JP2017515792A5 - - Google Patents
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- JP2017515792A5 JP2017515792A5 JP2016555508A JP2016555508A JP2017515792A5 JP 2017515792 A5 JP2017515792 A5 JP 2017515792A5 JP 2016555508 A JP2016555508 A JP 2016555508A JP 2016555508 A JP2016555508 A JP 2016555508A JP 2017515792 A5 JP2017515792 A5 JP 2017515792A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- antigen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1403875.6A GB201403875D0 (en) | 2014-03-05 | 2014-03-05 | Novel antibodies and uses thereof |
| GB1403875.6 | 2014-03-05 | ||
| PCT/GB2015/050647 WO2015132602A1 (en) | 2014-03-05 | 2015-03-05 | Anti human interleukin-1 receptor accessory protein (il1 rap) antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515792A JP2017515792A (ja) | 2017-06-15 |
| JP2017515792A5 true JP2017515792A5 (enExample) | 2018-04-12 |
| JP6396488B2 JP6396488B2 (ja) | 2018-09-26 |
Family
ID=50490826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555508A Active JP6396488B2 (ja) | 2014-03-05 | 2015-03-05 | 抗ヒトインターロイキン−１受容体アクセサリータンパク質（ｉｌ１ ｒａｐ）抗体およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9796783B2 (enExample) |
| EP (2) | EP3114145B1 (enExample) |
| JP (1) | JP6396488B2 (enExample) |
| KR (1) | KR102519196B1 (enExample) |
| CN (1) | CN106459195B (enExample) |
| AU (1) | AU2015225948B2 (enExample) |
| CA (1) | CA2941437C (enExample) |
| DK (2) | DK3114145T3 (enExample) |
| ES (2) | ES2646550T3 (enExample) |
| GB (1) | GB201403875D0 (enExample) |
| IL (1) | IL247459B (enExample) |
| LT (1) | LT3114145T (enExample) |
| MX (1) | MX360497B (enExample) |
| PL (1) | PL3114145T3 (enExample) |
| PT (1) | PT3114145T (enExample) |
| RU (1) | RU2710787C2 (enExample) |
| SG (1) | SG11201607322PA (enExample) |
| WO (1) | WO2015132602A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| RU2597831C2 (ru) | 2011-01-19 | 2016-09-20 | Кантаргия Аб | Анти-il1rap антитела и их применение при лечении людей |
| EP3653212B1 (en) | 2012-12-20 | 2023-04-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| MX381141B (es) | 2014-02-10 | 2025-03-12 | Merck Patent Gmbh | INHIBICIÓN DIRIGIDA DEL FACTOR DE CRECIMIENTO TRANSFORMADOR ß (TGF ß). |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| EP3218515B1 (en) | 2014-11-10 | 2023-04-26 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for il-33-mediated disorders |
| CA2960297A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| CA2990305A1 (en) | 2015-06-26 | 2016-12-29 | Mab Discovery Gmbh | Monoclonal anti-il-1racp antibodies |
| US10183060B2 (en) * | 2015-10-01 | 2019-01-22 | Heat Biologics, Inc. | Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins |
| US20180275121A1 (en) * | 2015-10-02 | 2018-09-27 | Tgr Biosciences Pty Ltd. | Analyte Detection with Multiple Substrates |
| MA43164A (fr) * | 2015-11-02 | 2018-09-12 | Janssen Pharmaceutica Nv | Anticorps anti-il1rap, molécules bispécifiques de liaison à un antigène liant il1rap et cd3 et leurs utilisations |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| US11359025B2 (en) | 2016-10-16 | 2022-06-14 | Cantargia Ab | Anti-IL1-RAP antibodies |
| FI3548515T3 (fi) | 2016-12-01 | 2026-03-04 | Regeneron Pharma | Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen |
| WO2018102795A2 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| AU2018219909B2 (en) | 2017-02-10 | 2025-02-27 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-LAG3 antibodies for immuno-PET imaging |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| WO2018169922A2 (en) * | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| EP3638320A4 (en) | 2017-05-05 | 2021-01-20 | Centre for Probe Development and Commercialization | IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF |
| US10093741B1 (en) * | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| WO2018204869A1 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| EP3401332A1 (en) * | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| JP7657440B2 (ja) * | 2017-06-12 | 2025-04-07 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗－ｉｌ１ｒａｐ抗体および抗体薬物コンジュゲート |
| IL316355A (en) | 2017-07-24 | 2024-12-01 | Regeneron Pharma | Anti-CD8 antibodies and their uses |
| JP2020533960A (ja) * | 2017-08-01 | 2020-11-26 | シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ | 抗ｉｌ１ｒａｐ抗体 |
| EP3489259A1 (en) * | 2017-11-23 | 2019-05-29 | Etablissement Français du Sang | Anti-il-1rap-car-t cells and their use |
| AU2019209428B2 (en) | 2018-01-22 | 2025-06-26 | Endocyte, Inc. | Methods of use for CAR T cells |
| CA3090089A1 (en) | 2018-02-06 | 2019-08-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| TW202000229A (zh) | 2018-02-23 | 2020-01-01 | 美商安德賽特公司 | Car t細胞療法之順序方法 |
| CN110759989B (zh) * | 2018-07-27 | 2021-08-17 | 中国人民解放军总医院 | IL-36γ作为动脉粥样硬化的标志物 |
| CN112638946A (zh) * | 2018-08-16 | 2021-04-09 | 坎塔吉亚有限责任公司 | 抗il1rap抗体组合物 |
| TW202021618A (zh) * | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| IT201800009282A1 (it) * | 2018-10-09 | 2020-04-09 | Metis Prec Medicine Sb Srl | Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| BR112021010799A2 (pt) * | 2018-12-03 | 2021-08-24 | Fusion Pharmaceuticals Inc. | Terapia combinada com radioimunoconjugados e inibidor do ponto de verificação |
| EP3898673A1 (en) | 2018-12-21 | 2021-10-27 | 23Andme, Inc. | Anti-il-36 antibodies and methods of use thereof |
| WO2020176478A1 (en) | 2019-02-25 | 2020-09-03 | The University Of Chicago | Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents |
| CN110564848A (zh) * | 2019-04-15 | 2019-12-13 | 上海市同仁医院 | 白介素-36在制备结直肠癌预后产品中的应用 |
| WO2020215051A1 (en) * | 2019-04-19 | 2020-10-22 | Rpi Consulting Llc | Treatments for pregnancy-related conditions |
| MA56397A (fr) * | 2019-06-26 | 2022-05-04 | Glaxosmithkline Ip Dev Ltd | Protéines de liaison à l'il1rap |
| EP4013794A4 (en) | 2019-08-12 | 2023-11-22 | City of Hope | ANTI-IL1RAP ANTIBODIES |
| EP4100428A4 (en) | 2020-02-04 | 2024-03-06 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | CHIMERIC ANTI-DINITROPHENOL ANTIGEN RECEPTORS |
| CA3174680A1 (en) | 2020-03-13 | 2021-09-16 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| CN115942975A (zh) * | 2020-04-10 | 2023-04-07 | 西雅图儿童医院（Dba西雅图儿童研究所） | 白细胞介素-1受体辅助蛋白的特异性结合域和嵌合抗原受体 |
| IL298075A (en) * | 2020-05-12 | 2023-01-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | St2 antigen binding protein |
| JP2023541627A (ja) * | 2020-09-14 | 2023-10-03 | イシュノス サイエンシズ ソシエテ アノニム | Ｉｌ１ｒａｐに結合する抗体及びその使用 |
| MX2023007611A (es) | 2020-12-23 | 2023-07-12 | Cantargia Ab | Anticuerpo anti-il1rap. |
| WO2022170008A2 (en) * | 2021-02-05 | 2022-08-11 | Boehringer Ingelheim International Gmbh | Anti-il1rap antibodies |
| US20220411517A1 (en) | 2021-05-21 | 2022-12-29 | Leo Pharma A/S | IL-1 Receptor Accessory Protein Inhibitors and Uses Thereof |
| AU2023303517A1 (en) * | 2022-07-06 | 2025-01-23 | Bluefin Biomedicine, Inc. | Methods of treating disease using anti-il1rap antibodies and antibody drug conjugates |
| CA3268115A1 (en) | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Humanized Anti-IL-1R3 Antibodies and Methods of Use |
| AU2024270136A1 (en) * | 2023-05-05 | 2025-11-20 | Otsuka Pharmaceutical Co., Ltd. | Anti-il1rap antibodies |
| WO2025126157A1 (en) * | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
| WO2025201513A1 (zh) * | 2024-03-29 | 2025-10-02 | 珠海丹序生物制药有限公司 | 抗il1rap抗体及其用途 |
| WO2026022232A1 (en) | 2024-07-24 | 2026-01-29 | Almirall, S.A. | Il-1rap inhibitor for treating or preventing hidradenitis suppurativa |
| CN118772268B (zh) * | 2024-09-10 | 2025-02-11 | 山东第二医科大学 | 猴痘病毒a29l单克隆抗体、试剂盒及应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| PE64396A1 (es) † | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US20030215453A1 (en) | 2002-05-14 | 2003-11-20 | Dedera Douglas A. | Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein |
| GB0131112D0 (en) | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| EP2003196A3 (en) | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| ES2426817T3 (es) | 2004-08-04 | 2013-10-25 | Mentrik Biotech, Llc | Regiones Fc variantes |
| JP2010507366A (ja) * | 2006-10-19 | 2010-03-11 | メルク アンド カンパニー インコーポレイテッド | インターロイキン−１３受容体α１の抗体アンタゴニスト |
| AU2008205512B2 (en) * | 2007-01-16 | 2014-06-12 | Abbvie Inc. | Methods for treating psoriasis |
| PL4160212T3 (pl) | 2008-01-15 | 2024-08-12 | The Board Of Trustees Of The Leland Stanford Junior University | Markery komórek macierzystych ostrej białaczki szpikowej |
| US20110044894A1 (en) | 2008-03-26 | 2011-02-24 | Cellerant Therapeutics, Inc. | Immunoglobulin and/or Toll-Like Receptor Proteins Associated with Myelogenous Haematological Proliferative Disorders and Uses Thereof |
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| RU2597831C2 (ru) * | 2011-01-19 | 2016-09-20 | Кантаргия Аб | Анти-il1rap антитела и их применение при лечении людей |
| AU2012273153A1 (en) * | 2011-06-21 | 2013-05-02 | Oncofactor Corporation | Compositions and methods for the therapy and diagnosis of cancer |
| CN103077969B (zh) | 2011-10-26 | 2016-03-30 | 中国科学院微电子研究所 | 一种mos器件及其制造方法 |
| US10126304B2 (en) | 2013-01-16 | 2018-11-13 | George Mason Research Foundation, Inc. | Binding domain mapping |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| GB201413913D0 (en) | 2014-08-06 | 2014-09-17 | Cantargia Ab | Novel antibodies and uses thereof |
| CA2990305A1 (en) | 2015-06-26 | 2016-12-29 | Mab Discovery Gmbh | Monoclonal anti-il-1racp antibodies |
| MA43164A (fr) | 2015-11-02 | 2018-09-12 | Janssen Pharmaceutica Nv | Anticorps anti-il1rap, molécules bispécifiques de liaison à un antigène liant il1rap et cd3 et leurs utilisations |
| US11359025B2 (en) | 2016-10-16 | 2022-06-14 | Cantargia Ab | Anti-IL1-RAP antibodies |
| WO2018071910A2 (en) | 2016-10-16 | 2018-04-19 | Cellerant Therapeutics, Inc. | Anti-il1-rap antibodies |
-
2014
- 2014-03-05 GB GBGB1403875.6A patent/GB201403875D0/en not_active Ceased
-
2015
- 2015-03-05 MX MX2016011414A patent/MX360497B/es active IP Right Grant
- 2015-03-05 JP JP2016555508A patent/JP6396488B2/ja active Active
- 2015-03-05 PL PL15714603T patent/PL3114145T3/pl unknown
- 2015-03-05 WO PCT/GB2015/050647 patent/WO2015132602A1/en not_active Ceased
- 2015-03-05 ES ES15714603.6T patent/ES2646550T3/es active Active
- 2015-03-05 AU AU2015225948A patent/AU2015225948B2/en active Active
- 2015-03-05 ES ES17185792T patent/ES2861582T5/es active Active
- 2015-03-05 EP EP15714603.6A patent/EP3114145B1/en active Active
- 2015-03-05 DK DK15714603.6T patent/DK3114145T3/da active
- 2015-03-05 RU RU2016139068A patent/RU2710787C2/ru active
- 2015-03-05 EP EP17185792.3A patent/EP3293202B2/en active Active
- 2015-03-05 SG SG11201607322PA patent/SG11201607322PA/en unknown
- 2015-03-05 CA CA2941437A patent/CA2941437C/en active Active
- 2015-03-05 CN CN201580019206.1A patent/CN106459195B/zh active Active
- 2015-03-05 PT PT157146036T patent/PT3114145T/pt unknown
- 2015-03-05 DK DK17185792.3T patent/DK3293202T3/da active
- 2015-03-05 LT LTEP15714603.6T patent/LT3114145T/lt unknown
- 2015-03-05 KR KR1020167027523A patent/KR102519196B1/ko active Active
-
2016
- 2016-08-24 IL IL24745916A patent/IL247459B/en active IP Right Grant
- 2016-09-02 US US15/255,585 patent/US9796783B2/en active Active
-
2017
- 2017-09-18 US US15/707,593 patent/US10287357B2/en active Active
-
2019
- 2019-03-19 US US16/358,459 patent/US10752692B2/en active Active
-
2020
- 2020-07-16 US US16/930,631 patent/US11236172B2/en active Active
-
2021
- 2021-12-15 US US17/551,908 patent/US12398213B2/en active Active
-
2025
- 2025-07-14 US US19/267,857 patent/US20250340657A1/en active Pending
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