CL2013002874A1 - Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2). - Google Patents

Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2).

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Publication number
CL2013002874A1
CL2013002874A1 CL2013002874A CL2013002874A CL2013002874A1 CL 2013002874 A1 CL2013002874 A1 CL 2013002874A1 CL 2013002874 A CL2013002874 A CL 2013002874A CL 2013002874 A CL2013002874 A CL 2013002874A CL 2013002874 A1 CL2013002874 A1 CL 2013002874A1
Authority
CL
Chile
Prior art keywords
masp
lactin
antibody
inhibitor
activation
Prior art date
Application number
CL2013002874A
Other languages
English (en)
Inventor
Gregory A Demopulos
Tom Dudler
Hans-Wilhelm Schwaeble
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of CL2013002874A1 publication Critical patent/CL2013002874A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
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CL2013002874A 2011-04-08 2013-10-07 Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2). CL2013002874A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161473698P 2011-04-08 2011-04-08

Publications (1)

Publication Number Publication Date
CL2013002874A1 true CL2013002874A1 (es) 2014-03-07

Family

ID=46966283

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Application Number Title Priority Date Filing Date
CL2013002874A CL2013002874A1 (es) 2011-04-08 2013-10-07 Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2).

Country Status (18)

Country Link
US (5) US8951522B2 (es)
EP (3) EP2694108B1 (es)
JP (4) JP5937197B2 (es)
KR (6) KR20210021101A (es)
CN (3) CN107638565B (es)
AU (1) AU2012239889B2 (es)
BR (1) BR112013025917A2 (es)
CA (4) CA2977009C (es)
CL (1) CL2013002874A1 (es)
DK (2) DK3287142T3 (es)
ES (2) ES2683307T3 (es)
HK (1) HK1250342A1 (es)
IL (3) IL228758B (es)
MX (2) MX355648B (es)
NZ (5) NZ617298A (es)
PL (1) PL3287142T3 (es)
RU (2) RU2662563C2 (es)
WO (1) WO2012139081A2 (es)

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US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
AU2012356170B2 (en) 2011-12-21 2016-06-16 Novartis Ag Compositions and methods for antibodies targeting Factor P
RU2018114903A (ru) * 2012-04-06 2019-03-04 Омерос Корпорейшн Композиции и способы ингибирования masp-1, и/или masp-2, и/или masp-3 для лечения пароксизмальной ночной гемоглобинурии
KR20220100997A (ko) * 2012-06-18 2022-07-18 오메로스 코포레이션 다양한 질환 및 장애의 치료를 위해 masp-1 및/또는 masp-2 및/또는 masp-3를 억제하는 조성물 및 방법
CA2889170C (en) 2012-10-25 2021-09-07 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
RS63212B1 (sr) 2012-11-02 2022-06-30 Bioverativ Usa Inc Antikomplementna c1s antitela i njihove primene
EP2968546B1 (en) * 2013-03-15 2023-09-20 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
JP2016539919A (ja) * 2013-10-17 2016-12-22 オメロス コーポレーション Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法
WO2015070041A1 (en) * 2013-11-08 2015-05-14 Icahn School Of Medicine At Mount Sinai Methods for monitoring kidney dysfunction
EP4223317A3 (en) 2014-06-12 2023-09-27 RA Pharmaceuticals, Inc. Modulation of complement activity
EP3988110A1 (en) 2015-01-28 2022-04-27 RA Pharmaceuticals, Inc. Modulators of complement activity
EP4212175A1 (en) 2015-04-06 2023-07-19 Bioverativ USA Inc. Humanized anti-c1s antibodies and methods of use thereof
GEP20247583B (en) 2015-11-09 2024-01-10 Univ Leicester Methods for treating condi tions associated with masp-2 dependent complement activation
MX2018007352A (es) 2015-12-16 2019-05-16 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
CA3009393C (en) * 2015-12-23 2023-08-22 Greenovation Biotech Gmbh Polypeptides for inhibiting complement activation
IL294411A (en) 2016-01-05 2022-08-01 Omeros Corp masp-2 suppressors for use in suppressing fibrosis
CA3018774C (en) * 2016-03-31 2023-02-28 Omeros Corporation Methods for inhibiting angiogenesis in a subject in need thereof
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
JOP20190068A1 (ar) * 2016-10-13 2019-04-01 Omeros Corp طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي
BR112019011053A2 (pt) 2016-12-07 2019-10-15 Ra Pharmaceuticals Inc moduladores da atividade do complemento
WO2018124132A1 (ja) * 2016-12-26 2018-07-05 日本ビーシージー製造株式会社 細菌細胞壁骨格成分を含有する水中油型エマルション製剤
AU2018232367A1 (en) * 2017-03-09 2019-10-03 Kyowa Kirin Co., Ltd. Nucleic acid capable of inhibiting expression of MASP2
JP6967810B2 (ja) * 2017-07-28 2021-11-17 レモネックス インコーポレイテッドLemonex Inc. 肝癌の予防または治療用の薬学的組成物
CN111683672A (zh) 2017-12-04 2020-09-18 Ra制药公司 补体活性调节剂
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
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