EP1140171A4 - Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine - Google Patents

Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine

Info

Publication number
EP1140171A4
EP1140171A4 EP99967362A EP99967362A EP1140171A4 EP 1140171 A4 EP1140171 A4 EP 1140171A4 EP 99967362 A EP99967362 A EP 99967362A EP 99967362 A EP99967362 A EP 99967362A EP 1140171 A4 EP1140171 A4 EP 1140171A4
Authority
EP
European Patent Office
Prior art keywords
products
methods
pathway associated
complement
regulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99967362A
Other languages
German (de)
English (en)
Other versions
EP1140171A1 (fr
Inventor
Gregory L Stahl
Charles D Collard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of EP1140171A1 publication Critical patent/EP1140171A1/fr
Publication of EP1140171A4 publication Critical patent/EP1140171A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP99967362A 1998-12-15 1999-12-15 Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine Withdrawn EP1140171A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11239098P 1998-12-15 1998-12-15
PCT/US1999/029919 WO2000035483A1 (fr) 1998-12-15 1999-12-15 Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine
US112390P 2008-11-07

Publications (2)

Publication Number Publication Date
EP1140171A1 EP1140171A1 (fr) 2001-10-10
EP1140171A4 true EP1140171A4 (fr) 2002-03-13

Family

ID=22343639

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99967362A Withdrawn EP1140171A4 (fr) 1998-12-15 1999-12-15 Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine

Country Status (4)

Country Link
EP (1) EP1140171A4 (fr)
JP (1) JP2002532079A (fr)
CA (1) CA2347734A1 (fr)
WO (1) WO2000035483A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083786B2 (en) 1997-04-03 2006-08-01 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
US7273925B1 (en) 1998-12-15 2007-09-25 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
AU781805B2 (en) * 1999-08-13 2005-06-16 Brigham And Women's Hospital Inhibitors of the lectin complement pathway (LCP) and their use
US7112414B2 (en) * 2000-07-13 2006-09-26 Jens Christian Jensenius Masp-2, a complement-fixing enzyme, and uses for it
EP1186299A1 (fr) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnostic, prévention et/ou traitement d' athérosclérose, infections et perturbations du système immunitaire
CN101897969B (zh) 2003-02-21 2014-04-02 健泰科生物技术公司 补体抑制剂在制备用于预防或抑制组织损伤的药物中的用途
SI2374819T1 (sl) 2003-05-12 2017-09-29 Helion Biotech Aps Protitelesa proteina MASP-2
GB0412966D0 (en) 2004-06-10 2004-07-14 Univ Leicester Genetically modified non-human mammals and cells
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US8524453B2 (en) 2006-02-10 2013-09-03 The Brigham And Woman's Hospital, Inc. Lectin complement pathway assays and related compositions and methods
US8703136B2 (en) 2006-10-10 2014-04-22 Regenesance B.V. Complement inhibition for improved nerve regeneration
CN106390117A (zh) 2009-10-16 2017-02-15 奥默罗斯公司 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法
DK3323830T3 (da) 2010-06-19 2023-09-25 Memorial Sloan Kettering Cancer Center Anti-gd2 antibodies
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
EP2694108B1 (fr) 2011-04-08 2018-06-06 University Of Leicester Méthodes de traitement d'états associés à une activation du complément dépendant de masp-2
KR102024016B1 (ko) 2011-05-04 2019-11-04 오메로스 코포레이션 Masp-2 의존적 보체 활성화를 억제하는 조성물
CA2903576C (fr) 2013-03-15 2021-06-08 Nai-Kong V. Cheung Anticorps anti-gd2 a haute affinite
CN108588033B (zh) * 2018-04-24 2021-09-24 富恩生物技术（成都）有限公司 杂交瘤细胞株、cd31单克隆抗体、制备方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001519A1 (fr) * 1987-08-20 1989-02-23 Children's Hospital Corporation Proteine humaine liant le mannose
WO1991006010A1 (fr) * 1989-10-11 1991-05-02 Institute Of Child Health Procedure de diagnostic
JPH06121695A (ja) * 1992-10-13 1994-05-06 Fuji Yakuhin Kogyo Kk 抗ヒトマンノース結合蛋白モノクローナル抗体およびその利用
JPH07238100A (ja) * 1994-02-25 1995-09-12 Sumitomo Electric Ind Ltd ヒトのｍａｓｐに対するモノクローナル抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270199A (en) 1987-08-20 1993-12-14 The Children's Medical Center Corporation Human mannose-binding protein
DE3927723A1 (de) * 1989-01-26 1990-08-02 Ulrich Prof Dr Speck N - acetylglucosamin zur buccalen anwendung
WO1993018775A1 (fr) * 1992-03-19 1993-09-30 The University Of British Columbia Procede et composition permettant de supprimer les effets secondaires de medicaments anti-inflammatoires
US5998173A (en) * 1996-02-20 1999-12-07 The University Of Bristish Columbia Process for producing N-acetyl-D-glucosamine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001519A1 (fr) * 1987-08-20 1989-02-23 Children's Hospital Corporation Proteine humaine liant le mannose
WO1991006010A1 (fr) * 1989-10-11 1991-05-02 Institute Of Child Health Procedure de diagnostic
JPH06121695A (ja) * 1992-10-13 1994-05-06 Fuji Yakuhin Kogyo Kk 抗ヒトマンノース結合蛋白モノクローナル抗体およびその利用
JPH07238100A (ja) * 1994-02-25 1995-09-12 Sumitomo Electric Ind Ltd ヒトのｍａｓｐに対するモノクローナル抗体

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHAKA W ET AL: "Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of cryptococcus neoformans involves human mannose binding protein", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, 1997, pages 2979 - 2985, XP002145899, ISSN: 0022-1767 *
COLLARD C D ET AL: "ENDOTHELIAL REOXYGENATION ACTIVATES THE LECTIN COMPLEMENT PATHWAY: INHIBITION WITH ANTI-HUMAN MANNOSE BINDING LECTIN(MBL) THERAPY", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 36, no. 4/5, March 1999 (1999-03-01), pages 278, XP000944464, ISSN: 0026-895X *
COLLARD C D ET AL: "REOXYGENATION OF HYPOXIC HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVECS) ACTIVATES THE LECTIN COMPLEMENT PATHWAY (LCP)", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A29, XP000944437, ISSN: 0892-6638 *
ENDO M ET AL: "GLOMERULA DEPOSITION OF MANNOSE-BINDING LECTIN (MBL) INDICATES A NOVEL MECHANISM OF COMPLEMENT ACTIVATION IN IGA NEPHROPATHY", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 13, no. 8, 1998, pages 1984 - 1990, XP000874166, ISSN: 0931-0509 *
LHOTTA K ET AL: "GLOMERULAR DEPOSITION OF MANNOSE-BINDING LECTIN IN HUMAN GLOMERULONEPHRITIS", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 14, no. 4, April 1999 (1999-04-01), pages 881 - 886, XP000944395, ISSN: 0931-0509 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 410 (C - 1232) 2 August 1994 (1994-08-02) *
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 01 31 January 1996 (1996-01-31) *
See also references of WO0035483A1 *
TENNER A J ET AL: "MANNOSE BINDING PROTEIN (MBP) ENHANCES MONONUCLEAR PHAGOCYTE FUNCTION VIA A RECEPTOR THAT CONTAINS THE 126,00 MR COMPONENT OF THE C1Q RECEPTOR", IMMUNITY, CELL PRESS, US, vol. 3, no. 4, 1 October 1995 (1995-10-01), pages 485 - 493, XP002058774, ISSN: 1074-7613 *
TERAI I ET AL: "ALPHA2-MACROGLOBULIN BINDS TO AND INHIBITS MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASE", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 7, no. 10, October 1995 (1995-10-01), pages 1579 - 1584, XP001034131, ISSN: 0953-8178 *

Also Published As

Publication number Publication date
JP2002532079A (ja) 2002-10-02
CA2347734A1 (fr) 2000-06-22
EP1140171A1 (fr) 2001-10-10
WO2000035483A1 (fr) 2000-06-22

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