JP2014533281A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014533281A5 JP2014533281A5 JP2014541351A JP2014541351A JP2014533281A5 JP 2014533281 A5 JP2014533281 A5 JP 2014533281A5 JP 2014541351 A JP2014541351 A JP 2014541351A JP 2014541351 A JP2014541351 A JP 2014541351A JP 2014533281 A5 JP2014533281 A5 JP 2014533281A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- ring
- sulfur
- oxygen
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 86
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 64
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 64
- 125000005842 heteroatom Chemical group 0.000 claims description 64
- 229910052757 nitrogen Inorganic materials 0.000 claims description 64
- 229910052760 oxygen Inorganic materials 0.000 claims description 64
- 239000001301 oxygen Substances 0.000 claims description 64
- 229910052717 sulfur Inorganic materials 0.000 claims description 62
- 239000011593 sulfur Substances 0.000 claims description 62
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 42
- 229920006395 saturated elastomer Polymers 0.000 claims description 32
- 229910052736 halogen Inorganic materials 0.000 claims description 30
- 150000002367 halogens Chemical class 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 26
- 125000001931 aliphatic group Chemical group 0.000 claims description 24
- 125000002950 monocyclic group Chemical group 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000001047 cyclobutenyl group Chemical group C1(=CCC1)* 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 208000030159 metabolic disease Diseases 0.000 claims description 8
- 125000003566 oxetanyl group Chemical group 0.000 claims description 8
- 208000008589 Obesity Diseases 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 235000020824 obesity Nutrition 0.000 claims description 6
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 4
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 208000030852 Parasitic disease Diseases 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 125000002837 carbocyclic group Chemical group 0.000 claims description 4
- 229910052805 deuterium Inorganic materials 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000002538 fungal effect Effects 0.000 claims description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 4
- 230000003071 parasitic effect Effects 0.000 claims description 4
- 230000002062 proliferating effect Effects 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 208000008020 Cohen syndrome Diseases 0.000 claims description 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
- 102000004877 Insulin Human genes 0.000 claims description 2
- 108090001061 Insulin Proteins 0.000 claims description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 2
- 208000012708 MOMO syndrome Diseases 0.000 claims description 2
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 2
- 229940100389 Sulfonylurea Drugs 0.000 claims description 2
- 229940123464 Thiazolidinedione Drugs 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 229940125681 anticonvulsant agent Drugs 0.000 claims description 2
- 239000001961 anticonvulsive agent Substances 0.000 claims description 2
- 239000000935 antidepressant agent Substances 0.000 claims description 2
- 229940005513 antidepressants Drugs 0.000 claims description 2
- 239000000164 antipsychotic agent Substances 0.000 claims description 2
- 229940005529 antipsychotics Drugs 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000005605 benzo group Chemical group 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 229940124558 contraceptive agent Drugs 0.000 claims description 2
- 239000003433 contraceptive agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000003054 hormonal effect Effects 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 229940125396 insulin Drugs 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 125000002971 oxazolyl group Chemical group 0.000 claims description 2
- 229960002036 phenytoin Drugs 0.000 claims description 2
- FIADGNVRKBPQEU-UHFFFAOYSA-N pizotifen Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CCC2=C1C=CS2 FIADGNVRKBPQEU-UHFFFAOYSA-N 0.000 claims description 2
- 229960004572 pizotifen Drugs 0.000 claims description 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 2
- 150000001467 thiazolidinediones Chemical class 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 229940102566 valproate Drugs 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 6
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 6
- 108010018763 Biotin carboxylase Proteins 0.000 description 6
- 0 C*CCC(C)N(C(C(C(*)=C(C)*1)=C1N1*)=O)C1=O Chemical compound C*CCC(C)N(C(C(C(*)=C(C)*1)=C1N1*)=O)C1=O 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559023P | 2011-11-11 | 2011-11-11 | |
| US61/559,023 | 2011-11-11 | ||
| US201261615092P | 2012-03-23 | 2012-03-23 | |
| US61/615,092 | 2012-03-23 | ||
| US201261651878P | 2012-05-25 | 2012-05-25 | |
| US61/651,878 | 2012-05-25 | ||
| US201261675513P | 2012-07-25 | 2012-07-25 | |
| US61/675,513 | 2012-07-25 | ||
| PCT/US2012/064528 WO2013071169A1 (en) | 2011-11-11 | 2012-11-09 | Acc inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051746A Division JP6276442B2 (ja) | 2011-11-11 | 2017-03-16 | Ａｃｃ阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533281A JP2014533281A (ja) | 2014-12-11 |
| JP2014533281A5 true JP2014533281A5 (enExample) | 2015-12-24 |
| JP6114297B2 JP6114297B2 (ja) | 2017-04-12 |
Family
ID=48281206
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541351A Active JP6114297B2 (ja) | 2011-11-11 | 2012-11-09 | Ａｃｃ阻害剤およびその使用 |
| JP2017051746A Active JP6276442B2 (ja) | 2011-11-11 | 2017-03-16 | Ａｃｃ阻害剤およびその使用 |
| JP2018002648A Active JP6543358B2 (ja) | 2011-11-11 | 2018-01-11 | Ａｃｃ阻害剤およびその使用 |
| JP2019111246A Active JP6756014B2 (ja) | 2011-11-11 | 2019-06-14 | Ａｃｃ阻害剤およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051746A Active JP6276442B2 (ja) | 2011-11-11 | 2017-03-16 | Ａｃｃ阻害剤およびその使用 |
| JP2018002648A Active JP6543358B2 (ja) | 2011-11-11 | 2018-01-11 | Ａｃｃ阻害剤およびその使用 |
| JP2019111246A Active JP6756014B2 (ja) | 2011-11-11 | 2019-06-14 | Ａｃｃ阻害剤およびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US8969557B2 (enExample) |
| EP (3) | EP3628320B1 (enExample) |
| JP (4) | JP6114297B2 (enExample) |
| KR (3) | KR102172902B1 (enExample) |
| CN (3) | CN104105485B (enExample) |
| AU (3) | AU2012335088B2 (enExample) |
| BR (2) | BR122019026836B1 (enExample) |
| CA (1) | CA2855372C (enExample) |
| CL (1) | CL2014001241A1 (enExample) |
| CY (2) | CY1120224T1 (enExample) |
| DK (2) | DK2776038T3 (enExample) |
| EA (2) | EA033598B1 (enExample) |
| ES (3) | ES2665580T3 (enExample) |
| HR (2) | HRP20180534T1 (enExample) |
| HU (2) | HUE037444T2 (enExample) |
| LT (2) | LT3329919T (enExample) |
| MX (3) | MX344490B (enExample) |
| PL (3) | PL3329919T3 (enExample) |
| PT (2) | PT2776038T (enExample) |
| RS (1) | RS57157B1 (enExample) |
| SI (2) | SI3329919T1 (enExample) |
| SM (1) | SMT201800191T1 (enExample) |
| TW (4) | TWI582095B (enExample) |
| UA (2) | UA114901C2 (enExample) |
| WO (1) | WO2013071169A1 (enExample) |
| ZA (3) | ZA201403633B (enExample) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| CA2855372C (en) | 2011-11-11 | 2022-03-22 | Nimbus Apollo, Inc. | 2,4-dioxo-thieno[2,3-d]pyrimidinyl derivatives and pharmaceutical compositions thereof used as acc inhibitors |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| PT2861611T (pt) | 2012-05-25 | 2016-10-11 | Janssen Sciences Ireland Uc | Nucleósidos de espirooxetano de uracilo |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| HK1215166A1 (zh) | 2012-12-18 | 2016-08-19 | Almirall, S.A. | 具有β2肾上腺素激动剂及M3毒蕈碱拮抗剂活性的新型环己基和奎宁环基氨基甲酸酯衍生物 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| HK1221411A1 (zh) | 2013-05-10 | 2017-06-02 | Gilead Apollo, Inc. | Acc抑制剂和其用途 |
| CN105358143B (zh) | 2013-05-10 | 2019-01-22 | 吉利德阿波罗公司 | Acc抑制剂和其用途 |
| HK1221420A1 (zh) | 2013-05-10 | 2017-06-02 | Gilead Apollo, Inc. | Acc抑制剂和其用途 |
| KR20160007598A (ko) * | 2013-05-10 | 2016-01-20 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| WO2015003879A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicylic derivatives |
| WO2015003881A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007451A1 (en) | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015010832A1 (en) * | 2013-07-22 | 2015-01-29 | Syngenta Participations Ag | Microbiocidal heterocyclic derivatives |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| HK1217448A1 (zh) | 2013-09-12 | 2017-01-13 | 辉瑞大药厂 | 乙酰辅酶a羧化酶抑制剂用於治疗寻常痤疮的用途 |
| EP3055313B1 (de) | 2013-10-07 | 2017-11-22 | Bayer Pharma Aktiengesellschaft | Cyclische thienouracil-carboxamide und ihre verwendung |
| EP3670496A3 (en) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 inhibitors |
| RU2674977C2 (ru) * | 2013-10-30 | 2018-12-14 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения |
| HUE040254T2 (hu) | 2013-12-19 | 2019-02-28 | Novartis Ag | Protozoa proteaszóma inhibitor [1,2,4]triazolo[1,5-a]pirimidinszármazékok paraziták által okozott betegségek, például leishmaniasis kezelésére |
| EP3180345B1 (en) * | 2014-08-11 | 2018-10-10 | Hydra Biosciences, Inc. | Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| CN105779463B (zh) * | 2014-12-25 | 2019-08-09 | 深圳华大生命科学研究院 | Vps13b基因突变体及其应用 |
| EP3242722A4 (en) * | 2015-01-09 | 2018-07-11 | Gilead Apollo, LLC | Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease |
| UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
| US11078259B2 (en) * | 2015-06-05 | 2021-08-03 | Joslin Diabetes Center, Inc. | Methods and compositions for promoting thermogenic potential |
| CN105009933B (zh) * | 2015-06-10 | 2018-08-14 | 邓娟 | 一种以通风曲方式栽培草菇的工艺 |
| KR102443575B1 (ko) | 2015-07-06 | 2022-09-16 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| JP2018536660A (ja) * | 2015-11-25 | 2018-12-13 | ギリアド アポロ， エルエルシー | エステルａｃｃ阻害剤およびその使用 |
| AU2016361428A1 (en) * | 2015-11-25 | 2018-05-24 | Gilead Apollo, Llc | Triazole ACC inhibitors and uses thereof |
| MX2018006286A (es) * | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc pirazolicos y usos de los mismos. |
| EP3379933B1 (en) * | 2015-11-25 | 2023-02-15 | Gilead Apollo, LLC | Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine |
| JP7071917B2 (ja) | 2015-12-09 | 2022-05-19 | カデント セラピューティクス，インコーポレーテッド | ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用 |
| EP3386990B1 (en) | 2015-12-09 | 2023-04-19 | Novartis AG | Thienopyrimidinone nmda receptor modulators and uses thereof |
| WO2017147161A1 (en) * | 2016-02-23 | 2017-08-31 | Raju Mohan | Treatment of dermatological disorders or conditions |
| CA3220447C (en) * | 2016-03-02 | 2025-08-05 | Gilead Apollo, Llc | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND THEIR PRODUCTION PROCESSES |
| CN107286174B (zh) * | 2016-04-11 | 2020-08-18 | 上海勋和医药科技有限公司 | 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用 |
| CN107629071B (zh) * | 2016-07-19 | 2019-12-27 | 上海勋和医药科技有限公司 | 取代2，4-（1h,3h）嘧啶二酮作为parp抑制剂及其应用 |
| WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
| SG11201902588PA (en) | 2016-09-23 | 2019-05-30 | Bayer Ag | N3-Cyclically Substituted Thienouracils And Use Thereof |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| KR102577824B1 (ko) * | 2017-01-22 | 2023-09-13 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 티에노피리미딘 유도체 및 의약에서 이의 용도 |
| JP2020509038A (ja) * | 2017-03-03 | 2020-03-26 | ギリアド アポロ， エルエルシー | 殺真菌剤化合物を調製するための方法 |
| PL3589636T3 (pl) | 2017-03-03 | 2024-02-19 | Gilead Sciences, Inc. | Sposoby wytwarzania inhibitorów acc i ich form stałych |
| WO2018171699A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| TW201900167A (zh) | 2017-03-28 | 2019-01-01 | 美商基利科學股份有限公司 | 治療肝疾病之方法 |
| JP6906626B2 (ja) | 2017-03-28 | 2021-07-21 | ギリアード サイエンシーズ， インコーポレイテッド | 肝疾患を処置するための治療的組み合わせ |
| MX2019011543A (es) | 2017-03-31 | 2019-12-16 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical. |
| US20180333401A1 (en) | 2017-04-12 | 2018-11-22 | Gilead Sciences, Inc. | Methods of treating liver disease |
| CN107151251A (zh) * | 2017-05-10 | 2017-09-12 | 江苏开元药业有限公司 | 一种acc抑制剂药物关键中间体的制备方法 |
| US10495648B2 (en) | 2017-06-13 | 2019-12-03 | Gilead Sciences, Inc. | Methods of treating liver fibrosis |
| CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| US10995099B2 (en) * | 2017-07-17 | 2021-05-04 | Nanjing Ruijie Pharmatech Co., Ltd. | Compounds and their uses as ACC inhibitors |
| WO2019020041A1 (zh) * | 2017-07-26 | 2019-01-31 | 南京圣和药业股份有限公司 | 作为acc抑制剂的化合物及其应用 |
| JP2020528060A (ja) * | 2017-07-28 | 2020-09-17 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ピリミドンヘテロアリール誘導体の製造方法およびピリミドンヘテロアリール誘導体の中間体 |
| WO2019031384A1 (ja) * | 2017-08-07 | 2019-02-14 | 日本曹達株式会社 | １，３，５，６－テトラ置換チエノ［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤 |
| KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
| TWI814744B (zh) | 2017-10-06 | 2023-09-11 | 美商基利科學股份有限公司 | 包含acc抑制劑之組合療法 |
| WO2019072478A1 (en) | 2017-10-10 | 2019-04-18 | Galderma Research & Development | SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE |
| WO2019094777A1 (en) | 2017-11-13 | 2019-05-16 | Gilead Sciences, Inc. | Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes |
| CN108129251A (zh) * | 2017-12-22 | 2018-06-08 | 上海应用技术大学 | 一种2-乙基苯乙烯的合成工艺 |
| CN112218871B (zh) * | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
| JOP20210020A1 (ar) | 2018-08-03 | 2021-01-25 | Cadent Therapeutics Inc | معدلات عطرية غير متجانسة لمستقبل nmda واستخداماتها |
| CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| CN112739705B (zh) * | 2018-11-20 | 2022-08-16 | 中国医药研究开发中心有限公司 | 螺环类化合物及其医药用途 |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| IL284061B2 (en) | 2018-12-19 | 2025-02-01 | Corcept Therapeutics Inc | A preparation containing a relaxant |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| EP3669652A1 (en) | 2018-12-21 | 2020-06-24 | Bayer AG | Active compound combination |
| EA202191566A1 (ru) | 2019-01-15 | 2021-11-01 | Джилид Сайенсиз, Инк. | Соединения, модулирующие fxr (nr1h4) |
| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| US11058670B2 (en) | 2019-02-22 | 2021-07-13 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| CN113573700A (zh) | 2019-03-11 | 2021-10-29 | 吉利德科学公司 | 化合物的制剂及其用途 |
| CN111747916A (zh) * | 2019-03-27 | 2020-10-09 | 尚科生物医药（上海）有限公司 | (r)-2-(2-甲氧基苯基)-2-(四氢吡喃-4-氧基)乙-1-醇的制备方法 |
| CN109810085B (zh) * | 2019-04-19 | 2019-07-19 | 上海皓元生物医药科技有限公司 | Acc抑制剂及其中间体的制备方法 |
| CN111850061B (zh) * | 2019-04-30 | 2022-12-09 | 浙江工业大学 | 一种井冈羟胺a酯化物的制备方法 |
| CN110343650B (zh) * | 2019-05-28 | 2020-12-29 | 浙江工业大学 | 一种产两性霉素b的重组结节链霉菌及其应用 |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2020255946A1 (ja) * | 2019-06-17 | 2020-12-24 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物及び農園芸用殺菌剤 |
| JP7374233B2 (ja) * | 2019-07-02 | 2023-11-06 | ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 | 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用 |
| AR119594A1 (es) * | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| US20220347190A1 (en) | 2019-09-19 | 2022-11-03 | Novartis Ag | Treatment comprising fxr agonists |
| CN112574253B (zh) * | 2019-09-29 | 2021-08-27 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途 |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| EP4053120A4 (en) | 2019-10-28 | 2023-11-01 | Nippon Soda Co., Ltd. | COMPOUND 2,6-DIOXO-3,6-DIHYDROPYRIMIDINE, AGRICULTURAL AND HORTICULTURAL BACTERICIDE, NEMATICIDE AND MEDICAL AND VETERINARY ANTIFUNGAL AGENT |
| CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
| KR102775995B1 (ko) | 2019-11-15 | 2025-03-11 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도 |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| ES2960703T3 (es) | 2019-12-05 | 2024-03-06 | Zhangzhou Pien Tze Huang Pharm | Forma cristalina del compuesto de tieno[2,3-c]piridazina-4(1H)-ona, método de preparación de la misma y uso de la misma |
| EP4071154B1 (en) | 2019-12-05 | 2023-08-23 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form as inhibitor of acc1 and acc2, and preparation method therefor and use thereof |
| WO2021119432A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| US11655237B2 (en) | 2020-03-30 | 2023-05-23 | Gilead Sciences, Inc. | Solid forms of a Cot inhibitor compound |
| KR102850022B1 (ko) | 2020-04-02 | 2025-08-26 | 길리애드 사이언시즈, 인코포레이티드 | Cot 저해제 화합물의 제조 방법 |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN111513022B (zh) * | 2020-05-08 | 2021-11-12 | 武汉市农业科学院 | 一种低皮脂率的小体型肉鸭的选育方法 |
| WO2021235508A1 (ja) | 2020-05-21 | 2021-11-25 | 塩野義製薬株式会社 | 脂肪性肝疾患の治療用医薬 |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| JP7591066B2 (ja) | 2020-06-03 | 2024-11-27 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニスト及びそれらの使用 |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| CN113967213A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 一种包含苯基取代类acc抑制剂的组合物及其用途 |
| CN111888349B (zh) * | 2020-07-29 | 2021-10-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 印楝素在制备促进缺血超长随意皮瓣存活药物的作用 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CN116745299A (zh) * | 2021-02-07 | 2023-09-12 | 正大天晴药业集团股份有限公司 | 噻吩并嘧啶衍生物 |
| US12091404B2 (en) | 2021-03-11 | 2024-09-17 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| KR20230158542A (ko) | 2021-03-29 | 2023-11-20 | 길리애드 사이언시즈, 인코포레이티드 | Khk 억제제 |
| EP4344545A4 (en) | 2021-04-28 | 2025-03-26 | Nippon Soda Co., Ltd. | AGRICULTURAL AND HORTICULTURAL FUNGICIDE COMPOSITION |
| WO2022240879A1 (en) | 2021-05-11 | 2022-11-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| JP7691522B2 (ja) | 2021-05-13 | 2025-06-11 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｐａ受容体アンタゴニスト及びそれらの使用 |
| TW202345826A (zh) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑 |
| EP4434520A4 (en) | 2021-11-19 | 2025-10-29 | Shionogi & Co | PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF HEART DISEASE OR SKELETAL MUSCLE DISEASE |
| WO2023106175A1 (ja) * | 2021-12-08 | 2023-06-15 | 日本曹達株式会社 | ウラシル化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
| CA3238094A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| CA3263377A1 (en) | 2022-08-05 | 2024-02-08 | Gilead Sciences, Inc. | SARS-CoV-2 MAJOR PROTEASE INHIBITORS |
| EP4598513A1 (en) | 2022-10-06 | 2025-08-13 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| IL320512A (en) | 2022-10-28 | 2025-06-01 | Corcept Therapeutics Inc | Amyotrophic lateral sclerosis treatments using desocorilant |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3060084A (en) | 1961-06-09 | 1962-10-23 | Du Pont | Improved homogeneous, readily dispersed, pesticidal concentrate |
| US3299566A (en) | 1964-06-01 | 1967-01-24 | Olin Mathieson | Water soluble film containing agricultural chemicals |
| US3325503A (en) | 1965-02-18 | 1967-06-13 | Diamond Alkali Co | Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation |
| US3296272A (en) | 1965-04-01 | 1967-01-03 | Dow Chemical Co | Sulfinyl- and sulfonylpyridines |
| US4144050A (en) | 1969-02-05 | 1979-03-13 | Hoechst Aktiengesellschaft | Micro granules for pesticides and process for their manufacture |
| US3920442A (en) | 1972-09-18 | 1975-11-18 | Du Pont | Water-dispersible pesticide aggregates |
| US4172714A (en) | 1976-12-20 | 1979-10-30 | E. I. Du Pont De Nemours And Company | Dry compactible, swellable herbicidal compositions and pellets produced therefrom |
| GB2095558B (en) | 1981-03-30 | 1984-10-24 | Avon Packers Ltd | Formulation of agricultural chemicals |
| DE3338292A1 (de) | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide |
| CA1249832A (en) | 1984-02-03 | 1989-02-07 | Shionogi & Co., Ltd. | Azolyl cycloalkanol derivatives and agricultural fungicides |
| US5304732A (en) | 1984-03-06 | 1994-04-19 | Mgi Pharma, Inc. | Herbicide resistance in plants |
| BR8600161A (pt) | 1985-01-18 | 1986-09-23 | Plant Genetic Systems Nv | Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio |
| DE3545319A1 (de) | 1985-12-20 | 1987-06-25 | Basf Ag | Acrylsaeureester und fungizide, die diese verbindungen enthalten |
| ES2018274T5 (es) | 1986-03-11 | 1996-12-16 | Plant Genetic Systems Nv | Celulas vegetales resistentes a los inhibidores de glutamina sintetasa, preparadas por ingenieria genetica. |
| US4670560A (en) | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
| CN1050538A (zh) | 1986-05-02 | 1991-04-10 | 施托福化学公司 | 杀真菌性吡啶基亚胺组合物及杀真菌方法 |
| DE256503T1 (de) | 1986-08-12 | 1990-02-08 | Mitsubishi Kasei Corp., Tokio/Tokyo | Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel. |
| FR2629098B1 (fr) | 1988-03-23 | 1990-08-10 | Rhone Poulenc Agrochimie | Gene chimerique de resistance herbicide |
| US5180587A (en) | 1988-06-28 | 1993-01-19 | E. I. Du Pont De Nemours And Company | Tablet formulations of pesticides |
| CA2005658A1 (en) | 1988-12-19 | 1990-06-19 | Eliahu Zlotkin | Insecticidal toxins, genes encoding these toxins, antibodies binding to them and transgenic plant cells and plants expressing these toxins |
| JPH02225485A (ja) * | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| DE69034081T2 (de) | 1989-03-24 | 2004-02-12 | Syngenta Participations Ag | Krankheitsresistente transgene Pflanze |
| DK0777964T3 (da) | 1989-08-30 | 2002-03-11 | Kynoch Agrochemicals Proprieta | Fremgangsmåde til fremstilling af et doseringssystem |
| DE69018772T2 (de) | 1989-11-07 | 1996-03-14 | Pioneer Hi Bred Int | Larven abtötende Lektine und darauf beruhende Pflanzenresistenz gegen Insekten. |
| US6187773B1 (en) | 1989-11-10 | 2001-02-13 | Agro-Kanesho Co., Ltd. | Hexahydrotriazine compounds and insecticides |
| US5372989A (en) | 1990-03-12 | 1994-12-13 | E. I. Du Pont De Nemours And Company | Water-dispersible or water-soluble pesticide grandules from heat-activated binders |
| DE69132939T2 (de) | 1990-06-25 | 2002-11-14 | Monsanto Technology Llc | Glyphosattolerante pflanzen |
| EP0480679B1 (en) | 1990-10-11 | 1996-09-18 | Sumitomo Chemical Company Limited | Pesticidal composition |
| JP2828186B2 (ja) | 1991-09-13 | 1998-11-25 | 宇部興産株式会社 | アクリレート系化合物、その製法及び殺菌剤 |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| DE4322211A1 (de) | 1993-07-03 | 1995-01-12 | Basf Ag | Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung |
| JP3811196B2 (ja) * | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法 |
| TW276256B (enExample) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
| US5530195A (en) | 1994-06-10 | 1996-06-25 | Ciba-Geigy Corporation | Bacillus thuringiensis gene encoding a toxin active against insects |
| WO2000061583A1 (en) | 1995-06-07 | 2000-10-19 | Cell Therapeutics, Inc. | Xanthine derivatives and analogs as cell signaling inhibitors |
| CA2227384A1 (en) | 1995-08-17 | 1997-02-27 | Toshifumi Watanabe | Thienopyrimidine derivatives, their production and use |
| JPH09110873A (ja) * | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | チエノピリミジン誘導体、その製造法および用途 |
| US5773704A (en) | 1996-04-29 | 1998-06-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herbicide resistant rice |
| JP2007302703A (ja) * | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | 医薬組成物 |
| WO1997040846A1 (en) | 1996-04-30 | 1997-11-06 | Takeda Chemical Industries, Ltd. | COMBINED USE OF GnRH AGONIST AND ANTAGONIST |
| EA003297B1 (ru) | 1996-07-17 | 2003-04-24 | Мишиген Стейт Юниверсити | Линия клеток растения сахарной свеклы и растение сахарной свеклы, устойчивые к имидазолиноновым и сульфонилмочевинным гербицидам, семена указанного растения, способы получения указанной клеточной линии и гибридных растений свеклы, устойчивых к данным гербицидам, и применение имидазолинонового гербицида для борьбы с сорняками, растущими на полях с указанными растениями сахарной свеклы |
| US5773702A (en) | 1996-07-17 | 1998-06-30 | Board Of Trustees Operating Michigan State University | Imidazolinone herbicide resistant sugar beet plants |
| DE19650197A1 (de) | 1996-12-04 | 1998-06-10 | Bayer Ag | 3-Thiocarbamoylpyrazol-Derivate |
| TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6984644B2 (en) * | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
| US6420605B1 (en) | 1997-09-18 | 2002-07-16 | Basf Aktiengesellschaft | Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides |
| DE19750012A1 (de) | 1997-11-12 | 1999-05-20 | Bayer Ag | Isothiazolcarbonsäureamide |
| EP1035772A4 (en) | 1997-12-04 | 2001-03-28 | Dow Agrosciences Llc | FUNGICIDAL COMPOSITIONS AND METHODS, AND COMPOUNDS AND METHODS FOR THEIR PRODUCTION |
| DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| US6348643B1 (en) | 1998-10-29 | 2002-02-19 | American Cyanamid Company | DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use |
| ATE305465T1 (de) | 1998-11-17 | 2005-10-15 | Kumiai Chemical Industry Co | Pyrimidinylbenzimidazol- und triazinylbenzimidazol-derivate und agrikulte/hortikulte fungizide |
| IT1303800B1 (it) | 1998-11-30 | 2001-02-23 | Isagro Ricerca Srl | Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico. |
| JP3417862B2 (ja) | 1999-02-02 | 2003-06-16 | 新東工業株式会社 | 酸化チタン光触媒高担持シリカゲルおよびその製造方法 |
| AU770077B2 (en) | 1999-03-11 | 2004-02-12 | Dow Agrosciences Llc | Heterocyclic substituted isoxazolidines and their use as fungicides |
| US6586617B1 (en) | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
| UA73307C2 (uk) | 1999-08-05 | 2005-07-15 | Куміаі Кемікал Індастрі Ко., Лтд. | Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення |
| DE10021412A1 (de) | 1999-12-13 | 2001-06-21 | Bayer Ag | Fungizide Wirkstoffkombinationen |
| CN100488362C (zh) | 2000-01-25 | 2009-05-20 | 辛根塔参与股份公司 | 除草组合物 |
| US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
| IL167954A (en) | 2000-02-04 | 2007-10-31 | Sumitomo Chemical Co | History of pyrimidine |
| MX233208B (es) | 2000-04-28 | 2005-12-20 | Basf Ag | Uso del gen mutante ahas 2 del maiz xi12 y herbicidas de imidazolinona para la seleccion de plantas de maiz, arroz y trigo, monocotiledoneas transgenicas, resistentes a los herbicidas de imidazolinona. |
| AU8590001A (en) | 2000-08-25 | 2002-03-04 | Syngenta Participations Ag | Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins |
| JP2004518629A (ja) | 2000-09-18 | 2004-06-24 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺菌・殺カビ剤として使用するためのピリジニルアミド類およびイミド類 |
| ATE462429T1 (de) | 2000-11-17 | 2010-04-15 | Dow Agrosciences Llc | Verbindungen mit fungizider wirkung und verfahren zur ihrer herstellung und verwendung |
| MXPA03004926A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas. |
| JP5034142B2 (ja) | 2001-04-20 | 2012-09-26 | 住友化学株式会社 | 植物病害防除剤組成物 |
| DE10136065A1 (de) | 2001-07-25 | 2003-02-13 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
| AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
| FR2828196A1 (fr) | 2001-08-03 | 2003-02-07 | Aventis Cropscience Sa | Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture |
| CA2456314C (en) | 2001-08-09 | 2012-11-13 | University Of Saskatchewan | Wheat plants having increased resistance to imidazolinone herbicides |
| AR036138A1 (es) | 2001-08-09 | 2004-08-11 | Univ Saskatchewan | Plantas de trigo que tienen resistencia aumentada a herbicidas de imidazolinona |
| EP2604107B1 (en) | 2001-08-09 | 2018-10-10 | Northwest Plant Breeding Company | Wheat plants having increased resistance to imidazolinone herbicides |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| AU2002327096B2 (en) | 2001-08-17 | 2007-11-22 | Sankyo Agro Company, Limited | 3-phenoxy-4-pyridazinol derivative and herbicide composition containing the same |
| US7230167B2 (en) | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
| AU2002361696A1 (en) | 2001-12-17 | 2003-06-30 | Syngenta Participations Ag | Novel corn event |
| WO2003053145A1 (en) | 2001-12-21 | 2003-07-03 | Nissan Chemical Industries, Ltd. | Bactericidal composition |
| TWI327462B (en) | 2002-01-18 | 2010-07-21 | Sumitomo Chemical Co | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same |
| DE10204390A1 (de) | 2002-02-04 | 2003-08-14 | Bayer Cropscience Ag | Disubstituierte Thiazolylcarboxanilide |
| DE60301491T2 (de) | 2002-02-27 | 2006-05-18 | Pfizer Products Inc., Groton | Acc-hemmer |
| EP1480955B1 (en) | 2002-03-05 | 2007-06-27 | Syngenta Participations AG | O-cyclopropyl-carboxanilides and their use as fungicides |
| WO2004016073A2 (en) | 2002-07-10 | 2004-02-26 | The Department Of Agriculture, Western Australia | Wheat plants having increased resistance to imidazolinone herbicides |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| GB0227966D0 (en) | 2002-11-29 | 2003-01-08 | Syngenta Participations Ag | Organic Compounds |
| EP1585392B1 (en) * | 2003-01-06 | 2009-03-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides. |
| EP1591446B1 (en) * | 2003-01-29 | 2013-03-06 | Takeda Pharmaceutical Company Limited | Thienopyrimidine compounds and use thereof |
| WO2004083193A1 (ja) | 2003-03-17 | 2004-09-30 | Sumitomo Chemical Company, Limited | アミド化合物およびこれを含有する殺菌剤組成物 |
| MXPA05012733A (es) | 2003-05-28 | 2006-05-17 | Basf Ag | Plantas de trigo que tienen tolerancia incrementada a los herbicidas de imidazolinona. |
| US20070028318A1 (en) | 2003-08-29 | 2007-02-01 | Instituto Nacional De Technologia Agropecuaria | Rice plants having increased tolerance to imidazolinone herbicides |
| TWI355894B (en) | 2003-12-19 | 2012-01-11 | Du Pont | Herbicidal pyrimidines |
| CN1930165A (zh) | 2004-03-10 | 2007-03-14 | 巴斯福股份公司 | 5,6－二烷基－7－氨基三唑并嘧啶、其制备方法、在防治致病性真菌中的用途以及包含所述化合物的试剂 |
| CA2557781C (en) | 2004-03-10 | 2012-01-10 | Basf Aktiengesellschaft | 5,6-dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said compounds |
| WO2005120234A2 (en) | 2004-06-03 | 2005-12-22 | E.I. Dupont De Nemours And Company | Fungicidal mixtures of amidinylphenyl compounds |
| PE20060096A1 (es) | 2004-06-18 | 2006-03-16 | Basf Ag | (orto-fenil)-anilidas de acido 1-metil-3-difluorometil-pirazol-4-carboxilico como agentes fungicidas |
| ATE458722T1 (de) | 2004-06-18 | 2010-03-15 | Basf Se | 1-methyl-3-trifluormethyl-pyrazol-4-carbonsäure (ortho-phenyl)-anilide und ihre verwendung als fungizid |
| WO2006014647A2 (en) * | 2004-07-21 | 2006-02-09 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| GB0418048D0 (en) | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Method for protecting useful plants or plant propagation material |
| DE102005007160A1 (de) | 2005-02-16 | 2006-08-24 | Basf Ag | Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
| EA200701625A1 (ru) | 2005-02-16 | 2008-02-28 | Басф Акциенгезельшафт | 5-алкоксиалкил-6-алкил-7-аминоазолопиримидины, способ их получения и их применение для борьбы с патогенными грибами, а также содержащее их средство |
| DE102005009458A1 (de) | 2005-03-02 | 2006-09-07 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
| PL1973881T3 (pl) | 2006-01-13 | 2010-04-30 | Dow Agrosciences Llc | 6-(wielo-podstawione arylo)-4-aminopikoliniany i ich zastosowanie jako herbicydy |
| US8124565B2 (en) | 2006-02-09 | 2012-02-28 | Syngenta Crop Protection, Inc. | Method of protecting a plant propagation material, a plant, and/or plant organs |
| JP2009528389A (ja) * | 2006-03-02 | 2009-08-06 | シーブイ・セラピューティクス・インコーポレイテッド | Ａ２ａアデノシン受容体拮抗剤 |
| WO2008143262A1 (ja) | 2007-05-21 | 2008-11-27 | Takeda Pharmaceutical Company Limited | 複素環化合物およびその用途 |
| JP5535931B2 (ja) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| TWI574968B (zh) * | 2009-12-29 | 2017-03-21 | 波克賽爾公司 | Ａｍｐｋ（ａｍｐ－活化蛋白激酶）活化劑及其醫療用途 |
| CA2855372C (en) | 2011-11-11 | 2022-03-22 | Nimbus Apollo, Inc. | 2,4-dioxo-thieno[2,3-d]pyrimidinyl derivatives and pharmaceutical compositions thereof used as acc inhibitors |
| KR20160007598A (ko) * | 2013-05-10 | 2016-01-20 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| EP3379933B1 (en) | 2015-11-25 | 2023-02-15 | Gilead Apollo, LLC | Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine |
| MX2018006286A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc pirazolicos y usos de los mismos. |
| AU2016361428A1 (en) | 2015-11-25 | 2018-05-24 | Gilead Apollo, Llc | Triazole ACC inhibitors and uses thereof |
| JP2018536660A (ja) | 2015-11-25 | 2018-12-13 | ギリアド アポロ， エルエルシー | エステルａｃｃ阻害剤およびその使用 |
| CA3220447C (en) | 2016-03-02 | 2025-08-05 | Gilead Apollo, Llc | SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND THEIR PRODUCTION PROCESSES |
-
2012
- 2012-11-09 CA CA2855372A patent/CA2855372C/en active Active
- 2012-11-09 KR KR1020197037686A patent/KR102172902B1/ko active Active
- 2012-11-09 WO PCT/US2012/064528 patent/WO2013071169A1/en not_active Ceased
- 2012-11-09 TW TW102116925A patent/TWI582095B/zh active
- 2012-11-09 HU HUE12848361A patent/HUE037444T2/hu unknown
- 2012-11-09 TW TW106143212A patent/TWI655193B/zh active
- 2012-11-09 TW TW107147492A patent/TWI701253B/zh active
- 2012-11-09 EA EA201692104A patent/EA033598B1/ru unknown
- 2012-11-09 MX MX2014005693A patent/MX344490B/es active IP Right Grant
- 2012-11-09 EP EP19190936.5A patent/EP3628320B1/en active Active
- 2012-11-09 CN CN201280066192.5A patent/CN104105485B/zh active Active
- 2012-11-09 CN CN201910342735.5A patent/CN109970760B/zh active Active
- 2012-11-09 PT PT128483617T patent/PT2776038T/pt unknown
- 2012-11-09 AU AU2012335088A patent/AU2012335088B2/en active Active
- 2012-11-09 MX MX2020000331A patent/MX390746B/es unknown
- 2012-11-09 US US13/673,610 patent/US8969557B2/en active Active
- 2012-11-09 PL PL17209455T patent/PL3329919T3/pl unknown
- 2012-11-09 SM SM20180191T patent/SMT201800191T1/it unknown
- 2012-11-09 KR KR1020147015759A patent/KR102033806B1/ko active Active
- 2012-11-09 KR KR1020197010275A patent/KR102060290B1/ko active Active
- 2012-11-09 SI SI201231695T patent/SI3329919T1/sl unknown
- 2012-11-09 LT LTEP17209455.9T patent/LT3329919T/lt unknown
- 2012-11-09 CN CN201710148365.2A patent/CN106905346B/zh active Active
- 2012-11-09 SI SI201231264T patent/SI2776038T1/en unknown
- 2012-11-09 ES ES12848361.7T patent/ES2665580T3/es active Active
- 2012-11-09 EA EA201490826A patent/EA030264B1/ru unknown
- 2012-11-09 ES ES17209455T patent/ES2767956T3/es active Active
- 2012-11-09 HR HRP20180534TT patent/HRP20180534T1/hr unknown
- 2012-11-09 MX MX2016016733A patent/MX370976B/es unknown
- 2012-11-09 LT LTEP12848361.7T patent/LT2776038T/lt unknown
- 2012-11-09 DK DK12848361.7T patent/DK2776038T3/en active
- 2012-11-09 HU HUE17209455A patent/HUE047049T2/hu unknown
- 2012-11-09 TW TW105139289A patent/TWI612050B/zh active
- 2012-11-09 RS RS20180415A patent/RS57157B1/sr unknown
- 2012-11-09 PL PL12848361T patent/PL2776038T3/pl unknown
- 2012-11-09 DK DK17209455T patent/DK3329919T3/da active
- 2012-11-09 PL PL19190936.5T patent/PL3628320T3/pl unknown
- 2012-11-09 BR BR122019026836-3A patent/BR122019026836B1/pt active IP Right Grant
- 2012-11-09 JP JP2014541351A patent/JP6114297B2/ja active Active
- 2012-11-09 PT PT172094559T patent/PT3329919T/pt unknown
- 2012-11-09 ES ES19190936T patent/ES2912574T3/es active Active
- 2012-11-09 UA UAA201406462A patent/UA114901C2/uk unknown
- 2012-11-09 BR BR112014011351-3A patent/BR112014011351B1/pt active IP Right Grant
- 2012-11-09 EP EP17209455.9A patent/EP3329919B1/en active Active
- 2012-11-09 UA UAA201703473A patent/UA123760C2/uk unknown
- 2012-11-09 EP EP12848361.7A patent/EP2776038B1/en active Active
-
2014
- 2014-05-12 CL CL2014001241A patent/CL2014001241A1/es unknown
- 2014-05-19 ZA ZA2014/03633A patent/ZA201403633B/en unknown
-
2015
- 2015-01-23 US US14/604,497 patent/US9453026B2/en active Active
-
2016
- 2016-03-11 US US15/067,634 patent/US9944655B2/en active Active
-
2017
- 2017-03-16 JP JP2017051746A patent/JP6276442B2/ja active Active
- 2017-06-19 ZA ZA2017/04192A patent/ZA201704192B/en unknown
- 2017-06-19 ZA ZA2017/04173A patent/ZA201704173B/en unknown
- 2017-11-23 AU AU2017265088A patent/AU2017265088B2/en active Active
-
2018
- 2018-01-11 JP JP2018002648A patent/JP6543358B2/ja active Active
- 2018-03-09 US US15/917,190 patent/US10472374B2/en active Active
- 2018-04-05 CY CY20181100386T patent/CY1120224T1/el unknown
-
2019
- 2019-06-14 JP JP2019111246A patent/JP6756014B2/ja active Active
- 2019-09-20 US US16/577,455 patent/US20200102323A1/en not_active Abandoned
- 2019-10-23 AU AU2019253834A patent/AU2019253834B2/en active Active
- 2019-12-06 HR HRP20192202TT patent/HRP20192202T1/hr unknown
-
2020
- 2020-02-03 CY CY20201100086T patent/CY1122657T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014533281A5 (enExample) | ||
| JP2016520063A5 (enExample) | ||
| JP2016520064A5 (enExample) | ||
| JP2016526024A5 (enExample) | ||
| JP2016520065A5 (enExample) | ||
| EA201590581A1 (ru) | Соединения бис-(фторалкил)-1,4-бензодиазепинона и их пролекарства | |
| AR099134A1 (es) | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina | |
| AR103222A1 (es) | Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina | |
| AR086100A1 (es) | Compuestos de cromenona y composiciones farmaceuticas que los contienen | |
| BR112015023948A2 (pt) | composto de fórmula (i), composição farmacêutica, método para o tratamento e/ou prevenção de uma doença proliferativa e para a inibição ou a diferenciação do crescimento de uma célula tronco do câncer | |
| RU2017111200A (ru) | Циклогексилэтилзамещенные диаза- и триаза-трициклические соединения в качестве антагонистов индоламин-2,3-диоксигеназы для лечения рака | |
| EA201490650A1 (ru) | Фармацевтические композиции | |
| JP2015505296A5 (enExample) | ||
| AR085155A1 (es) | Procesos para preparar compuestos de quinolina y composiciones farmaceuticas que contienen dichos compuestos | |
| EA201391568A1 (ru) | Новые производные имидазола, подходящие для лечения артрита | |
| JP2016535732A5 (enExample) | ||
| EA201071298A1 (ru) | Соединение 3-аминокарбазола, фармацевтическая композиция, его содержащая, и способ их получения | |
| EA201390917A1 (ru) | Дигетероарильные соединения в качестве ингибиторов vps34 | |
| EA201490103A1 (ru) | Гидроксиметиларилзамещенные пирролотриазины в качестве ингибиторов alk1 | |
| RU2017101829A (ru) | Пиразоловые соединения в качестве модуляторов fshr и пути их применения | |
| TN2016000014A1 (fr) | Nouveaux dérivés d'indolizine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent | |
| AR100191A1 (es) | Método para tratar adenocarcinoma de pulmón | |
| EA201491747A1 (ru) | Замещенные пиридопиримидиновые соединения и их применение в качестве flt3 ингибиторов | |
| JP2015522589A5 (enExample) | ||
| RU2013116801A (ru) | Ингибиторы notum пектинацетилэстеразы и способы их применения |