EP1140171A4 - Methods and products for regulating lectin complement pathway associated complement activation - Google Patents
Methods and products for regulating lectin complement pathway associated complement activationInfo
- Publication number
- EP1140171A4 EP1140171A4 EP99967362A EP99967362A EP1140171A4 EP 1140171 A4 EP1140171 A4 EP 1140171A4 EP 99967362 A EP99967362 A EP 99967362A EP 99967362 A EP99967362 A EP 99967362A EP 1140171 A4 EP1140171 A4 EP 1140171A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- products
- methods
- pathway associated
- complement
- regulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11239098P | 1998-12-15 | 1998-12-15 | |
PCT/US1999/029919 WO2000035483A1 (en) | 1998-12-15 | 1999-12-15 | Methods and products for regulating lectin complement pathway associated complement activation |
US112390P | 2008-11-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1140171A1 EP1140171A1 (en) | 2001-10-10 |
EP1140171A4 true EP1140171A4 (en) | 2002-03-13 |
Family
ID=22343639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99967362A Withdrawn EP1140171A4 (en) | 1998-12-15 | 1999-12-15 | Methods and products for regulating lectin complement pathway associated complement activation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1140171A4 (en) |
JP (1) | JP2002532079A (en) |
CA (1) | CA2347734A1 (en) |
WO (1) | WO2000035483A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
US7273925B1 (en) | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
JP2003507338A (en) * | 1999-08-13 | 2003-02-25 | ザ ブリグハム アンド ウイメンズ ホスピタル インコーポレイテッド | Lectin complement pathway (LCP) inhibitors and uses thereof |
NZ523900A (en) * | 2000-07-13 | 2004-02-27 | Jens Christian Jensenius | Isolation and characterisation of a mannan-binding lectin (MBL) associated serine protease (MASP-2) and uses thereof to treat infections |
EP1186299A1 (en) | 2000-09-12 | 2002-03-13 | Universitair Medisch Centrum Utrecht | The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system |
EP2422812A1 (en) * | 2003-02-21 | 2012-02-29 | Genentech, Inc. | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
HUE024996T2 (en) | 2003-05-12 | 2016-01-28 | Helion Biotech Aps | Antibodies to masp-2 |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
GB0412966D0 (en) | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US8524453B2 (en) | 2006-02-10 | 2013-09-03 | The Brigham And Woman's Hospital, Inc. | Lectin complement pathway assays and related compositions and methods |
EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
CA2971474C (en) | 2009-10-16 | 2022-11-22 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
ES2961381T3 (en) | 2010-06-19 | 2024-03-11 | Memorial Sloan Kettering Cancer Center | Anti-GD2 antibodies |
NZ709997A (en) | 2011-04-08 | 2016-03-31 | Univ Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
ME03755B (en) | 2011-05-04 | 2021-04-20 | Omeros Corp | Compositions for inhibiting masp-2 dependent complement acitivation |
RU2680267C2 (en) | 2013-03-15 | 2019-02-19 | Мемориал Слоан Кеттеринг Кэнсер Сентер | High-affinity anti-gd2 antibodies |
CN108588033B (en) * | 2018-04-24 | 2021-09-24 | 富恩生物技术(成都)有限公司 | Hybridoma cell strain, CD31 monoclonal antibody, preparation method and application |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001519A1 (en) * | 1987-08-20 | 1989-02-23 | Children's Hospital Corporation | Human mannose binding protein |
WO1991006010A1 (en) * | 1989-10-11 | 1991-05-02 | Institute Of Child Health | Diagnostic procedure |
JPH06121695A (en) * | 1992-10-13 | 1994-05-06 | Fuji Yakuhin Kogyo Kk | Antihuman mannose binding protein monoclonal antibody and its utilization |
JPH07238100A (en) * | 1994-02-25 | 1995-09-12 | Sumitomo Electric Ind Ltd | Monoclonal antibody to human masp |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270199A (en) | 1987-08-20 | 1993-12-14 | The Children's Medical Center Corporation | Human mannose-binding protein |
DE3927723A1 (en) * | 1989-01-26 | 1990-08-02 | Ulrich Prof Dr Speck | N - ACETYL GLUCOSAMINE FOR BUCCAL USE |
AU3881493A (en) * | 1992-03-19 | 1993-10-21 | University Of British Columbia, The | Method and composition for suppression of side effects of anti-inflammatory drugs |
US5998173A (en) * | 1996-02-20 | 1999-12-07 | The University Of Bristish Columbia | Process for producing N-acetyl-D-glucosamine |
-
1999
- 1999-12-15 EP EP99967362A patent/EP1140171A4/en not_active Withdrawn
- 1999-12-15 WO PCT/US1999/029919 patent/WO2000035483A1/en active Application Filing
- 1999-12-15 JP JP2000587802A patent/JP2002532079A/en active Pending
- 1999-12-15 CA CA002347734A patent/CA2347734A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001519A1 (en) * | 1987-08-20 | 1989-02-23 | Children's Hospital Corporation | Human mannose binding protein |
WO1991006010A1 (en) * | 1989-10-11 | 1991-05-02 | Institute Of Child Health | Diagnostic procedure |
JPH06121695A (en) * | 1992-10-13 | 1994-05-06 | Fuji Yakuhin Kogyo Kk | Antihuman mannose binding protein monoclonal antibody and its utilization |
JPH07238100A (en) * | 1994-02-25 | 1995-09-12 | Sumitomo Electric Ind Ltd | Monoclonal antibody to human masp |
Non-Patent Citations (10)
Title |
---|
CHAKA W ET AL: "Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of cryptococcus neoformans involves human mannose binding protein", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, 1997, pages 2979 - 2985, XP002145899, ISSN: 0022-1767 * |
COLLARD C D ET AL: "ENDOTHELIAL REOXYGENATION ACTIVATES THE LECTIN COMPLEMENT PATHWAY: INHIBITION WITH ANTI-HUMAN MANNOSE BINDING LECTIN(MBL) THERAPY", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 36, no. 4/5, March 1999 (1999-03-01), pages 278, XP000944464, ISSN: 0026-895X * |
COLLARD C D ET AL: "REOXYGENATION OF HYPOXIC HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVECS) ACTIVATES THE LECTIN COMPLEMENT PATHWAY (LCP)", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A29, XP000944437, ISSN: 0892-6638 * |
ENDO M ET AL: "GLOMERULA DEPOSITION OF MANNOSE-BINDING LECTIN (MBL) INDICATES A NOVEL MECHANISM OF COMPLEMENT ACTIVATION IN IGA NEPHROPATHY", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 13, no. 8, 1998, pages 1984 - 1990, XP000874166, ISSN: 0931-0509 * |
LHOTTA K ET AL: "GLOMERULAR DEPOSITION OF MANNOSE-BINDING LECTIN IN HUMAN GLOMERULONEPHRITIS", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 14, no. 4, April 1999 (1999-04-01), pages 881 - 886, XP000944395, ISSN: 0931-0509 * |
PATENT ABSTRACTS OF JAPAN vol. 018, no. 410 (C - 1232) 2 August 1994 (1994-08-02) * |
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 01 31 January 1996 (1996-01-31) * |
See also references of WO0035483A1 * |
TENNER A J ET AL: "MANNOSE BINDING PROTEIN (MBP) ENHANCES MONONUCLEAR PHAGOCYTE FUNCTION VIA A RECEPTOR THAT CONTAINS THE 126,00 MR COMPONENT OF THE C1Q RECEPTOR", IMMUNITY, CELL PRESS, US, vol. 3, no. 4, 1 October 1995 (1995-10-01), pages 485 - 493, XP002058774, ISSN: 1074-7613 * |
TERAI I ET AL: "ALPHA2-MACROGLOBULIN BINDS TO AND INHIBITS MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASE", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 7, no. 10, October 1995 (1995-10-01), pages 1579 - 1584, XP001034131, ISSN: 0953-8178 * |
Also Published As
Publication number | Publication date |
---|---|
EP1140171A1 (en) | 2001-10-10 |
JP2002532079A (en) | 2002-10-02 |
CA2347734A1 (en) | 2000-06-22 |
WO2000035483A1 (en) | 2000-06-22 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20010613 |
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Effective date: 20020124 |
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Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 39/395 A, 7C 12N 5/06 B, 7C 12N 5/16 B, 7G 01N 33/50 B |
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17Q | First examination report despatched |
Effective date: 20020912 |
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17Q | First examination report despatched |
Effective date: 20020912 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20080529 |