DK2694108T3 - Fremgangsmåder til behandling af lidelser associeret med masp-2-afhængig komplementaktivering - Google Patents

Fremgangsmåder til behandling af lidelser associeret med masp-2-afhængig komplementaktivering Download PDF

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DK2694108T3
DK2694108T3 DK12767899.3T DK12767899T DK2694108T3 DK 2694108 T3 DK2694108 T3 DK 2694108T3 DK 12767899 T DK12767899 T DK 12767899T DK 2694108 T3 DK2694108 T3 DK 2694108T3
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masp
antibody
complement
fragment
activation
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Hans-Wilhelm Schwaeble
Gregory A Demopulos
Tom Dudler
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Univ Leicester
Omeros Corp
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Claims (15)

1. Monoklonalt MASP-2-antistof eller fragment deraf, som inhiberer MASP-2-afhængig lectin-vej komplementaktivering til anvendelse i behandlingen af et individ, som lider af paroxystisk nokturn hæmoglobinuri (PNH), hvor nævnte MASP-2-antistof eller fragment deraf specifikt binder til en del af SEQ ID NO:6 og selektivt inhiberer MASP-2-afhængig lectin-vej komplementaktivering samtidig med at Clq-afhængig klassisk vej komplementaktivering efterlades intakt.
2. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor nævnte antistof eller fragment deraf øger overlevelsen af røde blodlegemer i individet.
3. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor nævnte individ tidligere har gennemgået, eller er i gang med at gennemgå behandling med en terminal komplement-inhibitor, der inhiberer spaltning af komplementprotein C5.
4. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1 hvor nævnte individ udviser et eller flere symptomer valgt fra gruppen bestående af (i) under normale hæmoglobinniveauer, (ii) under normale blodpladeniveauer; (iii) over normale retikulocytniveauer, og (iv) over normale bilirubinniveauer.
5. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 3, hvor den terminale komplement-inhibitor, der inhiberer spaltning af komplement-protein C5 er et humaniseret anti-C5 antistof eller antigen-bindende fragment deraf.
6. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 5, hvor anti-C5-antistoffet eller det antigen-bindende fragment deraf er eculizumab.
7. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor antistoffet eller fragmentet deraf er et rekombinant antistof.
8. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor antistoffet har reduceret effektorfunktion.
9. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor antistoffet eller fragmentet deraf er et kimært antistof.
10. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor antistoffet eller fragmentet deraf er humaniseret.
11. MASP-2-antistof eller fragment deraf til anvendelse ifølge krav 1, hvor antistoffet eller fragmentet deraf er humant.
12. Farmaceutisk sammensætning egnet til at inhibere MASP-2-afhængig lectin-vej komplementaktivering til anvendelse ifølge et hvilket som helst af kravene 1 til 11 omfattende en terapeutisk effektiv mængde af et MASP-2-inhiberende monoklonalt antistof eller fragment deraf og en farmaceutisk acceptabel bærer, hvor nævnte MASP-2-antistof eller fragment deraf specifikt binder til en del af SEQ ID NO:6 og selektivt inhiberer MASP-2-afhængig lectin-vej komplementaktivering samtidig med at Clq-afhængig klassisk vej komplementaktivering efterlades intakt.
13. Sammensætning til anvendelse ifølge krav 12, hvor sammensætningen er formuleret til systemisk indgivelse.
14. Sammensætning til anvendelse ifølge krav 12, hvor sammensætningen er formuleret til subkutan indgivelse.
15. Sammensætning til anvendelse ifølge krav 12, hvor sammensætningen yderligere omfatter en terminal komplement-inhibitor, der inhiberer spaltning af komplement-protein C5, såsom et humaniseret anti-C5 antistof eller antigenbindende fragment deraf.
DK12767899.3T 2011-04-08 2012-04-06 Fremgangsmåder til behandling af lidelser associeret med masp-2-afhængig komplementaktivering DK2694108T3 (da)

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PCT/US2012/032650 WO2012139081A2 (en) 2011-04-08 2012-04-06 Methods for treating conditions associated with masp-2 dependent complement activation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8951522B2 (en) 2011-04-08 2015-02-10 University Of Leicester Methods for treating conditions associated with MASP-2 dependent complement activation
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
BR112014015111A2 (pt) * 2011-12-21 2017-06-13 Novartis Ag composições e processos para anticorpos que se direcionam ao fator p
SI2833907T1 (en) * 2012-04-06 2018-07-31 Omeros Corporation COMPOSITION AND METHODS OF INJECTION OF MASP-1 AND / OR MASP-3 FOR TREATMENT OF PAROXYSIMAL NIGHT CHEMOGLOBINURIA
AU2013277309B2 (en) * 2012-06-18 2018-03-29 Omeros Corporation Compositions and methods of inhibiting MASP-1 and/or MASP-2 and/or MASP-3 for the treatment of various diseases and disorders
CA3124553A1 (en) 2012-10-25 2014-05-01 Bioverativ Usa Inc. Anti-complement c1s antibodies and uses thereof
JP6543572B2 (ja) 2012-11-02 2019-07-10 バイオベラティブ・ユーエスエイ・インコーポレイテッド 抗補体Ｃ１ｓ抗体とそれらの用途
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
AU2014229020B2 (en) * 2013-03-15 2017-09-28 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
MX2016005017A (es) * 2013-10-17 2016-11-07 Omeros Corp Metodos para el tratamiento de condiciones asociadas con la activacion del complemento dependiente de masp-2.
WO2015070041A1 (en) * 2013-11-08 2015-05-14 Icahn School Of Medicine At Mount Sinai Methods for monitoring kidney dysfunction
PL3628680T3 (pl) 2014-06-12 2022-01-10 Ra Pharmaceuticals, Inc. Modulowanie aktywności dopełniacza
PT3250230T (pt) 2015-01-28 2021-12-07 Ra Pharmaceuticals Inc Moduladores da atividade do complemento
LT3280440T (lt) 2015-04-06 2023-02-27 Bioverativ Usa Inc. Humanizuoti antikūnai prieš c1s ir jų panaudojimo būdai
GEP20237574B (en) * 2015-11-09 2023-12-25 Univ Leicester Methods for treating conditions associated with masp-2 dependent complement activation
CA3007772A1 (en) 2015-12-16 2017-06-22 Ra Pharmaceuticals, Inc. Modulators of complement activity
EP3394089B1 (en) * 2015-12-23 2021-07-28 eleva GmbH Polypeptides for inhibiting complement activation
GEP20217290B (en) * 2016-01-05 2021-09-10 Univ Leicester Masp-2 antibodies for inhibiting fibrosis
US10870708B2 (en) 2016-03-31 2020-12-22 University Of Leicester Methods for inhibiting angiogenesis in a subject in need thereof
JOP20170170B1 (ar) * 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
JOP20190068A1 (ar) * 2016-10-13 2019-04-01 Omeros Corp طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي
CA3045114A1 (en) 2016-12-07 2018-06-14 Ra Pharmaceuticals, Inc. Modulators of complement activity
JP6442703B2 (ja) * 2016-12-26 2018-12-26 日本ビーシージー製造株式会社 細菌細胞壁骨格成分を含有する水中油型エマルション製剤
KR20190128674A (ko) * 2017-03-09 2019-11-18 쿄와 기린 가부시키가이샤 Masp2의 발현을 억제하는 핵산
JP6967810B2 (ja) * 2017-07-28 2021-11-17 レモネックス インコーポレイテッドLemonex Inc. 肝癌の予防または治療用の薬学的組成物
WO2019112984A1 (en) 2017-12-04 2019-06-13 Ra Pharmaceuticals, Inc. Modulators of complement activity
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
JP2021525728A (ja) * 2018-05-29 2021-09-27 オメロス コーポレーション Ｍａｓｐ−２阻害剤および使用方法
RU2699040C1 (ru) * 2018-07-23 2019-09-03 Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) Способ экстренной профилактики и лечения острой лучевой болезни (варианты)
WO2020038377A1 (zh) 2018-08-21 2020-02-27 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
EP3628735A1 (en) 2018-09-25 2020-04-01 Centre National De La Recherche Scientifique Antisense rna targeting pmp22 for the treatment of charcot-marie-tooth 1a disease
US11896674B2 (en) 2018-09-30 2024-02-13 Suzhou Ribo Life Science Co., Ltd. SiRNA conjugate, preparation method therefor and use thereof
TW202039840A (zh) * 2018-11-15 2020-11-01 美商伊奧尼斯醫藥公司 Irf5表現調節劑
EP3960858A4 (en) * 2018-12-25 2023-02-15 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences SMALL RNA DRUG USED TO PREVENT AND TREAT INFLAMMATION-RELATED DISEASES AND COMBINATIONS THEREOF
CN113543796A (zh) 2019-03-08 2021-10-22 Ra制药公司 齐鲁考普作为深层组织穿透性c5抑制剂
JPWO2020184700A1 (da) * 2019-03-14 2020-09-17
WO2020205501A1 (en) 2019-03-29 2020-10-08 Ra Pharmaceuticals, Inc. Complement modulators and related methods
TW202106290A (zh) 2019-04-24 2021-02-16 美商Ｒａ製藥公司 用於調節補體活性之組成物及方法
WO2020233651A1 (zh) * 2019-05-22 2020-11-26 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN111024947A (zh) * 2019-11-19 2020-04-17 江苏美克医学技术有限公司 白色念珠菌荧光免疫层析测定试剂盒及其制备方法
EP4050957B1 (en) 2019-11-27 2024-03-06 Kyocera Corporation Method and apparatus for avoiding paging collisions in a multi-sim user equipment
MX2022006750A (es) 2019-12-04 2022-06-14 Omeros Corp Inhibidores de masp-2 y metodos de uso.
CA3159159A1 (en) 2019-12-04 2021-06-10 Neil S. Cutshall Masp-2 inhibitors and methods of use
EP4069678A1 (en) 2019-12-04 2022-10-12 Omeros Corporation Masp-2 inhibitors and methods of use
CA3159176A1 (en) 2019-12-04 2021-06-10 Neil S. Cutshall Masp-2 inhibitors and methods of use
EP4107165A1 (en) * 2020-02-19 2022-12-28 Alnylam Pharmaceuticals, Inc. Mannan binding lectin serine peptidase 2 (masp2) irna compositions and methods of use thereof
KR102314642B1 (ko) * 2020-04-17 2021-10-20 재단법인 아산사회복지재단 파브리 병 진단용 바이오 마커 및 이의 용도
CN113674860B (zh) * 2020-05-15 2024-05-17 北京大学人民医院 一种难治性iTTP风险预测装置、系统及其应用
WO2022228364A1 (zh) * 2021-04-25 2022-11-03 江苏恒瑞医药股份有限公司 抗masp2抗体、其抗原结合片段及医药用途
WO2024026258A2 (en) * 2022-07-25 2024-02-01 Amgen Inc. Rnai constructs and methods for inhibiting fam13a expression

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4526909A (en) 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
JPH0662679B2 (ja) 1985-06-21 1994-08-17 新田ゼラチン株式会社 組織親和性コラ−ゲンとその製法
US5453566A (en) 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
KR970010758B1 (ko) 1987-12-15 1997-06-30 진 쉬어즈 피티와이. 리미티드 올리고리보뉴클레오티드 화합물
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8822492D0 (en) 1988-09-24 1988-10-26 Considine J Apparatus for removing tumours from hollow organs of body
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0438803B1 (en) 1990-01-26 1997-03-12 Immunomedics, Inc. Vaccines against cancer and infectious diseases
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
US5789573A (en) 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5856121A (en) 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
JPH07238100A (ja) 1994-02-25 1995-09-12 Sumitomo Electric Ind Ltd ヒトのｍａｓｐに対するモノクローナル抗体
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US5739119A (en) 1996-11-15 1998-04-14 Galli; Rachel L. Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
US7083786B2 (en) 1997-04-03 2006-08-01 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
WO2001007067A2 (en) 1999-07-21 2001-02-01 Omeros Medical Systems, Inc. Solutions and methods for inhibition of pain, inflammation and cartilage degradation
US7273925B1 (en) 1998-12-15 2007-09-25 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
CA2347734A1 (en) 1998-12-15 2000-06-22 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
CN1433466A (zh) 1999-12-02 2003-07-30 詹斯·C·詹斯尼厄斯 Masp－3,一种固定补体的酶,及其应用
US6649592B1 (en) 2000-01-14 2003-11-18 Science & Technology Corporation @ Unm Peptide inhibitors of LFA-1/ICAM-1 interaction
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
ATE434661T1 (de) 2000-07-13 2009-07-15 Helion Biotech Aps Masp-2, ein komplement fixierendes enzym, und dessen verwendungen
EP1416962A4 (en) 2001-07-26 2006-05-24 Alexion Pharma Inc METHOD FOR IMPROVING THE COGNITIVE FUNCTION
AU2003212898B2 (en) 2002-02-01 2008-10-02 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
WO2003081206A2 (en) 2002-03-18 2003-10-02 Alexion Pharmaceuticals, Inc. Stratification of patient populations having or suspected of having rheumatoid arthritis
CN100519643C (zh) 2002-07-19 2009-07-29 奥默罗斯公司 可生物降解的三嵌段共聚物,它们的合成方法和从它制得的水凝胶和生物材料
PT1534313E (pt) 2002-07-30 2013-01-25 Omeros Corp Soluções e método de irrigação oftalmológica
ITRM20020511A1 (it) * 2002-10-09 2004-04-10 Santa Anna Acuto Uso dell'insulator sns di riccio di mare per la terapia genica di malattie delle cellule eritroidi.
EP1570075A2 (en) 2002-12-03 2005-09-07 Aarhus Universitet Method for determing predisposition to manifestation of immune system related diseases
WO2004075837A2 (en) 2003-02-21 2004-09-10 Tanox, Inc. Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury
WO2004083250A1 (ja) * 2003-03-17 2004-09-30 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute フォンビルブランド因子特異的切断酵素に対する抗体の認識領域からなる構成物
WO2004106384A1 (en) 2003-05-12 2004-12-09 Natimmune A/S Antibodies to masp-2
US20050169921A1 (en) * 2004-02-03 2005-08-04 Leonard Bell Method of treating hemolytic disease
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US8951522B2 (en) 2011-04-08 2015-02-10 University Of Leicester Methods for treating conditions associated with MASP-2 dependent complement activation
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US20060018896A1 (en) 2004-06-10 2006-01-26 University Of Leicester Methods for treating conditions associated with lectin-dependent complement activation
GB0412966D0 (en) 2004-06-10 2004-07-14 Univ Leicester Genetically modified non-human mammals and cells
EP3530288A3 (en) 2004-06-10 2019-12-18 Omeros Corporation Methods for treating conditions associated with masp-2 dependent complement activation
WO2006133955A1 (en) * 2005-06-17 2006-12-21 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
ATE487133T1 (de) 2006-01-27 2010-11-15 Rappaport Family Inst For Res Verfahren zur blutgerinnungsbestimmung
DK2596807T3 (da) 2006-03-08 2016-03-07 Archemix Llc Komplementbindende aptamere og anti-c5-midler, som kan anvendes ved behandlingen af øjensygdomme
LT2894165T (lt) 2008-11-10 2023-03-10 Alexion Pharmaceuticals, Inc. Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui
WO2010151526A1 (en) 2009-06-23 2010-12-29 Alexion Pharmaceuticals, Inc. Bispecific antibodies that bind to complement proteins
KR102184713B1 (ko) 2009-07-17 2020-12-01 오메로스 코포레이션 보체 활성화의 억제제로서의 masp 이소형
ES2617920T3 (es) 2009-10-16 2017-06-20 Omeros Corporation Métodos para el tratamiento de la coagulación intravascular diseminada mediante la inhibición de la activación del complemento dependiente de MASP-2
KR20120130748A (ko) * 2009-11-05 2012-12-03 알렉시온 캠브리지 코포레이션 발작성 야간 혈색소뇨증, 용혈성 빈혈, 및 혈관내 및 혈관외 용혈을 수반한 질환 상태의 치료
NZ602219A (en) 2010-03-01 2014-10-31 Alexion Pharma Inc Methods and compositions for treating degos’ disease
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US20150166676A1 (en) 2011-04-08 2015-06-18 Omeros Corporation Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation
CA3131223C (en) 2011-05-04 2024-01-30 Omeros Corporation Compositions for inhibiting masp-2 dependent complement activation
AU2013277309B2 (en) 2012-06-18 2018-03-29 Omeros Corporation Compositions and methods of inhibiting MASP-1 and/or MASP-2 and/or MASP-3 for the treatment of various diseases and disorders
MX2016005017A (es) 2013-10-17 2016-11-07 Omeros Corp Metodos para el tratamiento de condiciones asociadas con la activacion del complemento dependiente de masp-2.
GEP20237574B (en) 2015-11-09 2023-12-25 Univ Leicester Methods for treating conditions associated with masp-2 dependent complement activation
WO2018070521A1 (ja) * 2016-10-14 2018-04-19 公立大学法人福島県立医科大学 補体の活性化経路を阻害する融合ポリペプチド

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