PL2281035T3 - Wytwarzanie kwasu nukleinowego - Google Patents
Wytwarzanie kwasu nukleinowegoInfo
- Publication number
- PL2281035T3 PL2281035T3 PL09730379T PL09730379T PL2281035T3 PL 2281035 T3 PL2281035 T3 PL 2281035T3 PL 09730379 T PL09730379 T PL 09730379T PL 09730379 T PL09730379 T PL 09730379T PL 2281035 T3 PL2281035 T3 PL 2281035T3
- Authority
- PL
- Poland
- Prior art keywords
- production
- nucleic acid
- nucleic
- acid
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0806562.5A GB0806562D0 (en) | 2008-04-10 | 2008-04-10 | Production of nucleic acid |
| PCT/EP2009/054329 WO2009125006A2 (en) | 2008-04-10 | 2009-04-09 | Production of nucleic acid |
| EP09730379.6A EP2281035B1 (en) | 2008-04-10 | 2009-04-09 | Production of nucleic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2281035T3 true PL2281035T3 (pl) | 2015-07-31 |
Family
ID=39433452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09730379T PL2281035T3 (pl) | 2008-04-10 | 2009-04-09 | Wytwarzanie kwasu nukleinowego |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8835148B2 (enExample) |
| EP (4) | EP3375870B1 (enExample) |
| JP (5) | JP5642662B2 (enExample) |
| KR (4) | KR102082768B1 (enExample) |
| CN (2) | CN107058258A (enExample) |
| AU (1) | AU2009235368B2 (enExample) |
| CA (1) | CA2721117A1 (enExample) |
| ES (1) | ES2647272T3 (enExample) |
| GB (1) | GB0806562D0 (enExample) |
| IL (2) | IL208578A (enExample) |
| NZ (1) | NZ588468A (enExample) |
| PL (1) | PL2281035T3 (enExample) |
| SG (1) | SG10201503327QA (enExample) |
| WO (1) | WO2009125006A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9771565B2 (en) * | 2000-05-26 | 2017-09-26 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| EP2325303B1 (en) | 2002-09-13 | 2013-11-06 | Life Technologies Corporation | Thermostable reverse transcriptases and uses thereof |
| US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| GB0806562D0 (en) * | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| EP2957641B1 (en) * | 2009-10-15 | 2017-05-17 | Ibis Biosciences, Inc. | Multiple displacement amplification |
| EP2604688B1 (en) * | 2010-08-13 | 2018-01-10 | Kyoto University | Variant reverse transcriptase |
| KR101818126B1 (ko) | 2011-02-09 | 2018-01-15 | (주)바이오니아 | 열안정성이 증가된 역전사효소 |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9745571B2 (en) * | 2013-03-07 | 2017-08-29 | Bio-Rad Laboratories, Inc. | Repetitive reverse transcription partition assay |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| WO2015075842A1 (ja) * | 2013-11-25 | 2015-05-28 | 国立大学法人京都大学 | 変異型逆転写酵素 |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| US9663770B2 (en) | 2014-01-22 | 2017-05-30 | Life Technologies Corporation | Reverse transcriptases for use in high temperature nucleic acid synthesis |
| CN106414704B (zh) | 2014-03-14 | 2020-11-03 | 生命技术公司 | 用于核酸扩增和检测的集成系统 |
| CN104250642A (zh) * | 2014-04-30 | 2014-12-31 | 厦门安普利生物工程有限公司 | 一种提取纯化m-mlv逆转录酶的方法 |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP2018518157A (ja) | 2015-05-11 | 2018-07-12 | イラミーナ インコーポレーテッド | 治療薬剤の発見および分析のためのプラットフォーム |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| US11046940B2 (en) | 2016-04-12 | 2021-06-29 | Solis Biodyne Ou | Synthetic reverse transcriptases and uses thereof |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US9580698B1 (en) * | 2016-09-23 | 2017-02-28 | New England Biolabs, Inc. | Mutant reverse transcriptase |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| JP7061078B2 (ja) * | 2016-12-14 | 2022-04-27 | タカラバイオ株式会社 | 耐熱性の逆転写酵素変異体 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| JP6928668B2 (ja) * | 2017-04-11 | 2021-09-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 増大した熱安定性を有する変異型逆転写酵素、ならびにそれに関する生成物、方法および使用 |
| EP4375376A3 (en) | 2017-04-26 | 2024-08-14 | 10X Genomics, Inc. | Mmlv reverse transcriptase variants |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3728633A1 (en) | 2017-12-22 | 2020-10-28 | Thermo Fisher Scientific Baltics Uab | Polymerase chain reaction composition comprising amines |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| US12188014B1 (en) | 2018-07-25 | 2025-01-07 | 10X Genomics, Inc. | Compositions and methods for nucleic acid processing using blocking agents |
| US20220411783A1 (en) * | 2018-10-12 | 2022-12-29 | The Broad Institute, Inc. | Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020093322A1 (zh) * | 2018-11-08 | 2020-05-14 | 深圳华大生命科学研究院 | 一种微流控芯片及其制备方法和dna合成方法 |
| CN113785053B (zh) * | 2018-12-26 | 2024-07-12 | 深圳华大生命科学研究院 | 酶活性提高的逆转录酶及其应用 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20220290112A1 (en) * | 2019-07-26 | 2022-09-15 | Toyobo Co., Ltd. | Variant reverse transcriptase exhibiting excellent stability |
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| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN112795546B (zh) * | 2019-11-13 | 2024-02-27 | 广州达安基因股份有限公司 | 一种具有高逆转录效率的耐高温逆转录酶突变体及其应用 |
| CN112795549B (zh) * | 2019-11-13 | 2023-11-28 | 广州达安基因股份有限公司 | 一种逆转录酶突变体 |
| CN112795547B (zh) * | 2019-11-13 | 2024-05-31 | 广州达安基因股份有限公司 | 高逆转录效率的逆转录酶突变体 |
| CN112795548A (zh) * | 2019-11-13 | 2021-05-14 | 中山大学达安基因股份有限公司 | 具有高逆转录效率的耐高温逆转录酶突变体及其应用 |
| CN112795551B (zh) * | 2019-11-13 | 2024-01-30 | 广州达安基因股份有限公司 | 一种耐高温逆转录酶突变体及其应用 |
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| CN112481234B (zh) * | 2020-12-03 | 2023-09-22 | 重庆工业职业技术学院 | 一种焦磷酸酶突变体合成核酸糖类似物及其应用 |
| CN112251423B (zh) * | 2020-12-08 | 2021-03-19 | 北京健为医学检验实验室有限公司 | 一种m-mlv逆转录酶体及其应用 |
| CN113234858A (zh) * | 2021-05-20 | 2021-08-10 | 阿吉安(福州)基因医学检验实验室有限公司 | 一种covid-19的检测试剂盒 |
| CN113174381B (zh) * | 2021-06-08 | 2023-05-12 | 翌圣生物科技(上海)股份有限公司 | 增强型mmlv逆转录酶突变体及其应用 |
| CN118401656A (zh) * | 2021-12-17 | 2024-07-26 | 东洋纺株式会社 | 热稳定性优异的逆转录酶 |
| CN114214299A (zh) * | 2022-01-26 | 2022-03-22 | 苏州译酶生物科技有限公司 | 一种m-mlv逆转录酶及其制备方法 |
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| CN116004568B (zh) * | 2023-02-07 | 2025-10-17 | 北京诺派生物科技有限公司 | 一种可用于核酸检测的耐高温反转录酶及其制备方法与应用 |
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| CN116694598B (zh) * | 2023-06-30 | 2024-12-13 | 翌圣生物科技(上海)股份有限公司 | 一种鼠白血病病毒逆转录酶突变体及其应用 |
| CN118345060A (zh) * | 2023-06-30 | 2024-07-16 | 翌圣生物科技(上海)股份有限公司 | 一种鼠白血病病毒逆转录酶突变体及其应用 |
| CN116732141B (zh) * | 2023-07-10 | 2024-04-02 | 海南大学 | 一种快速检测生物dna特异性的方法 |
| CN117025724A (zh) * | 2023-08-23 | 2023-11-10 | 翌圣生物科技(上海)股份有限公司 | Rna链特异性建库试剂盒及建库方法 |
| CN117925558B (zh) * | 2023-12-13 | 2025-03-25 | 郑州玛特瑞斯生物科技有限公司 | 突变型逆转录酶及其应用 |
| CN118406670B (zh) * | 2024-05-06 | 2025-06-27 | 湖南艾科瑞生物工程有限公司 | 一种mmlv逆转录酶突变体及其应用 |
| WO2026003215A1 (fr) | 2024-06-27 | 2026-01-02 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Bases modifiées chimiquement avec un groupement clivable et méthodes de sélection d'acides nucléiques fonctionnels les comprenant |
| CN119955759B (zh) * | 2025-01-07 | 2025-08-08 | 湖南艾科瑞生物工程有限公司 | 一种mmlv逆转录酶突变体及其应用 |
| CN121249621B (zh) * | 2025-12-08 | 2026-03-31 | 翌圣生物科技(上海)股份有限公司 | 一种mmlv逆转录酶突变体及其制备方法、产品和应用 |
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