JP2014520526A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014520526A5 JP2014520526A5 JP2014518556A JP2014518556A JP2014520526A5 JP 2014520526 A5 JP2014520526 A5 JP 2014520526A5 JP 2014518556 A JP2014518556 A JP 2014518556A JP 2014518556 A JP2014518556 A JP 2014518556A JP 2014520526 A5 JP2014520526 A5 JP 2014520526A5
- Authority
- JP
- Japan
- Prior art keywords
- mitochondrial
- various embodiments
- cell
- bioenergetic
- oocyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002611 ovarian Effects 0.000 description 5
- KZNIFHPLKGYRTM-UHFFFAOYSA-N Apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 4
- IQPNAANSBPBGFQ-UHFFFAOYSA-N Luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 4
- 230000002715 bioenergetic Effects 0.000 description 4
- 230000002438 mitochondrial Effects 0.000 description 4
- 210000000287 oocyte Anatomy 0.000 description 4
- 210000001519 tissues Anatomy 0.000 description 4
- BAWFJGJZGIEFAR-NNYOXOHSSA-N Nicotinamide adenine dinucleotide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 3
- 210000004027 cells Anatomy 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000002609 media Substances 0.000 description 3
- FNCOVSWSZZVFBQ-UHFFFAOYSA-N 2-[(4-hydroxyphenyl)methylidene]propanedinitrile Chemical compound OC1=CC=C(C=C(C#N)C#N)C=C1 FNCOVSWSZZVFBQ-UHFFFAOYSA-N 0.000 description 2
- 229940117893 Apigenin Drugs 0.000 description 2
- YBHILYKTIRIUTE-UHFFFAOYSA-N Berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 2
- 229940093265 Berberine Drugs 0.000 description 2
- 210000001185 Bone Marrow Anatomy 0.000 description 2
- 229920000460 Mitochondrial DNA Polymers 0.000 description 2
- 235000008714 apigenin Nutrition 0.000 description 2
- 229930015400 berberine Natural products 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 235000009498 luteolin Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229950006238 nadide Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002407 ATP formation Effects 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 102100003279 CD38 Human genes 0.000 description 1
- 101700044948 CD38 Proteins 0.000 description 1
- 101700037527 DAZL Proteins 0.000 description 1
- 210000001671 Embryonic Stem Cells Anatomy 0.000 description 1
- 208000007984 Female Infertility Diseases 0.000 description 1
- 210000004700 Fetal Blood Anatomy 0.000 description 1
- 206010021928 Infertility female Diseases 0.000 description 1
- 210000003470 Mitochondria Anatomy 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 229940052665 NADH Drugs 0.000 description 1
- 206010033165 Ovarian failure Diseases 0.000 description 1
- IASPBORHOMBZMY-UHFFFAOYSA-N SRT1720 Chemical compound C=1N=C2C=CC=CC2=NC=1C(=O)NC1=CC=CC=C1C(N=C1SC=2)=CN1C=2CN1CCNCC1 IASPBORHOMBZMY-UHFFFAOYSA-N 0.000 description 1
- 241000862969 Stella Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000038129 antigens Human genes 0.000 description 1
- 108091007172 antigens Proteins 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000006143 cell culture media Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000002708 enhancing Effects 0.000 description 1
- 210000004420 female germ cell Anatomy 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 230000001605 fetal Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 230000000394 mitotic Effects 0.000 description 1
- 231100000539 ovarian failure Toxicity 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000004017 vitrification Methods 0.000 description 1
Description
前述の態様のいずれか、又は本明細書に記載の本発明のいずれかの態様の様々な実施形態では、本発明の組成物は、細胞培地、卵母細胞回収液、卵母細胞洗浄液、卵母細胞体外成熟培地、卵胞体外成熟培地、卵母細胞体外受精培地、ガラス化液及び低温保存液の１つ以上から選択される溶液をさらに含有する。様々な実施形態では、本組成物は、卵巣組織、卵胞、骨髄、臍帯血若しくは末梢血を含有する。他の実施形態では、ＯＳＣは、単離された非胚性幹細胞であり、これは、有糸分裂能があり、且つＶａｓａ、Ｏｃｔ−４、Ｄａｚｌ、Ｓｔｅｌｌａ、及び任意選択でステージ特異的胎児抗原の１つ以上を発現する。他の実施形態では、ＯＳＣは、卵巣組織から得る。様々な実施形態において、ＯＳＣは、非卵巣組織から得る。特定の実施形態では、非卵巣組織は、血液又は骨髄である。様々な実施形態において、細胞は、卵巣幹細胞であり、ここで、細胞は、生体エネルギー物質と接触している。別の実施形態では、接触させた細胞は、増加したミトコンドリアＤＮＡコピー数及び／又は増加したＡＴＰ生産能力を有する。さらに別の実施形態では、ミトコンドリアの数は、約１０％、２０％、３０％、４０％、５０％若しくは６０％増加する。前述の態様のいずれか、又は本明細書に記載の本発明のいずれかの態様の様々な実施形態において、ミトコンドリア機能の増大は、ｍｔＤＮＡ含量、ＡＴＰ、ＮＡＤ＋／ＮＡＤＨ、ミトコンドリア質量、膜電位、並びに既知ミトコンドリア量調節因子の遺伝子発現、及び電子伝達系成分をアッセイすることにより検出する。
ＣＤ３８を阻害することがわかっている数種の生体エネルギー物質が、ベースライン（ＤＭＳＯのみ）を超える活性を生成し、プラスの結果として評点されたが、このようなものとして、アピゲニン、ルテオリン、チルホスチン８、ベルベリン及びＳＲＴ−１７２０が挙げられる。従って、これらの生体エネルギー物質は、ミトコンドリアパラメータを有益な様式で増加することがわかった。
アピゲニン、ルテオリン、ベルベリン、及びチルホスチン８などの生体エネルギー物質は、ＮＡＤ＋レベルを高めると共に、ミトコンドリアパラメータを有益な様式で増加することが証明された。一実施形態では、このような物質は、化学療法、老化及び未成熟卵巣不全に関連する雌性不妊の治療のための雌性生殖細胞を増強する上で有用である。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502840P | 2011-06-29 | 2011-06-29 | |
| US61/502,840 | 2011-06-29 | ||
| US201261600529P | 2012-02-17 | 2012-02-17 | |
| US61/600,529 | 2012-02-17 | ||
| PCT/US2012/033672 WO2013002880A1 (en) | 2011-06-29 | 2012-04-13 | Compositions and methods for enhancing bioenergetic status in female germ cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017116146A Division JP6496359B2 (ja) | 2011-06-29 | 2017-06-13 | 雌性生殖細胞における生体エネルギー状態を増強するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520526A JP2014520526A (ja) | 2014-08-25 |
| JP2014520526A5 true JP2014520526A5 (ja) | 2017-08-03 |
| JP6284475B2 JP6284475B2 (ja) | 2018-02-28 |
Family
ID=47424472
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518556A Expired - Fee Related JP6284475B2 (ja) | 2011-06-29 | 2012-04-13 | 雌性生殖細胞における生体エネルギー状態を増強するための組成物及び方法 |
| JP2017116146A Expired - Fee Related JP6496359B2 (ja) | 2011-06-29 | 2017-06-13 | 雌性生殖細胞における生体エネルギー状態を増強するための組成物及び方法 |
| JP2018202431A Pending JP2019030326A (ja) | 2011-06-29 | 2018-10-29 | インビボで雌性生殖細胞の生体エネルギー状態を増強するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017116146A Expired - Fee Related JP6496359B2 (ja) | 2011-06-29 | 2017-06-13 | 雌性生殖細胞における生体エネルギー状態を増強するための組成物及び方法 |
| JP2018202431A Pending JP2019030326A (ja) | 2011-06-29 | 2018-10-29 | インビボで雌性生殖細胞の生体エネルギー状態を増強するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9845482B2 (ja) |
| EP (2) | EP2726601B1 (ja) |
| JP (3) | JP6284475B2 (ja) |
| CN (1) | CN103827293A (ja) |
| AU (2) | AU2012276038B2 (ja) |
| BR (1) | BR112013033797A2 (ja) |
| CA (1) | CA2847292A1 (ja) |
| EA (1) | EA201490050A1 (ja) |
| IL (2) | IL230212B (ja) |
| MX (1) | MX356815B (ja) |
| UA (1) | UA117448C2 (ja) |
| WO (1) | WO2013002880A1 (ja) |
| ZA (1) | ZA201309707B (ja) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7955846B2 (en) | 2004-05-17 | 2011-06-07 | The General Hospital Corporation | Compositions comprising female germline stem cells and methods of use thereof |
| AU2012242591B2 (en) * | 2011-04-14 | 2014-10-23 | The General Hospital Corporation | Compositions and methods for autologous germline mitochondrial energy transfer |
| WO2013035101A1 (en) | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| WO2013171752A1 (en) | 2012-05-16 | 2013-11-21 | Minovia Therapeutics Ltd. | Compositions and methods for inducing angiogenesis |
| PL2968306T3 (pl) | 2013-03-15 | 2024-01-29 | Washington University | Podawanie mononukleotydu nikotynamidu do leczenia zespołu suchego oka |
| CA2934579A1 (en) * | 2013-12-20 | 2015-06-25 | Fertilify Inc. | Compositions comprising vitamin c, vitamin e, and coenzyme q10 and use thereof for promoting female fertility and reproductive health |
| CN104188966B (zh) * | 2014-07-14 | 2017-12-12 | 吴效科 | 小檗碱在制备治疗排卵障碍性不孕症的药物中的应用 |
| PL3670522T3 (pl) | 2014-07-24 | 2022-02-21 | W.R. Grace & Co. - Conn. | Krystaliczna postać chlorku rybozydu nikotynamidu |
| CN104164401A (zh) * | 2014-08-12 | 2014-11-26 | 沈阳洁瑞生物技术有限公司 | 精子洗涤液及其制备方法 |
| EP2995948A1 (en) * | 2014-09-09 | 2016-03-16 | Ecole Polytechnique Federale de Lausanne (EPFL) | Methods and compounds useful in hematopoietic stem cell medicine |
| TW201619194A (zh) * | 2014-09-16 | 2016-06-01 | 歐把科學股份有限公司 | 特異性結合至人類vasa蛋白質的抗體、抗體製劑、經分離核酸分子、細胞及分離表現vasa蛋白質的細胞的方法 |
| RU2017125036A (ru) * | 2014-12-24 | 2019-01-24 | Пьер Фабр Медикамент | Новое гуманизированное антитело к adam17 |
| JP7015169B2 (ja) | 2015-02-26 | 2022-02-02 | ミノヴィア セラピューティクス リミテッド | 機能性ミトコンドリアで富化された哺乳動物細胞 |
| KR102629310B1 (ko) | 2015-03-09 | 2024-01-24 | 더블유.알. 그레이스 앤드 캄파니-콘. | 니코틴아미드 리보사이드의 결정 형태 |
| CN104814974A (zh) * | 2015-03-16 | 2015-08-05 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备抗衰老药物或保健品的应用 |
| CN106244548B (zh) * | 2015-06-09 | 2019-07-05 | 成都中医药大学 | 木犀草素在诱导间充质干细胞向神经细胞定向分化中的用途 |
| WO2016210232A1 (en) * | 2015-06-25 | 2016-12-29 | N.V. Perricone Llc | Niacinamide mononucleotide formulations for skin aging |
| WO2017079428A1 (en) * | 2015-11-04 | 2017-05-11 | President And Fellows Of Harvard College | Site specific germline modification |
| JP7166636B2 (ja) | 2016-07-15 | 2022-11-08 | エイチツー ウォーター テクノロジーズ リミテッド | 水素豊富水を生成するための組成物及び他の製品 |
| CN109803644A (zh) * | 2016-09-26 | 2019-05-24 | 学校法人圣玛丽安娜医科大学 | 卵巢功能降低预防或改善剂 |
| US11633421B2 (en) * | 2016-11-29 | 2023-04-25 | University Of Iowa Research Foundation | Use of NAD precursors for improving maternal health and/or offspring health |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018143258A1 (ja) * | 2017-01-31 | 2018-08-09 | オリエンタル酵母工業株式会社 | 多分化能性幹細胞増殖促進剤 |
| RU2662983C1 (ru) * | 2017-01-31 | 2018-07-31 | Алексей Юрьевич Грязнов | Культуральная среда для ооцитов и эмбрионов |
| WO2018160920A1 (en) * | 2017-03-02 | 2018-09-07 | Orig3N, Inc. | Systems and methods of assisted reproduction and prevention of genetic defects in offspring using induced pluripotent stem cells |
| WO2018200357A1 (en) * | 2017-04-26 | 2018-11-01 | Elysium Health, Inc. | Methods and compositions of improving fertility |
| US20200179441A1 (en) * | 2017-04-27 | 2020-06-11 | H2 Water Technologies Ltd. | Synergistic compositions for increasing mitochondrial function and energy |
| US11179423B2 (en) * | 2017-05-31 | 2021-11-23 | Palo Alto Investors | Methods of enhancing female fertility |
| CN107308200A (zh) * | 2017-06-19 | 2017-11-03 | 北正赛欧（北京）生物科技有限公司 | 用于治疗宫颈癌的组合物及其应用 |
| AU2018309558A1 (en) * | 2017-07-31 | 2020-02-27 | Newsouth Innovations Pty Limited | Methods for increasing fertility |
| NZ762985A (en) | 2017-09-22 | 2024-03-22 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| HUE061607T2 (hu) | 2017-10-18 | 2023-07-28 | Jubilant Epipad LLC | Imidazopiridin vegyületek mint PAD inhibitorok |
| CN111386265A (zh) | 2017-11-06 | 2020-07-07 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物 |
| EP3704120B1 (en) | 2017-11-24 | 2024-03-06 | Jubilant Episcribe LLC | Heterocyclic compounds as prmt5 inhibitors |
| CN108384751A (zh) * | 2018-03-12 | 2018-08-10 | 山大生殖研发中心有限公司 | 卵母细胞体外成熟培养方法和培养基 |
| BR112020018610A2 (pt) | 2018-03-13 | 2020-12-29 | Jubilant Prodel LLC | Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas |
| CN108642001B (zh) * | 2018-05-08 | 2022-09-02 | 中国农业科学院北京畜牧兽医研究所 | 一种提高牛性控冻精体外受精能力的方法 |
| WO2019221813A1 (en) * | 2018-05-15 | 2019-11-21 | Jumpstart Fertility Pty Ltd | Inorganic salts of nicotinic acid mononucleotide as anti-aging agents |
| US11951135B2 (en) | 2018-07-22 | 2024-04-09 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| EP3829715A1 (en) * | 2018-08-01 | 2021-06-09 | Jumpstart Fertility Pty Ltd | Quaternary ammonium salts of nicotinic acid and nicotinamide mononucloetides and ribosides as anti-aging agents |
| WO2020028684A1 (en) * | 2018-08-01 | 2020-02-06 | Jumpstart Fertility Pty Ltd | Salts of nicotinic acid and nicotinamide as anti-aging agents |
| CA3122246A1 (en) * | 2018-12-05 | 2020-06-11 | Celagenex Research (India) Pvt. Ltd. | Synergistic compositions of bioactive agents for optimizing cellular health |
| CN109674808A (zh) * | 2019-01-30 | 2019-04-26 | 四川大学 | β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途 |
| CN111617093A (zh) * | 2019-06-13 | 2020-09-04 | 中国科学院广州生物医药与健康研究院 | 化合物在制备药物中的用途 |
| WO2020257285A1 (en) * | 2019-06-17 | 2020-12-24 | The Brigham And Women's Hospital, Inc. | Materials and methods for generating functional oocytes |
| JPWO2020262325A1 (ja) * | 2019-06-28 | 2020-12-30 | ||
| JP2023512605A (ja) * | 2020-02-03 | 2023-03-27 | ファイト テック コーポレーション | エルゴチオネインの使用に関連する方法および組成物 |
| WO2021168419A1 (en) * | 2020-02-20 | 2021-08-26 | Northeastern University | Methods and compositions for use of mitochondrial therapies to improve female reproductive potential |
| JP7289042B2 (ja) * | 2020-03-04 | 2023-06-09 | パナソニックＩｐマネジメント株式会社 | 洗濯機 |
| TWI753404B (zh) * | 2020-04-16 | 2022-01-21 | 國立屏東科技大學 | 輸卵管幹細胞促進卵母細胞體外成熟和胚發育之製劑、製備方法及其用途 |
| CN111500531A (zh) * | 2020-05-15 | 2020-08-07 | 扬州大学 | 一种鸡PGCs在体外长期培养的方法 |
| WO2021247776A1 (en) * | 2020-06-02 | 2021-12-09 | Mediwel Labs, LLC | Biologically active compositions and methods of using |
| CN116096376A (zh) * | 2020-09-08 | 2023-05-09 | 未来生物科学实验室株式会社 | 精子运动性改善剂以及精子运动性改善方法 |
| CN111925986B (zh) * | 2020-09-24 | 2021-01-19 | 深圳市一五零生命科技有限公司 | 一种脐带间充质干细胞无血清培养基及其制备方法 |
| CN114561342A (zh) * | 2020-11-27 | 2022-05-31 | 童国庆 | Nad信号通路激动剂在体外胚胎培养中的应用 |
| KR20230144547A (ko) * | 2021-01-19 | 2023-10-16 | 갤런트 펫, 인코포레이티드. | 임상 적용을 위한 생식 조직 유래 세포 수율 및 생존율을최적화하기 위한 방법 |
| CN115074388B (zh) * | 2021-06-29 | 2023-04-28 | 北京大学深圳医院 | 母源因子诱导的2c样全能干细胞及其转化应用 |
| CN113403264A (zh) * | 2021-07-21 | 2021-09-17 | 中国农业大学 | 一种gv期冷冻卵母细胞解冻后体外成熟培养液及其应用 |
| CN113599371A (zh) * | 2021-09-06 | 2021-11-05 | 郑州大学 | 二甲双胍在制备预防胸腺退化和/或促进胸腺组织再生药物中的应用 |
| CN113797186A (zh) * | 2021-10-27 | 2021-12-17 | 宁夏医科大学 | 二甲双胍在激活雌性生殖干细胞的应用 |
| CN113750242A (zh) * | 2021-10-28 | 2021-12-07 | 复旦大学附属中山医院 | Nmn联合cd38抑制剂在制备预防或治疗阿霉素所致心脏毒性药物中的应用 |
| CA3237199A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
| CN115247146A (zh) * | 2021-12-31 | 2022-10-28 | 温州医科大学 | 一种人类胚胎体外培养基及提高体外培养人类胚胎发育潜能的方法 |
| JP2023156553A (ja) * | 2022-04-13 | 2023-10-25 | 克昭 團 | 卵巣機能活性化剤、抗老化剤、医薬品、化粧品および食品または飲料 |
| CN114917215B (zh) * | 2022-04-27 | 2024-01-23 | 中国科学院生物物理研究所 | 活性化合物预防或治疗卵巢功能障碍性疾病的用途 |
| CN115590017B (zh) * | 2022-11-04 | 2023-09-12 | 中国农业大学 | 一种通过降低线粒体温度提高卵母细胞冷冻效果的方法 |
| CN115956506B (zh) * | 2023-02-16 | 2023-11-03 | 云南省农业科学院茶叶研究所 | 一种茶树离体再生组织的构建方法 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE285564C (ja) | 1913-07-25 | |||
| US3854470A (en) | 1973-11-23 | 1974-12-17 | L Augspurger | Reproduction processes for cellular bodies |
| IT1057895B (it) | 1975-02-17 | 1982-03-30 | Serono Lab | Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione |
| FR2322860A1 (fr) | 1975-09-05 | 1977-04-01 | Aron Sarl | Procede de preparation de chlorhydrate de dimethylbiguanide |
| US4193392A (en) | 1977-09-23 | 1980-03-18 | Barnett Gordon R | Method for removing ova from animals |
| US4326505A (en) | 1980-01-07 | 1982-04-27 | Occidental Petroleum Corporation | Surgical procedure for embryo transplants on animals |
| US4339434A (en) | 1981-08-17 | 1982-07-13 | Gametrics Limited | Method of increasing the incidence of female offspring |
| US4845077A (en) | 1984-04-03 | 1989-07-04 | Serono Laboratories, Inc. | Method of inducing ovulation |
| FR2563726B1 (fr) | 1984-05-04 | 1986-10-10 | Robert Cassou | Appareil d'insemination artificielle, notamment des carnivores |
| US4642094A (en) | 1984-05-29 | 1987-02-10 | North Jr Walter L | Non-surgical embryo transfer device |
| US4589402A (en) | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
| US4725579A (en) | 1985-02-21 | 1988-02-16 | Serono Laboratories, Inc. | Method of in vitro fertilization by a unique combination of gonadotropins |
| FR2580933B1 (fr) | 1985-04-24 | 1987-08-07 | Lenck Lucien | Capacite trans-uterine pour fecondation " in vitro in vivo " |
| FR2589879B1 (fr) | 1985-11-08 | 1989-05-12 | Claude Ranoux | Conteneur pour culture anaerobie d'embryons humains |
| AT387718B (de) | 1986-04-09 | 1989-03-10 | Fischl Franz H Dr | Katheder zur kuenstlichen befruchtung |
| FR2608037A1 (fr) | 1986-12-10 | 1988-06-17 | Lenck Lucien | Methode d'intubation destinee a permettre la transplantation de l'oeuf ou de la matiere embryonnaire, et moyens pour sa mise en oeuvre |
| FR2609885B1 (fr) | 1987-01-22 | 1989-04-14 | Cassou Robert | Instrument pour l'insemination artificielle, le transfert d'embryons ou le prelevement de liquides folliculaires chez les mammiferes |
| US5538948A (en) | 1987-01-30 | 1996-07-23 | Novo Nordisk A/S | Method for treating infertility comprising administering GnRH analog, gonadotrophins, and growth hormone |
| US4865589A (en) | 1987-04-22 | 1989-09-12 | Ludwig Simmet | Instrument for the transfer of materials such as sperm and embryos |
| FR2614626B1 (fr) | 1987-04-30 | 1989-07-21 | Ranoux Claude | Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal |
| US5160312A (en) | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
| US5147315A (en) | 1990-04-06 | 1992-09-15 | C. R. Bard, Inc. | Access catheter and system for use in the female reproductive system |
| US5627066A (en) | 1991-05-14 | 1997-05-06 | Mount Sinai School Of Medicine Of The City University Of New York | Method and apparatus for in vitro fertilization |
| AU2016392A (en) | 1991-05-14 | 1992-12-30 | Mount Sinai School Of Medicine Of The City University Of New York, The | Method and apparatus for (in vitro) fertilization |
| FR2678506B1 (fr) | 1991-07-01 | 2000-03-10 | Claude Ranoux | Procede de fecondation en cycle spontane. |
| US5744366A (en) | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells |
| US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
| GB9227123D0 (en) | 1992-12-30 | 1993-02-24 | Applied Research Systems | Method |
| US5563059A (en) | 1993-02-23 | 1996-10-08 | Genentech, Inc. | Use of human inhibin and human activin to increase the number of mature primate oocytes |
| GB9305984D0 (en) | 1993-03-23 | 1993-05-12 | Royal Free Hosp School Med | Predictive assay |
| US5360389A (en) | 1993-05-25 | 1994-11-01 | Chenette Philip E | Methods for endometrial implantation of embryos |
| US5541081A (en) | 1994-03-22 | 1996-07-30 | President And Fellows Of Harvard College | Process for assessing oocyte and embryo quality |
| GB9410639D0 (en) | 1994-05-27 | 1994-07-13 | Queen Mary & Westfield College | Method of improving fertilization |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| JP3660026B2 (ja) | 1995-09-04 | 2005-06-15 | 扶桑薬品工業株式会社 | 体外受精用培地組成物 |
| US5827174A (en) | 1995-09-26 | 1998-10-27 | Reuss, Jr.; William Alexander | Biological speciman containment and incubation pouch |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US6007839A (en) | 1996-02-16 | 1999-12-28 | The Liposome Company, Inc. | Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes |
| US6040340A (en) | 1996-05-07 | 2000-03-21 | Schering Aktiengesellschaft | Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors |
| US5824548A (en) | 1996-05-29 | 1998-10-20 | Wisconsin Alumni Research Foundation | Method of increasing survival of cultured primate embryos in medium containing exogenous gonadotrophin releasor hormone |
| DE69738806D1 (de) * | 1996-10-10 | 2008-08-14 | Invitrogen Corp | Tierzellkulturmedium mit pflanzlichen nährstoffen |
| CA2199663C (en) | 1997-03-11 | 2004-08-10 | Ruth Miriam Moses | In vitro maturation and fertilization of mammalian oocytes |
| US5935968A (en) | 1997-03-17 | 1999-08-10 | Merck & Co., Inc. | Methods for treating polycystic ovary syndrome |
| AU8285998A (en) | 1997-07-02 | 1999-01-25 | Sdg, Inc. | Targeted liposomal constructs for diagnostic and therapeutic uses |
| US5961444A (en) | 1997-10-17 | 1999-10-05 | Medworks Corporation | In vitro fertilization procedure using direct vision |
| US6010448A (en) | 1997-10-17 | 2000-01-04 | Medworks Corp | Embryo transfer arrangement |
| US6196965B1 (en) | 1998-05-21 | 2001-03-06 | Cryofacets, Inc. | Compositions methods and devices for embryo implantation for in vitro fertilization |
| EP1156821B1 (en) | 1999-02-24 | 2007-05-02 | Novo Nordisk A/S | Treatment of infertility |
| DE60025905T2 (de) | 1999-02-24 | 2006-09-14 | Novo Nordisk A/S | In vitro methode zur synchronisation von oozytenreifung |
| CA2389117A1 (en) * | 1999-10-27 | 2001-05-03 | Mount Sinai Hospital | Methods and compositions for enhancing developmental potential of oocytes and zygotes |
| WO2001036445A1 (en) | 1999-11-18 | 2001-05-25 | The Brigham And Women's Hospital, Inc. | Compositions and methods for the improved diagnosis and treatment of germ cell tumors |
| US6875854B1 (en) | 1999-11-18 | 2005-04-05 | The Brigham And Women's Hospital, Inc. | Compositions and methods for the improved diagnosis and treatment of germ cell tumors |
| US6544166B1 (en) | 1999-11-25 | 2003-04-08 | Groendahl Christian | Treatment of human infertility |
| US6762053B2 (en) * | 2000-06-09 | 2004-07-13 | Vitrolife, Inc. | Mammalian gamete and embryo culture media and culture media supplements |
| FR2812004B1 (fr) | 2000-07-24 | 2002-12-27 | Ccd Lab | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
| US7226994B2 (en) | 2001-01-18 | 2007-06-05 | Cambridge University Technical Services Limited | Cell surface expressed marker of pluripotency |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| CA2529510A1 (en) | 2003-07-01 | 2005-01-13 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| WO2005007687A1 (en) | 2003-07-09 | 2005-01-27 | Dana-Farber Cancer Institute, Inc | Compositions and methods for modulating ovarian follicular initiation |
| US20050130302A1 (en) | 2003-09-29 | 2005-06-16 | Reprocell Inc. | Method and composition for regulating expansion of stem cells |
| EP1708689A2 (en) | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US7955846B2 (en) * | 2004-05-17 | 2011-06-07 | The General Hospital Corporation | Compositions comprising female germline stem cells and methods of use thereof |
| JP2008512990A (ja) | 2004-05-17 | 2008-05-01 | ザ ジェネラル ホスピタル コーポレーション | 骨髄由来の生殖細胞系列幹細胞から生殖細胞を産生するための方法及び組成物 |
| CN1964627B (zh) * | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| JP2008527002A (ja) * | 2005-01-13 | 2008-07-24 | サートリス ファーマシューティカルズ， インコーポレイテッド | 神経変性障害および血液凝固障害を予防および処置するための新規組成物 |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20090137681A1 (en) | 2005-04-08 | 2009-05-28 | David A Sinclair | Sirtuin Inhibiting Compounds |
| US20080050347A1 (en) * | 2006-08-23 | 2008-02-28 | Ichim Thomas E | Stem cell therapy for cardiac valvular dysfunction |
| WO2008026018A1 (en) * | 2006-09-01 | 2008-03-06 | Topotarget Switzerland Sa | New method for the treatment of inflammatory diseases |
| WO2008089439A2 (en) * | 2007-01-18 | 2008-07-24 | Fred Hutchinson Cancer Research Center | Methods and compositions for enhancing lifespan involving sirtuin-modulating compounds and chalcogenides |
| US8062222B2 (en) | 2007-06-13 | 2011-11-22 | Litron Laboratories, Ltd. | Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment |
| US20090111764A1 (en) | 2007-10-25 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Mitochondrial selection |
| NO331476B1 (no) * | 2007-12-21 | 2012-01-16 | Jaffar Ali Bin M Abdullah | Proteinfri gamete- og embryo-handtering samt dyrkningsmedieprodukter inneholdende metylcellulose |
| US8415094B2 (en) * | 2007-12-21 | 2013-04-09 | Jaffar Ali bin M. Abdullah | Protein-free gamete and embryo handling and culture media products |
| WO2009087568A2 (en) | 2008-01-10 | 2009-07-16 | Universidade De Coimbra | Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties |
| EP2213288A1 (en) | 2009-01-30 | 2010-08-04 | Karl Welte | NAMPT and vitamin B3 for treating or preventing diseases |
| US8527209B2 (en) | 2010-06-24 | 2013-09-03 | The Invention Science Fund I, Llc | Rejuvenation or preservation of germ cells |
| US8338178B2 (en) | 2010-10-28 | 2012-12-25 | The Invention Science Fund I, Llc | Mitochondrial enhancement of cells |
| JP2012105585A (ja) * | 2010-11-17 | 2012-06-07 | Nippon Ika Kikai Seisakusho:Kk | 人工受精用組成物 |
| AU2012242591B2 (en) | 2011-04-14 | 2014-10-23 | The General Hospital Corporation | Compositions and methods for autologous germline mitochondrial energy transfer |
| WO2013002879A1 (en) | 2011-06-29 | 2013-01-03 | President And Fellows Of Harvard College | Small molecule cd38 inhibitors and methods of using same |
-
2012
- 2012-04-13 EP EP12804411.2A patent/EP2726601B1/en not_active Not-in-force
- 2012-04-13 AU AU2012276038A patent/AU2012276038B2/en not_active Ceased
- 2012-04-13 EP EP18203134.4A patent/EP3495470A1/en not_active Withdrawn
- 2012-04-13 EA EA201490050A patent/EA201490050A1/ru unknown
- 2012-04-13 WO PCT/US2012/033672 patent/WO2013002880A1/en active Application Filing
- 2012-04-13 CN CN201280040259.8A patent/CN103827293A/zh active Pending
- 2012-04-13 US US13/447,083 patent/US9845482B2/en active Active
- 2012-04-13 JP JP2014518556A patent/JP6284475B2/ja not_active Expired - Fee Related
- 2012-04-13 BR BR112013033797A patent/BR112013033797A2/pt active Search and Examination
- 2012-04-13 UA UAA201400826A patent/UA117448C2/uk unknown
- 2012-04-13 CA CA2847292A patent/CA2847292A1/en not_active Abandoned
- 2012-04-13 MX MX2014000201A patent/MX356815B/es active IP Right Grant
-
2013
- 2013-12-20 ZA ZA2013/09707A patent/ZA201309707B/en unknown
- 2013-12-26 IL IL230212A patent/IL230212B/en active IP Right Grant
-
2015
- 2015-02-26 US US14/632,754 patent/US20160024527A1/en not_active Abandoned
-
2017
- 2017-06-13 JP JP2017116146A patent/JP6496359B2/ja not_active Expired - Fee Related
- 2017-10-27 AU AU2017251852A patent/AU2017251852A1/en not_active Abandoned
- 2017-11-17 US US15/816,647 patent/US20180100166A1/en not_active Abandoned
-
2018
- 2018-03-14 IL IL258129A patent/IL258129A/en unknown
- 2018-07-13 US US16/034,446 patent/US20190002919A1/en not_active Abandoned
- 2018-10-29 JP JP2018202431A patent/JP2019030326A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014520526A5 (ja) | ||
| Agarwal et al. | Oxidative stress and assisted reproduction: a comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment | |
| Baldini et al. | Sperm selection for ICSI: do we have a winner? | |
| Hodjat et al. | A systematic review on the role of environmental toxicants in stem cells aging | |
| JP2014514928A5 (ja) | ||
| Tamburrino et al. | Cryopreservation of human spermatozoa: Functional, molecular and clinical aspects | |
| JP2019500395A5 (ja) | ||
| You et al. | 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin can alter the sex ratio of embryos with decreased viability of Y spermatozoa in mice | |
| Rizvi et al. | Lipid antigen presentation through CD1d pathway in mouse lung epithelial cells, macrophages and dendritic cells and its suppression by poly-dispersed single-walled carbon nanotubes | |
| Nikitaras et al. | Improving sperm oxidative stress and embryo quality in advanced paternal age using idebenone in vitro—A proof-of-concept study | |
| Aydos et al. | Sperm selection procedures for optimizing the outcome of ICSI in patients with NOA | |
| Alhomaidi et al. | Biosynthesis of silver nanoparticles using Lawsonia inermis and their biomedical application | |
| Di Giuseppe et al. | Cryopreservation effects on Wharton’s jelly stem cells proteome | |
| Chen et al. | Glucose-6-phosphate dehydrogenase, redox homeostasis and embryogenesis | |
| Ivanova et al. | Redox homeostasis and regulation in pluripotent stem cells: uniqueness or versatility? | |
| Asadi et al. | Exogenous melatonin ameliorates the negative effect of osmotic stress in human and bovine ovarian stromal cells | |
| Foutouhi et al. | Comparative oxidative metabolism in mammalian sperm | |
| El Andaloussi et al. | Intravenous infusion of nucleated peripheral blood cells restores fertility in mice with chemotherapy-induced premature ovarian failure | |
| Baharvand et al. | A new chemical approach to the efficient generation of mouse embryonic stem cells | |
| Park et al. | Effect of passage number of conditioned medium collected from equine amniotic fluid mesenchymal stem cells: porcine oocyte maturation and embryo development | |
| JP2023052757A (ja) | 生物学的試料の取り扱い | |
| Ďuračka et al. | Strategies for Bacterial Eradication from Human and Animal Semen Samples: Current Options and Future Alternatives | |
| JP5204600B2 (ja) | 催奇形性の予測方法 | |
| Xu et al. | Vitrification of Pronuclear Zygotes Perturbs Porcine Zygotic Genome Activation | |
| Cimini et al. | Catechin versus MoS2 Nanoflakes Functionalized with Catechin: Improving the Sperm Fertilizing Ability—An In Vitro Study in a Swine Model |