AU2012342114B2 - Methods and materials for enzymatic synthesis of mogroside compounds - Google Patents

Methods and materials for enzymatic synthesis of mogroside compounds Download PDF

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Publication number
AU2012342114B2
AU2012342114B2 AU2012342114A AU2012342114A AU2012342114B2 AU 2012342114 B2 AU2012342114 B2 AU 2012342114B2 AU 2012342114 A AU2012342114 A AU 2012342114A AU 2012342114 A AU2012342114 A AU 2012342114A AU 2012342114 B2 AU2012342114 B2 AU 2012342114B2
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mogroside
polypeptide
amino acid
seq
set forth
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AU2012342114A1 (en
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Monika KHARE
Jung Yeop Lee
Yaoquan Liu
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Danstar Ferment AG
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Danstar Ferment AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2012342114A 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds Active AU2012342114B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017235907A AU2017235907A1 (en) 2011-11-23 2017-09-26 Methods and materials for enzymatic synthesis of mogroside compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

Related Child Applications (1)

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AU2017235907A Division AU2017235907A1 (en) 2011-11-23 2017-09-26 Methods and materials for enzymatic synthesis of mogroside compounds

Publications (2)

Publication Number Publication Date
AU2012342114A1 AU2012342114A1 (en) 2014-05-22
AU2012342114B2 true AU2012342114B2 (en) 2017-12-21

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AU2012342114A Active AU2012342114B2 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds
AU2017235907A Withdrawn AU2017235907A1 (en) 2011-11-23 2017-09-26 Methods and materials for enzymatic synthesis of mogroside compounds

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AU2017235907A Withdrawn AU2017235907A1 (en) 2011-11-23 2017-09-26 Methods and materials for enzymatic synthesis of mogroside compounds

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US (2) US9920349B2 (enExample)
EP (1) EP2783009B1 (enExample)
JP (1) JP6084983B2 (enExample)
KR (1) KR101791597B1 (enExample)
CN (1) CN103958693B (enExample)
AU (2) AU2012342114B2 (enExample)
BR (1) BR112014012543A2 (enExample)
CA (1) CA2853677C (enExample)
IN (1) IN2014CN03557A (enExample)
MX (1) MX342851B (enExample)
MY (1) MY170686A (enExample)
RU (1) RU2633644C2 (enExample)
SG (1) SG11201401927PA (enExample)
WO (1) WO2013076577A1 (enExample)

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AU2012342114B2 (en) 2011-11-23 2017-12-21 Danstar Ferment Ag Methods and materials for enzymatic synthesis of mogroside compounds
TW201402599A (zh) * 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
WO2016050890A2 (en) 2014-10-01 2016-04-07 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
US9932619B2 (en) * 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3191584A4 (en) 2014-09-11 2018-07-18 The State of Israel - Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Methods of producing mogrosides and compositions comprising same and uses thereof
EP3208342A4 (en) * 2014-10-17 2018-07-04 Suntory Holdings Limited Mogrol glycosyltransferase and gene encoding same
CA2974185A1 (en) 2015-01-20 2016-07-28 Suntory Holdings Limited Method for preparing mogroside
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
JP6949838B2 (ja) 2015-10-29 2021-10-13 フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ 高甘味度甘味料
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017198681A1 (en) * 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109477126B (zh) 2016-07-19 2023-06-20 三得利控股株式会社 罗汉果醇或罗汉果醇糖苷的生产方法
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
JP7285786B2 (ja) 2017-05-03 2023-06-02 フィルメニッヒ インコーポレイテッド 高強度の甘味料の製造方法
JP7285788B2 (ja) 2017-05-19 2023-06-02 ザ コカ・コーラ カンパニー シアメノシドｉ甘味料入り組成物及びその使用
CN116941752A (zh) 2017-06-02 2023-10-27 奇华顿股份有限公司 组合物
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
JP2022512931A (ja) 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
US12286661B2 (en) 2018-11-07 2025-04-29 Firmenich Incorporated Methods for making high intensity sweeteners
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
MX2022011627A (es) * 2020-03-17 2022-12-15 Coca Cola Co Nuevo sistema y métodos de producción de mogrósidos.
CA3179775A1 (en) 2020-04-20 2021-10-28 Givaudan Sa Compositions
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
CN121127603A (zh) 2023-04-20 2025-12-12 帝斯曼知识产权资产管理有限公司 用于产生罗汉果苷的菌株和方法

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EP1510573A1 (en) * 2003-09-01 2005-03-02 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Method for detoxification of mycotoxins
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RU2444900C2 (ru) * 2005-11-23 2012-03-20 Дзе Кока-Кола Компани Молочная композиция с интенсивным подсластителем
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GB0904639D0 (en) * 2009-03-18 2009-04-29 Univ York Assay
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
AU2012342114B2 (en) 2011-11-23 2017-12-21 Danstar Ferment Ag Methods and materials for enzymatic synthesis of mogroside compounds
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds

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Also Published As

Publication number Publication date
US20140308698A1 (en) 2014-10-16
US20180237819A1 (en) 2018-08-23
CA2853677A1 (en) 2013-05-30
EP2783009A1 (en) 2014-10-01
JP6084983B2 (ja) 2017-02-22
CA2853677C (en) 2019-01-29
KR101791597B1 (ko) 2017-10-30
AU2017235907A1 (en) 2017-10-12
MX2014006276A (es) 2014-10-13
EP2783009B1 (en) 2016-04-13
BR112014012543A2 (pt) 2017-06-13
CN103958693A (zh) 2014-07-30
KR20140099281A (ko) 2014-08-11
SG11201401927PA (en) 2014-09-26
WO2013076577A1 (en) 2013-05-30
CN103958693B (zh) 2016-08-24
RU2014125216A (ru) 2015-12-27
US9920349B2 (en) 2018-03-20
MY170686A (en) 2019-08-26
RU2633644C2 (ru) 2017-10-16
HK1200494A1 (zh) 2015-08-07
JP2014533518A (ja) 2014-12-15
US10738340B2 (en) 2020-08-11
MX342851B (es) 2016-10-14
AU2012342114A1 (en) 2014-05-22
IN2014CN03557A (enExample) 2015-10-09

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Free format text: (2017) APO 57: DECISION: THE SPECIFICATION IS CONSIDERED CLEAR ENOUGH AND COMPLETE ENOUGH FOR THE INVENTION TO BE PERFORMED BY THE SKILLED PERSON. I DIRECT THE APPLICATION TO PROCEED TO ACCEPTANCE.

Effective date: 20171114

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Owner name: DANSTAR FERMENT AG

Free format text: FORMER NAME(S): EVOLVA SA