JP2013528223A5 - - Google Patents
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- Publication number
- JP2013528223A5 JP2013528223A5 JP2013514346A JP2013514346A JP2013528223A5 JP 2013528223 A5 JP2013528223 A5 JP 2013528223A5 JP 2013514346 A JP2013514346 A JP 2013514346A JP 2013514346 A JP2013514346 A JP 2013514346A JP 2013528223 A5 JP2013528223 A5 JP 2013528223A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- methylpyrrolidin
- propoxy
- clomen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 4 - ((S) -2 - ((R) -3- methylpyrrolidin-1-yl) propoxy) phenyl Chemical group 0.000 claims description 65
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 4
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- MGYRMOBJZIUBQC-JDLBOKMSSA-N 4-methyl-2-[4-[(2s)-2-[(3r)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-3-(4-methylsulfonylphenyl)-2h-chromen-6-ol Chemical compound C([C@H](C)N1C[C@H](C)CC1)OC(C=C1)=CC=C1C1OC2=CC=C(O)C=C2C(C)=C1C1=CC=C(S(C)(=O)=O)C=C1 MGYRMOBJZIUBQC-JDLBOKMSSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35353110P | 2010-06-10 | 2010-06-10 | |
| US61/353,531 | 2010-06-10 | ||
| PCT/US2011/039669 WO2011156518A2 (en) | 2010-06-10 | 2011-06-08 | Estrogen receptor modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016149008A Division JP6465840B2 (ja) | 2010-06-10 | 2016-07-28 | エストロゲン受容体モジュレーターおよびその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013528223A JP2013528223A (ja) | 2013-07-08 |
| JP2013528223A5 true JP2013528223A5 (enExample) | 2015-12-03 |
Family
ID=45098650
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514346A Pending JP2013528223A (ja) | 2010-06-10 | 2011-06-08 | エストロゲン受容体モジュレーターおよびその用途 |
| JP2016149008A Active JP6465840B2 (ja) | 2010-06-10 | 2016-07-28 | エストロゲン受容体モジュレーターおよびその用途 |
| JP2018153006A Pending JP2018203751A (ja) | 2010-06-10 | 2018-08-15 | エストロゲン受容体モジュレーターおよびその用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016149008A Active JP6465840B2 (ja) | 2010-06-10 | 2016-07-28 | エストロゲン受容体モジュレーターおよびその用途 |
| JP2018153006A Pending JP2018203751A (ja) | 2010-06-10 | 2018-08-15 | エストロゲン受容体モジュレーターおよびその用途 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8703810B2 (enExample) |
| EP (2) | EP3205648A1 (enExample) |
| JP (3) | JP2013528223A (enExample) |
| KR (1) | KR101698238B1 (enExample) |
| CN (1) | CN102939287B (enExample) |
| AU (1) | AU2011264858B2 (enExample) |
| BR (1) | BR112012031464A2 (enExample) |
| CA (1) | CA2800673A1 (enExample) |
| CY (1) | CY1120450T1 (enExample) |
| DK (1) | DK2580210T5 (enExample) |
| EA (1) | EA022551B1 (enExample) |
| ES (1) | ES2627692T3 (enExample) |
| HR (1) | HRP20170786T1 (enExample) |
| HU (1) | HUE033581T2 (enExample) |
| IL (1) | IL223044B (enExample) |
| LT (1) | LT2580210T (enExample) |
| MX (1) | MX2012014431A (enExample) |
| PH (1) | PH12012502419A1 (enExample) |
| PL (1) | PL2580210T3 (enExample) |
| PT (1) | PT2580210T (enExample) |
| RS (1) | RS56042B1 (enExample) |
| SG (1) | SG185637A1 (enExample) |
| SI (1) | SI2580210T1 (enExample) |
| WO (1) | WO2011156518A2 (enExample) |
| ZA (1) | ZA201208603B (enExample) |
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| EP2791132A4 (en) | 2011-12-14 | 2015-08-05 | Seragon Pharmaceuticals Inc | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| BR112014014767A2 (pt) * | 2011-12-16 | 2017-06-13 | Olema Pharmaceuticals Inc | novos compostos de benzopirano, composições e usos dos mesmos |
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| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
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| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
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