JP2014158473A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014158473A5 JP2014158473A5 JP2014059605A JP2014059605A JP2014158473A5 JP 2014158473 A5 JP2014158473 A5 JP 2014158473A5 JP 2014059605 A JP2014059605 A JP 2014059605A JP 2014059605 A JP2014059605 A JP 2014059605A JP 2014158473 A5 JP2014158473 A5 JP 2014158473A5
- Authority
- JP
- Japan
- Prior art keywords
- reverse transcriptase
- mutation
- mutations
- activity
- corresponding wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100034343 Integrase Human genes 0.000 claims 14
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 14
- 230000035772 mutation Effects 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 241000713869 Moloney murine leukemia virus Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 102220473257 Crossover junction endonuclease EME1_I49V_mutation Human genes 0.000 claims 1
- 102220562954 Cytochrome c oxidase subunit 7C, mitochondrial_M39V_mutation Human genes 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102220266397 rs1555186808 Human genes 0.000 claims 1
- 102200163844 rs17127898 Human genes 0.000 claims 1
- 102220253369 rs201879717 Human genes 0.000 claims 1
- 102220271817 rs771550822 Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0806562.5 | 2008-04-10 | ||
| GBGB0806562.5A GB0806562D0 (en) | 2008-04-10 | 2008-04-10 | Production of nucleic acid |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503454A Division JP5642662B2 (ja) | 2008-04-10 | 2009-04-09 | 核酸の生成 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015230724A Division JP6140792B2 (ja) | 2008-04-10 | 2015-11-26 | 核酸の生成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014158473A JP2014158473A (ja) | 2014-09-04 |
| JP2014158473A5 true JP2014158473A5 (enExample) | 2015-06-25 |
Family
ID=39433452
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503454A Active JP5642662B2 (ja) | 2008-04-10 | 2009-04-09 | 核酸の生成 |
| JP2014059605A Pending JP2014158473A (ja) | 2008-04-10 | 2014-03-24 | 核酸の生成 |
| JP2015230724A Active JP6140792B2 (ja) | 2008-04-10 | 2015-11-26 | 核酸の生成 |
| JP2017091035A Active JP6236563B2 (ja) | 2008-04-10 | 2017-05-01 | 核酸の生成 |
| JP2017208710A Active JP6473795B2 (ja) | 2008-04-10 | 2017-10-30 | 核酸の生成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503454A Active JP5642662B2 (ja) | 2008-04-10 | 2009-04-09 | 核酸の生成 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015230724A Active JP6140792B2 (ja) | 2008-04-10 | 2015-11-26 | 核酸の生成 |
| JP2017091035A Active JP6236563B2 (ja) | 2008-04-10 | 2017-05-01 | 核酸の生成 |
| JP2017208710A Active JP6473795B2 (ja) | 2008-04-10 | 2017-10-30 | 核酸の生成 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8835148B2 (enExample) |
| EP (4) | EP3098308B1 (enExample) |
| JP (5) | JP5642662B2 (enExample) |
| KR (4) | KR102082768B1 (enExample) |
| CN (2) | CN107058258A (enExample) |
| AU (1) | AU2009235368B2 (enExample) |
| CA (1) | CA2721117A1 (enExample) |
| ES (1) | ES2647272T3 (enExample) |
| GB (1) | GB0806562D0 (enExample) |
| IL (2) | IL208578A (enExample) |
| NZ (1) | NZ588468A (enExample) |
| PL (1) | PL2281035T3 (enExample) |
| SG (1) | SG10201503327QA (enExample) |
| WO (1) | WO2009125006A2 (enExample) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9771565B2 (en) * | 2000-05-26 | 2017-09-26 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| EP1554377B1 (en) | 2002-09-13 | 2012-11-07 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| GB0806562D0 (en) * | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| US9890408B2 (en) * | 2009-10-15 | 2018-02-13 | Ibis Biosciences, Inc. | Multiple displacement amplification |
| EP2604688B1 (en) * | 2010-08-13 | 2018-01-10 | Kyoto University | Variant reverse transcriptase |
| KR101818126B1 (ko) * | 2011-02-09 | 2018-01-15 | (주)바이오니아 | 열안정성이 증가된 역전사효소 |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9745571B2 (en) * | 2013-03-07 | 2017-08-29 | Bio-Rad Laboratories, Inc. | Repetitive reverse transcription partition assay |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2015075842A1 (ja) * | 2013-11-25 | 2015-05-28 | 国立大学法人京都大学 | 変異型逆転写酵素 |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| US9663770B2 (en) | 2014-01-22 | 2017-05-30 | Life Technologies Corporation | Reverse transcriptases for use in high temperature nucleic acid synthesis |
| CN106414704B (zh) | 2014-03-14 | 2020-11-03 | 生命技术公司 | 用于核酸扩增和检测的集成系统 |
| CN104250642A (zh) * | 2014-04-30 | 2014-12-31 | 厦门安普利生物工程有限公司 | 一种提取纯化m-mlv逆转录酶的方法 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN107810415B (zh) * | 2015-05-11 | 2021-06-22 | 亿明达股份有限公司 | 用于发现和分析治疗剂的平台 |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017178986A1 (en) | 2016-04-12 | 2017-10-19 | Solis Biodyne Oü | Synthetic reverse transcriptases and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US9580698B1 (en) * | 2016-09-23 | 2017-02-28 | New England Biolabs, Inc. | Mutant reverse transcriptase |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US11220677B2 (en) | 2016-12-14 | 2022-01-11 | Takara Bio Inc. | Heat-resistant reverse transcriptase mutant |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| EP3610006B1 (en) | 2017-04-11 | 2021-05-19 | Roche Diagnostics GmbH | Mutant reverse transcriptase with increased thermal stability as well as products, methods and uses involving the same |
| SG11201908596WA (en) * | 2017-04-26 | 2019-11-28 | 10X Genomics Inc | Mmlv reverse transcriptase variants |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019051097A1 (en) | 2017-09-08 | 2019-03-14 | The Regents Of The University Of California | RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019122200A1 (en) | 2017-12-22 | 2019-06-27 | Thermo Fisher Scientific Baltics Uab | Polymerase chain reaction composition comprising amines |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| US12188014B1 (en) | 2018-07-25 | 2025-01-07 | 10X Genomics, Inc. | Compositions and methods for nucleic acid processing using blocking agents |
| US20220411783A1 (en) * | 2018-10-12 | 2022-12-29 | The Broad Institute, Inc. | Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN112969527A (zh) * | 2018-11-08 | 2021-06-15 | 深圳华大生命科学研究院 | 一种微流控芯片及其制备方法和dna合成方法 |
| WO2020132966A1 (zh) * | 2018-12-26 | 2020-07-02 | 深圳华大生命科学研究院 | 酶活性提高的逆转录酶及其应用 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN114174503B (zh) * | 2019-07-26 | 2024-06-28 | 东洋纺株式会社 | 稳定性优异的突变型逆转录酶 |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN112795547B (zh) * | 2019-11-13 | 2024-05-31 | 广州达安基因股份有限公司 | 高逆转录效率的逆转录酶突变体 |
| CN112795546B (zh) * | 2019-11-13 | 2024-02-27 | 广州达安基因股份有限公司 | 一种具有高逆转录效率的耐高温逆转录酶突变体及其应用 |
| CN112795548A (zh) * | 2019-11-13 | 2021-05-14 | 中山大学达安基因股份有限公司 | 具有高逆转录效率的耐高温逆转录酶突变体及其应用 |
| CN112795551B (zh) * | 2019-11-13 | 2024-01-30 | 广州达安基因股份有限公司 | 一种耐高温逆转录酶突变体及其应用 |
| CN112795549B (zh) * | 2019-11-13 | 2023-11-28 | 广州达安基因股份有限公司 | 一种逆转录酶突变体 |
| EP4461810A3 (en) | 2019-12-11 | 2025-04-09 | 10X Genomics, Inc. | Reverse transcriptase variants |
| EP4107273A1 (en) | 2020-02-21 | 2022-12-28 | Limagrain Europe | Prime editing technology for plant genome engineering |
| WO2021188840A1 (en) * | 2020-03-19 | 2021-09-23 | Rewrite Therapeutics, Inc. | Methods and compositions for directed genome editing |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN111849938B (zh) * | 2020-06-05 | 2022-02-15 | 广州英赞生物科技有限公司 | 一种突变型逆转录酶及其制备方法与应用 |
| CN111647576B (zh) * | 2020-06-24 | 2021-02-09 | 南京诺唯赞生物科技股份有限公司 | 一种热稳定性逆转录酶突变体及其应用 |
| US12559734B2 (en) | 2020-07-20 | 2026-02-24 | Integrated Dna Technologies, Inc. | Reverse transcriptase mutants with increased activity and thermostability |
| US12435318B2 (en) | 2020-07-20 | 2025-10-07 | Integrated Dna Technologies, Inc. | Reverse transcriptase mutants with increased activity and thermostability |
| CN114480331A (zh) * | 2020-11-13 | 2022-05-13 | 广州达安基因股份有限公司 | Mmlv酶组合突变体 |
| CN114480330B (zh) * | 2020-11-13 | 2024-11-01 | 广州达安基因股份有限公司 | 多突变位点的逆转录酶突变体 |
| CN114480335B (zh) * | 2020-11-13 | 2024-06-07 | 广州达安基因股份有限公司 | 逆转录酶及逆转录检测试剂 |
| CN114480332B (zh) * | 2020-11-13 | 2023-12-05 | 广州达安基因股份有限公司 | 耐高温m-mlv酶突变体及其应用 |
| CN114480336B (zh) * | 2020-11-13 | 2023-10-20 | 广州达安基因股份有限公司 | 含有逆转录酶突变体的核酸检测试剂盒 |
| WO2022115579A1 (en) * | 2020-11-24 | 2022-06-02 | Saliogen Therapeutics, Inc. | Mammalian mobile element compositions, systems and therapeutic applications |
| CN112481234B (zh) * | 2020-12-03 | 2023-09-22 | 重庆工业职业技术学院 | 一种焦磷酸酶突变体合成核酸糖类似物及其应用 |
| CN112251423B (zh) * | 2020-12-08 | 2021-03-19 | 北京健为医学检验实验室有限公司 | 一种m-mlv逆转录酶体及其应用 |
| CN113234858A (zh) * | 2021-05-20 | 2021-08-10 | 阿吉安(福州)基因医学检验实验室有限公司 | 一种covid-19的检测试剂盒 |
| CN113174381B (zh) * | 2021-06-08 | 2023-05-12 | 翌圣生物科技(上海)股份有限公司 | 增强型mmlv逆转录酶突变体及其应用 |
| JPWO2023112947A1 (enExample) * | 2021-12-17 | 2023-06-22 | ||
| CN114214299A (zh) * | 2022-01-26 | 2022-03-22 | 苏州译酶生物科技有限公司 | 一种m-mlv逆转录酶及其制备方法 |
| US11639499B1 (en) | 2022-03-08 | 2023-05-02 | Watchmaker Genomics, Inc. | Reverse transcriptase variants |
| CN114657165B (zh) * | 2022-03-25 | 2023-04-07 | 江苏百时美生物科技有限公司 | 一种提高热稳定性和抑制剂耐受性的逆转录酶突变体及其应用 |
| CN114591930B (zh) * | 2022-05-10 | 2022-08-12 | 翌圣生物科技(上海)股份有限公司 | 增强型逆转录酶、编码dna、试剂盒及其在rna文库构建中的应用 |
| CN117106745B (zh) * | 2022-06-01 | 2025-02-14 | 北京擎科生物科技股份有限公司 | 逆转录突变体及其应用 |
| CN116064460B (zh) * | 2022-08-01 | 2023-09-26 | 南京诺唯赞生物科技股份有限公司 | 一种mmlv突变体及其应用 |
| CN117586983B (zh) * | 2022-08-11 | 2026-05-29 | 菲鹏生物股份有限公司 | 一种逆转录酶、核酸分子及合成cDNA的方法 |
| CN115747186B (zh) * | 2022-09-13 | 2025-05-27 | 天罗诊断科技江苏有限公司 | 一种耐热的高效率逆转录酶突变体及其应用 |
| CN116814581A (zh) * | 2022-10-13 | 2023-09-29 | 苏州拜科生物科技有限公司 | 一种热稳定性反转录酶突变体基因、制备方法和应用 |
| CN116042569B (zh) * | 2023-02-01 | 2023-08-15 | 珠海宝锐生物科技有限公司 | Mmlv逆转录酶突变体及其应用 |
| CN116004568B (zh) * | 2023-02-07 | 2025-10-17 | 北京诺派生物科技有限公司 | 一种可用于核酸检测的耐高温反转录酶及其制备方法与应用 |
| WO2024211850A1 (en) * | 2023-04-05 | 2024-10-10 | Primrose Bio, Inc. | Methods and compositions for protein engineering |
| CN116622669B (zh) * | 2023-06-30 | 2024-06-07 | 翌圣生物科技(上海)股份有限公司 | 一种鼠白血病病毒逆转录酶突变体及其应用 |
| CN119592538A (zh) * | 2023-06-30 | 2025-03-11 | 翌圣生物科技(上海)股份有限公司 | 一种鼠白血病病毒逆转录酶突变体及其应用 |
| CN116732141B (zh) * | 2023-07-10 | 2024-04-02 | 海南大学 | 一种快速检测生物dna特异性的方法 |
| CN117025724A (zh) * | 2023-08-23 | 2023-11-10 | 翌圣生物科技(上海)股份有限公司 | Rna链特异性建库试剂盒及建库方法 |
| CN117925558B (zh) * | 2023-12-13 | 2025-03-25 | 郑州玛特瑞斯生物科技有限公司 | 突变型逆转录酶及其应用 |
| CN118406670B (zh) * | 2024-05-06 | 2025-06-27 | 湖南艾科瑞生物工程有限公司 | 一种mmlv逆转录酶突变体及其应用 |
| WO2026003215A1 (fr) | 2024-06-27 | 2026-01-02 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Bases modifiées chimiquement avec un groupement clivable et méthodes de sélection d'acides nucléiques fonctionnels les comprenant |
| US20260184995A1 (en) * | 2024-12-30 | 2026-07-02 | Life Technologies Corporation | Non-ionic surfactants and methods of making and using the same |
| WO2026147782A1 (en) | 2024-12-30 | 2026-07-09 | Life Technologies Corporation | Non-ionic surfactants and methods of using the same |
| WO2026147784A1 (en) | 2024-12-30 | 2026-07-09 | Life Technologies Corporation | Non-ionic surfactants and methods of using the same |
| CN119955759B (zh) * | 2025-01-07 | 2025-08-08 | 湖南艾科瑞生物工程有限公司 | 一种mmlv逆转录酶突变体及其应用 |
| CN121249621B (zh) * | 2025-12-08 | 2026-03-31 | 翌圣生物科技(上海)股份有限公司 | 一种mmlv逆转录酶突变体及其制备方法、产品和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6236563A (ja) | 1985-08-12 | 1987-02-17 | Koji Ando | 可動導体型計器 |
| US5244797B1 (en) * | 1988-01-13 | 1998-08-25 | Life Technologies Inc | Cloned genes encoding reverse transcriptase lacking rnase h activity |
| ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
| US6183967B1 (en) * | 1995-06-07 | 2001-02-06 | Nexstar Pharmaceuticals | Nucleic acid ligand inhibitors to DNA polymerases |
| US6395524B2 (en) | 1996-11-27 | 2002-05-28 | University Of Washington | Thermostable polymerases having altered fidelity and method of identifying and using same |
| CA2287542A1 (en) | 1997-04-22 | 1998-10-29 | Invitrogen Corporation | Methods for the production of aslv reverse transcriptases composed of multiple subunits |
| ATE358177T1 (de) | 1997-07-07 | 2007-04-15 | Medical Res Council | Ein in vitro sortierverfahren |
| US6136582A (en) * | 1998-01-20 | 2000-10-24 | The Trustees Of Columbia University In The City | Reverse transcriptase of moloney murine leukemia virus with RNA polymerase activity |
| JP4193079B2 (ja) | 1998-11-10 | 2008-12-10 | 東洋紡績株式会社 | 変異型逆転写酵素 |
| AU2611700A (en) * | 1999-01-15 | 2000-08-01 | Molecular Biology Resources | Biologically active reverse transcriptases |
| US7056716B2 (en) | 2000-03-15 | 2006-06-06 | Invitrogen Corporation | High fidelity reverse transcriptases and uses thereof |
| WO2001075097A2 (en) | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
| EP2295551B1 (en) * | 2000-05-26 | 2016-04-06 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| US7078208B2 (en) | 2000-05-26 | 2006-07-18 | Invitrogen Corporation | Thermostable reverse transcriptases and uses thereof |
| GB0022458D0 (en) | 2000-09-13 | 2000-11-01 | Medical Res Council | Directed evolution method |
| WO2003025132A2 (en) | 2001-09-14 | 2003-03-27 | Invitrogen Corporation | Dna polymerases and mutants thereof |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US7597700B2 (en) | 2002-04-30 | 2009-10-06 | Abbott Laboratories | Lancet removal tool |
| AU2003260786B2 (en) * | 2002-09-06 | 2008-03-13 | Isogenica Limited | In vitro peptide expression libraray |
| GB0221053D0 (en) | 2002-09-11 | 2002-10-23 | Medical Res Council | Single-molecule in vitro evolution |
| EP1554377B1 (en) * | 2002-09-13 | 2012-11-07 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| EP1691792A4 (en) * | 2003-11-24 | 2008-05-28 | Yeda Res & Dev | COMPOSITIONS AND PROCESSES FOR SORTING IN VITRO OF MOLECULE AND CELL LIBRARIES |
| EP1712617A4 (en) | 2004-01-13 | 2007-07-18 | Inst Biophysics Cn Acad Sci | RECOMBINANT REVERSE TRANSCRIPTASE OF THE MOUSE LEUKEMIA VIRUS, AND A CODING GENE AND METHOD FOR THE EXPRESSION THEREOF |
| US7595179B2 (en) * | 2004-04-19 | 2009-09-29 | Applied Biosystems, Llc | Recombinant reverse transcriptases |
| US20080004436A1 (en) | 2004-11-15 | 2008-01-03 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Directed Evolution and Selection Using in Vitro Compartmentalization |
| JPWO2007011045A1 (ja) * | 2005-07-20 | 2009-02-05 | 株式会社クラレ | パージング剤 |
| JP5203200B2 (ja) * | 2005-08-10 | 2013-06-05 | アジレント・テクノロジーズ・インク | 変異体逆転写酵素および使用方法 |
| WO2008029085A2 (en) | 2006-09-06 | 2008-03-13 | Medical Research Council | Polymerase |
| GB0806562D0 (en) * | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
-
2008
- 2008-04-10 GB GBGB0806562.5A patent/GB0806562D0/en not_active Ceased
-
2009
- 2009-04-09 EP EP16177660.4A patent/EP3098308B1/en active Active
- 2009-04-09 JP JP2011503454A patent/JP5642662B2/ja active Active
- 2009-04-09 KR KR1020197003483A patent/KR102082768B1/ko active Active
- 2009-04-09 CN CN201611027264.1A patent/CN107058258A/zh active Pending
- 2009-04-09 CN CN200980121472XA patent/CN102057039A/zh active Pending
- 2009-04-09 NZ NZ588468A patent/NZ588468A/xx not_active IP Right Cessation
- 2009-04-09 CA CA2721117A patent/CA2721117A1/en not_active Abandoned
- 2009-04-09 EP EP09730379.6A patent/EP2281035B1/en active Active
- 2009-04-09 KR KR1020107025153A patent/KR101653775B1/ko active Active
- 2009-04-09 EP EP18168458.0A patent/EP3375870B1/en active Active
- 2009-04-09 WO PCT/EP2009/054329 patent/WO2009125006A2/en not_active Ceased
- 2009-04-09 KR KR1020187003649A patent/KR101947101B1/ko active Active
- 2009-04-09 PL PL09730379T patent/PL2281035T3/pl unknown
- 2009-04-09 KR KR1020167013385A patent/KR101828902B1/ko active Active
- 2009-04-09 ES ES13167553.0T patent/ES2647272T3/es active Active
- 2009-04-09 SG SG10201503327QA patent/SG10201503327QA/en unknown
- 2009-04-09 AU AU2009235368A patent/AU2009235368B2/en not_active Ceased
- 2009-04-09 EP EP13167553.0A patent/EP2639300B1/en active Active
-
2010
- 2010-10-07 US US12/899,641 patent/US8835148B2/en active Active
- 2010-10-07 IL IL208578A patent/IL208578A/en active IP Right Grant
-
2012
- 2012-02-29 US US13/408,732 patent/US8580548B2/en active Active
-
2013
- 2013-06-19 US US13/921,989 patent/US9683251B2/en active Active
-
2014
- 2014-03-24 JP JP2014059605A patent/JP2014158473A/ja active Pending
-
2015
- 2015-11-26 JP JP2015230724A patent/JP6140792B2/ja active Active
-
2016
- 2016-06-22 IL IL246396A patent/IL246396B/en unknown
-
2017
- 2017-05-01 JP JP2017091035A patent/JP6236563B2/ja active Active
- 2017-05-02 US US15/584,565 patent/US10287614B2/en active Active
- 2017-10-30 JP JP2017208710A patent/JP6473795B2/ja active Active
-
2018
- 2018-04-20 US US15/959,090 patent/US10358670B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016073298A5 (enExample) | ||
| JP2017518750A5 (enExample) | ||
| MX2023002841A (es) | Composiciones detergentes y sus usos. | |
| JP2016135874A5 (enExample) | ||
| MX2022000369A (es) | Cepa bacteriana de bifidobacterium bifidum, las composiciones de la misma y usos relacionados. | |
| WO2017060493A9 (en) | Polypeptides | |
| EP4643946A3 (en) | Treatment of hyperbilirubinemia | |
| SA519400792B1 (ar) | مشتقات إيميدازو [1،2-a] بيريدين، طرق لتحضيرهم واستخدامهم | |
| AU2017249444A1 (en) | Methods and compositions for treatment of concrete wash water | |
| PH12017500403A1 (en) | Anti-il-25 antibodies and uses thereof | |
| WO2015138870A3 (en) | Compositions and methods for targeted epigenetic modification | |
| MX2023010365A (es) | Proteina liofilizada estable a temperatura ambiente. | |
| WO2017015622A8 (en) | Gdf11 binding proteins and uses thereof | |
| EP4275705A3 (en) | Pancreatitis treatment | |
| MX2021015661A (es) | Metodos y composiciones para tratar la obesidad, prevenir el aumento de peso, promover la perdida de peso, promover el adelgazamiento o tratar o prevenir el desarrollo de la diabetes. | |
| WO2015161243A3 (en) | Beta-lactamases with improved properties for therapy | |
| JP2016518114A5 (enExample) | ||
| MX378784B (es) | Proteína. | |
| HK1254432A1 (zh) | 用於治疗纤维性疾病的方法和组合物 | |
| WO2017200873A8 (en) | COMPOSITIONS AND METHODS FOR TREATING ACNE | |
| JP2017502045A5 (enExample) | ||
| EP4413996A3 (en) | Novel antibodies against factor xi and uses thereof | |
| MX2018011980A (es) | 3-epimerasa y polinucleotido que la codifica. | |
| WO2018013775A3 (en) | Granulin compositions and uses related thereto | |
| PH12019500535A1 (en) | 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof |