JP2009518005A5 - - Google Patents
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- JP2009518005A5 JP2009518005A5 JP2008542473A JP2008542473A JP2009518005A5 JP 2009518005 A5 JP2009518005 A5 JP 2009518005A5 JP 2008542473 A JP2008542473 A JP 2008542473A JP 2008542473 A JP2008542473 A JP 2008542473A JP 2009518005 A5 JP2009518005 A5 JP 2009518005A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hybridoma cell
- produced
- cell line
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 10
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 10
- 210000004408 hybridoma Anatomy 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 238000012286 ELISA Assay Methods 0.000 claims 2
- 102000004473 OX40 Ligand Human genes 0.000 claims 2
- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73965905P | 2005-11-25 | 2005-11-25 | |
| US60/739,659 | 2005-11-25 | ||
| PCT/US2006/045522 WO2007062245A2 (en) | 2005-11-25 | 2006-11-27 | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161779A Division JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009518005A JP2009518005A (ja) | 2009-05-07 |
| JP2009518005A5 true JP2009518005A5 (enExample) | 2010-01-14 |
| JP5476517B2 JP5476517B2 (ja) | 2014-04-23 |
Family
ID=38067974
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542473A Active JP5476517B2 (ja) | 2005-11-25 | 2006-11-27 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
| JP2013161779A Active JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161779A Active JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8283450B2 (enExample) |
| EP (4) | EP3098238B1 (enExample) |
| JP (2) | JP5476517B2 (enExample) |
| KR (1) | KR101340699B1 (enExample) |
| CN (1) | CN101331150B (enExample) |
| AU (1) | AU2006318329B2 (enExample) |
| CA (1) | CA2631015C (enExample) |
| DK (1) | DK3345927T5 (enExample) |
| ES (3) | ES2938625T3 (enExample) |
| FI (1) | FI3345927T3 (enExample) |
| HU (3) | HUE037642T2 (enExample) |
| LT (1) | LT3345927T (enExample) |
| PL (3) | PL3098238T3 (enExample) |
| PT (3) | PT3098238T (enExample) |
| SI (1) | SI3345927T1 (enExample) |
| TW (1) | TWI461436B (enExample) |
| WO (1) | WO2007062245A2 (enExample) |
Families Citing this family (93)
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| TWI461436B (zh) * | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| US20100136030A1 (en) * | 2007-02-27 | 2010-06-03 | Lamhamedi-Cherradi Salah-Eddine | Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases |
| US20090022720A1 (en) * | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
| KR101577843B1 (ko) | 2007-12-14 | 2015-12-16 | 브리스톨-마이어스 스큅 컴퍼니 | 인간 ｏｘ４０ 수용체에 대한 결합 분자 |
| AU2014202213B2 (en) * | 2007-12-14 | 2016-05-12 | Bristol-Myers Squibb Company | Binding Molecules to the Human OX40 Receptor |
| AU2016203429B2 (en) * | 2007-12-14 | 2018-01-25 | Bristol-Myers Squibb Company | Binding Molecules to the Human OX40 Receptor |
| BRPI1008692B8 (pt) | 2009-02-17 | 2021-05-25 | Ucb Biopharma Sprl | anticorpo antagonista tendo especificidade para ox40 humano, sequência de dna isolado, vetor de clonagem ou de expressão, célula hospedeira, processo para a produção do referido anticorpo, composição farmacêutica, uso do 5 referido anticorpo e proteína de fusão |
| WO2012027328A2 (en) | 2010-08-23 | 2012-03-01 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| CA2824279A1 (en) * | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
| US20130209449A9 (en) | 2011-06-13 | 2013-08-15 | Abgenomics Cooperatief U.A. | Anti-psgl-1 antibodies and uses thereof |
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| KR101685262B1 (ko) * | 2011-08-23 | 2016-12-21 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 항-ｏｘ４０ 항체 및 이의 사용 방법 |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| US9518112B2 (en) | 2012-03-08 | 2016-12-13 | Ludwig Institute For Cancer Research Ltd | TGF-β1 specific antibodies and methods and uses thereof |
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| US10533054B2 (en) | 2013-01-31 | 2020-01-14 | Thomas Jefferson University | Agonist fusion protein for CD40 and OX40 and methods of stimulating the immune system |
| MD20180107A2 (ro) | 2013-03-18 | 2019-06-30 | Biocerox Products B.V. | Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora |
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| MA40682B1 (fr) * | 2014-03-31 | 2020-01-31 | Hoffmann La Roche | Anticorps anti-ox40 et procédés d'utilisation correspondants |
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| US9139653B1 (en) | 2015-04-30 | 2015-09-22 | Kymab Limited | Anti-human OX40L antibodies and methods of treatment |
| AU2016256911B2 (en) * | 2015-05-07 | 2022-03-31 | Agenus Inc. | Anti-OX40 antibodies and methods of use thereof |
| EA035412B1 (ru) | 2015-05-29 | 2020-06-10 | Бристол-Майерс Сквибб Компани | Антитела к ox40 и их применение |
| CN106699888B (zh) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | 一种pd-1抗体及其制备方法和应用 |
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| CN107815465B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
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