JP2009518005A5 - - Google Patents
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- JP2009518005A5 JP2009518005A5 JP2008542473A JP2008542473A JP2009518005A5 JP 2009518005 A5 JP2009518005 A5 JP 2009518005A5 JP 2008542473 A JP2008542473 A JP 2008542473A JP 2008542473 A JP2008542473 A JP 2008542473A JP 2009518005 A5 JP2009518005 A5 JP 2009518005A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hybridoma cell
- produced
- cell line
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 10
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 10
- 210000004408 hybridoma Anatomy 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 238000012286 ELISA Assay Methods 0.000 claims 2
- 102000004473 OX40 Ligand Human genes 0.000 claims 2
- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73965905P | 2005-11-25 | 2005-11-25 | |
| US60/739,659 | 2005-11-25 | ||
| PCT/US2006/045522 WO2007062245A2 (en) | 2005-11-25 | 2006-11-27 | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161779A Division JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009518005A JP2009518005A (ja) | 2009-05-07 |
| JP2009518005A5 true JP2009518005A5 (enExample) | 2010-01-14 |
| JP5476517B2 JP5476517B2 (ja) | 2014-04-23 |
Family
ID=38067974
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542473A Active JP5476517B2 (ja) | 2005-11-25 | 2006-11-27 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
| JP2013161779A Active JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161779A Active JP5802245B2 (ja) | 2005-11-25 | 2013-08-02 | ヒトモノクローナル抗体ヒトｃｄ１３４（ｏｘ４０）ならびにその作製および使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8283450B2 (enExample) |
| EP (4) | EP4219557A1 (enExample) |
| JP (2) | JP5476517B2 (enExample) |
| KR (1) | KR101340699B1 (enExample) |
| CN (1) | CN101331150B (enExample) |
| AU (1) | AU2006318329B2 (enExample) |
| CA (1) | CA2631015C (enExample) |
| DK (1) | DK3345927T5 (enExample) |
| ES (3) | ES2602263T5 (enExample) |
| FI (1) | FI3345927T3 (enExample) |
| HU (3) | HUE031037T2 (enExample) |
| LT (1) | LT3345927T (enExample) |
| PL (3) | PL1951760T5 (enExample) |
| PT (3) | PT3098238T (enExample) |
| SI (1) | SI3345927T1 (enExample) |
| TW (1) | TWI461436B (enExample) |
| WO (1) | WO2007062245A2 (enExample) |
Families Citing this family (89)
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| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| MX2009009194A (es) * | 2007-02-27 | 2009-10-08 | Genentech Inc | Anticuerpos ox40 antagonistas y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes. |
| US20090022720A1 (en) * | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
| AU2016203429B2 (en) * | 2007-12-14 | 2018-01-25 | Bristol-Myers Squibb Company | Binding Molecules to the Human OX40 Receptor |
| AU2014202213B2 (en) * | 2007-12-14 | 2016-05-12 | Bristol-Myers Squibb Company | Binding Molecules to the Human OX40 Receptor |
| ES2425269T3 (es) * | 2007-12-14 | 2013-10-14 | Bristol-Myers Squibb Company | Moléculas de unión al receptor OX40 humano |
| US8614295B2 (en) * | 2009-02-17 | 2013-12-24 | Ucb Pharma S.A. | Antibody molecules having specificity for human OX40 |
| ME02678B (me) | 2010-08-23 | 2017-06-20 | Univ Texas | Antitijela na ox-40 i postupci njihove primjene |
| AU2011349049B2 (en) * | 2010-12-22 | 2016-08-11 | Teva Pharmaceuticals Australia Pty Ltd | Modified antibody with improved half-life |
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| CA2845810C (en) * | 2011-08-23 | 2017-03-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
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| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| EP2822592B1 (en) | 2012-03-08 | 2018-08-15 | Ludwig Institute for Cancer Research Limited | Tgf- 1 specific antibodies and methods and uses thereof |
| BR112014022200A2 (pt) | 2012-03-08 | 2019-09-24 | Selig Sealing Products Inc | membro de vedação de recipiente com compodnente de segurança protegido e aba de remoção |
| US9650411B2 (en) | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| PL2925350T3 (pl) | 2012-12-03 | 2019-07-31 | Bristol-Myers Squibb Company | Zwiększenie aktywności przeciwnowotworowej immunomodulacyjnych białek fuzyjnych fc |
| US10533054B2 (en) | 2013-01-31 | 2020-01-14 | Thomas Jefferson University | Agonist fusion protein for CD40 and OX40 and methods of stimulating the immune system |
| UA119319C2 (uk) | 2013-03-18 | 2019-06-10 | Біосерокс Продактс Б.В. | Гуманізоване антитіло до cd134 (ox40) і його застосування |
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| PL3148579T3 (pl) | 2014-05-28 | 2021-07-19 | Agenus Inc. | Przeciwciała anty-gitr i sposoby ich zastosowania |
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