|
US4503035B1
(en)
|
1978-11-24 |
1996-03-19 |
Hoffmann La Roche |
Protein purification process and product
|
|
US4530901A
(en)
|
1980-01-08 |
1985-07-23 |
Biogen N.V. |
Recombinant DNA molecules and their use in producing human interferon-like polypeptides
|
|
US5231176A
(en)
|
1984-08-27 |
1993-07-27 |
Genentech, Inc. |
Distinct family DNA encoding of human leukocyte interferons
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
|
AU7180787A
(en)
|
1986-04-22 |
1987-10-29 |
Salk Institute For Biological Studies, The |
Fibroblast growth factor
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4843155A
(en)
|
1987-11-19 |
1989-06-27 |
Piotr Chomczynski |
Product and process for isolating RNA
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5468468A
(en)
|
1989-02-09 |
1995-11-21 |
The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services |
Method for making a monoclonal antibody, monoclonal antibodies to α PD
|
|
US5252725A
(en)
|
1989-06-23 |
1993-10-12 |
The Trustees Of The University Of Pennsylvania |
α-1-antichymotrypsin, analogues and methods of production
|
|
US5668264A
(en)
|
1990-06-11 |
1997-09-16 |
Nexstar Pharmaceuticals, Inc. |
High affinity PDGF nucleic acid ligands
|
|
US5674685A
(en)
|
1990-06-11 |
1997-10-07 |
Nexstar Pharmaceuticals, Inc. |
High affinity PDGF nucleic acid ligands
|
|
US5023264A
(en)
|
1990-07-16 |
1991-06-11 |
American Home Products Corporation |
Rapamycin oximes
|
|
US5120726A
(en)
|
1991-03-08 |
1992-06-09 |
American Home Products Corporation |
Rapamycin hydrazones
|
|
US5023263A
(en)
|
1990-08-09 |
1991-06-11 |
American Home Products Corporation |
42-oxorapamycin
|
|
US5023262A
(en)
|
1990-08-14 |
1991-06-11 |
American Home Products Corporation |
Hydrogenated rapamycin derivatives
|
|
US5358944A
(en)
|
1990-09-19 |
1994-10-25 |
American Home Products Corporation |
Rapamycin esters for treating transplantation rejection
|
|
US5130307A
(en)
|
1990-09-28 |
1992-07-14 |
American Home Products Corporation |
Aminoesters of rapamycin
|
|
US5378696A
(en)
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
|
US5221670A
(en)
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
|
US5233036A
(en)
|
1990-10-16 |
1993-08-03 |
American Home Products Corporation |
Rapamycin alkoxyesters
|
|
JPH06503966A
(ja)
|
1990-12-21 |
1994-05-12 |
クリエイティブ バイオモレキュルズ インコーポレイテッド |
生合成したｐｄｇｆアンタゴニスト
|
|
EP0584082B1
(en)
|
1991-01-31 |
2000-05-31 |
Cor Therapeutics, Inc. |
Domains of extracellular region of human platelet derived growth factor receptor polypeptides
|
|
GB9106678D0
(en)
|
1991-03-28 |
1991-05-15 |
Ferguson Mark W J |
Wound healing
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5194447A
(en)
|
1992-02-18 |
1993-03-16 |
American Home Products Corporation |
Sulfonylcarbamates of rapamycin
|
|
US5138051A
(en)
|
1991-08-07 |
1992-08-11 |
American Home Products Corporation |
Rapamycin analogs as immunosuppressants and antifungals
|
|
US5480883A
(en)
|
1991-05-10 |
1996-01-02 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
DE69222637T2
(de)
|
1991-05-10 |
1998-02-26 |
Rhone Poulenc Rorer Int |
Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase
|
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
|
US5120725A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Bicyclic rapamycins
|
|
US5120727A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Rapamycin dimers
|
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
|
US5169851A
(en)
|
1991-08-07 |
1992-12-08 |
American Home Products Corporation |
Rapamycin analog as immunosuppressants and antifungals
|
|
US5202332A
(en)
|
1991-08-07 |
1993-04-13 |
American Home Products Corporation |
Rapamycin analog as immunosuppressant
|
|
US5162333A
(en)
|
1991-09-11 |
1992-11-10 |
American Home Products Corporation |
Aminodiesters of rapamycin
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
|
US5164399A
(en)
|
1991-11-18 |
1992-11-17 |
American Home Products Corporation |
Rapamycin pyrazoles
|
|
US5817310A
(en)
|
1991-12-02 |
1998-10-06 |
Cor Therapeutics, Inc. |
Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
|
|
US5238950A
(en)
|
1991-12-17 |
1993-08-24 |
Schering Corporation |
Inhibitors of platelet-derived growth factor
|
|
US5221740A
(en)
|
1992-01-16 |
1993-06-22 |
American Home Products Corporation |
Oxepane isomers of rapamycin useful as immunosuppressive agents
|
|
EP0552108B1
(en)
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Energy transfer phase-modulation fluoro-immunoassay
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
US5262424A
(en)
|
1992-02-18 |
1993-11-16 |
American Home Products Corporation |
Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith
|
|
US5260299A
(en)
|
1992-03-05 |
1993-11-09 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents
|
|
US5177203A
(en)
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
|
TW225528B
(cg-RX-API-DMAC10.html)
|
1992-04-03 |
1994-06-21 |
Ciba Geigy Ag |
|
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
|
US5821234A
(en)
|
1992-09-10 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of proliferation of vascular smooth muscle cell
|
|
US5869462A
(en)
|
1992-09-10 |
1999-02-09 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of proliferation of vascular smooth muscle cell
|
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
|
US5411967A
(en)
|
1992-10-13 |
1995-05-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5489680A
(en)
|
1992-10-13 |
1996-02-06 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5434260A
(en)
|
1992-10-13 |
1995-07-18 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5480988A
(en)
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5302584A
(en)
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5480989A
(en)
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5262423A
(en)
|
1992-10-29 |
1993-11-16 |
American Home Products Corporation |
Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5620687A
(en)
|
1993-02-25 |
1997-04-15 |
Zymogenetics, Inc. |
Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors
|
|
US5976534A
(en)
|
1993-02-25 |
1999-11-02 |
Zymogenetics, Inc. |
Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin
|
|
AU693475B2
(en)
|
1993-10-01 |
1998-07-02 |
Novartis Ag |
Pyrimidineamine derivatives and processes for the preparation thereof
|
|
US5378836A
(en)
|
1993-10-08 |
1995-01-03 |
American Home Products Corporation |
Rapamycin oximes and hydrazones
|
|
US5391730A
(en)
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
|
US5373014A
(en)
|
1993-10-08 |
1994-12-13 |
American Home Products Corporation |
Rapamycin oximes
|
|
US5952304A
(en)
|
1993-10-22 |
1999-09-14 |
Trigen Limited |
Platelet-derived growth factor analogues
|
|
US5656643A
(en)
|
1993-11-08 |
1997-08-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
JPH07133280A
(ja)
|
1993-11-09 |
1995-05-23 |
Takeda Chem Ind Ltd |
セフェム化合物、その製造法および抗菌組成物
|
|
US5385910A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
|
US5385909A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
|
US5385908A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
|
BR9408323A
(pt)
|
1993-12-17 |
1997-08-19 |
Sandoz Ag |
Derivados de rapamicina
|
|
US5389639A
(en)
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
|
US6384192B1
(en)
|
1993-12-30 |
2002-05-07 |
President & Fellows Of Harvard College |
Vertebrate embryonic pattern-inducing proteins
|
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5504291A
(en)
|
1994-02-14 |
1996-04-02 |
Square D Company |
Contact blade assembly for a circuit breaker
|
|
WO1995024190A2
(en)
|
1994-03-07 |
1995-09-14 |
Sugen, Inc. |
Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
|
|
US5525610A
(en)
|
1994-03-31 |
1996-06-11 |
American Home Products Corporation |
42-Epi-rapamycin and pharmaceutical compositions thereof
|
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
|
ES2109796T3
(es)
|
1994-05-03 |
1998-01-16 |
Ciba Geigy Ag |
Derivados de pirrolopirimidilo con efecto antiproliferante.
|
|
US5463048A
(en)
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
|
US5958942A
(en)
|
1994-07-15 |
1999-09-28 |
Takeda Chemical Industries, Ltd. |
Tricyclic nitrogen ring compounds, their production and use
|
|
CA2156767A1
(en)
|
1994-08-25 |
1996-02-26 |
Kenichi Matsunaga |
Binding agent for growth factor
|
|
US5476851A
(en)
|
1994-09-08 |
1995-12-19 |
Rhone-Poulenc Rorer Pharmaceuticals, Inc. |
Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase
|
|
US5795910A
(en)
|
1994-10-28 |
1998-08-18 |
Cor Therapeutics, Inc. |
Method and compositions for inhibiting protein kinases
|
|
US5491231A
(en)
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
|
US5563145A
(en)
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ATE446955T1
(de)
|
1995-03-30 |
2009-11-15 |
Pfizer Prod Inc |
Chinazolinone derivate
|
|
JP4249804B2
(ja)
|
1995-04-03 |
2009-04-08 |
ノバルティス・アクチエンゲゼルシャフト |
ピラゾール誘導体およびその製造法
|
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US6331555B1
(en)
|
1995-06-01 |
2001-12-18 |
University Of California |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
US5723594A
(en)
|
1995-06-07 |
1998-03-03 |
Nexstar Pharmaceuticals, Inc. |
High affinity PDGF nucleic acid ligands
|
|
ES2276405T3
(es)
|
1995-06-02 |
2007-06-16 |
Gilead Sciences, Inc. |
Ligandos de oligonucleotidos de alta afinidad a pdgf.
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US5618837A
(en)
|
1995-06-07 |
1997-04-08 |
Zymogenetics, Inc. |
PDGF antagonists III
|
|
US5650415A
(en)
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
|
US6229002B1
(en)
|
1995-06-07 |
2001-05-08 |
Nexstar Pharmaceuticlas, Inc. |
Platelet derived growth factor (PDGF) nucleic acid ligand complexes
|
|
DE69624921T2
(de)
|
1995-06-09 |
2003-09-11 |
Novartis Ag, Basel |
Rapamycinderivate
|
|
DE69632402T2
(de)
|
1995-06-30 |
2005-05-19 |
Zymogenetics, Inc., Seattle |
4-(2-(n-(-2-carboxamidoindole)aminiethyl)-benzensulfonamide oder sulfonylharnstoffe als pdgf antagoniste
|
|
PL188959B1
(pl)
|
1995-07-06 |
2005-05-31 |
Novartis Ag |
Pirolopirymidyny i sposoby ich wytwarzania
|
|
DK9500262U4
(da)
|
1995-07-07 |
1996-10-07 |
Bonus Energy As |
Bundramme til vindmøllehus samt vindmølle omfattende samme
|
|
FR2736550B1
(fr)
|
1995-07-14 |
1998-07-24 |
Sandoz Sa |
Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
|
|
AR004010A1
(es)
|
1995-10-11 |
1998-09-30 |
Glaxo Group Ltd |
Compuestos heterociclicos
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
EP0857210B1
(en)
|
1995-10-23 |
2003-09-03 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic compositions and methods
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
DK0780386T3
(da)
|
1995-12-20 |
2003-02-03 |
Hoffmann La Roche |
Matrixmetalloproteaseinhibitorer
|
|
US5780462A
(en)
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
|
US6140317A
(en)
|
1996-01-23 |
2000-10-31 |
Novartis Ag |
Pyrrolopyrimidines and processes for their preparation
|
|
JP3406763B2
(ja)
|
1996-01-30 |
2003-05-12 |
東レ・ダウコーニング・シリコーン株式会社 |
シリコーンゴム組成物
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9603097D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
|
NZ331191A
(en)
|
1996-03-05 |
2000-03-27 |
Zeneca Ltd |
4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
|
|
DE19629652A1
(de)
|
1996-03-06 |
1998-01-29 |
Thomae Gmbh Dr K |
4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
DE19608588A1
(de)
|
1996-03-06 |
1997-09-11 |
Thomae Gmbh Dr K |
Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
EP0929694A4
(en)
|
1996-03-15 |
2002-05-02 |
Penn State Res Found |
DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
|
|
DE59710417D1
(de)
|
1996-03-15 |
2003-08-14 |
Novartis Ag |
N-7 HETEROCYCLYL-PYRROLO[ 2,3-d]PYRIMIDINE UND IHRE VERWENDUNG
|
|
US5882644A
(en)
|
1996-03-22 |
1999-03-16 |
Protein Design Labs, Inc. |
Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
|
|
CN100503580C
(zh)
|
1996-04-12 |
2009-06-24 |
沃尼尔·朗伯公司 |
酪氨酸激酶的不可逆抑制剂
|
|
GB9607729D0
(en)
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
|
BR9709959A
(pt)
|
1996-06-24 |
2000-05-09 |
Pfizer |
Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
|
|
BR9709974A
(pt)
|
1996-06-27 |
1999-08-10 |
Pfizer |
Derivados de 2-(2-oxo-etidileno)-imidazolidin-4-ona e seu uso como inibidores da transferase da proteina de farnesila
|
|
CA2259157A1
(en)
|
1996-07-05 |
1998-01-15 |
Mount Sinai Hospital Corporation |
Oligomerized receptors which affect pathways regulated by transmembrane ligands for elk-related receptor tyrosine kinases
|
|
WO1998002441A2
(en)
|
1996-07-12 |
1998-01-22 |
Ariad Pharmaceuticals, Inc. |
Non immunosuppressive antifungal rapalogs
|
|
US6171779B1
(en)
|
1996-07-12 |
2001-01-09 |
University Of Medicine & Dentistry Of New Jersey |
HMGI proteins in cancer
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
AR007855A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
|
|
US6391874B1
(en)
|
1996-07-13 |
2002-05-21 |
Smithkline Beecham Corporation |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
EP0922030A1
(en)
|
1996-08-23 |
1999-06-16 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
PT938486E
(pt)
|
1996-08-23 |
2008-03-27 |
Novartis Ag |
Pirrolopirimidinas substituídas e processos para a sua preparação
|
|
US5922730A
(en)
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
|
AU719392B2
(en)
|
1996-10-01 |
2000-05-11 |
Kyowa Hakko Kirin Co., Ltd. |
Nitrogen-containing heterocyclic compounds
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
WO1998014449A1
(en)
|
1996-10-02 |
1998-04-09 |
Novartis Ag |
Fused pyrazole derivatives and processes for their preparation
|
|
CA2266519C
(en)
|
1996-10-02 |
2007-01-23 |
Novartis Ag |
Pyrimidine derivatives and processes for the preparation thereof
|
|
EP0837063A1
(en)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
|
GB9621757D0
(en)
|
1996-10-18 |
1996-12-11 |
Ciba Geigy Ag |
Phenyl-substituted bicyclic heterocyclyl derivatives and their use
|
|
US6077864A
(en)
|
1997-01-06 |
2000-06-20 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
HUP0000852A2
(hu)
|
1997-02-03 |
2001-05-28 |
Pfizer Products Inc. |
Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
|
|
ES2301194T3
(es)
|
1997-02-05 |
2008-06-16 |
Warner-Lambert Company Llc |
Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular.
|
|
US5945422A
(en)
|
1997-02-05 |
1999-08-31 |
Warner-Lambert Company |
N-oxides of amino containing pyrido 2,3-D! pyrimidines
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
NZ336836A
(en)
|
1997-02-11 |
2001-02-23 |
Pfizer |
Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments
|
|
CA2289102A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
US6251628B1
(en)
|
1997-05-20 |
2001-06-26 |
Ludwig Institute For Cancer Research |
Isolated nucleic acid molecules encoding Smad7
|
|
US6180632B1
(en)
|
1997-05-28 |
2001-01-30 |
Aventis Pharmaceuticals Products Inc. |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
|
|
US6245760B1
(en)
|
1997-05-28 |
2001-06-12 |
Aventis Pharmaceuticals Products, Inc |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
|
|
US6159978A
(en)
|
1997-05-28 |
2000-12-12 |
Aventis Pharmaceuticals Product, Inc. |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
|
|
CA2291709A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
WO1999007701A1
(en)
|
1997-08-05 |
1999-02-18 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
|
TR200000368T2
(tr)
|
1997-08-08 |
2000-07-21 |
Pfizer Products Inc. |
Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
|
|
DE69838172T2
(de)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
US6015815A
(en)
|
1997-09-26 |
2000-01-18 |
Abbott Laboratories |
Tetrazole-containing rapamycin analogs with shortened half-lives
|
|
AU744939B2
(en)
|
1997-09-26 |
2002-03-07 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
TW557297B
(en)
|
1997-09-26 |
2003-10-11 |
Abbott Lab |
Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
|
|
SK6652000A3
(en)
|
1997-11-11 |
2002-05-09 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
US5932580A
(en)
|
1997-12-01 |
1999-08-03 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
PDGF receptor kinase inhibitory compounds their preparation and compositions
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
JPH11236333A
(ja)
|
1997-12-30 |
1999-08-31 |
Pfizer Prod Inc |
抗ガン剤として有用なイミダゾリン−４−オン誘導体
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
AU4079999A
(en)
|
1998-05-15 |
1999-12-06 |
Imclone Systems Incorporated |
Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
|
|
KR100743287B1
(ko)
|
1998-05-29 |
2007-07-26 |
수젠, 인크. |
피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
US7342108B2
(en)
|
1998-06-25 |
2008-03-11 |
The General Hospital Corporation |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
|
|
US7368551B2
(en)
|
1998-06-25 |
2008-05-06 |
The General Hospital Corporation |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
|
|
US6566131B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad6 expression
|
|
US6015809A
(en)
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
|
CA2341739C
(en)
|
1998-08-27 |
2005-07-12 |
Pfizer Products Inc. |
Quinolin-2-one derivatives useful as anticancer agents
|
|
KR20010072991A
(ko)
|
1998-08-27 |
2001-07-31 |
실버스타인 아써 에이. |
항암제로서 유용한 알키닐-치환된 퀴놀린-2-온 유도체
|
|
AU5914299A
(en)
|
1998-09-11 |
2000-04-03 |
Eli Lilly And Company |
Antagonists of fibroblast growth factor
|
|
US6410323B1
(en)
|
1999-08-31 |
2002-06-25 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of human Rho family gene expression
|
|
NZ510588A
(en)
|
1998-09-18 |
2003-08-29 |
Abbott Gmbh & Co |
Pyrrolopyrimidines as protein kinase inhibitors
|
|
EP1004578B1
(en)
|
1998-11-05 |
2004-02-25 |
Pfizer Products Inc. |
5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
|
|
EP1006113A1
(en)
|
1998-12-02 |
2000-06-07 |
Pfizer Products Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
|
|
US6107091A
(en)
|
1998-12-03 |
2000-08-22 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of G-alpha-16 expression
|
|
US5981732A
(en)
|
1998-12-04 |
1999-11-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-13 expression
|
|
WO2000035455A1
(en)
|
1998-12-15 |
2000-06-22 |
Telik, Inc. |
Heteroaryl-aryl ureas as igf-1 receptor antagonists
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
JP3270834B2
(ja)
|
1999-01-27 |
2002-04-02 |
ファイザー・プロダクツ・インク |
抗がん剤として有用なヘテロ芳香族二環式誘導体
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
WO2000046380A2
(en)
|
1999-02-08 |
2000-08-10 |
Chiron Corporation |
Fibroblast growth factor receptor-immunoglobulin fusion
|
|
TR200201296T2
(tr)
|
1999-02-11 |
2002-07-22 |
Pfizer Products Inc. |
Antikanser maddeleri olarak faydalı heteroaril-ikame edilmiş kinolin-2-on türevleri
|
|
US6586447B1
(en)
|
1999-04-01 |
2003-07-01 |
Pfizer Inc |
3,3-disubstituted-oxindole derivatives useful as anticancer agents
|
|
US6046321A
(en)
|
1999-04-09 |
2000-04-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-i1 expression
|
|
IL144977A0
(en)
|
1999-05-21 |
2002-06-30 |
Bristol Myers Squibb Co |
Pyrrolotriazine derivatives and pharmaceutical compositions containing the same
|
|
ES2161655B1
(es)
|
1999-07-01 |
2002-06-01 |
Consejo Superior Investigacion |
Procedimiento para determinar la capacidad invasiva y metastasica de un tumor epitelial mediante el uso de snail.
|
|
US6455525B1
(en)
|
1999-11-04 |
2002-09-24 |
Cephalon, Inc. |
Heterocyclic substituted pyrazolones
|
|
US6358954B1
(en)
|
1999-11-09 |
2002-03-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
|
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
UA75055C2
(uk)
|
1999-11-30 |
2006-03-15 |
Пфайзер Продактс Інк. |
Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
|
|
ES2212971T3
(es)
|
1999-11-30 |
2004-08-16 |
Pfizer Products Inc. |
Derivados de quinolina utiles para la inhibicion de la farnesil protein transferasa.
|
|
US6448086B1
(en)
|
2000-01-18 |
2002-09-10 |
Diagnostic Systems Laboratories, Inc. |
Insulin-like growth factor system and cancer
|
|
HN2000000266A
(es)
|
2000-01-21 |
2001-05-21 |
Pfizer Prod Inc |
Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
|
|
WO2001068912A2
(en)
|
2000-03-15 |
2001-09-20 |
Epigenomics Ag |
Diagnosis of diseases associated with tumor suppressor genes and oncogenes
|
|
JP2003526367A
(ja)
|
2000-03-16 |
2003-09-09 |
ジェネティカ インコーポレイテッド |
Ｒｎａ干渉の方法とｒｎａ干渉組成物
|
|
AU2001252940A1
(en)
|
2000-03-22 |
2001-10-03 |
Amgen Inc. |
Fibroblast growth factor receptor-like molecules and uses thereof
|
|
TWI310684B
(en)
|
2000-03-27 |
2009-06-11 |
Bristol Myers Squibb Co |
Synergistic pharmaceutical kits for treating cancer
|
|
AU2000240570A1
(en)
|
2000-03-29 |
2001-10-08 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
US6365354B1
(en)
|
2000-07-31 |
2002-04-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of lysophospholipase I expression
|
|
JP2004519422A
(ja)
|
2000-08-04 |
2004-07-02 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
|
|
US6566135B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of caspase 6 expression
|
|
US20020169562A1
(en)
|
2001-01-29 |
2002-11-14 |
Gregory Stephanopoulos |
Defining biological states and related genes, proteins and patterns
|
|
TWI238824B
(en)
|
2001-05-14 |
2005-09-01 |
Novartis Ag |
4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
|
|
US20030053995A1
(en)
|
2001-06-15 |
2003-03-20 |
Mien-Chie Hung |
Methods and compositions for inhibiting EGF receptor activity
|
|
SE0102168D0
(sv)
|
2001-06-19 |
2001-06-19 |
Karolinska Innovations Ab |
New use and new compounds
|
|
IL159177A0
(en)
|
2001-06-20 |
2004-06-01 |
Prochon Biotech Ltd |
Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
FR2828601B1
(fr)
|
2001-08-10 |
2003-11-07 |
Iroc Technologies |
Ensemble de circuits electroniques comportant des moyens de decontamination de parties contaminees par des erreurs
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
CN100391958C
(zh)
|
2001-09-19 |
2008-06-04 |
安万特医药股份有限公司 |
化合物
|
|
JP2005512962A
(ja)
|
2001-09-20 |
2005-05-12 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
抗ｐｄｇｆ抗体および設計抗体の産生方法
|
|
WO2003035619A1
(en)
|
2001-10-25 |
2003-05-01 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
AU2002348393A1
(en)
|
2001-10-25 |
2003-05-06 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
AU2002348394A1
(en)
|
2001-10-25 |
2003-05-06 |
Merck And Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2003035616A2
(en)
|
2001-10-25 |
2003-05-01 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
|
SE0104140D0
(sv)
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
AU2002358279A1
(en)
|
2001-12-21 |
2003-07-30 |
Arcturus Engineering, Inc. |
Biomarkers for breast cancer
|
|
US20030144260A1
(en)
|
2002-01-03 |
2003-07-31 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method
|
|
JP2005532036A
(ja)
|
2002-01-09 |
2005-10-27 |
理化学研究所 |
癌プロフィール
|
|
US7553485B2
(en)
|
2002-01-18 |
2009-06-30 |
Pierre Fabre Medicament |
Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
|
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
AU2003209340A1
(en)
|
2002-01-18 |
2003-09-02 |
Bristol-Myers Squibb Company |
Predictor sets for tyrosine kinase pathways
|
|
EP1476192B1
(en)
|
2002-02-14 |
2007-04-25 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for treating hyperproliferative conditions
|
|
US7081340B2
(en)
|
2002-03-13 |
2006-07-25 |
Genomic Health, Inc. |
Gene expression profiling in biopsied tumor tissues
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
AU2003233576A1
(en)
|
2002-05-17 |
2003-12-02 |
Sugen, Inc. |
Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
|
|
MXPA04011624A
(es)
|
2002-05-24 |
2005-03-07 |
Schering Corp |
Anticuerpo neutralizante humano anti-igfr.
|
|
PE20040522A1
(es)
|
2002-05-29 |
2004-09-28 |
Novartis Ag |
Derivados de diarilurea dependientes de la cinasa de proteina
|
|
SI1509230T1
(sl)
|
2002-06-05 |
2007-06-30 |
Cedars Sinai Medical Center |
Gefitinib (iressa) za zdravljenje raka
|
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
WO2004000102A2
(en)
|
2002-06-19 |
2003-12-31 |
Abgenix, Inc. |
Method for predicting response to epidermal growth factor receptor-directed therapy
|
|
TW200401638A
(en)
|
2002-06-20 |
2004-02-01 |
Bristol Myers Squibb Co |
Heterocyclic inhibitors of kinases
|
|
GB0215844D0
(en)
|
2002-07-09 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
|
WO2004005891A2
(en)
|
2002-07-10 |
2004-01-15 |
The Regents Of The University Of Michigan |
Expression profile of lung cancer
|
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
|
AU2003265349A1
(en)
|
2002-08-02 |
2004-02-23 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
|
US7084270B2
(en)
|
2002-08-14 |
2006-08-01 |
Hoffman-La Roche Inc. |
Pyrimido compounds having antiproliferative activity
|
|
US20040209930A1
(en)
|
2002-10-02 |
2004-10-21 |
Carboni Joan M. |
Synergistic methods and compositions for treating cancer
|
|
TW200501960A
(en)
|
2002-10-02 |
2005-01-16 |
Bristol Myers Squibb Co |
Synergistic kits and compositions for treating cancer
|
|
US7129351B2
(en)
|
2002-11-04 |
2006-10-31 |
Hoffmann-La Roche Inc. |
Pyrimido compounds having antiproliferative activity
|
|
US8008003B2
(en)
|
2002-11-15 |
2011-08-30 |
Genomic Health, Inc. |
Gene expression profiling of EGFR positive cancer
|
|
PL377620A1
(pl)
|
2002-11-18 |
2006-02-06 |
F. Hoffmann-La Roche Ag |
Diazynopirymidyny
|
|
AU2003297297A1
(en)
|
2002-11-22 |
2004-06-18 |
North Shore-Long Island Jewish Research Institute |
Elf3 gene compositions and methods
|
|
AU2003300899A1
(en)
|
2002-12-12 |
2004-06-30 |
Oncotech, Inc. |
Genes related to sensitivity and resistance to chemotherapeutic drug treatment
|
|
TWI299664B
(en)
|
2003-01-06 |
2008-08-11 |
Osi Pharm Inc |
(2-carboxamido)(3-amino)thiophene compounds
|
|
US7696225B2
(en)
|
2003-01-06 |
2010-04-13 |
Osi Pharmaceuticals, Inc. |
(2-carboxamido)(3-Amino) thiophene compounds
|
|
EP1597558A2
(en)
|
2003-01-08 |
2005-11-23 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
|
|
WO2004065602A1
(es)
|
2003-01-17 |
2004-08-05 |
Universidad Autónoma de Madrid |
Procedimiento para identificar la transición epitelio-mesenquimal de células mesoteliales (temcm) e identificar compuestos moduladores de temcm, composiciones farmacéuticas y su uso en el diagnóstico y tratamiento de enfermedades que cursan con temcm
|
|
WO2004071572A2
(en)
|
2003-02-06 |
2004-08-26 |
Genomic Health, Inc. |
Gene expression markers for response to egfr inhibitor drugs
|
|
US7253166B2
(en)
|
2003-04-22 |
2007-08-07 |
Irm Llc |
6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells
|
|
JP2007506442A
(ja)
|
2003-05-30 |
2007-03-22 |
ゲノミック ヘルス， インコーポレイテッド |
Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー
|
|
US20060078941A1
(en)
|
2003-06-09 |
2006-04-13 |
Santin Alessandro D |
Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium
|
|
US20070092881A1
(en)
|
2003-07-10 |
2007-04-26 |
Central Institute For Experimental Animals |
Gene markers of tumor metastasis
|
|
ES2905579T3
(es)
|
2003-07-10 |
2022-04-11 |
Genomic Health Inc |
Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama
|
|
AU2004260689B8
(en)
|
2003-07-29 |
2008-05-15 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
EP1664716A4
(en)
|
2003-08-15 |
2008-08-13 |
Smithkline Beecham Corp |
CANCER BIOMARKERS
|
|
JP4795237B2
(ja)
|
2003-08-21 |
2011-10-19 |
オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー |
Ｎ−置換ピラゾリル−アミジル−ベンズイミダゾリルｃ−Ｋｉｔ阻害剤
|
|
AP2006003552A0
(en)
|
2003-08-21 |
2006-04-30 |
Osi Pharm Inc |
N3 - substituted imidazopyridine C-kit inhibitors.
|
|
BRPI0413746A
(pt)
|
2003-08-21 |
2006-10-24 |
Osi Pharm Inc |
composto ou um seu n-óxido ou seu sal farmaceuticamente aceitável, composição, e, método de tratamento de distúrbio hiperproliferativo
|
|
EP1980629A3
(en)
|
2003-08-28 |
2008-12-17 |
Ipsogen |
Identification of an erbb2 gene expression signature in breast cancers
|
|
DE10342503A1
(de)
|
2003-09-12 |
2005-04-14 |
Merck Patent Gmbh |
Benzyl-Benzimidazolylderivate
|
|
GB0321694D0
(en)
|
2003-09-16 |
2003-10-15 |
Ark Therapeutics Ltd |
Genes and their therapeutic use
|
|
ES2372694T3
(es)
|
2003-10-15 |
2012-01-25 |
OSI Pharmaceuticals, LLC |
Inhibidores de tirosina cinasa de imidazo[1,5-a]pirazina.
|
|
JP2007509613A
(ja)
|
2003-10-16 |
2007-04-19 |
ジェノミック ヘルス， インコーポレイテッド |
遺伝子発現プロファイリングのためのｑＲＴ−ＰＣＲアッセイシステム
|
|
AR046639A1
(es)
|
2003-11-21 |
2005-12-14 |
Schering Corp |
Combinaciones terapeuticas de anticuerpo anti- igfr1
|
|
DE10356579A1
(de)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
Aminderivate
|
|
JP5192632B2
(ja)
|
2003-12-12 |
2013-05-08 |
愛知県 |
肺癌組織中の遺伝子発現強度を識別する方法
|
|
WO2005066211A2
(en)
|
2003-12-19 |
2005-07-21 |
Five Prime Therapeutics, Inc. |
Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
|
|
EP1759010A4
(en)
|
2004-01-07 |
2008-12-24 |
Bristol Myers Squibb Co |
BIOMARKERS AND METHOD FOR DETERMINING SENSITIVITY AGAINST MODULATORS OF EGF (EPIDERMAL GROWTH FACTOR) RECEPTORS
|
|
US20080113874A1
(en)
|
2004-01-23 |
2008-05-15 |
The Regents Of The University Of Colorado |
Gefitinib sensitivity-related gene expression and products and methods related thereto
|
|
US8017321B2
(en)
|
2004-01-23 |
2011-09-13 |
The Regents Of The University Of Colorado, A Body Corporate |
Gefitinib sensitivity-related gene expression and products and methods related thereto
|
|
JP4848355B2
(ja)
|
2004-02-27 |
2011-12-28 |
アンスティテュ・キュリ |
臨床診療における新規増殖マーカーおよび癌の予後または診断のためのそれらの用途
|
|
JP2007530954A
(ja)
|
2004-03-26 |
2007-11-01 |
ブリストル−マイヤーズ スクイブ カンパニー |
非小細胞肺癌において上皮細胞増殖因子レセプターモジュレーターに対する感受性を決定するためのバイオマーカーおよび方法
|
|
US20060019268A1
(en)
|
2004-03-26 |
2006-01-26 |
Research Development Foundation |
Molecular markers of cisplatin resistance in cancer and uses thereof
|
|
WO2005099363A2
(en)
|
2004-03-26 |
2005-10-27 |
Whitehead Institute For Biomedical Research |
Methods of diagnosing, preventing and treating cancer metastasis
|
|
MXPA06011423A
(es)
|
2004-04-02 |
2007-01-23 |
Osi Pharm Inc |
Inhibidores de proteina cinasa heterobiciclica sustituida en el anillo 6,6-biciclico.
|
|
US20050256154A1
(en)
|
2004-05-04 |
2005-11-17 |
Kin-Chun Luk |
4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
|
|
WO2005107803A2
(en)
|
2004-05-06 |
2005-11-17 |
Vernalis Plc |
Methods of determining the prognosis and treatment of subjects with lung cancer
|
|
US7741035B2
(en)
|
2004-05-21 |
2010-06-22 |
Board Of Trustees Of The University Of Arkansas |
Use of gene expression profiling to predict survival in cancer patient
|
|
EP1766086A4
(en)
|
2004-05-21 |
2009-10-28 |
Univ Arkansas |
USE OF GENETIC EXPRESSION PROFILING TO PREVENT THE CHANCE OF SURVIVAL OF A PATIENT WITH CANCER
|
|
JP5422120B2
(ja)
|
2004-05-27 |
2014-02-19 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト |
癌患者による上皮成長因子受容体阻害薬に対する臨床転帰の予測方法
|
|
US7102002B2
(en)
|
2004-06-16 |
2006-09-05 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
|
CN101014365B
(zh)
|
2004-07-16 |
2011-04-13 |
辉瑞产品公司 |
使用抗-igf-1r抗体联合治疗非血液的恶性肿瘤
|
|
FR2875601B1
(fr)
|
2004-09-17 |
2007-04-13 |
Genome Express S A Sa |
Vimentine phosphorylee comme marqueur de l'agressivite et/ou l'invasivite des tumeurs
|
|
ES2365858T3
(es)
|
2004-10-13 |
2011-10-11 |
Merck Patent Gmbh |
Derivados de fenilurea como sustancia inhibidora de tirosina-quinasas para el tratamiento de enfermedades tumorales.
|
|
US7151176B2
(en)
|
2004-10-21 |
2006-12-19 |
Bristol-Myers Squibb Company |
Pyrrolotriazine compounds
|
|
CA2584804A1
(en)
|
2004-10-21 |
2006-05-04 |
The Penn State Research Foundation |
Eph receptor tumor biomarkers
|
|
DE102004054215A1
(de)
|
2004-11-10 |
2006-05-11 |
Merck Patent Gmbh |
Pyridopyrimidinonderivate
|
|
DE102004054216A1
(de)
|
2004-11-10 |
2006-05-11 |
Merck Patent Gmbh |
Substituierte 4-Amino-pyridopyrimidinone
|
|
EP2281841A3
(en)
|
2004-12-03 |
2013-10-23 |
Merck Sharp & Dohme Corp. |
Biomarkers for pre-selection of patients for anti-IGF1R therapy
|
|
US7666595B2
(en)
|
2005-02-25 |
2010-02-23 |
The Brigham And Women's Hospital, Inc. |
Biomarkers for predicting prostate cancer progression
|
|
DE102005011058A1
(de)
|
2005-03-10 |
2006-09-14 |
Merck Patent Gmbh |
Substituierte Tetrahydro-pyrrolo-chinolinderivate
|
|
JP2008533053A
(ja)
|
2005-03-11 |
2008-08-21 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド |
ヒストン脱アセチル化酵素阻害剤は、がん細胞を上皮増殖因子受容体阻害剤に対して感受性にする
|
|
WO2006101925A2
(en)
|
2005-03-16 |
2006-09-28 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
US8383357B2
(en)
|
2005-03-16 |
2013-02-26 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
DE102005015253A1
(de)
|
2005-04-04 |
2006-10-05 |
Merck Patent Gmbh |
Pyrazolderivate
|
|
DE102005017259A1
(de)
|
2005-04-14 |
2006-10-19 |
Merck Patent Gmbh |
Purinderivate
|
|
US20090061422A1
(en)
|
2005-04-19 |
2009-03-05 |
Linke Steven P |
Diagnostic markers of breast cancer treatment and progression and methods of use thereof
|
|
KR20080011199A
(ko)
|
2005-04-19 |
2008-01-31 |
교와 핫꼬 고교 가부시끼가이샤 |
질소 함유 복소환 화합물
|
|
WO2006121991A2
(en)
|
2005-05-06 |
2006-11-16 |
Diadexus, Inc. |
Compositions and methods for detection, prognosis and treatment of breast cancer
|
|
WO2006134989A1
(ja)
|
2005-06-15 |
2006-12-21 |
Kyowa Hakko Kogyo Co., Ltd. |
含窒素複素環化合物
|
|
SI1913157T2
(sl)
|
2005-06-28 |
2017-02-28 |
Genentech, Inc. |
EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem
|
|
US8133692B2
(en)
|
2005-07-20 |
2012-03-13 |
University Of South Florida |
Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments
|
|
GB0515026D0
(en)
|
2005-07-21 |
2005-08-31 |
Novartis Ag |
Organic compounds
|
|
NZ565511A
(en)
|
2005-07-22 |
2011-03-31 |
Five Prime Therapeutics Inc |
Compositions and methods of treating disease with FGFR fusion proteins
|
|
US20090155786A1
(en)
|
2005-08-15 |
2009-06-18 |
President And Fellows Of Harvard College |
Compositions and methods for detecting markers of cancer
|
|
AU2005335661A1
(en)
|
2005-08-16 |
2007-02-22 |
F. Hoffmann-La Roche Ag |
Novel 4-amino-thieno[3,2-C]pyridine-7-carboxylic acid amides
|
|
AU2006287175A1
(en)
|
2005-09-01 |
2007-03-08 |
Precision Therapeutics, Inc. |
Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
|
|
AU2006292278B2
(en)
|
2005-09-20 |
2012-03-08 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
US20070154916A1
(en)
|
2005-11-04 |
2007-07-05 |
Johji Inazawa |
Method for detecting cancer and a method for suppressing cancer
|
|
US8445198B2
(en)
|
2005-12-01 |
2013-05-21 |
Medical Prognosis Institute |
Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
|
|
US20070128636A1
(en)
|
2005-12-05 |
2007-06-07 |
Baker Joffre B |
Predictors Of Patient Response To Treatment With EGFR Inhibitors
|
|
US20080299113A1
(en)
|
2005-12-19 |
2008-12-04 |
Arnold Lee D |
Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
|
|
JP2007175021A
(ja)
|
2005-12-28 |
2007-07-12 |
Sysmex Corp |
大腸がんのリンパ節転移マーカー
|
|
WO2008121102A2
(en)
|
2006-02-21 |
2008-10-09 |
The Regents Of The University Of Michigan |
Hedgehog signaling pathway antagonist cancer treatment
|
|
US20070218512A1
(en)
|
2006-02-28 |
2007-09-20 |
Alex Strongin |
Methods related to mmp26 status as a diagnostic and prognostic tool in cancer management
|
|
US20070231822A1
(en)
|
2006-02-28 |
2007-10-04 |
Michael Mitas |
Methods for the detection and treatment of cancer
|
|
JP2009529329A
(ja)
|
2006-03-09 |
2009-08-20 |
トラスティーズ オブ ボストン ユニバーシティ |
鼻腔上皮細胞の遺伝子発現プロファイルを用いた、肺疾患のための診断および予後診断の方法
|
|
JP2009532027A
(ja)
|
2006-03-28 |
2009-09-10 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
抗ｉｇｆ−１ｒ抗体およびその使用
|
|
US7812143B2
(en)
|
2006-03-31 |
2010-10-12 |
Memorial Sloan-Kettering Cancer Center |
Biomarkers for cancer treatment
|
|
AU2007255110B8
(en)
|
2006-06-02 |
2014-04-10 |
Pfizer Products Inc. |
Circulating tumor cell assay
|
|
US20080026481A1
(en)
|
2006-06-16 |
2008-01-31 |
Michael Mitas |
Molecular based two-marker assays that predict outcome of adenocarcinoma patients
|
|
WO2008005469A2
(en)
|
2006-06-30 |
2008-01-10 |
Schering Corporation |
Igfbp2 biomarker
|
|
US20080167532A1
(en)
|
2006-10-13 |
2008-07-10 |
Mayo Foundation For Medical Education And Research |
Assessing cancer treatment responsiveness
|
|
US7622456B2
(en)
|
2006-11-06 |
2009-11-24 |
Non-Profit Organization Chang Gung Memorial Hospital |
Method on clinical applications in head neck cancer by using DSG3 molecule for predicting malignant degree of cancer, serving as a molecular target and using RNA jamming sequence on inhibition-specific of DSG3 expression
|
|
DK2087139T3
(en)
|
2006-11-07 |
2017-02-13 |
Univ Arkansas |
Gene expression profiling-based identification of high-risk multiple myeloma genomic signatures
|
|
WO2008070460A2
(en)
|
2006-11-27 |
2008-06-12 |
The Regents Of The University Of California |
The use of soluble e-cadherin as a novel serum marker
|
|
WO2008073290A1
(en)
|
2006-12-08 |
2008-06-19 |
The Board Of Trustees Of The University Of Arkansas |
Tp53 gene expression and uses thereof
|
|
US7838234B2
(en)
|
2007-01-30 |
2010-11-23 |
Pharmacyclics, Inc. |
Methods for determining cancer resistance to histone deacetylase inhibitors
|
|
US20100323373A1
(en)
|
2007-02-27 |
2010-12-23 |
Stefan Evers |
Method for the assessment of the inhibitory activity of antibodies against insulin-like growth factor i receptor
|
|
ES2707551T3
(es)
|
2007-03-02 |
2019-04-04 |
Amgen Inc |
Métodos y composiciones para tratar enfermedades tumorales
|
|
WO2008115470A2
(en)
|
2007-03-16 |
2008-09-25 |
East Carolina University |
Hox-gene expression as a biomarker for igf-1r therapeutics
|
|
US8377636B2
(en)
|
2007-04-13 |
2013-02-19 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to kinase inhibitors
|
|
EP2145021A2
(en)
|
2007-05-17 |
2010-01-20 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
|
|
WO2009023172A2
(en)
|
2007-08-09 |
2009-02-19 |
The Johns Hopkins University |
Predictions of responsiveness to egfr inhibitors
|
|
US8622606B2
(en)
|
2007-09-25 |
2014-01-07 |
State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University |
Micro-channels, micro-mixers, and micro-reactors
|
|
AU2008307634A1
(en)
|
2007-10-03 |
2009-04-09 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
US8048621B2
(en)
|
2007-10-03 |
2011-11-01 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
WO2009049228A2
(en)
|
2007-10-10 |
2009-04-16 |
The Regents Of The University Of Michigan |
Compositions and methods for assessing disorders
|
|
ES2397672T3
(es)
*
|
2007-12-05 |
2013-03-08 |
The Wistar Institute Of Anatomy And Biology |
Método de diagnóstico de cánceres de pulmón utilizando perfiles de expresión genética en células mononucleares de sangre periférica
|
|
JP2011511005A
(ja)
|
2008-02-04 |
2011-04-07 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
２−アミノピリジン系キナーゼ阻害薬
|
|
US7998688B2
(en)
*
|
2008-03-07 |
2011-08-16 |
OSI Pharmaceuticals, LLC |
Inhibition of EMT induction in tumor cells by anti-cancer agents
|
|
JP2012500631A
(ja)
|
2008-08-20 |
2012-01-12 |
ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド， ア ボディー コーポレイト |
Ｉｇｆ−１ｒ処置に対する癌の感受性を評価するためのマーカー
|
|
WO2010120966A1
(en)
|
2009-04-17 |
2010-10-21 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
US20110143960A1
(en)
*
|
2009-12-10 |
2011-06-16 |
Labarbera Daniel V |
3d-models for high-throughput screening drug discovery and development
|
|
WO2012061510A2
(en)
*
|
2010-11-03 |
2012-05-10 |
Merck Sharp & Dohme Corp. |
Methods of predicting cancer cell response to therapeutic agents
|