DK3287142T3 - Fremgangsmåder til behandling af tilstande, som er forbundet med masp-2-afhængig komplementaktivering - Google Patents
Fremgangsmåder til behandling af tilstande, som er forbundet med masp-2-afhængig komplementaktivering Download PDFInfo
- Publication number
- DK3287142T3 DK3287142T3 DK17191208.2T DK17191208T DK3287142T3 DK 3287142 T3 DK3287142 T3 DK 3287142T3 DK 17191208 T DK17191208 T DK 17191208T DK 3287142 T3 DK3287142 T3 DK 3287142T3
- Authority
- DK
- Denmark
- Prior art keywords
- masp
- activation
- methods
- conditions associated
- treating conditions
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161473698P | 2011-04-08 | 2011-04-08 | |
EP12767899.3A EP2694108B1 (en) | 2011-04-08 | 2012-04-06 | Methods for treating conditions associated with masp-2 dependent complement activation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3287142T3 true DK3287142T3 (da) | 2021-11-01 |
Family
ID=46966283
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17191208.2T DK3287142T3 (da) | 2011-04-08 | 2012-04-06 | Fremgangsmåder til behandling af tilstande, som er forbundet med masp-2-afhængig komplementaktivering |
DK12767899.3T DK2694108T3 (da) | 2011-04-08 | 2012-04-06 | Fremgangsmåder til behandling af lidelser associeret med masp-2-afhængig komplementaktivering |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12767899.3T DK2694108T3 (da) | 2011-04-08 | 2012-04-06 | Fremgangsmåder til behandling af lidelser associeret med masp-2-afhængig komplementaktivering |
Country Status (18)
Country | Link |
---|---|
US (5) | US8951522B2 (da) |
EP (3) | EP3964233A1 (da) |
JP (4) | JP5937197B2 (da) |
KR (6) | KR102217658B1 (da) |
CN (3) | CN110075294A (da) |
AU (1) | AU2012239889B2 (da) |
BR (1) | BR112013025917A2 (da) |
CA (4) | CA3076975A1 (da) |
CL (1) | CL2013002874A1 (da) |
DK (2) | DK3287142T3 (da) |
ES (2) | ES2894342T3 (da) |
HK (1) | HK1250342A1 (da) |
IL (3) | IL228758B (da) |
MX (2) | MX339002B (da) |
NZ (5) | NZ709997A (da) |
PL (1) | PL3287142T3 (da) |
RU (2) | RU2662563C2 (da) |
WO (1) | WO2012139081A2 (da) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
RU2662563C2 (ru) | 2011-04-08 | 2018-07-26 | Юниверсити Оф Лестер | Способы лечения состояний, связанных с masp-2 зависимой активацией комплемента |
CN106831985A (zh) | 2011-12-21 | 2017-06-13 | 诺华股份有限公司 | 用于抗体靶定p因子的组合物和方法 |
ES2670668T3 (es) * | 2012-04-06 | 2018-05-31 | Omeros Corporation | Composiciones y métodos para inhibir la MASP-1 y/o la MASP-3 para el tratamiento de la hemoglobinuria nocturna paroxísmica |
NZ629473A (en) * | 2012-06-18 | 2017-02-24 | Univ Leicester | Compositions and methods of inhibiting masp-1 and/or masp-2 and/or masp-3 for the treatment of various diseases and disorders |
AU2013334229B2 (en) * | 2012-10-25 | 2018-02-15 | Bioverativ Usa Inc. | Anti-complement C1s antibodies and uses thereof |
DK2914291T3 (da) | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
ES2964340T3 (es) * | 2013-03-15 | 2024-04-05 | Omeros Corp | Métodos para generar anticuerpos portadores de péptidos bioactivos y composiciones que comprenden los mismos |
US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
HUE051746T2 (hu) * | 2013-10-17 | 2021-03-29 | Omeros Corp | Eljárások MASP-2-függõ komplement aktiválással kapcsolatos állapotok kezelésére |
WO2015070041A1 (en) * | 2013-11-08 | 2015-05-14 | Icahn School Of Medicine At Mount Sinai | Methods for monitoring kidney dysfunction |
KR102503319B1 (ko) | 2014-06-12 | 2023-02-28 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절 |
ES2900998T3 (es) | 2015-01-28 | 2022-03-21 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento |
HUE061076T2 (hu) | 2015-04-06 | 2023-05-28 | Bioverativ Usa Inc | Humanizált anti-C1s ellenanyagok alkalmazási eljárások |
EP3373963A4 (en) | 2015-11-09 | 2019-07-10 | Omeros Corporation | METHODS OF TREATING SUFFERING RELATED TO MASP-2-DEPENDENT COMPLEMENTAL ACTIVATION |
EP3389692B1 (en) | 2015-12-16 | 2020-03-04 | RA Pharmaceuticals, Inc. | Modulators of complement activity |
BR112018012844A2 (pt) * | 2015-12-23 | 2018-12-04 | Greenovation Biotech Gmbh | polipeptídeos para inibir a ativação de complemento |
KR102564616B1 (ko) * | 2016-01-05 | 2023-08-08 | 유니버시티 오브 레스터 | 필요로 하는 대상체에서 섬유증의 억제 방법 |
CA3096270C (en) | 2016-03-31 | 2024-05-21 | Omeros Corporation | Methods for inhibiting angiogenesis in a subject in need thereof |
JOP20170170B1 (ar) * | 2016-08-31 | 2022-09-15 | Omeros Corp | صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق |
JOP20190068A1 (ar) * | 2016-10-13 | 2019-04-01 | Omeros Corp | طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي |
CA3045114A1 (en) | 2016-12-07 | 2018-06-14 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
WO2018124132A1 (ja) * | 2016-12-26 | 2018-07-05 | 日本ビーシージー製造株式会社 | 細菌細胞壁骨格成分を含有する水中油型エマルション製剤 |
JPWO2018164186A1 (ja) * | 2017-03-09 | 2020-01-09 | 協和キリン株式会社 | Masp2の発現を抑制する核酸 |
US20210093654A1 (en) * | 2017-07-28 | 2021-04-01 | Lemonex Inc. | Pharmaceutical composition for preventing or treating liver cancer |
RU2020117578A (ru) | 2017-12-04 | 2022-01-14 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
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