JP2013525266A5 - - Google Patents
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- JP2013525266A5 JP2013525266A5 JP2012554464A JP2012554464A JP2013525266A5 JP 2013525266 A5 JP2013525266 A5 JP 2013525266A5 JP 2012554464 A JP2012554464 A JP 2012554464A JP 2012554464 A JP2012554464 A JP 2012554464A JP 2013525266 A5 JP2013525266 A5 JP 2013525266A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- synuclein
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 24
- 208000015122 neurodegenerative disease Diseases 0.000 claims 9
- 102000003802 alpha-Synuclein Human genes 0.000 claims 8
- 108090000185 alpha-Synuclein Proteins 0.000 claims 8
- 208000018737 Parkinson disease Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 201000002832 Lewy body dementia Diseases 0.000 claims 4
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 3
- 230000003902 lesion Effects 0.000 claims 3
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 102000003799 beta-Synuclein Human genes 0.000 claims 1
- 108090000182 beta-Synuclein Proteins 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30863810P | 2010-02-26 | 2010-02-26 | |
| US61/308,638 | 2010-02-26 | ||
| US40626010P | 2010-10-25 | 2010-10-25 | |
| US61/406,260 | 2010-10-25 | ||
| PCT/IB2011/050826 WO2011104696A1 (en) | 2010-02-26 | 2011-02-25 | Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525266A JP2013525266A (ja) | 2013-06-20 |
| JP2013525266A5 true JP2013525266A5 (enExample) | 2014-05-15 |
| JP5894939B2 JP5894939B2 (ja) | 2016-03-30 |
Family
ID=44227520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554464A Active JP5894939B2 (ja) | 2010-02-26 | 2011-02-25 | プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8632776B2 (enExample) |
| EP (1) | EP2539366B1 (enExample) |
| JP (1) | JP5894939B2 (enExample) |
| CN (3) | CN102869680B (enExample) |
| AU (1) | AU2011219414B2 (enExample) |
| CA (1) | CA2789963C (enExample) |
| CY (1) | CY1120014T1 (enExample) |
| DK (1) | DK2539366T3 (enExample) |
| ES (1) | ES2661925T3 (enExample) |
| HR (1) | HRP20180230T8 (enExample) |
| HU (1) | HUE038313T2 (enExample) |
| LT (1) | LT2539366T (enExample) |
| NO (1) | NO2539366T3 (enExample) |
| PL (1) | PL2539366T3 (enExample) |
| PT (1) | PT2539366T (enExample) |
| RS (1) | RS57029B1 (enExample) |
| RU (1) | RU2555526C2 (enExample) |
| SI (1) | SI2539366T1 (enExample) |
| SM (1) | SMT201800044T1 (enExample) |
| WO (1) | WO2011104696A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5747414B2 (ja) | 2008-04-29 | 2015-07-15 | バイオアークティック ニューロサイエンス アーベー | α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン |
| NO2539366T3 (enExample) | 2010-02-26 | 2018-04-07 | ||
| US10989718B2 (en) * | 2014-09-11 | 2021-04-27 | Amprion, Inc. | Detection of misfolded alpha synuclein protein |
| EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
| SI2804878T1 (sl) * | 2012-01-20 | 2018-12-31 | Genzyme Corporation | Protitelesa proti-CXCR3 |
| US9534044B2 (en) * | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| WO2015075011A1 (en) | 2013-11-21 | 2015-05-28 | F. Hoffmann-La Roche Ag | ANTI-alpha-SYNUCLEIN ANTIBODIES AND METHODS OF USE |
| SMT202100263T1 (it) * | 2014-07-10 | 2021-07-12 | Eisai R&D Man Co Ltd | Anticorpi leganti protofibrille a-beta migliorati |
| JP2017536102A (ja) | 2014-10-16 | 2017-12-07 | ジェネンテック， インコーポレイテッド | 抗アルファ−シヌクレイン抗体及び使用方法 |
| WO2016137947A1 (en) * | 2015-02-24 | 2016-09-01 | Rpeptide, Llc | Anti-amyloid-beta antibodies |
| EP3091087A1 (en) | 2015-05-08 | 2016-11-09 | Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol | Method for in vitro diagnosis of synucleinopathies using alpha-synuclein gene transcripts |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| AU2016295650A1 (en) | 2015-07-21 | 2018-01-25 | Bioarctic Neuroscience Ab | Method for treatment of traumatic brain injury targeting aggregated peptides |
| CN108350052A (zh) | 2015-11-09 | 2018-07-31 | 英属哥伦比亚大学 | 淀粉样蛋白β中间区域中的表位及其构象选择性抗体 |
| KR20180094876A (ko) | 2015-11-09 | 2018-08-24 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타 에피토프 및 이에 대한 항체 |
| HK1259325A1 (zh) | 2015-11-09 | 2019-11-29 | 英属哥伦比亚大学 | 淀粉样蛋白β中的N-末端表位及其构象选择性抗体 |
| US10537633B2 (en) | 2016-03-04 | 2020-01-21 | Jn Biosciences Llc | Antibodies to TIGIT |
| WO2017207739A1 (en) | 2016-06-02 | 2017-12-07 | Medimmune Limited | Antibodies to alpha-synuclein and uses thereof |
| MA45684A (fr) * | 2016-07-14 | 2019-05-22 | Bioarctic Neuroscience Ab | Protéine d'apport du cerveau |
| US12071472B2 (en) | 2016-07-18 | 2024-08-27 | The University Of British Columbia | Methods of reducing toxicity induced by Amyloid beta (A-beta) oligomers using antibodies specific to A-beta oligomers |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US10889635B2 (en) * | 2016-11-15 | 2021-01-12 | H. Lundbeck A/S | Agents, uses and methods for the treatment of synucleinopathy |
| BR112018016717A2 (pt) | 2016-12-16 | 2018-12-26 | H Lundbeck As | agentes, usos e métodos |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| KR102014066B1 (ko) * | 2017-01-06 | 2019-10-21 | 에이비엘바이오 주식회사 | 항 α-syn 항체 및 그 용도 |
| EP3567054A4 (en) * | 2017-01-06 | 2021-03-10 | ABL Bio Inc. | ANTI-ALPHA SYN ANTIBODIES AND USES THEREOF |
| BR112019016374A2 (pt) * | 2017-02-17 | 2020-04-07 | Bristol-Myers Squibb Company | anticorpos para alfa-sinucleína e usos dos mesmos |
| WO2018191786A1 (en) * | 2017-04-21 | 2018-10-25 | Implicit Bioscience Pty Ltd | Cd 14 antagonist antibodies for treating neurodegenerative diseases |
| WO2018204352A1 (en) * | 2017-05-01 | 2018-11-08 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| CN110869763B (zh) | 2017-05-16 | 2022-07-29 | 安培里翁公司 | 错误折叠tau蛋白质的检测 |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| US11098108B2 (en) | 2017-08-02 | 2021-08-24 | Stressmarq Biosciences Inc. | Antibody binding active alpha-synuclein |
| US11155608B2 (en) | 2017-08-23 | 2021-10-26 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against pathological alpha-synuclein, and methods using same |
| RU2657763C1 (ru) * | 2017-09-12 | 2018-06-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики болезни паркинсона |
| AU2018370279B2 (en) * | 2017-11-17 | 2022-11-03 | Abl Bio Inc. | Antibodies to a-synuclein and uses thereof |
| BR112020011875A2 (pt) | 2017-12-14 | 2020-11-24 | Abl Bio Inc. | anticorpo biespecífico ao a-syn/igf1r e uso do mesmo |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) * | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| EP4273882A3 (en) | 2017-12-19 | 2024-01-03 | Chase Therapeutics Corporation | Method for assessing a synucleinopathy |
| US20200309796A1 (en) * | 2017-12-21 | 2020-10-01 | H. Lundbeck A/S | Assay, method and treatment of alpha-synucleinopathies |
| CN109957547A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向cd317的嵌合抗原受体t细胞及其制备方法和应用 |
| CN109957546A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向cd317的嵌合抗原受体t细胞及其制备方法和应用 |
| EP3773692A4 (en) * | 2018-04-04 | 2022-03-16 | University of Florida Research Foundation, Inc. | MATERIALS AND METHODS FOR TREATMENT OF LEWY BODY DEMENTIA |
| WO2019217833A1 (en) * | 2018-05-10 | 2019-11-14 | Abvision, Inc. | Monoclonal antibodies activating cd40 and uses thereof |
| WO2020009482A1 (ko) * | 2018-07-03 | 2020-01-09 | 에이비엘바이오 주식회사 | 항 알파-시누클레인 항체 및 그 용도 |
| US20210324056A1 (en) | 2018-07-24 | 2021-10-21 | Eisai R&D Management Co., Ltd. | Methods of treatment and prevention of alzheimer's disease |
| CA3111907A1 (en) * | 2018-10-19 | 2020-04-23 | Janssen Vaccines & Prevention B.V. | Anti-synuclein antibodies |
| JP7196311B2 (ja) * | 2018-12-12 | 2022-12-26 | ウーシー バイオロジクス アイルランド リミテッド | 抗ｔｉｍ－３抗体とその利用 |
| RU2703430C1 (ru) * | 2018-12-13 | 2019-10-16 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) | Способ прогнозирования развития нейродегенеративных заболеваний, в основе патогенеза которых лежит гамма-синуклеинопатия |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
| EP3946266A4 (en) * | 2019-03-28 | 2023-07-12 | The Chinese University Of Hong Kong | SUMO PEPTIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| CN114341343B (zh) * | 2019-04-30 | 2024-11-15 | 才思治疗公司 | α-突触核蛋白测定 |
| US20220291240A1 (en) * | 2019-08-27 | 2022-09-15 | The Johns Hopkins University | Biomarkers for neurodegenerative disorders |
| IL294408A (en) | 2019-12-31 | 2022-08-01 | Chase Therapeutics Corp | Kinases as biomarkers for neurodegenerative conditions |
| CN111171152B (zh) * | 2020-01-15 | 2023-04-18 | 吉林医药学院 | Pcsk9抗体及其制备方法和应用 |
| NL2025332B1 (en) * | 2020-04-10 | 2021-10-26 | Syngle Therapeutics B V | Novel alpha-synuclein binding antibodies, or antigen binding portions thereof. |
| CR20220611A (es) | 2020-06-02 | 2023-06-07 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| MD4172199T2 (ro) * | 2020-06-26 | 2025-09-30 | Bioarctic Ab | Anticorpi care leagă protofibrila de alfa-sinucleină |
| US20230365665A1 (en) | 2020-09-17 | 2023-11-16 | Qatar Foundation For Education, Science And Community Development | ANTIBODY COMPOSITIONS TARGETING NON-PHOSPHORYLATED a-SYNUCLEIN AGGREGATES |
| US20250163135A1 (en) | 2021-07-09 | 2025-05-22 | Eisai R&D Management Co., Ltd. | Biomarkers for alzheimer's disease treatment |
| JP2024532438A (ja) | 2021-08-30 | 2024-09-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗Ａβプロトフィブリル抗体の皮下製剤及びその使用方法 |
| CA3243435A1 (en) | 2022-02-02 | 2023-08-10 | Eisai R&D Management Co., Ltd. | TREATMENT METHODS USING THE P-TAU181 LEVEL |
| JP2023132247A (ja) * | 2022-03-10 | 2023-09-22 | 公立大学法人大阪 | シヌクレイノパシー検出用バイオマーカー及びその利用 |
| CN117430686B (zh) * | 2022-07-22 | 2025-07-01 | 深圳市安群生物工程有限公司 | α-突触核蛋白抗原表位肽及测定唾液中SNCA试剂盒和在帕金森病诊断中的应用 |
| CN116589567B (zh) * | 2022-11-30 | 2024-03-19 | 西南大学 | 马铃薯x病毒单克隆抗体pvx-2及其应用 |
| WO2025245381A1 (en) | 2024-05-23 | 2025-11-27 | The Trustrees Of Dartmouth College | Methods and compositions for enhancing the persistence of car expressing tregs in the cns and other tissues |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000002053A2 (en) | 1998-07-03 | 2000-01-13 | Innogenetics N.V. | Differential diagnosis of neurodegeneration |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| AU2001268005A1 (en) | 2000-07-07 | 2002-01-21 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| US20060018918A1 (en) | 2000-12-27 | 2006-01-26 | Board Of Regents, The University Of Texas System | Production of stabilized conformational isomers of disease associated proteins |
| TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US20080014194A1 (en) | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| GEP20104991B (en) * | 2003-11-07 | 2010-05-25 | Immunex Corp | Antibodies that bind interleukin-4 receptor |
| US7674599B2 (en) | 2003-11-08 | 2010-03-09 | Elan Pharmaceuticals, Inc. | Methods of using antibodies to detect alpha-synuclein in fluid samples |
| WO2005108423A1 (en) | 2004-05-11 | 2005-11-17 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| EP1989330A4 (en) | 2006-01-31 | 2009-10-21 | Elan Pharm Inc | ALPHA-SYNUCLEINE KINASE |
| PL2004688T5 (pl) | 2006-03-23 | 2014-09-30 | Bioarctic Neuroscience Ab | Ulepszone przeciwciała wobec protofibryli oraz ich zastosowania |
| US8147833B2 (en) | 2007-02-23 | 2012-04-03 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| CN101161245B (zh) * | 2007-11-29 | 2011-11-09 | 首都医科大学宣武医院 | 二苯乙烯苷及其衍生物抑制突触核蛋白过度表达的用途 |
| JP5747414B2 (ja) | 2008-04-29 | 2015-07-15 | バイオアークティック ニューロサイエンス アーベー | α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン |
| PL2448968T3 (pl) | 2009-06-29 | 2021-09-13 | Bioarctic Ab | Antybiotyki selektywne względem n-końcowych skróconych protofibryli/oligomerów amyloidu beta |
| NO2539366T3 (enExample) | 2010-02-26 | 2018-04-07 |
-
2011
- 2011-02-25 NO NO11713058A patent/NO2539366T3/no unknown
- 2011-02-25 SI SI201131419T patent/SI2539366T1/en unknown
- 2011-02-25 ES ES11713058.3T patent/ES2661925T3/es active Active
- 2011-02-25 PT PT117130583T patent/PT2539366T/pt unknown
- 2011-02-25 CA CA2789963A patent/CA2789963C/en active Active
- 2011-02-25 CN CN201180011363.XA patent/CN102869680B/zh active Active
- 2011-02-25 RU RU2012140954/10A patent/RU2555526C2/ru active
- 2011-02-25 EP EP11713058.3A patent/EP2539366B1/en active Active
- 2011-02-25 PL PL11713058T patent/PL2539366T3/pl unknown
- 2011-02-25 SM SM20180044T patent/SMT201800044T1/it unknown
- 2011-02-25 LT LTEP11713058.3T patent/LT2539366T/lt unknown
- 2011-02-25 HR HRP20180230TT patent/HRP20180230T8/hr unknown
- 2011-02-25 HU HUE11713058A patent/HUE038313T2/hu unknown
- 2011-02-25 US US13/578,710 patent/US8632776B2/en active Active
- 2011-02-25 CN CN201910950804.0A patent/CN110655573B/zh active Active
- 2011-02-25 AU AU2011219414A patent/AU2011219414B2/en active Active
- 2011-02-25 RS RS20180129A patent/RS57029B1/sr unknown
- 2011-02-25 JP JP2012554464A patent/JP5894939B2/ja active Active
- 2011-02-25 DK DK11713058.3T patent/DK2539366T3/en active
- 2011-02-25 CN CN201610801424.7A patent/CN106397588B/zh active Active
- 2011-02-25 WO PCT/IB2011/050826 patent/WO2011104696A1/en not_active Ceased
-
2013
- 2013-08-01 US US13/957,239 patent/US8859501B2/en active Active
-
2014
- 2014-08-28 US US14/472,036 patent/US8968734B2/en active Active
-
2015
- 2015-02-02 US US14/611,690 patent/US9084832B2/en active Active
-
2018
- 2018-02-05 CY CY20181100140T patent/CY1120014T1/el unknown
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