PL3670522T3 - Krystaliczna postać chlorku rybozydu nikotynamidu - Google Patents
Krystaliczna postać chlorku rybozydu nikotynamiduInfo
- Publication number
- PL3670522T3 PL3670522T3 PL20153772T PL20153772T PL3670522T3 PL 3670522 T3 PL3670522 T3 PL 3670522T3 PL 20153772 T PL20153772 T PL 20153772T PL 20153772 T PL20153772 T PL 20153772T PL 3670522 T3 PL3670522 T3 PL 3670522T3
- Authority
- PL
- Poland
- Prior art keywords
- crystalline form
- nicotinamide riboside
- riboside chloride
- chloride
- nicotinamide
- Prior art date
Links
- YABIFCKURFRPPO-IVOJBTPCSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride Chemical compound [Cl-].NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 YABIFCKURFRPPO-IVOJBTPCSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028702P | 2014-07-24 | 2014-07-24 | |
| EP20153772.7A EP3670522B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside chloride |
| EP15825253.6A EP3174891B1 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
| PCT/US2015/041956 WO2016014927A2 (en) | 2014-07-24 | 2015-07-24 | Crystalline form of nicotinamide riboside |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3670522T3 true PL3670522T3 (pl) | 2022-02-21 |
Family
ID=55163976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20153772T PL3670522T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać chlorku rybozydu nikotynamidu |
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15825253T PL3174891T3 (pl) | 2014-07-24 | 2015-07-24 | Krystaliczna postać rybozydu nikotynamidu |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10323058B2 (pl) |
| EP (2) | EP3670522B1 (pl) |
| CN (1) | CN106715454B (pl) |
| CA (1) | CA2956163C (pl) |
| ES (2) | ES2908332T3 (pl) |
| PL (2) | PL3670522T3 (pl) |
| WO (1) | WO2016014927A2 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3268379B1 (en) * | 2015-03-09 | 2023-11-01 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
| US9855289B2 (en) | 2015-08-05 | 2018-01-02 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| WO2017161165A1 (en) | 2016-03-16 | 2017-09-21 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
| EP3538099B1 (en) | 2016-11-11 | 2026-04-22 | The Queen's University of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および/または子の健康を向上させるためのnad前駆体の使用 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| SG11201912267SA (en) | 2017-06-19 | 2020-01-30 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| CN112020363A (zh) | 2017-12-22 | 2020-12-01 | 益力舒健康公司 | 烟酰胺核苷氯化物的结晶形式 |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| WO2019219895A1 (en) | 2018-05-18 | 2019-11-21 | Roche Diagnostics Gmbh | (thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| EP3893873A4 (en) | 2018-12-10 | 2023-01-11 | Chromadex, Inc. | CRYSTALLINE FORMS OF NICOTINOYL RIBOSIDES, THEIR DERIVATIVES AND METHODS OF PREPARING THEM |
| WO2020131578A2 (en) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| EP3927715A4 (en) | 2019-02-21 | 2023-03-01 | Chromadex, Inc. | Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| BR112022000963A2 (pt) | 2019-07-19 | 2022-04-05 | Biosynth Ag | Método de fabricação de sais de nicotinamida ribofuranosídeo, sais de nicotinamida ribofuranosídeo como tal e usos dos mesmos |
| CN111808156A (zh) * | 2020-07-15 | 2020-10-23 | 许昌远志生物科技有限公司 | 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法 |
| US20230271995A1 (en) * | 2020-09-15 | 2023-08-31 | Societe Des Produits Nestle S.A. | Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride |
| AU2022281388A1 (en) | 2021-05-27 | 2023-12-07 | Metro International Biotech, Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
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| GB1190080A (en) | 1966-08-08 | 1970-04-29 | Kyowa Hakko Kogyo Company Ltd | Process for producing Nicotinamide Adenine Dinucleotide |
| US3728111A (en) | 1971-09-21 | 1973-04-17 | Asea Ab | Method of manufacturing billets from powder |
| DK0981534T3 (da) | 1997-02-06 | 2006-09-04 | Inspire Pharmaceuticals Inc | Dinukleotider og deres anvendelser |
| GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| WO2002048165A2 (en) | 2000-12-15 | 2002-06-20 | Pharmasset Ltd. | Antiviral agents for treatment of flaviviridae infections |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050020587A1 (en) | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US8114626B2 (en) | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| JP2007521835A (ja) | 2004-02-10 | 2007-08-09 | トラスティーズ・オブ・ダートマウス・カレッジ | ニコチンアミドリボシドキナーゼ組成物およびそれらの使用方法 |
| JP2008501343A (ja) | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
| NZ561613A (en) | 2005-02-18 | 2010-12-24 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| US20060229265A1 (en) * | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| EP3369738B1 (en) * | 2005-11-18 | 2020-05-20 | Cornell Research Foundation, Inc. | Method for making nicotinoyl ribosides and nicotinamide beta-riboside |
| EP1957109A2 (en) | 2005-12-02 | 2008-08-20 | Sirtris Pharmaceuticals, Inc. | Modulators of cdc2-like kinases (clks) and methods of use thereof |
| WO2007136744A1 (en) | 2006-05-19 | 2007-11-29 | The Johns Hopkins University | Crystal structure of a substrate complex of nampt/pbef/visfatin |
| EP2129660A2 (en) | 2006-12-19 | 2009-12-09 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| EP2124985A4 (en) | 2007-01-26 | 2011-06-08 | Univ Washington | METHOD AND COMPOSITIONS FOR TREATING NERVOUS ELEMENTS |
| CA2725481A1 (en) | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| WO2010002586A2 (en) | 2008-06-30 | 2010-01-07 | Elc Management Llc | Topical compositions comprising isonicotinamide |
| EP2324042B1 (en) | 2008-08-06 | 2012-11-28 | Sicor, Inc. | Process for preparing azacytidine intermediate |
| US20120164670A1 (en) | 2009-06-23 | 2012-06-28 | President And Fellows Of Harvard College | Methods and kits for measuring enzyme activity |
| WO2011011721A2 (en) | 2009-07-24 | 2011-01-27 | Amazentis Sa | Compounds, compositions and methods for protecting brain health in neurodegenerative disorders |
| US8507251B2 (en) | 2009-09-28 | 2013-08-13 | Robert J. Greenstein | Medium and method for culturing Mycobacterium avium subspecies paratuberculosis |
| US9603862B2 (en) | 2009-12-14 | 2017-03-28 | Cornell University | Activation and activators of SIRT5 |
| US20130165398A1 (en) | 2010-03-29 | 2013-06-27 | Paul Hochegger | Concentration-enhancing drink |
| JP5663576B2 (ja) | 2010-07-06 | 2015-02-04 | 秀則 上西 | 神経突起伸長剤 |
| WO2012114204A2 (en) | 2011-02-15 | 2012-08-30 | Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto | Methods of treating mitochondrial dysfunction |
| US20120107888A1 (en) | 2011-02-17 | 2012-05-03 | Qteros, Inc. | Modulation of fermentation products through vitamin supplementation |
| US20120328526A1 (en) | 2011-06-27 | 2012-12-27 | University Of Maryland, Baltimore | Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof |
| CA2847292A1 (en) | 2011-06-29 | 2013-01-03 | The General Hospital Corporation | Compositions and methods for enhancing bioenergetic status in female germ cells |
| EP3345901A3 (en) | 2011-06-29 | 2018-09-12 | President and Fellows of Harvard College | Small molecules as antiaging agents |
| CN104780782A (zh) | 2012-07-09 | 2015-07-15 | 诺格罗有限责任公司 | 使用膳食补充剂预防酒精反应 |
| US20140256760A1 (en) | 2012-07-09 | 2014-09-11 | Noglo Llc | Reduction or prevention of alcohol reaction with dietary supplements |
| EP2872128B1 (en) | 2012-07-16 | 2020-02-19 | Cornell University | Nicotinamide riboside to treat hearing loss |
| AU2013329312A1 (en) | 2012-10-09 | 2015-05-28 | Massachusetts Institute Of Technology | Treatment of age-related and mitochondrial diseases by inhibition of HIF-1 alpha function |
| WO2014111906A1 (en) | 2013-01-21 | 2014-07-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Bioluminescence imaging of small biomolecules |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| EP3060311B1 (en) | 2013-10-24 | 2019-05-22 | The Procter and Gamble Company | Skin lightening cosmetic compositions and methods |
| WO2015064988A1 (ko) | 2013-10-29 | 2015-05-07 | 한림대학교 산학협력단 | 니코틴아마이드 라이보사이드를 유효성분으로 포함하는 패혈증 치료 또는 예방용 약제학적 조성물 |
| KR20220098049A (ko) | 2013-10-30 | 2022-07-08 | 크로마덱스 아이엔씨. | 피부 질환 치료에서의 국소적 사용을 위한 니코틴아미드 리보사이드 조성물 |
| CN105992521A (zh) | 2013-11-12 | 2016-10-05 | 奥索努特拉有限责任公司 | 基于特咖宁的补充剂及其使用方法 |
| WO2015099842A1 (en) | 2013-12-23 | 2015-07-02 | Abbott Laboratories | Hot beverage fortifier |
| KR20160132111A (ko) | 2014-03-13 | 2016-11-16 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Fxr 작용제와 제조방법 및 용도 |
| EP3116851B1 (en) | 2014-03-13 | 2023-07-26 | Salk Institute for Biological Studies | Analogs of fexaramine and methods of making and using |
| US20150297508A1 (en) | 2014-04-21 | 2015-10-22 | William Andriette | Topical Formulation to Enhance Genital Sensation and Function |
| JP2017518306A (ja) * | 2014-06-02 | 2017-07-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | 結晶性β−D−ニコチンアミドリボシドの製造および使用 |
| AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| CN107073027A (zh) | 2014-07-17 | 2017-08-18 | 斯克利普斯研究院 | 增强癌症疗法的方法和组合物 |
| EP3268379B1 (en) * | 2015-03-09 | 2023-11-01 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
-
2015
- 2015-07-24 US US15/328,664 patent/US10323058B2/en active Active
- 2015-07-24 PL PL20153772T patent/PL3670522T3/pl unknown
- 2015-07-24 EP EP20153772.7A patent/EP3670522B1/en active Active
- 2015-07-24 PL PL15825253T patent/PL3174891T3/pl unknown
- 2015-07-24 ES ES20153772T patent/ES2908332T3/es active Active
- 2015-07-24 CA CA2956163A patent/CA2956163C/en active Active
- 2015-07-24 EP EP15825253.6A patent/EP3174891B1/en active Active
- 2015-07-24 WO PCT/US2015/041956 patent/WO2016014927A2/en not_active Ceased
- 2015-07-24 ES ES15825253T patent/ES2776395T3/es active Active
- 2015-07-24 CN CN201580051724.1A patent/CN106715454B/zh active Active
-
2017
- 2017-10-23 US US15/791,097 patent/US10233207B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170210774A1 (en) | 2017-07-27 |
| PL3174891T3 (pl) | 2020-08-10 |
| US10323058B2 (en) | 2019-06-18 |
| EP3670522B1 (en) | 2022-01-19 |
| CN106715454B (zh) | 2020-06-16 |
| CN106715454A (zh) | 2017-05-24 |
| EP3174891B1 (en) | 2020-01-29 |
| WO2016014927A2 (en) | 2016-01-28 |
| EP3174891A2 (en) | 2017-06-07 |
| CA2956163C (en) | 2023-01-10 |
| US20180086783A1 (en) | 2018-03-29 |
| EP3174891A4 (en) | 2018-05-30 |
| WO2016014927A3 (en) | 2016-09-15 |
| EP3670522A1 (en) | 2020-06-24 |
| ES2908332T3 (es) | 2022-04-28 |
| CA2956163A1 (en) | 2016-01-28 |
| US10233207B2 (en) | 2019-03-19 |
| ES2776395T3 (es) | 2020-07-30 |
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