17 Firmenich Incorporated PROCESS FOR THE MANUFACTURING OF HIGHLY INTENSE SWEETENERS
US11653680B2 (en) 2017-05-19 2023-05-23 The Coca-Cola Company Siamenoside I sweetened compositions and uses of the same
CN110719738B (zh) 2017-06-02 2023-06-09 奇华顿股份有限公司 组合物
WO2021214008A1 (en) 2020-04-20 2021-10-28 Givaudan Sa Compositions
US11248248B2 (en) 2017-06-15 2022-02-15 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
KR20210090218A (ko) 2018-11-07 2021-07-19 피르메니히 인코포레이티드 고강도 감미료의 제조 방법
CN113286523A (zh) 2018-11-07 2021-08-20 弗门尼舍公司 制备高强度甜味剂的方法
CA3118924A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
MX2022011627A (es) * 2020-03-17 2022-12-15 Coca Cola Co Nuevo sistema y métodos de producción de mogrósidos.
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
WO2024218244A1 (en) 2023-04-20 2024-10-24 Dsm Ip Assets B.V. Strains and methods for the production of mogrosides

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RU2008122901A (ru) 2005-11-23 2009-12-27 Дзе Кока-Кола Компани (US) Композиция интенсивного подсластителя с сапонином и подслащенные ею композиции
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008062165A2 (en) * 2006-11-22 2008-05-29 The University Of York Monoterpenoid modifying enzymes
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CA3176307A1 (en) 2010-06-02 2011-12-08 Evolva Nutrition, Inc. Recombinant production of steviol glycosides
SG11201401927PA (en) 2011-11-23 2014-09-26 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
MX367859B (es) 2012-12-04 2019-09-09 Evolva Sa Metodos y materiales para la biosintesis de compuestos mogrosidos.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015536157A (ja) * 2012-12-04 2015-12-21 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料

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MX342851B (es) 2016-10-14
AU2012342114A1 (en) 2014-05-22
US9920349B2 (en) 2018-03-20
CA2853677A1 (en) 2013-05-30
CA2853677C (en) 2019-01-29
IN2014CN03557A (enExample) 2015-10-09
AU2012342114B2 (en) 2017-12-21
HK1200494A1 (zh) 2015-08-07
AU2017235907A1 (en) 2017-10-12
CN103958693A (zh) 2014-07-30
WO2013076577A1 (en) 2013-05-30
US20140308698A1 (en) 2014-10-16
US10738340B2 (en) 2020-08-11
JP2014533518A (ja) 2014-12-15
RU2633644C2 (ru) 2017-10-16
KR20140099281A (ko) 2014-08-11
MY170686A (en) 2019-08-26
SG11201401927PA (en) 2014-09-26
EP2783009A1 (en) 2014-10-01
CN103958693B (zh) 2016-08-24
RU2014125216A (ru) 2015-12-27
EP2783009B1 (en) 2016-04-13
US20180237819A1 (en) 2018-08-23
BR112014012543A2 (pt) 2017-06-13
KR101791597B1 (ko) 2017-10-30
MX2014006276A (es) 2014-10-13

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