JP2017530692A5 - - Google Patents
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- JP2017530692A5 JP2017530692A5 JP2017506267A JP2017506267A JP2017530692A5 JP 2017530692 A5 JP2017530692 A5 JP 2017530692A5 JP 2017506267 A JP2017506267 A JP 2017506267A JP 2017506267 A JP2017506267 A JP 2017506267A JP 2017530692 A5 JP2017530692 A5 JP 2017530692A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- cancer
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 68
- 239000000427 antigen Substances 0.000 claims 65
- 102000036639 antigens Human genes 0.000 claims 65
- 108091007433 antigens Proteins 0.000 claims 65
- 210000004027 cell Anatomy 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 102000044594 Interleukin-1 Receptor Accessory Human genes 0.000 claims 11
- 101710180389 Interleukin-1 receptor accessory protein Proteins 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 230000001613 neoplastic effect Effects 0.000 claims 10
- 230000011664 signaling Effects 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 108010002352 Interleukin-1 Proteins 0.000 claims 6
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- 239000000523 sample Substances 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 5
- 101000960952 Homo sapiens Interleukin-1 receptor accessory protein Proteins 0.000 claims 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 4
- 102000046828 human IL1RAP Human genes 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 3
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- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
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- 235000009508 confectionery Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
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- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
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- GTUJJVSZIHQLHA-XPWFQUROSA-N pApA Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@@H]1O)O[C@H](COP(O)(O)=O)[C@H]1OP(O)(=O)OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N1C(N=CN=C2N)=C2N=C1 GTUJJVSZIHQLHA-XPWFQUROSA-N 0.000 claims 1
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- 208000004593 pneumococcal meningitis Diseases 0.000 claims 1
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- 102000040430 polynucleotide Human genes 0.000 claims 1
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- 206010046766 uterine cancer Diseases 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1413913.3A GB201413913D0 (en) | 2014-08-06 | 2014-08-06 | Novel antibodies and uses thereof |
| GB1413913.3 | 2014-08-06 | ||
| PCT/EP2015/068208 WO2016020502A1 (en) | 2014-08-06 | 2015-08-06 | Novel antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530692A JP2017530692A (ja) | 2017-10-19 |
| JP2017530692A5 true JP2017530692A5 (enExample) | 2018-08-30 |
| JP6827411B2 JP6827411B2 (ja) | 2021-02-10 |
Family
ID=51587804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506267A Active JP6827411B2 (ja) | 2014-08-06 | 2015-08-06 | 新規の抗体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10100119B2 (enExample) |
| EP (1) | EP3193926B1 (enExample) |
| JP (1) | JP6827411B2 (enExample) |
| KR (1) | KR20170039685A (enExample) |
| CN (1) | CN107074946B (enExample) |
| AU (1) | AU2015298852A1 (enExample) |
| BR (1) | BR112017002342A2 (enExample) |
| CA (1) | CA2955056A1 (enExample) |
| GB (1) | GB201413913D0 (enExample) |
| MX (1) | MX2017001599A (enExample) |
| WO (1) | WO2016020502A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| EP2665749B1 (en) | 2011-01-19 | 2016-01-13 | Cantargia AB | Anti-il1rap antibodies and their use for treating solid tumours |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| SG11201703767XA (en) | 2014-11-10 | 2017-06-29 | Genentech Inc | Anti-interleukin-33 antibodies and uses thereof |
| CN107109494B (zh) | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
| JP7114460B2 (ja) | 2015-06-26 | 2022-08-08 | サノフィ・バイオテクノロジー | モノクローナル抗ＩＬ－１ＲＡｃＰ抗体 |
| CN107303299A (zh) * | 2016-04-19 | 2017-10-31 | 南京中硼联康医疗科技有限公司 | 含10B的化合物在制备和β淀粉样蛋白特异性结合药物中的应用 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| JP7032394B2 (ja) * | 2016-10-16 | 2022-03-30 | カンタージア アクチエボラーグ | 抗ｉｌ１－ｒａｐ抗体 |
| BR112019011186A2 (pt) | 2016-12-01 | 2019-10-08 | Regeneron Pharmaceuticals, Inc. | conjugado de anticorpo radiomarcado, composto, e, métodos de imageamento e para tratamento de um tumor. |
| JP7167041B2 (ja) | 2017-02-10 | 2022-11-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫ｐｅｔイメージングのための放射標識抗ｌａｇ３抗体 |
| EP3401332A1 (en) * | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| CN118994394A (zh) * | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| CN110997013B (zh) | 2017-07-24 | 2022-09-20 | 瑞泽恩制药公司 | 抗cd8抗体和其用途 |
| AU2018312563A1 (en) * | 2017-08-01 | 2020-03-12 | City Of Hope | Anti-IL1RAP antibodies |
| EP3489259A1 (en) * | 2017-11-23 | 2019-05-29 | Etablissement Français du Sang | Anti-il-1rap-car-t cells and their use |
| US12091455B2 (en) * | 2018-02-14 | 2024-09-17 | Yale University | Compositions for modulation of a TREM or TREML protein and methods of use |
| WO2020035577A1 (en) | 2018-08-16 | 2020-02-20 | Cantargia Ab | Anti-il1rap antibody compositions |
| TW202021618A (zh) | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| WO2020176478A1 (en) | 2019-02-25 | 2020-09-03 | The University Of Chicago | Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents |
| WO2021148884A1 (en) * | 2020-01-24 | 2021-07-29 | Tychan Pte. Ltd. | Anti-wuhan coronavirus antibodies |
| TW202144410A (zh) | 2020-03-13 | 2021-12-01 | 美商建南德克公司 | 抗介白素－３３抗體及其用途 |
| US20230303705A1 (en) * | 2020-04-10 | 2023-09-28 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Binders and chimeric antigen receptors specific for interleukin-1 receptor accessory protein |
| MX2023002901A (es) | 2020-09-14 | 2023-06-01 | Ichnos Sciences SA | Anticuerpos que se unen a la proteína auxiliar del receptor de interleucina-1 (il1rap) y usos de estos. |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| US20220411517A1 (en) | 2021-05-21 | 2022-12-29 | Leo Pharma A/S | IL-1 Receptor Accessory Protein Inhibitors and Uses Thereof |
| CA3262768A1 (en) | 2022-07-25 | 2024-02-01 | Interius Biotherapeutics Inc | Mutated polypeptides, compositions containing them, and their uses |
| KR20250060305A (ko) | 2022-09-21 | 2025-05-07 | 사노피 바이오테크놀로지 | 인간화 항-il-1r3 항체 및 사용 방법 |
| EP4662243A2 (en) * | 2023-02-09 | 2025-12-17 | City of Hope | Anti-il1rap antibodies and variants thereof |
| WO2024206214A1 (en) * | 2023-03-24 | 2024-10-03 | Paragon Therapeutics, Inc. | Fc fragments that bind fcrn and methods of use |
| WO2025126157A1 (en) * | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
| WO2025201513A1 (zh) * | 2024-03-29 | 2025-10-02 | 珠海丹序生物制药有限公司 | 抗il1rap抗体及其用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US20030215453A1 (en) | 2002-05-14 | 2003-11-20 | Dedera Douglas A. | Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| EP1776384B1 (en) | 2004-08-04 | 2013-06-05 | Mentrik Biotech, LLC | Variant fc regions |
| ES2988620T3 (es) | 2008-01-15 | 2024-11-21 | The Board Of Trustees Of The Leland Stanfordjunior Univ | Marcadores de las células madre de la leucemia mieloide aguda |
| EP2271673B1 (en) | 2008-03-26 | 2016-02-24 | Cellerant Therapeutics, Inc. | Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof |
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| EP2665749B1 (en) | 2011-01-19 | 2016-01-13 | Cantargia AB | Anti-il1rap antibodies and their use for treating solid tumours |
| CN103077969B (zh) | 2011-10-26 | 2016-03-30 | 中国科学院微电子研究所 | 一种mos器件及其制造方法 |
| JP7114460B2 (ja) | 2015-06-26 | 2022-08-08 | サノフィ・バイオテクノロジー | モノクローナル抗ＩＬ－１ＲＡｃＰ抗体 |
| CN108431042A (zh) | 2015-11-02 | 2018-08-21 | 詹森药业有限公司 | 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途 |
-
2014
- 2014-08-06 GB GBGB1413913.3A patent/GB201413913D0/en not_active Ceased
-
2015
- 2015-08-06 JP JP2017506267A patent/JP6827411B2/ja active Active
- 2015-08-06 WO PCT/EP2015/068208 patent/WO2016020502A1/en not_active Ceased
- 2015-08-06 CA CA2955056A patent/CA2955056A1/en not_active Abandoned
- 2015-08-06 BR BR112017002342A patent/BR112017002342A2/pt not_active Application Discontinuation
- 2015-08-06 US US15/501,710 patent/US10100119B2/en active Active
- 2015-08-06 EP EP15747487.5A patent/EP3193926B1/en active Active
- 2015-08-06 MX MX2017001599A patent/MX2017001599A/es unknown
- 2015-08-06 AU AU2015298852A patent/AU2015298852A1/en not_active Abandoned
- 2015-08-06 KR KR1020177004417A patent/KR20170039685A/ko not_active Withdrawn
- 2015-08-06 CN CN201580042011.9A patent/CN107074946B/zh active Active
-
2018
- 2018-08-22 US US16/109,017 patent/US10562971B2/en active Active