JP2014507138A5 - - Google Patents
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- JP2014507138A5 JP2014507138A5 JP2013552193A JP2013552193A JP2014507138A5 JP 2014507138 A5 JP2014507138 A5 JP 2014507138A5 JP 2013552193 A JP2013552193 A JP 2013552193A JP 2013552193 A JP2013552193 A JP 2013552193A JP 2014507138 A5 JP2014507138 A5 JP 2014507138A5
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| DK3092256T3 (da) | 2014-01-10 | 2022-06-20 | Birdie Biopharmaceuticals Inc | Forbindelser og sammensætninger til immunterapi |
| CN112851769A (zh) | 2014-01-27 | 2021-05-28 | 分子模板公司 | 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| CN106604934A (zh) | 2014-06-11 | 2017-04-26 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| EP3708227A1 (en) * | 2014-07-22 | 2020-09-16 | Sutro Biopharma, Inc. | Anti-cd74 antibodies, compositions comprising anti-cd74 antibodies and methods of using anti-cd74 antibodies |
| JP6826527B2 (ja) * | 2014-09-18 | 2021-02-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | カテプシンｓ阻害をモニタリングするための方法 |
| CN104280553B (zh) * | 2014-09-22 | 2016-06-08 | 中国人民解放军第二军医大学 | 一种小鼠源性可溶型cd74蛋白的elisa检测试剂盒及检测方法 |
| GB201416960D0 (en) | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| CN105543279A (zh) * | 2014-10-30 | 2016-05-04 | 常州卡斯比生物科技有限公司 | 一种防治辐射线损伤、肿瘤治疗的IL-12/Fc融合蛋白的制备方法及其药剂 |
| AU2015349878A1 (en) * | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| EP3253799B1 (en) | 2015-02-05 | 2020-12-02 | Molecular Templates, Inc. | Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| EP3865139B1 (en) | 2015-02-18 | 2023-05-03 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| GB201515321D0 (en) * | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| GB201517538D0 (en) * | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| US11510993B2 (en) | 2015-10-06 | 2022-11-29 | Merck Sharp & Dohme Llc | Antibody drug conjugate for anti-inflammatory applications |
| US10779991B2 (en) | 2015-12-23 | 2020-09-22 | The Regents of the University of Colorado, a body corporated | Ophthalmic knife and methods of use |
| CN113101047B (zh) | 2015-12-23 | 2023-08-04 | 科罗拉多大学董事会法人团体 | 眼科刀和使用方法 |
| CN106943597A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN109069627A (zh) | 2016-01-14 | 2018-12-21 | 纪念斯隆-凯特琳癌症中心 | 对foxp3衍生肽特异性的t细胞受体样抗体 |
| WO2017132615A1 (en) * | 2016-01-27 | 2017-08-03 | Sutro Biopharma, Inc. | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| US10869929B2 (en) | 2016-01-29 | 2020-12-22 | Merck Sharp & Dohme Corp. | Phosphonate linkers and their use to facilitate cellular retention of compounds |
| CN108602879A (zh) * | 2016-02-04 | 2018-09-28 | 倪劲松 | 用于治疗疾病的抗体-药物协同作用技术 |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| US9709386B1 (en) * | 2016-04-05 | 2017-07-18 | Kla-Tencor Corporation | Apparatus and methods for measuring properties in a TSV structure using beam profile reflectometry |
| GEP20227398B (en) | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
| JP7075125B2 (ja) * | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
| JP2019517565A (ja) * | 2016-06-06 | 2019-06-24 | リンクシス ベー．フェー． | 細胞標的化結合体 |
| CA3029627A1 (en) | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| WO2018106895A1 (en) | 2016-12-07 | 2018-06-14 | Molecular Templates, Inc. | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
| MX2019008840A (es) | 2017-01-25 | 2019-09-09 | Molecular Templates Inc | Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+. |
| KR102573821B1 (ko) | 2017-02-16 | 2023-08-31 | 마이크로서지컬 테크놀로지, 인코퍼레이티드 | 최소 침습 녹내장 수술을 위한 장치，시스템 및 방법 |
| CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| CA3067268A1 (en) | 2017-06-23 | 2018-12-27 | Birdie Biopharmaceuticals, Inc. | Crystalline resiquimod monosulfate anhydrate and its preparation and uses |
| WO2019023316A1 (en) | 2017-07-26 | 2019-01-31 | Sutro Biopharma, Inc. | METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN THE TREATMENT OF A T CELL LYMPHOMA |
| CA3073537A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| PL3691692T3 (pl) * | 2017-10-14 | 2021-07-19 | Abbvie Inc. | Koniugaty lek-aktywowalne przeciwciało anty-cd71 i sposoby ich wykorzystania |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| CN116368154A (zh) | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| CA3216098A1 (en) | 2021-07-30 | 2023-02-02 | Uwe Reusch | Duplexbodies |
| US20260070986A1 (en) | 2021-11-03 | 2026-03-12 | Affimed Gmbh | Bispecific cd16a binders |
| WO2023177761A2 (en) | 2022-03-16 | 2023-09-21 | Sight Sciences, Inc. | Devices and methods for intraocular tissue manipulation |
| US20250339570A1 (en) * | 2022-05-20 | 2025-11-06 | The Regents Of The University Of California | Radioimmunoconjugates and therapeutic uses thereof |
| KR20250057869A (ko) * | 2022-09-07 | 2025-04-29 | 잭세라 바이오파마슈티컬 (수조우) 씨오., 엘티디. | 항-trop2/egfr 항체 및 이의 용도 |
| EP4638504A1 (en) * | 2022-12-19 | 2025-10-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-pdl1 antibodies and uses thereof |
| CN116139267A (zh) * | 2023-01-28 | 2023-05-23 | 华中科技大学同济医学院附属同济医院 | 小鼠cd74单克隆抗体在制备治疗肿瘤药物中的应用 |
| CN116549499B (zh) * | 2023-06-07 | 2025-01-07 | 广东省九转生物医药有限公司 | 商陆果发酵液提取物有效部位在制备抗肿瘤药物中的用途 |
| AU2024302737A1 (en) * | 2023-06-16 | 2026-01-08 | Ohio State Innovation Foundation | Cd74 car-t therapy and methods of use thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN117866909B (zh) * | 2024-01-29 | 2024-09-03 | 华中科技大学同济医学院附属同济医院 | 一种杂交瘤细胞株及其在生产cd74单克隆抗体上的应用 |
| FR3163370A1 (fr) | 2024-06-18 | 2025-12-19 | Hospices Civils De Lyon | Compose inhibiteur de la proteine cd74 et ses utilisations |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312318B2 (en) | 2002-03-01 | 2007-12-25 | Immunomedics, Inc. | Internalizing anti-CD74 antibodies and methods of use |
| US8877901B2 (en) * | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| CA2508831C (en) * | 2002-12-13 | 2012-05-01 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| PT1737891E (pt) * | 2004-04-13 | 2013-04-16 | Hoffmann La Roche | Anticorpos anti p-selectina |
| EP2032606B1 (en) | 2006-05-30 | 2013-11-27 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| EP2523680A4 (en) * | 2010-01-11 | 2013-06-19 | Ct Molecular Med & Immunology | REINFORCED CYTOTOXICITY OF ANTIBODIES TO CD74 AND HLA-DR WITH INTERFERON GAMMA |
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- 2012-02-01 JP JP2013552193A patent/JP6261341B2/ja active Active
- 2012-02-01 RU RU2013140433A patent/RU2636029C2/ru active
- 2012-02-01 CN CN201280015984.XA patent/CN103458930B/zh active Active
- 2012-02-01 US US13/982,959 patent/US9540433B2/en active Active
- 2012-02-01 MX MX2013008832A patent/MX350200B/es active IP Right Grant
- 2012-02-01 AU AU2012213437A patent/AU2012213437B2/en active Active
- 2012-02-01 SG SG10201608138RA patent/SG10201608138RA/en unknown
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