AU2012239889B2 - Methods for treating conditions associated with MASP-2 dependent complement activation - Google Patents
Methods for treating conditions associated with MASP-2 dependent complement activation Download PDFInfo
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- AU2012239889B2 AU2012239889B2 AU2012239889A AU2012239889A AU2012239889B2 AU 2012239889 B2 AU2012239889 B2 AU 2012239889B2 AU 2012239889 A AU2012239889 A AU 2012239889A AU 2012239889 A AU2012239889 A AU 2012239889A AU 2012239889 B2 AU2012239889 B2 AU 2012239889B2
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- masp
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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-
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013201606A AU2013201606B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201626A AU2013201626B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201627A AU2013201627B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2015271989A AU2015271989B2 (en) | 2011-04-08 | 2015-12-21 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2016200531A AU2016200531A1 (en) | 2011-04-08 | 2016-01-29 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2017276333A AU2017276333B2 (en) | 2011-04-08 | 2017-12-15 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2018200437A AU2018200437B2 (en) | 2011-04-08 | 2018-01-19 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2020201271A AU2020201271A1 (en) | 2011-04-08 | 2020-02-21 | Methods for treating conditions associated with MASP-2 dependent complement activation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473698P | 2011-04-08 | 2011-04-08 | |
| US61/473,698 | 2011-04-08 | ||
| PCT/US2012/032650 WO2012139081A2 (en) | 2011-04-08 | 2012-04-06 | Methods for treating conditions associated with masp-2 dependent complement activation |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013201626A Division AU2013201626B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201606A Division AU2013201606B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201627A Division AU2013201627B2 (en) | 2011-04-08 | 2013-03-12 | Methods for treating conditions associated with MASP-2 dependent complement activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012239889A1 AU2012239889A1 (en) | 2013-03-14 |
| AU2012239889B2 true AU2012239889B2 (en) | 2015-09-03 |
Family
ID=46966283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012239889A Active AU2012239889B2 (en) | 2011-04-08 | 2012-04-06 | Methods for treating conditions associated with MASP-2 dependent complement activation |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US8951522B2 (enExample) |
| EP (3) | EP2694108B1 (enExample) |
| JP (4) | JP5937197B2 (enExample) |
| KR (6) | KR102217658B1 (enExample) |
| CN (3) | CN110075294A (enExample) |
| AU (1) | AU2012239889B2 (enExample) |
| BR (1) | BR112013025917A2 (enExample) |
| CA (4) | CA3237802A1 (enExample) |
| CL (1) | CL2013002874A1 (enExample) |
| DK (2) | DK2694108T3 (enExample) |
| ES (2) | ES2683307T3 (enExample) |
| IL (3) | IL228758B (enExample) |
| MX (3) | MX339002B (enExample) |
| NZ (5) | NZ617298A (enExample) |
| PL (1) | PL3287142T3 (enExample) |
| RU (2) | RU2743409C2 (enExample) |
| WO (1) | WO2012139081A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0688182B2 (ja) | 1986-09-08 | 1994-11-09 | バブコツク日立株式会社 | スタツド着脱装置 |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| DK2694108T3 (en) | 2011-04-08 | 2018-08-20 | Univ Leicester | METHODS OF TREATING DISEASES ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| SG10201703249PA (en) * | 2011-12-21 | 2017-05-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| NZ629675A (en) * | 2012-04-06 | 2017-02-24 | Omeros Corp | Compositions and methods of inhibiting masp-1, masp-2 and/or masp-3 for treatment of paroxysmal nocturnal hemoglobinuria |
| PT2861246T (pt) * | 2012-06-18 | 2021-04-05 | Univ Leicester | Composições e métodos para inibir masp-1 e/ou masp-2 e/ou masp-3 para o tratamento de várias doenças e perturbações |
| WO2014066744A2 (en) | 2012-10-25 | 2014-05-01 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
| ES2912396T3 (es) | 2012-11-02 | 2022-05-25 | Bioverativ Usa Inc | Anticuerpos anti-C1s del complemento y uso de los mismos |
| CA2906096C (en) * | 2013-03-15 | 2022-03-15 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| RS61351B1 (sr) * | 2013-10-17 | 2021-02-26 | Omeros Corp | Postupci za lečenje stanja udruženih sa aktivacijom komplementa zavisnom od masp-2 |
| WO2015070041A1 (en) * | 2013-11-08 | 2015-05-14 | Icahn School Of Medicine At Mount Sinai | Methods for monitoring kidney dysfunction |
| BR122021025449B1 (pt) | 2014-06-12 | 2024-02-15 | Ra Pharmaceuticals, Inc | Composto, polipeptídeo e composição compreendendo o mesmo |
| SMT202100688T1 (it) | 2015-01-28 | 2022-01-10 | Ra Pharmaceuticals Inc | Modulatori di attività del complemento |
| EP4212175A1 (en) | 2015-04-06 | 2023-07-19 | Bioverativ USA Inc. | Humanized anti-c1s antibodies and methods of use thereof |
| CN117398458A (zh) | 2015-11-09 | 2024-01-16 | 奥默罗斯公司 | 用于治疗与masp-2依赖性补体活化相关的病况的方法 |
| KR20260070290A (ko) | 2015-12-16 | 2026-05-18 | 유씨비 홀딩스 인코포레이티드 | 보체 활성의 조절인자 |
| LT3394089T (lt) * | 2015-12-23 | 2021-11-25 | eleva GmbH | Polipeptidai, skirti komplemento aktyvacijos inhibicijai |
| CA3010593C (en) * | 2016-01-05 | 2024-02-13 | University Of Leicester | Methods for inhibiting fibrosis in a subject in need thereof |
| NZ745531A (en) | 2016-03-31 | 2020-09-25 | Omeros Corp | Methods for inhibiting angiogenesis in a subject in need thereof |
| UY37376A (es) * | 2016-08-26 | 2018-03-23 | Amgen Inc | Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso |
| JOP20170170B1 (ar) | 2016-08-31 | 2022-09-15 | Omeros Corp | صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق |
| IL326479A (en) | 2016-10-12 | 2026-04-01 | Bioverativ Usa Inc | Anti-c1s antibodies and methods of use thereof |
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| US20050191298A1 (en) * | 2004-02-03 | 2005-09-01 | Leonard Bell | Method of treating hemolytic disease |
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