RU2633644C2 - Способы ферментативного синтеза могрозидных соединений - Google Patents

Способы ферментативного синтеза могрозидных соединений Download PDF

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Publication number
RU2633644C2
RU2633644C2 RU2014125216A RU2014125216A RU2633644C2 RU 2633644 C2 RU2633644 C2 RU 2633644C2 RU 2014125216 A RU2014125216 A RU 2014125216A RU 2014125216 A RU2014125216 A RU 2014125216A RU 2633644 C2 RU2633644 C2 RU 2633644C2
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mogroside
recombinant
mogroside compound
mogrol
polypeptide
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RU2014125216A
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English (en)
Russian (ru)
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RU2014125216A (ru
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Яоцюань Лю
Дзунг Йеоп ЛИ
Моника КХАРЕ
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Эвольва Са
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
RU2014125216A 2011-11-23 2012-11-19 Способы ферментативного синтеза могрозидных соединений RU2633644C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

Publications (2)

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RU2014125216A RU2014125216A (ru) 2015-12-27
RU2633644C2 true RU2633644C2 (ru) 2017-10-16

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RU2014125216A RU2633644C2 (ru) 2011-11-23 2012-11-19 Способы ферментативного синтеза могрозидных соединений

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US (2) US9920349B2 (enExample)
EP (1) EP2783009B1 (enExample)
JP (1) JP6084983B2 (enExample)
KR (1) KR101791597B1 (enExample)
CN (1) CN103958693B (enExample)
AU (2) AU2012342114B2 (enExample)
BR (1) BR112014012543A2 (enExample)
CA (1) CA2853677C (enExample)
IN (1) IN2014CN03557A (enExample)
MX (1) MX342851B (enExample)
MY (1) MY170686A (enExample)
RU (1) RU2633644C2 (enExample)
SG (1) SG11201401927PA (enExample)
WO (1) WO2013076577A1 (enExample)

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IN2014CN03557A (enExample) 2011-11-23 2015-10-09 Evolva Sa
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HK1215053A1 (zh) 2012-12-04 2016-08-12 Evolva Sa 用作生物合成罗汉果化合物的方法及材料
WO2016050890A2 (en) * 2014-10-01 2016-04-07 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
EP3179869A1 (en) 2014-08-11 2017-06-21 Evolva SA Production of steviol glycosides in recombinant hosts
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
WO2016038617A1 (en) 2014-09-11 2016-03-17 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of producing mogrosides and compositions comprising same and uses thereof
WO2016060276A1 (ja) 2014-10-17 2016-04-21 サントリーホールディングス株式会社 モグロール配糖体化酵素およびそれをコードする遺伝子
JP6850130B2 (ja) 2015-01-20 2021-03-31 サントリーホールディングス株式会社 モグロシドの調製方法
EP3250686A1 (en) 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
NZ741741A (en) 2015-10-29 2019-08-30 Senomyx Inc High intensity sweeteners
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
MY198001A (en) 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458598A1 (en) * 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2018016483A1 (ja) * 2016-07-19 2018-01-25 サントリーホールディングス株式会社 モグロールまたはモグロール配糖体の生産方法
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112019023104A2 (pt) 2017-05-03 2020-11-03 Firmenich Incorporated métodos para fazer adoçante de alta intensidade
EP3624595A4 (en) 2017-05-19 2021-03-03 The Coca-Cola Company COMPOSITIONS SWEETED WITH SIAMENOSIDE I AND USES THEREOF
EP3629764A1 (en) 2017-06-02 2020-04-08 Givaudan SA Compositions
WO2021214008A1 (en) 2020-04-20 2021-10-28 Givaudan Sa Compositions
US11248248B2 (en) 2017-06-15 2022-02-15 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
CN113286523A (zh) 2018-11-07 2021-08-20 弗门尼舍公司 制备高强度甜味剂的方法
WO2020096905A1 (en) 2018-11-07 2020-05-14 Firmenich Incorporated Methods for making high intensity sweeteners
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
BR112022018627A2 (pt) * 2020-03-17 2022-12-20 Coca Cola Co Sistemas e métodos inovadores de produção de mogrosídeo
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
EP4698673A1 (en) 2023-04-20 2026-02-25 DSM IP Assets B.V. Strains and methods for the production of mogrosides

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Also Published As

Publication number Publication date
CN103958693B (zh) 2016-08-24
EP2783009B1 (en) 2016-04-13
US20180237819A1 (en) 2018-08-23
BR112014012543A2 (pt) 2017-06-13
IN2014CN03557A (enExample) 2015-10-09
US20140308698A1 (en) 2014-10-16
EP2783009A1 (en) 2014-10-01
AU2012342114A1 (en) 2014-05-22
AU2017235907A1 (en) 2017-10-12
CA2853677A1 (en) 2013-05-30
JP6084983B2 (ja) 2017-02-22
US10738340B2 (en) 2020-08-11
MX342851B (es) 2016-10-14
CA2853677C (en) 2019-01-29
KR20140099281A (ko) 2014-08-11
AU2012342114B2 (en) 2017-12-21
JP2014533518A (ja) 2014-12-15
MY170686A (en) 2019-08-26
SG11201401927PA (en) 2014-09-26
MX2014006276A (es) 2014-10-13
RU2014125216A (ru) 2015-12-27
US9920349B2 (en) 2018-03-20
WO2013076577A1 (en) 2013-05-30
CN103958693A (zh) 2014-07-30
KR101791597B1 (ko) 2017-10-30
HK1200494A1 (zh) 2015-08-07

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Effective date: 20191120