JP2014503178A5 - - Google Patents
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- JP2014503178A5 JP2014503178A5 JP2013532287A JP2013532287A JP2014503178A5 JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5 JP 2013532287 A JP2013532287 A JP 2013532287A JP 2013532287 A JP2013532287 A JP 2013532287A JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5
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- tau
- antibody
- seq
- binding fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000013498 tau Proteins Human genes 0.000 claims description 83
- 108010026424 tau Proteins Proteins 0.000 claims description 83
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- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims description 2
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims description 2
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
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- 150000001413 amino acids Chemical class 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39175110P | 2010-10-11 | 2010-10-11 | |
| US61/391,751 | 2010-10-11 | ||
| EP10013494.9 | 2010-10-11 | ||
| EP10013494 | 2010-10-11 | ||
| PCT/IB2011/002786 WO2012049570A1 (en) | 2010-10-11 | 2011-10-11 | Human anti-tau antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Division JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503178A JP2014503178A (ja) | 2014-02-13 |
| JP2014503178A5 true JP2014503178A5 (enExample) | 2014-10-16 |
Family
ID=43602869
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532287A Pending JP2014503178A (ja) | 2010-10-11 | 2011-10-11 | ヒト抗タウ抗体 |
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US8940272B2 (enExample) |
| EP (1) | EP2627672B1 (enExample) |
| JP (2) | JP2014503178A (enExample) |
| CN (1) | CN103339146B (enExample) |
| AU (1) | AU2011315181B2 (enExample) |
| BR (1) | BR112013008765B8 (enExample) |
| CA (1) | CA2813493C (enExample) |
| CY (1) | CY1120951T1 (enExample) |
| DK (1) | DK2627672T3 (enExample) |
| EA (1) | EA031698B1 (enExample) |
| ES (1) | ES2686550T3 (enExample) |
| HR (1) | HRP20181320T8 (enExample) |
| IL (1) | IL225670B (enExample) |
| LT (1) | LT2627672T (enExample) |
| MX (1) | MX345092B (enExample) |
| NZ (1) | NZ609984A (enExample) |
| PL (1) | PL2627672T3 (enExample) |
| PT (1) | PT2627672T (enExample) |
| SG (1) | SG189174A1 (enExample) |
| SI (1) | SI2627672T1 (enExample) |
| TR (1) | TR201812636T4 (enExample) |
| WO (1) | WO2012049570A1 (enExample) |
| ZA (1) | ZA201303175B (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| CA2813493C (en) | 2010-10-11 | 2019-07-09 | University Of Zurich | Human anti-tau antibodies |
| US20120244174A1 (en) | 2011-01-31 | 2012-09-27 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| MX350311B (es) | 2011-12-20 | 2017-09-01 | Janssen Biotech Inc | Anticuerpos anti-phf-tau y sus usos. |
| SG10201708959WA (en) * | 2012-07-03 | 2017-11-29 | Univ Washington | Antibodies to tau |
| WO2014016737A1 (en) * | 2012-07-24 | 2014-01-30 | Pfizer Inc. | Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof |
| NZ630542A (en) * | 2012-08-16 | 2017-06-30 | Ipierian Inc | Methods of treating a tauopathy |
| US20140056901A1 (en) * | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| CA2896066C (en) * | 2012-12-21 | 2022-07-12 | Biogen Ma Inc. | Human anti-tau antibodies |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| US10501531B2 (en) | 2013-03-13 | 2019-12-10 | Prothena Biosciences Limited | Tau immunotherapy |
| WO2014150877A2 (en) * | 2013-03-15 | 2014-09-25 | Ac Immune S.A. | Anti-tau antibodies and methods of use |
| BR112015030356A2 (pt) * | 2013-06-10 | 2017-12-05 | Ipierian Inc | métodos de tratamento de uma taupatia |
| GB201312226D0 (en) * | 2013-07-08 | 2013-08-21 | Adx Neurosciences | Improved antibodies |
| BR112016010454A2 (pt) * | 2013-11-27 | 2017-12-05 | Ipierian Inc | métodos para tratar uma taupatia |
| AU2014368696A1 (en) | 2013-12-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Humanized anti-Tau(pS422) antibodies and methods of use |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン，インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| BR112016029579A2 (pt) * | 2014-06-26 | 2017-08-22 | Janssen Vaccines & Prevention Bv | anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos |
| ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TWI734975B (zh) * | 2014-06-27 | 2021-08-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| CA2954738A1 (en) | 2014-07-29 | 2016-02-04 | Neurimmune Holding Ag | Human-derived anti-huntingtin (htt) antibodies and uses thereof |
| WO2016054247A1 (en) * | 2014-09-30 | 2016-04-07 | Washington University | Tau kinetic measurements |
| CA3001724A1 (en) | 2014-10-10 | 2016-04-14 | National Research Council Of Canada | Anti-tau antibody and uses thereof |
| CN107428820B (zh) | 2014-11-19 | 2022-03-22 | 阿克松神经系统科学公司 | 在阿尔茨海默氏病中的人源化tau抗体 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| EP3261670A4 (en) * | 2015-02-24 | 2018-08-01 | Rpeptide, LLC | Anti-tau antibodies |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對ｔａｕ之抗體及其用途 |
| WO2016164530A1 (en) * | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
| NZ775762A (en) | 2015-06-05 | 2025-02-28 | Genentech Inc | Anti-tau antibodies and methods of use |
| WO2016207245A1 (en) | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Humanized anti-tau(ps422) antibodies and methods of use |
| WO2017005734A1 (en) * | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
| US10344081B2 (en) | 2015-07-06 | 2019-07-09 | Ucb Biopharma Sprl | Tau-binding antibodies |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| CN105388302A (zh) * | 2015-12-22 | 2016-03-09 | 中国医学科学院输血研究所 | 一种人免疫球蛋白制品中Tau蛋白抗体含量的检测方法 |
| EP4063858A1 (en) | 2016-03-14 | 2022-09-28 | Biogen International Neuroscience GmbH | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins |
| MX2018013386A (es) | 2016-05-02 | 2019-02-28 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau. |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| MY198194A (en) | 2016-05-02 | 2023-08-09 | Prothena Biosciences Ltd | Antibodies Recognizing Tau |
| CN114796481A (zh) | 2016-06-07 | 2022-07-29 | 生物基因国际神经科学有限责任公司 | 治疗阿尔茨海默病的方法 |
| PH12018502613B1 (en) * | 2016-07-12 | 2023-02-01 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| CA3030754C (en) * | 2016-07-20 | 2022-04-26 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| US20190330318A1 (en) | 2016-07-25 | 2019-10-31 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
| CA3032692A1 (en) | 2016-08-09 | 2018-02-15 | Eli Lilly And Company | Combination antibody therapy for the treatment of neurodegenerative diseases |
| EP3509622A4 (en) | 2016-09-08 | 2020-06-17 | Regenerative Research Foundation | BIFUNCTIONAL ANTI-TAU POLYPEPTIDES AND USE THEREOF |
| BR112018014281A2 (pt) | 2016-11-15 | 2018-12-18 | H Lundbeck As | agentes, usos e métodos para o tratamento da sinucleinopatia |
| MX2019006330A (es) | 2016-12-07 | 2019-09-26 | Genentech Inc | Anticuerpos anti-tau y metodos de uso. |
| UA128383C2 (uk) | 2016-12-07 | 2024-07-03 | Дженентек, Інк. | Антитіло до тау-білка та спосіб його застосування |
| US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| SG11201907422RA (en) * | 2017-02-17 | 2019-09-27 | Denali Therapeutics Inc | Anti-tau antibodies and methods of use thereof |
| JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| TWI771389B (zh) | 2017-03-16 | 2022-07-21 | 美商健生生物科技公司 | 抗phf-tau抗體及其用途 |
| EP3602046A1 (en) * | 2017-03-28 | 2020-02-05 | Janssen Vaccines & Prevention B.V. | Methods for detection of tau protein aggregation modulating compounds |
| CA3056517A1 (en) * | 2017-03-28 | 2018-10-04 | Janssen Vaccines & Prevention B.V. | Binding molecules that specifically bind to tau |
| EP3601337A1 (en) | 2017-03-28 | 2020-02-05 | Genentech, Inc. | Methods of treating neurodegenerative diseases |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| WO2018231254A1 (en) * | 2017-06-16 | 2018-12-20 | Bristol-Myers Squibb Company | Compositions and methods for treating tauopathies |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| EP3691639B1 (en) | 2017-10-02 | 2023-11-15 | Merck Sharp & Dohme LLC | Chromane monobactam compounds for the treatment of bacterial infections |
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| US12398201B2 (en) | 2018-02-19 | 2025-08-26 | New York University | Tau single domain antibodies |
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| CA3093200A1 (en) * | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Anti-phf-tau antibodies and uses thereof |
| CA3090356A1 (en) * | 2018-03-11 | 2019-09-19 | Koorosh Shahpasand | Conformation-independent antibodies against neurotoxic tau proteins |
| CA3107788A1 (en) | 2018-07-31 | 2020-02-06 | Eli Lilly And Company | Combination of anti-tau antibody and oga inhibitor for treatment of diseases characterized by aberrant tau aggregation |
| US20220089704A1 (en) | 2018-10-29 | 2022-03-24 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| CU24781B1 (es) * | 2018-11-08 | 2026-02-09 | Prothena Biosciences Ltd | Anticuerpos humanizados que reconocen tau |
| JP7630834B2 (ja) | 2019-03-03 | 2025-02-18 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| JP2022534406A (ja) * | 2019-05-27 | 2022-07-29 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | タウの立体配座特異的エピトープ、それらに対する抗体、およびそれらに関連する方法 |
| GB2585252A (en) | 2019-07-05 | 2021-01-06 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| JP7181438B2 (ja) | 2019-08-06 | 2022-11-30 | アプリノイア セラピューティクス リミテッド | 病理学的タウ種に結合する抗体及びその使用 |
| TWI793451B (zh) | 2019-09-20 | 2023-02-21 | 納維再生科技股份有限公司 | 個人化癌症免疫治療 |
| CA3183835A1 (en) | 2020-06-25 | 2021-12-30 | Jeanne E. Baker | High affinity antibodies targeting tau phosphorylated at serine 413 |
| WO2022144406A1 (en) * | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| JP2024534151A (ja) | 2021-08-27 | 2024-09-18 | ジェネンテック， インコーポレイテッド | タウ病態の治療方法 |
| US20250134952A1 (en) | 2021-09-20 | 2025-05-01 | Institut National de la Santé et de la Recherche Médicale | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
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