JP2014512363A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014512363A5 JP2014512363A5 JP2014504058A JP2014504058A JP2014512363A5 JP 2014512363 A5 JP2014512363 A5 JP 2014512363A5 JP 2014504058 A JP2014504058 A JP 2014504058A JP 2014504058 A JP2014504058 A JP 2014504058A JP 2014512363 A5 JP2014512363 A5 JP 2014512363A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- masp
- mbl
- wallis
- letter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473698P | 2011-04-08 | 2011-04-08 | |
| US61/473,698 | 2011-04-08 | ||
| PCT/US2012/032650 WO2012139081A2 (en) | 2011-04-08 | 2012-04-06 | Methods for treating conditions associated with masp-2 dependent complement activation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016095034A Division JP6239030B2 (ja) | 2011-04-08 | 2016-05-11 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512363A JP2014512363A (ja) | 2014-05-22 |
| JP2014512363A5 true JP2014512363A5 (enExample) | 2014-09-11 |
| JP5937197B2 JP5937197B2 (ja) | 2016-06-22 |
Family
ID=46966283
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504058A Active JP5937197B2 (ja) | 2011-04-08 | 2012-04-06 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2016095034A Active JP6239030B2 (ja) | 2011-04-08 | 2016-05-11 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2017209894A Active JP6584476B2 (ja) | 2011-04-08 | 2017-10-31 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2019160040A Active JP6893539B2 (ja) | 2011-04-08 | 2019-09-03 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016095034A Active JP6239030B2 (ja) | 2011-04-08 | 2016-05-11 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2017209894A Active JP6584476B2 (ja) | 2011-04-08 | 2017-10-31 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2019160040A Active JP6893539B2 (ja) | 2011-04-08 | 2019-09-03 | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US8951522B2 (enExample) |
| EP (3) | EP3964233A1 (enExample) |
| JP (4) | JP5937197B2 (enExample) |
| KR (6) | KR101870915B1 (enExample) |
| CN (3) | CN103781492A (enExample) |
| AU (1) | AU2012239889B2 (enExample) |
| BR (1) | BR112013025917A2 (enExample) |
| CA (4) | CA3237802A1 (enExample) |
| CL (1) | CL2013002874A1 (enExample) |
| DK (2) | DK2694108T3 (enExample) |
| ES (2) | ES2683307T3 (enExample) |
| IL (3) | IL228758B (enExample) |
| MX (3) | MX339002B (enExample) |
| NZ (5) | NZ617298A (enExample) |
| PL (1) | PL3287142T3 (enExample) |
| RU (2) | RU2662563C2 (enExample) |
| WO (1) | WO2012139081A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0688182B2 (ja) | 1986-09-08 | 1994-11-09 | バブコツク日立株式会社 | スタツド着脱装置 |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| BR112013025917A2 (pt) | 2011-04-08 | 2016-12-20 | Omeros Corp | uso de um anticorpo masp-2 ou fragmento do mesmo que inibe ativação de complemento dependente de masp-2 |
| ES2728278T3 (es) * | 2011-12-21 | 2019-10-23 | Novartis Ag | Composiciones que comprenden anticuerpos dirigidos al factor P y C5 |
| MX357540B (es) * | 2012-04-06 | 2018-07-13 | Omeros Corp | Composiciones y metodos para inhibir masp-1 y/o masp-2 y/o masp-3 para el tratamiento de la hemoglobinuria paroxistica nocturna. |
| BR112014031522A2 (pt) * | 2012-06-18 | 2017-08-01 | Omeros Corp | métodos para inibir a ativação de complemento dependente de masp-3, para inibir a ativação de complemento dependente de masp-2 e para fabricar um medicamento |
| EP3722320A3 (en) | 2012-10-25 | 2020-12-30 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
| DK2914291T3 (da) | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| NZ629682A (en) * | 2013-03-15 | 2017-03-31 | Omeros Corp | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| JP2016539919A (ja) * | 2013-10-17 | 2016-12-22 | オメロス コーポレーション | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| WO2015070041A1 (en) * | 2013-11-08 | 2015-05-14 | Icahn School Of Medicine At Mount Sinai | Methods for monitoring kidney dysfunction |
| EP3973994A1 (en) | 2014-06-12 | 2022-03-30 | RA Pharmaceuticals, Inc. | Modulation of complement activity |
| US9937222B2 (en) | 2015-01-28 | 2018-04-10 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
| CA2981321A1 (en) | 2015-04-06 | 2016-10-13 | True North Therapeutics, Inc. | Humanized anti-c1s antibodies and methods of use thereof |
| AU2016354117B2 (en) * | 2015-11-09 | 2019-11-28 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| RU2733720C2 (ru) | 2015-12-16 | 2020-10-06 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
| KR20180091097A (ko) * | 2015-12-23 | 2018-08-14 | 그리노파티온 바이오테크 게엠베하 | 보체 활성화를 억제하기 위한 폴리펩티드 |
| KR102528260B1 (ko) * | 2016-01-05 | 2023-05-04 | 유니버시티 오브 레스터 | 필요로 하는 대상체에서 섬유증의 억제 방법 |
| MX2018011648A (es) | 2016-03-31 | 2019-01-30 | Omeros Corp | Metodos para la inhibicion de fibrosis en un sujeto en necesidad del mismo. |
| UY37376A (es) * | 2016-08-26 | 2018-03-23 | Amgen Inc | Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso |
| JOP20170170B1 (ar) | 2016-08-31 | 2022-09-15 | Omeros Corp | صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق |
| CN110300520B (zh) | 2016-10-12 | 2022-10-04 | 美国比奥维拉迪维股份有限公司 | 抗C1s抗体及其使用方法 |
| EP3525798A4 (en) * | 2016-10-13 | 2020-07-08 | University Of Leicester | METHODS OF REDUCING PROTEINURY IN A HUMAN SUBJECT SUFFERING FROM IMMUNOGLOBULIN A NEPHROPATHY |
| KR20190093196A (ko) | 2016-12-07 | 2019-08-08 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절인자 |
| WO2018124132A1 (ja) * | 2016-12-26 | 2018-07-05 | 日本ビーシージー製造株式会社 | 細菌細胞壁骨格成分を含有する水中油型エマルション製剤 |
| AU2018232367A1 (en) * | 2017-03-09 | 2019-10-03 | Kyowa Kirin Co., Ltd. | Nucleic acid capable of inhibiting expression of MASP2 |
| CN116898870A (zh) * | 2017-07-28 | 2023-10-20 | 雷莫内克斯生物制药有限公司 | 用于预防或治疗肝癌的药物组合物 |
| CA3083970A1 (en) | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| EP3719127A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CN110944675B9 (zh) | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| EP3719126B1 (en) | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| CN111683672A (zh) | 2017-12-04 | 2020-09-18 | Ra制药公司 | 补体活性调节剂 |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| IL311042B1 (en) | 2018-05-29 | 2026-04-01 | Omeros Corp | MASP-2 inhibitors and methods of use |
| RU2699040C1 (ru) * | 2018-07-23 | 2019-09-03 | Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) | Способ экстренной профилактики и лечения острой лучевой болезни (варианты) |
| WO2020038377A1 (zh) | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| EP3628735A1 (en) | 2018-09-25 | 2020-04-01 | Centre National De La Recherche Scientifique | Antisense rna targeting pmp22 for the treatment of charcot-marie-tooth 1a disease |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| CR20210311A (es) * | 2018-11-15 | 2021-07-22 | Ionis Pharmaceuticals Inc | Moduladores de la expresión de irf5 |
| ES3031988T3 (en) * | 2018-12-25 | 2025-07-14 | Beijing Baishihekang Pharmaceutical Tech Bsjpharma Co Ltd | Small rna medicament for prevention and treatment of inflammation-related diseases and combination thereof |
| WO2020135673A1 (zh) | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| TW202100179A (zh) | 2019-03-08 | 2021-01-01 | 美商Ｒａ製藥公司 | 補體活性之調節劑 |
| US12492399B2 (en) * | 2019-03-14 | 2025-12-09 | Rena Therapeutics Inc. | Nucleic acid complex for regulating IHH expression |
| TW202102481A (zh) | 2019-03-29 | 2021-01-16 | 美商Ｒａ製藥公司 | 補體調節劑和相關方法 |
| SG11202109837SA (en) | 2019-04-24 | 2021-10-28 | Ra Pharmaceuticals Inc | Compositions and methods for modulating complement activity |
| JP7606758B2 (ja) * | 2019-05-22 | 2024-12-26 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| KR20220011689A (ko) | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| JP2022535411A (ja) | 2019-06-04 | 2022-08-08 | ラ ファーマシューティカルズ インコーポレイテッド | 補体阻害剤による炎症性疾患治療 |
| CN111024947A (zh) * | 2019-11-19 | 2020-04-17 | 江苏美克医学技术有限公司 | 白色念珠菌荧光免疫层析测定试剂盒及其制备方法 |
| JP7227401B2 (ja) | 2019-11-27 | 2023-02-21 | 京セラ株式会社 | 通信制御方法及びユーザ装置 |
| BR112022010895A2 (pt) | 2019-12-04 | 2022-09-06 | Omeros Corp | Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan |
| IL293588B1 (en) | 2019-12-04 | 2026-04-01 | Omeros Corp | 3-Amino-1-methylpyrazin-2(H1)-one derivatives as MASP-2 inhibitors, compositions containing them and uses thereof |
| EP4069676A1 (en) | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| EP4069678A1 (en) | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| EP4107165A4 (en) * | 2020-02-19 | 2025-05-21 | Alnylam Pharmaceuticals, Inc. | Mannan-binding lectin-serine peptide-2 (MASP2) RNA compositions and methods of using them |
| KR102314642B1 (ko) * | 2020-04-17 | 2021-10-20 | 재단법인 아산사회복지재단 | 파브리 병 진단용 바이오 마커 및 이의 용도 |
| JP2023525581A (ja) * | 2020-05-15 | 2023-06-16 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体の活性化を検出するための細胞外小胞の使用方法、並びに補体性疾患の処置を評価及び／又は監視するためのその使用 |
| CN113674860B (zh) * | 2020-05-15 | 2024-05-17 | 北京大学人民医院 | 一种难治性iTTP风险预测装置、系统及其应用 |
| CA3182800A1 (en) | 2020-06-14 | 2021-12-23 | Vertex Pharmaceuticals Inc. | Complement factor i-related compositions and methods |
| WO2022006470A1 (en) | 2020-07-01 | 2022-01-06 | Vanderbilt University | Methods of treatment for a kidney disease |
| CN120173118B (zh) * | 2020-12-16 | 2025-09-16 | 康诺亚生物医药科技（成都）有限公司 | 一种补体抑制剂的开发和应用 |
| TW202305010A (zh) * | 2021-04-25 | 2023-02-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｍａｓｐ２抗體、其抗原結合片段及醫藥用途 |
| US20230265215A1 (en) | 2021-12-10 | 2023-08-24 | Omeros Corporation | Therapeutic antibodies that bind to the serine protease domain of masp-2 and uses thereof |
| US20240084301A1 (en) * | 2022-07-25 | 2024-03-14 | Amgen Inc. | Rnai constructs and methods for inhibiting fam13a expression |
| EP4626891A1 (en) | 2022-11-30 | 2025-10-08 | Omeros Corporation | Fused pyrimidines as masp-2 inhibitors |
| US20250122225A1 (en) | 2023-10-06 | 2025-04-17 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| CN119978131B (zh) * | 2025-04-15 | 2025-06-27 | 北京赛斯维德生物科技有限公司 | 一种血管性血友病因子裂解蛋白酶(adamts13)单克隆抗体、制备方法及应用 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4526909A (en) | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
| US4563489A (en) | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| JPH0662679B2 (ja) | 1985-06-21 | 1994-08-17 | 新田ゼラチン株式会社 | 組織親和性コラ−ゲンとその製法 |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| MC2115A1 (fr) | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8822492D0 (en) | 1988-09-24 | 1988-10-26 | Considine J | Apparatus for removing tumours from hollow organs of body |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| IL108367A0 (en) | 1993-01-27 | 1994-04-12 | Hektoen Inst For Medical Resea | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5856121A (en) | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
| JPH07238100A (ja) | 1994-02-25 | 1995-09-12 | Sumitomo Electric Ind Ltd | ヒトのｍａｓｐに対するモノクローナル抗体 |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| JPH10510540A (ja) | 1994-12-12 | 1998-10-13 | オメロス メディカル システムズ，インコーポレーテッド | 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法 |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| US5739119A (en) | 1996-11-15 | 1998-04-14 | Galli; Rachel L. | Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA |
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US6297024B1 (en) | 1998-10-15 | 2001-10-02 | Cell Activation, Inc. | Methods for assessing complement activation |
| US7273925B1 (en) | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
| JP2002532079A (ja) | 1998-12-15 | 2002-10-02 | ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド | 補体活性化に関連するレクチン補体経路を調節するための方法および産物 |
| US6235494B1 (en) | 1999-02-08 | 2001-05-22 | The Scripps Research Institute | Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates |
| JP2003505427A (ja) | 1999-07-21 | 2003-02-12 | オメロス コーポレイション | 疼痛、炎症および軟骨分解の抑制のための溶液および方法 |
| US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| CN1433466A (zh) | 1999-12-02 | 2003-07-30 | 詹斯·C·詹斯尼厄斯 | Masp－3,一种固定补体的酶,及其应用 |
| US6649592B1 (en) | 2000-01-14 | 2003-11-18 | Science & Technology Corporation @ Unm | Peptide inhibitors of LFA-1/ICAM-1 interaction |
| SG98393A1 (en) | 2000-05-19 | 2003-09-19 | Inst Materials Research & Eng | Injectable drug delivery systems with cyclodextrin-polymer based hydrogels |
| RU2003104524A (ru) | 2000-07-13 | 2005-01-20 | Дженс Христиан ДЖЕНСЕНИУС (DK) | Masp-2, комплемент-связывающий фермент и его применение |
| WO2003009803A2 (en) | 2001-07-26 | 2003-02-06 | Alexion Pharmaceuticals Inc. | Method of improving cognitive function |
| CN1697647A (zh) | 2002-02-01 | 2005-11-16 | 奥默罗斯公司 | 用于抑制疼痛,炎症和软骨退化的溶液及方法 |
| WO2003081206A2 (en) | 2002-03-18 | 2003-10-02 | Alexion Pharmaceuticals, Inc. | Stratification of patient populations having or suspected of having rheumatoid arthritis |
| ES2601143T3 (es) | 2002-07-19 | 2017-02-14 | Omeros Corporation | Copolímeros tribloque biodegradables, métodos de síntesis de los mismos, e hidrogeles y biomateriales preparados a partir de los mismos |
| CN101327325A (zh) | 2002-07-30 | 2008-12-24 | 奥默罗斯公司 | 眼科冲洗液及方法 |
| ITRM20020511A1 (it) * | 2002-10-09 | 2004-04-10 | Santa Anna Acuto | Uso dell'insulator sns di riccio di mare per la terapia genica di malattie delle cellule eritroidi. |
| US20060275764A1 (en) | 2002-12-03 | 2006-12-07 | Aarhus Universitet | Method for determining predisposition to manifestation of immune system related diseases |
| US20060140939A1 (en) | 2003-02-21 | 2006-06-29 | Fung Sek C M | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
| EP1609804B1 (en) | 2003-03-17 | 2012-06-13 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Construct comprising recognition domain of antibody against von willebrand factor-specific cleaving enzyme |
| HUE024996T2 (en) | 2003-05-12 | 2016-01-28 | Helion Biotech Aps | Anti-MASP-2 antibodies |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| ES2631127T3 (es) | 2004-06-10 | 2017-08-28 | Omeros Corporation | Métodos para tratar afecciones asociadas con la activación del complemento dependiente de MASP-2 |
| GB0412966D0 (en) | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
| US20060018896A1 (en) | 2004-06-10 | 2006-01-26 | University Of Leicester | Methods for treating conditions associated with lectin-dependent complement activation |
| ATE544866T1 (de) | 2005-06-17 | 2012-02-15 | Baxter Int | Adamts13-haltige zusammensetzungen mit thrombolytischer wirkung |
| WO2007086069A1 (en) | 2006-01-27 | 2007-08-02 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kits for determining blood coagulation |
| NZ571791A (en) | 2006-03-08 | 2012-03-30 | Archemix Llc | Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders |
| CA2742802C (en) | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| CA2766565A1 (en) | 2009-06-23 | 2010-12-29 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
| US20120282285A1 (en) | 2009-07-17 | 2012-11-08 | Rigshospitalet | Masp isoforms as inhibitors of complement activation |
| DK2488203T3 (en) | 2009-10-16 | 2017-03-13 | Omeros Corp | METHODS OF TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITION OF MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
| CA2795311A1 (en) * | 2009-11-05 | 2011-05-12 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| ES2615732T3 (es) | 2010-03-01 | 2017-06-08 | Alexion Pharmaceuticals, Inc. | Composiciones para tratar la enfermedad de Degos |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US20150166676A1 (en) | 2011-04-08 | 2015-06-18 | Omeros Corporation | Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation |
| BR112013025917A2 (pt) | 2011-04-08 | 2016-12-20 | Omeros Corp | uso de um anticorpo masp-2 ou fragmento do mesmo que inibe ativação de complemento dependente de masp-2 |
| HUE049154T2 (hu) | 2011-05-04 | 2020-09-28 | Omeros Corp | Készítmények a MASP-2-függõ komplement-aktiválás gátlására |
| BR112014031522A2 (pt) | 2012-06-18 | 2017-08-01 | Omeros Corp | métodos para inibir a ativação de complemento dependente de masp-3, para inibir a ativação de complemento dependente de masp-2 e para fabricar um medicamento |
| JP2016539919A (ja) | 2013-10-17 | 2016-12-22 | オメロス コーポレーション | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| AU2016354117B2 (en) | 2015-11-09 | 2019-11-28 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| MX2018011648A (es) * | 2016-03-31 | 2019-01-30 | Omeros Corp | Metodos para la inhibicion de fibrosis en un sujeto en necesidad del mismo. |
| JPWO2018070521A1 (ja) * | 2016-10-14 | 2019-08-15 | 公立大学法人福島県立医科大学 | 補体の活性化経路を阻害する融合ポリペプチド |
-
2012
- 2012-04-06 BR BR112013025917A patent/BR112013025917A2/pt not_active Application Discontinuation
- 2012-04-06 ES ES12767899T patent/ES2683307T3/es active Active
- 2012-04-06 KR KR1020177007747A patent/KR101870915B1/ko active Active
- 2012-04-06 KR KR1020217004368A patent/KR20210021101A/ko not_active Ceased
- 2012-04-06 RU RU2013149792A patent/RU2662563C2/ru active
- 2012-04-06 KR KR1020187017317A patent/KR20180072851A/ko not_active Ceased
- 2012-04-06 KR KR1020137029501A patent/KR101720562B1/ko active Active
- 2012-04-06 DK DK12767899.3T patent/DK2694108T3/en active
- 2012-04-06 CA CA3237802A patent/CA3237802A1/en active Pending
- 2012-04-06 CA CA2977009A patent/CA2977009C/en active Active
- 2012-04-06 NZ NZ617298A patent/NZ617298A/en unknown
- 2012-04-06 CA CA3076975A patent/CA3076975C/en active Active
- 2012-04-06 CN CN201280028263.2A patent/CN103781492A/zh active Pending
- 2012-04-06 EP EP21188935.7A patent/EP3964233A1/en active Pending
- 2012-04-06 MX MX2013011721A patent/MX339002B/es active IP Right Grant
- 2012-04-06 US US13/441,827 patent/US8951522B2/en active Active
- 2012-04-06 KR KR1020227010108A patent/KR20220044616A/ko not_active Ceased
- 2012-04-06 MX MX2018005314A patent/MX381987B/es unknown
- 2012-04-06 JP JP2014504058A patent/JP5937197B2/ja active Active
- 2012-04-06 AU AU2012239889A patent/AU2012239889B2/en active Active
- 2012-04-06 NZ NZ717517A patent/NZ717517A/en unknown
- 2012-04-06 NZ NZ709997A patent/NZ709997A/en unknown
- 2012-04-06 CA CA2832187A patent/CA2832187C/en active Active
- 2012-04-06 EP EP17191208.2A patent/EP3287142B1/en active Active
- 2012-04-06 DK DK17191208.2T patent/DK3287142T3/da active
- 2012-04-06 NZ NZ746139A patent/NZ746139A/en unknown
- 2012-04-06 ES ES17191208T patent/ES2894342T3/es active Active
- 2012-04-06 MX MX2016006039A patent/MX355648B/es unknown
- 2012-04-06 EP EP12767899.3A patent/EP2694108B1/en active Active
- 2012-04-06 PL PL17191208T patent/PL3287142T3/pl unknown
- 2012-04-06 KR KR1020197037437A patent/KR102217658B1/ko active Active
- 2012-04-06 NZ NZ731596A patent/NZ731596A/en unknown
- 2012-04-06 CN CN201910000825.6A patent/CN110075294A/zh active Pending
- 2012-04-06 RU RU2018125514A patent/RU2743409C2/ru active
- 2012-04-06 WO PCT/US2012/032650 patent/WO2012139081A2/en not_active Ceased
- 2012-04-06 CN CN201710646474.7A patent/CN107638565B/zh active Active
-
2013
- 2013-10-06 IL IL228758A patent/IL228758B/en active IP Right Grant
- 2013-10-07 CL CL2013002874A patent/CL2013002874A1/es unknown
-
2014
- 2014-12-23 US US14/581,191 patent/US20150239985A1/en not_active Abandoned
-
2016
- 2016-05-11 JP JP2016095034A patent/JP6239030B2/ja active Active
- 2016-12-07 US US15/371,726 patent/US10202465B2/en active Active
-
2017
- 2017-10-31 JP JP2017209894A patent/JP6584476B2/ja active Active
-
2018
- 2018-12-17 US US16/222,188 patent/US20190292272A1/en not_active Abandoned
-
2019
- 2019-01-09 IL IL264172A patent/IL264172B/en unknown
- 2019-09-03 JP JP2019160040A patent/JP6893539B2/ja active Active
-
2020
- 2020-04-23 IL IL274206A patent/IL274206A/en unknown
-
2021
- 2021-09-09 US US17/470,386 patent/US20220089781A1/en not_active Abandoned
-
2025
- 2025-05-21 US US19/214,532 patent/US20260062498A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014512363A5 (enExample) | ||
| ES2563646T3 (es) | Composiciones y métodos relacionados con variantes de la proteína A (SpA) | |
| EA201190326A1 (ru) | Полипептиды гормона роста и способы их получения и применения | |
| JP2017528419A5 (enExample) | ||
| JP2015212284A5 (enExample) | ||
| PH12019500694A1 (en) | Factor viii compositions and methods of making and using the same | |
| BRPI0806578A8 (pt) | Promotores de lactococcus e usos dos mesmos | |
| CY1116099T1 (el) | Πρωτεϊνη συντηξης κατα του καρκινου | |
| EA201590543A1 (ru) | Основанные на фибронектине каркасные доменные белки, которые связываются с миостатином | |
| MX379069B (es) | Vacunas terapeuticas contra el vph16. | |
| WO2009108261A3 (en) | Compositions and methods for the treatment of viral infections | |
| PL397167A1 (pl) | Przeciwnowotworowe bialko fuzyjne | |
| PE20141727A1 (es) | Composiciones, usos y metodos para tratamiento de trastornos y enfermedades metabolicas | |
| IN2014CN00414A (enExample) | ||
| EA201200515A1 (ru) | Полипептиды и их применение | |
| WO2015020913A3 (en) | Influenza hemagglutinin proteins and methods of thereof | |
| HRP20150664T1 (hr) | Antikancerogeni fuzijski protein | |
| JP2019500414A5 (enExample) | ||
| RU2017119773A (ru) | Пептидные антагонисты пептидных гормонов из семейства кальцитонина (cgrp) и их применение | |
| EA201491277A1 (ru) | Противораковый слитый белок | |
| ATE500265T1 (de) | Synthetische mecp2-sequenz für die proteinersatztherapie | |
| NZ769391A (en) | Serpin fusion polypeptides and methods of use thereof | |
| WO2010007144A3 (en) | Mutated netrin-4 proteins, fragments thereof and their uses as drugs | |
| JP2019512693A5 (enExample) | ||
| BR112018003580A2 (pt) | molécula de ácido nucléico, método para apresentar um polipeptídeo alvo, proteína recombinante, partícula do tipo viral, composição farmacêutica, polipeptídeo, vetor, célula hospedeira e método para preparar a proteína recombinante |