RU2633644C2 - Способы ферментативного синтеза могрозидных соединений - Google Patents

Способы ферментативного синтеза могрозидных соединений Download PDF

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RU2633644C2
RU2633644C2 RU2014125216A RU2014125216A RU2633644C2 RU 2633644 C2 RU2633644 C2 RU 2633644C2 RU 2014125216 A RU2014125216 A RU 2014125216A RU 2014125216 A RU2014125216 A RU 2014125216A RU 2633644 C2 RU2633644 C2 RU 2633644C2
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mogroside
recombinant
mogroside compound
mogrol
polypeptide
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RU2014125216A
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English (en)
Russian (ru)
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RU2014125216A (ru
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Яоцюань Лю
Дзунг Йеоп ЛИ
Моника КХАРЕ
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Эвольва Са
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
RU2014125216A 2011-11-23 2012-11-19 Способы ферментативного синтеза могрозидных соединений RU2633644C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

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RU2014125216A RU2014125216A (ru) 2015-12-27
RU2633644C2 true RU2633644C2 (ru) 2017-10-16

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RU2014125216A RU2633644C2 (ru) 2011-11-23 2012-11-19 Способы ферментативного синтеза могрозидных соединений

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US (2) US9920349B2 (enExample)
EP (1) EP2783009B1 (enExample)
JP (1) JP6084983B2 (enExample)
KR (1) KR101791597B1 (enExample)
CN (1) CN103958693B (enExample)
AU (2) AU2012342114B2 (enExample)
BR (1) BR112014012543A2 (enExample)
CA (1) CA2853677C (enExample)
IN (1) IN2014CN03557A (enExample)
MX (1) MX342851B (enExample)
MY (1) MY170686A (enExample)
RU (1) RU2633644C2 (enExample)
SG (1) SG11201401927PA (enExample)
WO (1) WO2013076577A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101971818B1 (ko) 2010-06-02 2019-04-23 에볼바, 인크. 스테비올 글리코시드의 재조합 생산
EP3009508B1 (en) 2011-08-08 2020-11-25 Evolva SA Recombinant production of steviol glycosides
JP6084983B2 (ja) 2011-11-23 2017-02-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の酵素的合成のための方法および材料
TW201402599A (zh) * 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
KR20170041209A (ko) 2014-08-11 2017-04-14 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 생성
MY191735A (en) 2014-09-09 2022-07-13 Evolva Sa Production of steviol glycosides in recombinant hosts
US20170283844A1 (en) 2014-09-11 2017-10-05 The State of Israel, Ministry of Agriculture & Rural Development, Argricultural Research Organiza Methods of producing mogrosides and compositions comprising same and uses thereof
JP2017529860A (ja) 2014-10-01 2017-10-12 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料
CA2968331C (en) 2014-10-17 2024-02-06 Suntory Holdings Limited Mogrol glycosyltransferase and gene encoding same
EP3249044A4 (en) 2015-01-20 2018-11-07 Suntory Holdings Limited Method for preparing mogroside
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
MX2018001620A (es) 2015-08-07 2018-06-11 Evolva Sa Produccion de glucosidos de esteviol en hospedadores recombinantes.
HK1258515A1 (zh) 2015-10-29 2019-11-15 赛诺米克斯公司 高强度甜味剂
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
AU2017267214A1 (en) * 2016-05-16 2018-11-15 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3502265B1 (en) 2016-07-19 2020-12-02 Suntory Holdings Limited Method for producing mogrol or mogrol glycoside
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
MX2019012940A (es) * 2017-05-03 2019-12-16 Firmenich Incorporated Metodos para producir edulcorantes de alta intensidad.
WO2018213683A1 (en) 2017-05-19 2018-11-22 The Coca-Cola Company Siamenoside i sweetened compositions and uses of the same
CN116941752A (zh) 2017-06-02 2023-10-27 奇华顿股份有限公司 组合物
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
CA3118467A1 (en) 2018-11-07 2020-05-14 Firmenich Incorporated Methods for making high intensity sweeteners
EP3860363A1 (en) 2018-11-07 2021-08-11 Firmenich Incorporated Methods for making high intensity sweeteners
WO2020097588A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
JP2023523886A (ja) * 2020-03-17 2023-06-08 ザ コカ・コーラ カンパニー 新規モグロシド製造システム及び方法
EP4138574A1 (en) 2020-04-20 2023-03-01 Givaudan SA Compositions
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
WO2024218244A1 (en) 2023-04-20 2024-10-24 Dsm Ip Assets B.V. Strains and methods for the production of mogrosides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012845A1 (en) * 1999-08-18 2001-02-22 National Research Council Of Canada Screening for udp-glucose: glycoprotein glucosyltransferase (uggt) activity
RU2008123244A (ru) * 2005-11-23 2009-12-27 Дзе Кока-Кола Компани (US) Композиция интенсивного подсластителя с глюкозамином и подслащенные ею композиции

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1510573A1 (en) * 2003-09-01 2005-03-02 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Method for detoxification of mycotoxins
US20080148432A1 (en) * 2005-12-21 2008-06-19 Mark Scott Abad Transgenic plants with enhanced agronomic traits
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
US8257948B1 (en) * 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8956677B2 (en) 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008062165A2 (en) * 2006-11-22 2008-05-29 The University Of York Monoterpenoid modifying enzymes
WO2008065370A2 (en) 2006-12-01 2008-06-05 The University Of York Sesquiterpenoid modifying enzymes
GB0904639D0 (en) * 2009-03-18 2009-04-29 Univ York Assay
KR101971818B1 (ko) 2010-06-02 2019-04-23 에볼바, 인크. 스테비올 글리코시드의 재조합 생산
JP6084983B2 (ja) 2011-11-23 2017-02-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の酵素的合成のための方法および材料
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012845A1 (en) * 1999-08-18 2001-02-22 National Research Council Of Canada Screening for udp-glucose: glycoprotein glucosyltransferase (uggt) activity
RU2008123244A (ru) * 2005-11-23 2009-12-27 Дзе Кока-Кола Компани (US) Композиция интенсивного подсластителя с глюкозамином и подслащенные ею композиции

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
POPPENBERGER B. et al. "Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana", Journal of Biological Chemistry, 2003, v.278, no.48, p.47905-47914. *
RICHMAN A. et al. "Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana", The Plant Journal, 2005, v.41, p.56-67. *
RICHMAN A. et al. "Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana", The Plant Journal, 2005, v.41, p.56-67. TANG Q. et al. "An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis", BMC GENOMICS, 05.07.2011, v.12, no.343, p.1-13. SHAO Hui et al. "Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula", The Plant Cell, 2005, v.17, no.11, p.3141-3154. *
SHAO Hui et al. "Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula", The Plant Cell, 2005, v.17, no.11, p.3141-3154. *
TANG Q. et al. "An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis", BMC GENOMICS, 05.07.2011, v.12, no.343, p.1-13. *

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Publication number Publication date
KR101791597B1 (ko) 2017-10-30
CA2853677A1 (en) 2013-05-30
US20180237819A1 (en) 2018-08-23
EP2783009A1 (en) 2014-10-01
AU2012342114A1 (en) 2014-05-22
KR20140099281A (ko) 2014-08-11
MX2014006276A (es) 2014-10-13
MY170686A (en) 2019-08-26
US20140308698A1 (en) 2014-10-16
JP2014533518A (ja) 2014-12-15
BR112014012543A2 (pt) 2017-06-13
US10738340B2 (en) 2020-08-11
IN2014CN03557A (enExample) 2015-10-09
HK1200494A1 (zh) 2015-08-07
AU2017235907A1 (en) 2017-10-12
WO2013076577A1 (en) 2013-05-30
JP6084983B2 (ja) 2017-02-22
US9920349B2 (en) 2018-03-20
SG11201401927PA (en) 2014-09-26
CN103958693A (zh) 2014-07-30
RU2014125216A (ru) 2015-12-27
AU2012342114B2 (en) 2017-12-21
CA2853677C (en) 2019-01-29
CN103958693B (zh) 2016-08-24
MX342851B (es) 2016-10-14
EP2783009B1 (en) 2016-04-13

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