JP2014503178A5 - - Google Patents
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- JP2014503178A5 JP2014503178A5 JP2013532287A JP2013532287A JP2014503178A5 JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5 JP 2013532287 A JP2013532287 A JP 2013532287A JP 2013532287 A JP2013532287 A JP 2013532287A JP 2014503178 A5 JP2014503178 A5 JP 2014503178A5
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- JP
- Japan
- Prior art keywords
- tau
- antibody
- seq
- binding fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010026424 tau Proteins Proteins 0.000 claims description 83
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- 208000034799 Tauopathies Diseases 0.000 claims description 19
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- 102000029749 Microtubule Human genes 0.000 claims description 4
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- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 2
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- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims description 2
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims description 2
- 206010061216 Infarction Diseases 0.000 claims description 2
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- 230000001605 fetal effect Effects 0.000 claims description 2
- 102000057063 human MAPT Human genes 0.000 claims description 2
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- 238000002600 positron emission tomography Methods 0.000 claims description 2
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
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- 229940079593 drug Drugs 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39175110P | 2010-10-11 | 2010-10-11 | |
| EP10013494.9 | 2010-10-11 | ||
| EP10013494 | 2010-10-11 | ||
| US61/391,751 | 2010-10-11 | ||
| PCT/IB2011/002786 WO2012049570A1 (en) | 2010-10-11 | 2011-10-11 | Human anti-tau antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Division JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503178A JP2014503178A (ja) | 2014-02-13 |
| JP2014503178A5 true JP2014503178A5 (enExample) | 2014-10-16 |
Family
ID=43602869
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532287A Pending JP2014503178A (ja) | 2010-10-11 | 2011-10-11 | ヒト抗タウ抗体 |
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016975A Expired - Fee Related JP6300842B2 (ja) | 2010-10-11 | 2016-02-01 | ヒト抗タウ抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US8940272B2 (enExample) |
| EP (1) | EP2627672B1 (enExample) |
| JP (2) | JP2014503178A (enExample) |
| CN (1) | CN103339146B (enExample) |
| AU (1) | AU2011315181B2 (enExample) |
| BR (1) | BR112013008765B8 (enExample) |
| CA (1) | CA2813493C (enExample) |
| CY (1) | CY1120951T1 (enExample) |
| DK (1) | DK2627672T3 (enExample) |
| EA (1) | EA031698B1 (enExample) |
| ES (1) | ES2686550T3 (enExample) |
| HR (1) | HRP20181320T8 (enExample) |
| IL (1) | IL225670B (enExample) |
| LT (1) | LT2627672T (enExample) |
| MX (1) | MX345092B (enExample) |
| NZ (1) | NZ609984A (enExample) |
| PL (1) | PL2627672T3 (enExample) |
| PT (1) | PT2627672T (enExample) |
| SG (1) | SG189174A1 (enExample) |
| SI (1) | SI2627672T1 (enExample) |
| TR (1) | TR201812636T4 (enExample) |
| WO (1) | WO2012049570A1 (enExample) |
| ZA (1) | ZA201303175B (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| SG189174A1 (en) | 2010-10-11 | 2013-05-31 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
| US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| PT2794654T (pt) | 2011-12-20 | 2019-09-10 | Janssen Biotech Inc | Anticorpos anti-phf-tau e suas utilizações |
| JP6345655B2 (ja) * | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | タウに対する抗体 |
| WO2014016737A1 (en) * | 2012-07-24 | 2014-01-30 | Pfizer Inc. | Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof |
| DK2885010T3 (da) | 2012-08-16 | 2020-02-03 | Ipierian Inc | Fremgangsmåder til behandling med tauopati |
| US20140056901A1 (en) * | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| HRP20201422T1 (hr) * | 2012-12-21 | 2021-02-19 | Biogen Ma Inc. | Ljudska anti-tau antitijela |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| MX375354B (es) | 2013-03-13 | 2025-03-06 | Prothena Biosciences Ltd | Anticuerpos que se unen a tau y usos de los mismos. |
| BR112015023262B8 (pt) * | 2013-03-15 | 2024-02-06 | Ac Immune Sa | Anticorpo isolado, imunoconjugado, formulação farmacêutica e usos do anticorpo |
| LT3007726T (lt) * | 2013-06-10 | 2020-09-10 | Ipierian, Inc. | Tautopatijos gydymo būdai |
| GB201312226D0 (en) * | 2013-07-08 | 2013-08-21 | Adx Neurosciences | Improved antibodies |
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| SI3083680T1 (sl) | 2013-12-20 | 2020-06-30 | F. Hoffmann-La Roche Ag | Humanizirana protitelesa proti beljakovini Tau(pS422) in postopki uporabe |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン，インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| NZ727020A (en) * | 2014-06-26 | 2022-02-25 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TW202136296A (zh) * | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| CN107074937B (zh) | 2014-07-29 | 2021-07-27 | 神经免疫控股公司 | 人源抗亨廷顿蛋白(htt)抗体及其用途 |
| US10830775B2 (en) * | 2014-09-30 | 2020-11-10 | Washington University | Tau kinetic measurements |
| US10098973B2 (en) | 2014-10-10 | 2018-10-16 | National Research Council Of Canada | Anti-tau antibody and uses thereof |
| HRP20210124T1 (hr) | 2014-11-19 | 2021-03-19 | Axon Neuroscience Se | Humanizirana tau antitijela u alzheimerovoj bolesti |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| EP3261670A4 (en) | 2015-02-24 | 2018-08-01 | Rpeptide, LLC | Anti-tau antibodies |
| JO3576B1 (ar) | 2015-02-26 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لـ tau واستخداماتها |
| WO2016164530A1 (en) * | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
| UA126272C2 (uk) | 2015-06-05 | 2022-09-14 | Дженентек, Інк. | Антитіло проти тау-білка та спосіб його застосування |
| CN107810196B (zh) | 2015-06-24 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 人源化的抗-Tau(pS422)抗体和使用方法 |
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| EA037092B1 (ru) * | 2015-07-06 | 2021-02-04 | Юсб Биофарма Срл | Тау-связывающие антитела |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| CN105388302A (zh) * | 2015-12-22 | 2016-03-09 | 中国医学科学院输血研究所 | 一种人免疫球蛋白制品中Tau蛋白抗体含量的检测方法 |
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| EA201892412A1 (ru) | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
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| KR102551971B1 (ko) | 2016-07-12 | 2023-07-07 | 하. 룬드벡 아크티에셀스카브 | 과인산화된 타우에 특이적인 항체 및 이의 사용 방법 |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| EP3487524A4 (en) * | 2016-07-20 | 2020-03-25 | Anahit Ghochikyan | HUMANIZED ANTI-TAU ANTIBODIES, COMPOSITIONS AND MANUFACTURING METHODS AND METHODS OF USE IN THE TREATMENT, DIAGNOSIS AND MONITORING OF TAUOPATHIES |
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| EP3496750A2 (en) | 2016-08-09 | 2019-06-19 | Eli Lilly and Company | Combination therapy |
| US11072639B2 (en) | 2016-09-08 | 2021-07-27 | Regenerative Research Foundation | Bi-functional anti-tau polypeptides and use thereof |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| AR110321A1 (es) | 2016-12-07 | 2019-03-20 | Genentech Inc | Anticuerpos antitau y métodos de uso |
| KR20240035636A (ko) | 2016-12-07 | 2024-03-15 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
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