JP2011528561A5 - - Google Patents
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- JP2011528561A5 JP2011528561A5 JP2011519110A JP2011519110A JP2011528561A5 JP 2011528561 A5 JP2011528561 A5 JP 2011528561A5 JP 2011519110 A JP2011519110 A JP 2011519110A JP 2011519110 A JP2011519110 A JP 2011519110A JP 2011528561 A5 JP2011528561 A5 JP 2011528561A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- antibody according
- disease
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 12
- 125000003729 nucleotide group Chemical group 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 206010002022 amyloidosis Diseases 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 4
- 208000015756 familial Alzheimer disease Diseases 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 3
- 208000023697 ABri amyloidosis Diseases 0.000 claims 2
- 208000017227 ADan amyloidosis Diseases 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 201000000162 ITM2B-related cerebral amyloid angiopathy 1 Diseases 0.000 claims 2
- 201000000194 ITM2B-related cerebral amyloid angiopathy 2 Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 claims 1
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8230908P | 2008-07-21 | 2008-07-21 | |
| US61/082,309 | 2008-07-21 | ||
| PCT/EP2009/058803 WO2010009987A2 (en) | 2008-07-21 | 2009-07-10 | Diagnostic antibody assay |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175359A Division JP6307483B2 (ja) | 2008-07-21 | 2015-09-07 | 診断用抗体アッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528561A JP2011528561A (ja) | 2011-11-24 |
| JP2011528561A5 true JP2011528561A5 (enExample) | 2015-11-05 |
| JP5828762B2 JP5828762B2 (ja) | 2015-12-09 |
Family
ID=41059893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519110A Active JP5828762B2 (ja) | 2008-07-21 | 2009-07-10 | 診断用抗体アッセイ |
| JP2015175359A Active JP6307483B2 (ja) | 2008-07-21 | 2015-09-07 | 診断用抗体アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175359A Active JP6307483B2 (ja) | 2008-07-21 | 2015-09-07 | 診断用抗体アッセイ |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8058405B2 (enExample) |
| EP (4) | EP2320942B1 (enExample) |
| JP (2) | JP5828762B2 (enExample) |
| KR (1) | KR101706789B1 (enExample) |
| CN (2) | CN102131519B (enExample) |
| AU (1) | AU2009273387B9 (enExample) |
| BR (1) | BRPI0916366B1 (enExample) |
| CA (1) | CA2731044C (enExample) |
| EA (1) | EA028427B1 (enExample) |
| HK (1) | HK1222397A1 (enExample) |
| IL (1) | IL210225A (enExample) |
| MX (1) | MX2011000875A (enExample) |
| NZ (1) | NZ590563A (enExample) |
| WO (1) | WO2010009987A2 (enExample) |
| ZA (1) | ZA201100178B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2576617B1 (en) | 2010-06-04 | 2016-04-27 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | MONOCLONAL ANTIBODIES TARGETING Aß OLIGOMERS |
| WO2012021475A2 (en) * | 2010-08-12 | 2012-02-16 | Eli Lilly And Company | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| MY163521A (en) | 2010-08-12 | 2017-09-15 | Lilly Co Eli | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| MX343873B (es) | 2011-03-16 | 2016-11-25 | Probiodrug Ag | Ensayo de diagnostico de anticuerpo. |
| WO2012136552A1 (en) | 2011-04-08 | 2012-10-11 | H. Lundbeck A/S | ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ |
| CA2882449C (en) | 2012-08-21 | 2018-09-04 | Ronghui Lin | Haptens of aripiprazole and their use in immunoassays |
| CA2882596C (en) | 2012-08-21 | 2019-05-14 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine and use thereof |
| PL3385284T3 (pl) * | 2012-08-21 | 2020-09-21 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
| WO2014031603A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to paliperidone haptens and use thereof |
| EP2887952B1 (en) | 2012-08-21 | 2019-05-15 | Janssen Pharmaceutica NV | Antibodies to olanzapine haptens and use thereof |
| CN108640996A (zh) | 2012-08-21 | 2018-10-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
| CA2882492C (en) | 2012-08-21 | 2019-05-28 | Ortho-Clinical Diagnostics, Inc. | Antibodies to aripiprazole haptens and use thereof |
| CA2882563C (en) | 2012-08-21 | 2022-11-29 | Eric Hryhorenko | Antibodies to risperidone haptens and use thereof |
| CN104737017B (zh) | 2012-08-21 | 2017-03-08 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| PT3333195T (pt) | 2012-08-21 | 2020-10-12 | Janssen Pharmaceutica Nv | Anticorpos contra a quetiapina e sua utilização |
| WO2014031640A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to aripiprazole and use thereof |
| US9714953B2 (en) | 2014-04-04 | 2017-07-25 | Autotelic Llc | Methods, devices, and reagents for monitoring paclitaxel concentration in plasma for pharmacokinetic-guided dosing of paclitaxel |
| CA2944775A1 (en) * | 2014-04-04 | 2015-10-08 | Autotelic Llc | Methods, devices, and reagents for monitoring paclitaxel concentration in plasma for pharmacokinetic-guided dosing of paclitaxel |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| EP3234611A1 (en) | 2014-12-19 | 2017-10-25 | Probiodrug AG | Novel method for the detection of pglu-abeta peptides |
| WO2017011728A1 (en) * | 2015-07-15 | 2017-01-19 | Washington University | ANTIBODIES TO TUMOR ASSOCIATED COMPLEX N-GLYCANS WITH TERMINAL GlcNAcBeta RESIDUES AND METHODS OF USE THEREOF |
| CN108699139B (zh) * | 2015-07-16 | 2022-06-24 | 维沃永治疗公众有限公司 | 人源化抗体 |
| EP3390449A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica N.V. | Antibodies to risperidone and use thereof |
| CA3008812A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| JOP20170004B1 (ar) | 2016-01-15 | 2022-09-15 | Lilly Co Eli | الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته |
| TWI735600B (zh) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗－N3pGlu類澱粉β肽抗體及其用途 |
| TW201827467A (zh) * | 2016-11-03 | 2018-08-01 | 比利時商健生藥品公司 | 焦穀胺酸類澱粉蛋白－β之抗體及其用途 |
| JOP20190247A1 (ar) | 2017-04-20 | 2019-10-20 | Lilly Co Eli | أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| EP3946603A1 (en) | 2019-03-26 | 2022-02-09 | Janssen Pharmaceutica NV | Antibodies to pyroglutamate amyloid-ss and uses thereof |
| US20230151069A1 (en) | 2020-03-10 | 2023-05-18 | Lifearc | Cyclic Peptides |
| WO2022020652A2 (en) * | 2020-07-22 | 2022-01-27 | Fog Pharmaceuticals, Inc. | Stapled peptides and methods thereof |
| TWI843040B (zh) | 2021-01-11 | 2024-05-21 | 美商美國禮來大藥廠 | 抗N3pGlu類澱粉β抗體及其用途 |
| TW202300518A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗N3pGlu類澱粉β抗體及其用途 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| EP4422751A1 (en) | 2021-10-29 | 2024-09-04 | Eli Lilly and Company | Compounds and methods targeting interleukin-34 |
| JP7622019B2 (ja) | 2021-10-29 | 2025-01-27 | イーライ リリー アンド カンパニー | インターロイキン－３４を標的とする化合物及び方法 |
| KR20240099348A (ko) | 2021-10-29 | 2024-06-28 | 일라이 릴리 앤드 캄파니 | 인터류킨-34를 표적화하는 화합물 및 방법 |
| MX2024005145A (es) | 2021-10-29 | 2024-05-13 | Lilly Co Eli | Compuestos y metodos dirigidos a la interleucina-34. |
| KR20250134612A (ko) | 2022-12-22 | 2025-09-11 | 바이오악틱 에이비 | Abetape3에 결합하는 항체 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| CA2452104A1 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass |
| WO2003015691A2 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | RAPID IMPROVEMENT OF COGNITION IN CONDITIONS RELATED TO A$g(b) |
| WO2003068924A2 (en) * | 2002-02-13 | 2003-08-21 | Ludwig Institute For Cancer Research | Fusion proteins of humanized g250 specific antibodies and uses thereof |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| US7122374B1 (en) * | 2002-04-09 | 2006-10-17 | Takaomi Saido | Amyloid beta-protein 3(pE)-42 antibodies and uses thereof |
| CA2487528A1 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation |
| WO2004032868A2 (en) | 2002-10-09 | 2004-04-22 | Rinat Neuroscience Corp. | Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| KR20100106630A (ko) * | 2003-05-05 | 2010-10-01 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| JP4806628B2 (ja) * | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
| EP1480041A1 (en) * | 2003-05-22 | 2004-11-24 | Innogenetics N.V. | Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease |
| JP4996926B2 (ja) | 2004-02-05 | 2012-08-08 | プロビオドルグ エージー | グルタミニルシクラーゼの新規の阻害剤 |
| RU2015111675A (ru) | 2005-12-12 | 2015-08-10 | Ац Иммуне Са | Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами |
| DK2074145T5 (en) | 2006-10-02 | 2017-10-16 | Ac Immune Sa | HUMANIZED ANTIBODY AGAINST AMYLOID BETA |
| EP2091945B1 (en) | 2006-11-09 | 2014-01-15 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| WO2008055950A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| EP2091948B1 (en) * | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| US7803810B2 (en) | 2007-03-09 | 2010-09-28 | Probiodrug Ag | Inhibitors |
| JP5675343B2 (ja) | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としての尿素誘導体 |
| ES2478673T3 (es) | 2007-04-18 | 2014-07-22 | Probiodrug Ag | Derivados de tioxoquinazolinona como inhibidores de la glutaminil ciclasa |
| ES2474693T3 (es) | 2007-04-18 | 2014-07-09 | Probiodrug Ag | Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa |
| DK2142513T3 (da) | 2007-04-18 | 2014-06-10 | Probiodrug Ag | Nitrovinyl-diamin-derivater som glutaminyl-cyclase-inhibitorer |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| US8188094B2 (en) | 2007-04-20 | 2012-05-29 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| NZ583799A (en) | 2007-09-12 | 2011-12-22 | Probiodrug Ag | Transgenic mice comprising a DNA transgene encoding ABeta peptide |
| KR101606168B1 (ko) * | 2008-04-29 | 2016-03-24 | 샌디스크 아이엘 엘티디 | 프로그램, 검증 및, 읽기를 위한 참조 전압 레벨들의 적응적인 세팅을 갖는 비휘발성 멀티레벨 메모리 |
-
2009
- 2009-07-10 US US12/500,940 patent/US8058405B2/en active Active
- 2009-07-10 EA EA201100231A patent/EA028427B1/ru not_active IP Right Cessation
- 2009-07-10 JP JP2011519110A patent/JP5828762B2/ja active Active
- 2009-07-10 AU AU2009273387A patent/AU2009273387B9/en active Active
- 2009-07-10 KR KR1020117003879A patent/KR101706789B1/ko active Active
- 2009-07-10 CN CN200980132674.4A patent/CN102131519B/zh active Active
- 2009-07-10 WO PCT/EP2009/058803 patent/WO2010009987A2/en not_active Ceased
- 2009-07-10 EP EP09780421.5A patent/EP2320942B1/en active Active
- 2009-07-10 CN CN201510940307.4A patent/CN105481980A/zh active Pending
- 2009-07-10 EP EP18154636.7A patent/EP3338795A1/en not_active Withdrawn
- 2009-07-10 EP EP16157883.6A patent/EP3047854B1/en active Active
- 2009-07-10 CA CA2731044A patent/CA2731044C/en active Active
- 2009-07-10 NZ NZ590563A patent/NZ590563A/en unknown
- 2009-07-10 EP EP18154638.3A patent/EP3338796A1/en not_active Withdrawn
- 2009-07-10 MX MX2011000875A patent/MX2011000875A/es active IP Right Grant
- 2009-07-10 BR BRPI0916366-2A patent/BRPI0916366B1/pt active IP Right Grant
-
2010
- 2010-12-23 IL IL210225A patent/IL210225A/en active IP Right Grant
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2011
- 2011-01-06 ZA ZA2011/00178A patent/ZA201100178B/en unknown
- 2011-10-04 US US13/252,929 patent/US9156907B2/en active Active
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2015
- 2015-09-03 US US14/844,726 patent/US9676843B2/en active Active
- 2015-09-07 JP JP2015175359A patent/JP6307483B2/ja active Active
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2016
- 2016-09-02 HK HK16110512.0A patent/HK1222397A1/zh unknown