CY1120014T1 - Αντισωματα συνδεσης πρωτοϊνιδιου και χρηση αυτων σε θεραπευτικες και διαγνωστικες μεθοδους για ασθενεια parkinson, ανοια με σωματα lewy και αλλες αλφα-συνουκλεϊνοπαθειες - Google Patents
Αντισωματα συνδεσης πρωτοϊνιδιου και χρηση αυτων σε θεραπευτικες και διαγνωστικες μεθοδους για ασθενεια parkinson, ανοια με σωματα lewy και αλλες αλφα-συνουκλεϊνοπαθειεςInfo
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- CY1120014T1 CY1120014T1 CY20181100140T CY181100140T CY1120014T1 CY 1120014 T1 CY1120014 T1 CY 1120014T1 CY 20181100140 T CY20181100140 T CY 20181100140T CY 181100140 T CY181100140 T CY 181100140T CY 1120014 T1 CY1120014 T1 CY 1120014T1
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N2800/302—Schizophrenia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
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Abstract
Αντισώματα και θραύσματα αυτών έχουν υψηλή συνάφεια για πρωτοϊνίδια ανθρώπινης α-συνουκλεΐνης και χαμηλή σύνδεση μονομερών α-συνουκλεΐνης, όπου τα αντισώματα ή θραύσματα έχουν προδιαγραφείσες αλληλουχίες προσδιοριστικής περιοχής συμπληρωματικότητας (CDR). Συνθέσεις περιλαμβάνουν ένα τέτοιο αντίσωμα ή θραύσμα και μέθοδοι ανίχνευσης πρωτοϊνιδίων α-συνουκλεϊνης χρησιμοποιούν ένα τέτοιο αντίσωμα ή θραύσμα. Σε περαιτέρω πραγματοποιήσεις, μέθοδοι αποτροπής, καθυστέρησης εμφάνισης ή θεραπείας νευροεκφυλιστικής διαταραχής με α-συνουκλεΐνης παθολογία περιλαμβάνουν χορήγηση ενός τέτοιου αντισώματος ή θραύσματος και ένα τέτοιο αντίσωμα ή θραύσμα χρησιμοποιείται στη βιομηχανική κατασκευή μιας φαρμακευτικής σύνθεσης για θεραπεία νευροεκφυλιστικής διαταραχής με παθολογία α-συνουκλεΐνης. Ένα τέτοιο αντίσωμα ή θραύσμα χρησιμοποιείται στη διάγνωση ή παρακολούθηση της ανάπτυξης μιας νευροεκφυλιστικής διαταραχής με α-συνουκλεΐνης παθολογία και σε μεθόδους για μείωση ή αναστολή συσσωμάτωσης α-συνουκλεΐνης με χορήγηση ενός τέτοιου αντισώματος ή θραύσματος.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US30863810P | 2010-02-26 | 2010-02-26 | |
US40626010P | 2010-10-25 | 2010-10-25 | |
PCT/IB2011/050826 WO2011104696A1 (en) | 2010-02-26 | 2011-02-25 | Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies |
Publications (1)
Publication Number | Publication Date |
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CY1120014T1 true CY1120014T1 (el) | 2018-12-12 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20181100140T CY1120014T1 (el) | 2010-02-26 | 2018-02-05 | Αντισωματα συνδεσης πρωτοϊνιδιου και χρηση αυτων σε θεραπευτικες και διαγνωστικες μεθοδους για ασθενεια parkinson, ανοια με σωματα lewy και αλλες αλφα-συνουκλεϊνοπαθειες |
Country Status (19)
Country | Link |
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US (4) | US8632776B2 (el) |
EP (1) | EP2539366B1 (el) |
JP (1) | JP5894939B2 (el) |
CN (3) | CN102869680B (el) |
AU (1) | AU2011219414B2 (el) |
CA (1) | CA2789963C (el) |
CY (1) | CY1120014T1 (el) |
DK (1) | DK2539366T3 (el) |
ES (1) | ES2661925T3 (el) |
HR (1) | HRP20180230T8 (el) |
HU (1) | HUE038313T2 (el) |
LT (1) | LT2539366T (el) |
NO (1) | NO2539366T3 (el) |
PL (1) | PL2539366T3 (el) |
PT (1) | PT2539366T (el) |
RS (1) | RS57029B1 (el) |
RU (1) | RU2555526C2 (el) |
SI (1) | SI2539366T1 (el) |
WO (1) | WO2011104696A1 (el) |
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