JP2013524853A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013524853A5 JP2013524853A5 JP2013509203A JP2013509203A JP2013524853A5 JP 2013524853 A5 JP2013524853 A5 JP 2013524853A5 JP 2013509203 A JP2013509203 A JP 2013509203A JP 2013509203 A JP2013509203 A JP 2013509203A JP 2013524853 A5 JP2013524853 A5 JP 2013524853A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- butadiene
- reductase
- hydroxy
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 82
- 108090000854 Oxidoreductases Proteins 0.000 claims 24
- 102000004316 Oxidoreductases Human genes 0.000 claims 24
- 244000005700 microbiome Species 0.000 claims 23
- 108091000080 Phosphotransferase Proteins 0.000 claims 18
- 102000020233 phosphotransferase Human genes 0.000 claims 18
- 230000037361 pathway Effects 0.000 claims 17
- 239000001177 diphosphate Substances 0.000 claims 15
- 102000004190 Enzymes Human genes 0.000 claims 11
- 108090000790 Enzymes Proteins 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 11
- 239000004386 Erythritol Substances 0.000 claims 8
- 229940009714 erythritol Drugs 0.000 claims 8
- 102000004195 Isomerases Human genes 0.000 claims 7
- 108090000769 Isomerases Proteins 0.000 claims 7
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims 7
- KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- -1 1-hydroxy-2-butenyl Chemical group 0.000 claims 6
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 claims 6
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 150000001299 aldehydes Chemical class 0.000 claims 6
- OYCNZOVOKFUQPU-CKRMAKSASA-N 5-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3,5-dioxopentanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OYCNZOVOKFUQPU-CKRMAKSASA-N 0.000 claims 5
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 5
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims 5
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims 5
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 4
- WCASXYBKJHWFMY-NSCUHMNNSA-N 2-Buten-1-ol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 4
- RGPXHQLKXPEHMD-UHFFFAOYSA-N 3,5-dihydroxypentanoic acid Chemical compound OCCC(O)CC(O)=O RGPXHQLKXPEHMD-UHFFFAOYSA-N 0.000 claims 4
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 4
- QRDCEYBRRFPBMZ-IUYQGCFVSA-N D-erythritol 4-phosphate Chemical compound OC[C@H](O)[C@H](O)COP(O)(O)=O QRDCEYBRRFPBMZ-IUYQGCFVSA-N 0.000 claims 4
- NGHMDNPXVRFFGS-IUYQGCFVSA-N D-erythrose 4-phosphate Chemical compound O=C[C@H](O)[C@H](O)COP(O)(O)=O NGHMDNPXVRFFGS-IUYQGCFVSA-N 0.000 claims 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 4
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 4
- 235000019414 erythritol Nutrition 0.000 claims 4
- WCASXYBKJHWFMY-UHFFFAOYSA-N gamma-methylallyl alcohol Natural products CC=CCO WCASXYBKJHWFMY-UHFFFAOYSA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 108010011384 acyl-CoA dehydrogenase (NADP+) Proteins 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 claims 2
- DAZFQYSXXSTLKW-UHFFFAOYSA-N 3,5-dioxopentanoic acid Chemical compound OC(=O)CC(=O)CC=O DAZFQYSXXSTLKW-UHFFFAOYSA-N 0.000 claims 2
- ZHBPKXTYCQYISG-UHFFFAOYSA-N 3-hydroxy-5-oxopentanoic acid Chemical compound O=CCC(O)CC(O)=O ZHBPKXTYCQYISG-UHFFFAOYSA-N 0.000 claims 2
- IIYZSYKTQRIPRG-MJBWAWCGSA-N 5-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-hydroxy-5-oxopentanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 IIYZSYKTQRIPRG-MJBWAWCGSA-N 0.000 claims 2
- ANTBRXMMNBUYMS-UHFFFAOYSA-N 5-hydroxy-3-oxopentanoic acid Chemical compound OCCC(=O)CC(O)=O ANTBRXMMNBUYMS-UHFFFAOYSA-N 0.000 claims 2
- 102000016912 Aldehyde Reductase Human genes 0.000 claims 2
- 108010053754 Aldehyde reductase Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 claims 2
- MLUCVPSAIODCQM-UHFFFAOYSA-N crotonaldehyde Natural products CC=CC=O MLUCVPSAIODCQM-UHFFFAOYSA-N 0.000 claims 2
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 2
- 108010031246 erythritol kinase Proteins 0.000 claims 2
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims 2
- CCSDHAPTHIKZLY-RMNRSTNRSA-N 3-aminobutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(N)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CCSDHAPTHIKZLY-RMNRSTNRSA-N 0.000 claims 1
- 108010031139 3-aminobutyryl-CoA deaminase Proteins 0.000 claims 1
- QWLFCPJZHGPHDF-UHFFFAOYSA-N 3-hydroxy-5-[hydroxy(phosphonooxy)phosphoryl]oxypentanoic acid Chemical compound OC(=O)CC(O)CCOP(O)(=O)OP(O)(O)=O QWLFCPJZHGPHDF-UHFFFAOYSA-N 0.000 claims 1
- 108030005660 3-hydroxybutyryl-CoA dehydratases Proteins 0.000 claims 1
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims 1
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108010068207 Glutaconyl-CoA decarboxylase Proteins 0.000 claims 1
- 108010015451 Glutaryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102100028603 Glutaryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- YKQHKFCYCBOMGI-UHFFFAOYSA-N OC(C(=O)O)CCCOP(=O)(OP(=O)(O)O)O Chemical compound OC(C(=O)O)CCCOP(=O)(OP(=O)(O)O)O YKQHKFCYCBOMGI-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- SYKWLIJQEHRDNH-CKRMAKSASA-N glutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SYKWLIJQEHRDNH-CKRMAKSASA-N 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- URTLOTISFJPPOU-DEGQQWIJSA-N trans-4-carboxybut-2-enoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)\C=C\CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 URTLOTISFJPPOU-DEGQQWIJSA-N 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33181210P | 2010-05-05 | 2010-05-05 | |
| US61/331,812 | 2010-05-05 | ||
| PCT/US2011/035105 WO2011140171A2 (en) | 2010-05-05 | 2011-05-04 | Microorganisms and methods for the biosynthesis of butadiene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016068884A Division JP2016154551A (ja) | 2010-05-05 | 2016-03-30 | ブタジエンの生合成のための微生物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524853A JP2013524853A (ja) | 2013-06-20 |
| JP2013524853A5 true JP2013524853A5 (enExample) | 2014-06-26 |
| JP5911847B2 JP5911847B2 (ja) | 2016-04-27 |
Family
ID=45064763
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509203A Active JP5911847B2 (ja) | 2010-05-05 | 2011-05-04 | ブタジエンの生合成のための微生物および方法 |
| JP2016068884A Pending JP2016154551A (ja) | 2010-05-05 | 2016-03-30 | ブタジエンの生合成のための微生物および方法 |
| JP2018153224A Pending JP2018196387A (ja) | 2010-05-05 | 2018-08-16 | ブタジエンの生合成のための微生物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016068884A Pending JP2016154551A (ja) | 2010-05-05 | 2016-03-30 | ブタジエンの生合成のための微生物および方法 |
| JP2018153224A Pending JP2018196387A (ja) | 2010-05-05 | 2018-08-16 | ブタジエンの生合成のための微生物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8580543B2 (enExample) |
| EP (1) | EP2566969B1 (enExample) |
| JP (3) | JP5911847B2 (enExample) |
| KR (3) | KR20180005263A (enExample) |
| CN (2) | CN103080324B (enExample) |
| AU (2) | AU2011248182A1 (enExample) |
| BR (1) | BR112012028049A2 (enExample) |
| CA (1) | CA2797409C (enExample) |
| CO (1) | CO6630182A2 (enExample) |
| MX (1) | MX336229B (enExample) |
| SG (2) | SG10201503501TA (enExample) |
| TW (2) | TWI575072B (enExample) |
| WO (1) | WO2011140171A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ， インク． | Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| CN109136161A (zh) | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| MX336229B (es) * | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| JP2013535203A (ja) | 2010-07-26 | 2013-09-12 | ジェノマティカ・インコーポレイテッド | 芳香族、２，４−ペンタジエノエートおよび１，３−ブタジエンを生合成するための微生物および方法 |
| MX348334B (es) * | 2011-02-02 | 2017-06-07 | Genomatica Inc | Microorganismo y metodos para la biosintesis de butadieno. |
| WO2013188546A2 (en) * | 2012-06-15 | 2013-12-19 | Invista Technologies S.À.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9663801B2 (en) | 2011-06-17 | 2017-05-30 | Invista North America S.A.R.L. | Methods of producing four carbon molecules |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| SG11201400113XA (en) * | 2011-08-19 | 2014-08-28 | Genomatica Inc | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| BR112014008061A2 (pt) * | 2011-10-19 | 2017-04-11 | Scientist Of Fortune Sa | método para a produção enzimática de butadieno |
| DK2776571T3 (en) | 2011-11-09 | 2017-06-26 | Amyris Inc | PREPARATION OF ACETYL-COENZYM A-DERIVED ISOPRENOIDS |
| CN104321434A (zh) * | 2011-12-02 | 2015-01-28 | 英威达技术有限责任公司 | 生物合成1,3丁二烯的方法 |
| EP2791342B1 (en) * | 2011-12-16 | 2020-04-29 | Braskem S.A. | Modified microorganisms and methods of making butadiene using same |
| EP2794891A2 (en) * | 2011-12-20 | 2014-10-29 | Scientist of Fortune S.A. | Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates |
| US20150017698A1 (en) * | 2012-03-02 | 2015-01-15 | Codexis, Inc. a corporation | Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate |
| WO2013130481A1 (en) * | 2012-03-02 | 2013-09-06 | Codexis, Inc. | Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate |
| US9803209B2 (en) | 2012-05-18 | 2017-10-31 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| US20150152440A1 (en) * | 2012-06-18 | 2015-06-04 | Braskem S.A. | Modified microorganisms and methods of co-producing butadiene with 1-propanol and/or 1,2-propanediol |
| BR112015004488A2 (pt) * | 2012-08-28 | 2018-11-21 | Braskem Sa | método de coprodução de um terpeno e pelo menos um coproduto a partir de uma fonte de carbono fermentável |
| WO2014052630A1 (en) | 2012-09-27 | 2014-04-03 | Novozymes, Inc. | Bacterial mutants with improved transformation efficiency |
| WO2014055649A1 (en) * | 2012-10-02 | 2014-04-10 | Braskem S/A Ap 09 | Modified microorganisms and methods of using same for producing butadiene and succinate |
| WO2014063156A2 (en) * | 2012-10-19 | 2014-04-24 | Braskem S/A Ap 09 | Modified microorganisms and methods of using same for producing butadiene and one or more of 1,3-butanediol, 1,4-butanediol, and/or 1,3-propanediol |
| US11535874B2 (en) * | 2012-10-22 | 2022-12-27 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto |
| EP2920314A1 (en) * | 2012-11-13 | 2015-09-23 | Global Bioenergies | Process for the enzymatic preparation of isoprene from isoprenol |
| WO2014081973A1 (en) * | 2012-11-21 | 2014-05-30 | The Regents Of The University Of California | Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic archaea |
| CN104903455A (zh) | 2012-11-28 | 2015-09-09 | 英威达技术有限责任公司 | 用于异丁烯生物合成的方法 |
| JP6304924B2 (ja) * | 2012-11-29 | 2018-04-04 | 住友ゴム工業株式会社 | サイドウォール用ゴム組成物、及び空気入りタイヤ |
| WO2014089025A1 (en) * | 2012-12-04 | 2014-06-12 | Genomatica, Inc. | Increased yields of biosynthesized products |
| WO2014106122A1 (en) * | 2012-12-31 | 2014-07-03 | Genomatica, Inc. | Compositions and methods for bio-butadiene production screening |
| JP2014155455A (ja) * | 2013-02-15 | 2014-08-28 | Sekisui Chem Co Ltd | 組換え細胞、並びに、クロトニルＣｏＡ又はクロチルアルコールの生産方法 |
| JP2014161252A (ja) * | 2013-02-22 | 2014-09-08 | Sekisui Chem Co Ltd | 組換え細胞 |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| ES2728307T3 (es) | 2013-06-21 | 2019-10-23 | Danisco Us Inc | Composiciones y métodos para la transformación clostridial |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| EP3030668A1 (en) | 2013-08-05 | 2016-06-15 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
| CN105683385A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异戊二烯的方法 |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| WO2015100338A2 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| WO2015147644A1 (en) * | 2014-03-27 | 2015-10-01 | Photanol B.V. | Erythritol production in cyanobacteria |
| CN106795519A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生成戊二酸和戊二酸甲酯的方法 |
| US10487342B2 (en) | 2014-07-11 | 2019-11-26 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-CoA |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| CN104298866B (zh) * | 2014-09-30 | 2017-06-06 | 杭州电子科技大学 | 一种克劳斯硫磺回收过程中反应炉动态建模方法 |
| JP6432774B2 (ja) * | 2014-12-25 | 2018-12-05 | 江南化工株式会社 | 細胞賦活剤 |
| MX387737B (es) | 2015-02-27 | 2025-03-18 | White Dog Labs Inc | Método de fermentación mixotrófica para producir acetona, isopropanol, acido butírico y otros bioproductos, y mezclas de los mismos. |
| WO2016160812A1 (en) * | 2015-03-31 | 2016-10-06 | White Dog Labs, Inc. | Method of producing bioproducts |
| KR20170134682A (ko) * | 2015-04-09 | 2017-12-06 | 게노마티카 인코포레이티드 | 향상된 크로틸 알코올 생성을 위한 유전자조작 미생물 및 방법 |
| CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
| WO2017064606A1 (en) * | 2015-10-12 | 2017-04-20 | Reliance Industries Limited | Process for preparation of 1,3-butadiene |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| GB201605354D0 (en) | 2016-03-30 | 2016-05-11 | Zuvasyntha Ltd | Modified enzyme |
| US10919030B2 (en) | 2016-09-30 | 2021-02-16 | Regents Of The University Of Minnesota | Forming dienes from cyclic ethers and diols, including tetrahydrofuran and 2-methyl-1,4-butanediol |
| JP6317497B2 (ja) * | 2017-03-22 | 2018-04-25 | 住友ゴム工業株式会社 | トレッド用ゴム組成物、及び空気入りタイヤ |
| JP6317498B2 (ja) * | 2017-03-22 | 2018-04-25 | 住友ゴム工業株式会社 | スタッドレスタイヤ用トレッド用ゴム組成物、及びスタッドレスタイヤ |
| JP2020512351A (ja) * | 2017-03-31 | 2020-04-23 | ジェノマティカ， インコーポレイテッド | 発酵ブロスから１，３−ブタンジオールを取得するためのプロセスおよびシステム |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| WO2019006257A1 (en) | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| US20220258100A1 (en) * | 2019-07-16 | 2022-08-18 | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation | Products of manufacture and methods for methane capturing using biofiltration |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4076948A (en) | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| US3513209A (en) | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| GB1230276A (enExample) | 1968-12-09 | 1971-04-28 | ||
| US3965182A (en) | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (enExample) | 1970-09-04 | 1973-09-26 | ||
| GB1344557A (en) | 1972-06-23 | 1974-01-23 | Mitsubishi Petrochemical Co | Process for preparing 1,4-butanediol |
| JPS5543759B2 (enExample) | 1972-06-28 | 1980-11-07 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| DE2501499A1 (de) | 1975-01-16 | 1976-07-22 | Hoechst Ag | Verfahren zur herstellung von butandiol-(1.4) |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| ES2036188T3 (es) | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5182199A (en) | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| JPH01195596A (ja) | 1988-01-30 | 1989-08-07 | Casio Comput Co Ltd | 値札システム |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| CA2062753C (en) | 1989-04-27 | 2005-04-26 | N. Robert Ward, Jr. | Precipitate test for microorganisms |
| US5192673A (en) | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| EP0769557B1 (en) | 1990-10-15 | 2000-11-15 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| US5849970A (en) * | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| FR2736927B1 (fr) | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| JP2000506012A (ja) | 1996-02-27 | 2000-05-23 | ミシガン ステイト ユニヴァーシティー | サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け |
| US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| JP4101295B2 (ja) | 1996-07-01 | 2008-06-18 | バイオエンジニアリング・リソーシズ・インコーポレーテツド | 廃ガスからの酢酸の生物学的生産 |
| KR100459818B1 (ko) | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| US6117658A (en) | 1997-02-13 | 2000-09-12 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| DE19820652A1 (de) | 1998-05-08 | 1999-11-11 | Basf Ag | Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| WO2000004163A1 (en) | 1998-07-15 | 2000-01-27 | E.I. Du Pont De Nemours And Company | Tetrahydrofolate metabolism enzymes |
| DE19856136C2 (de) | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| WO2000046405A2 (en) | 1999-02-02 | 2000-08-10 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| US6448473B1 (en) | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| CA2374482C (en) | 1999-05-21 | 2012-09-18 | Cargill Dow Llc | Methods and materials for the synthesis of organic products |
| US6852517B1 (en) | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| NZ523484A (en) | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| JP4490628B2 (ja) | 2000-11-20 | 2010-06-30 | カーギル インコーポレイテッド | ３−ヒドロキシプロピオン酸および他の有機化合物 |
| US7109010B2 (en) | 2000-11-22 | 2006-09-19 | Nature Works Llc | Methods and materials for the synthesis of organic products |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| CA2434224C (en) | 2001-01-10 | 2013-04-02 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| US20030059792A1 (en) | 2001-03-01 | 2003-03-27 | Palsson Bernhard O. | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| JP4630486B2 (ja) | 2001-05-28 | 2011-02-09 | ダイセル化学工業株式会社 | 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| CA2356540A1 (en) | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| CA2466133A1 (en) | 2001-11-02 | 2003-05-15 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| DE60327804D1 (de) | 2002-01-18 | 2009-07-09 | Novozymes As | Alanin-2,3-aminomutase |
| WO2003066863A1 (fr) | 2002-02-06 | 2003-08-14 | Showa Denko K.K. | Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| EP1532516A4 (en) | 2002-07-10 | 2007-05-23 | Penn State Res Found | Method for determining gene knockout strategies |
| WO2004007688A2 (en) | 2002-07-15 | 2004-01-22 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| AU2003222214B2 (en) | 2002-10-15 | 2010-08-12 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| AU2003287625A1 (en) | 2002-11-06 | 2004-06-03 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| CN1802341A (zh) | 2003-01-13 | 2006-07-12 | 卡吉尔公司 | 制备工业化学品的方法 |
| US7432091B2 (en) | 2003-02-24 | 2008-10-07 | Research Institute Of Innovative Technology For The Earth | Highly efficient hydrogen production method using microorganism |
| RU2268300C2 (ru) | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| WO2005010182A1 (ja) | 2003-07-29 | 2005-02-03 | Research Institute Of Innovative Technology For The Earth | コリネ型細菌形質転換体及びそれを用いるジカルボン酸の製造方法 |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005026349A1 (ja) | 2003-09-17 | 2005-03-24 | Mitsubishi Chemical Corporation | 非アミノ有機酸の製造方法 |
| US7244610B2 (en) | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| CN1926240B (zh) | 2004-01-19 | 2010-06-02 | 帝斯曼知识产权资产管理有限公司 | 6-氨基己酸的生物化学合成 |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| US7262046B2 (en) | 2004-08-09 | 2007-08-28 | Rice University | Aerobic succinate production in bacteria |
| JP2008510485A (ja) * | 2004-08-26 | 2008-04-10 | ザ ペン ステイト リサーチ ファウンデーション | 微生物産生系の再設計法 |
| CN101044245B (zh) | 2004-08-27 | 2012-05-02 | 莱斯大学 | 具有增加的琥珀酸产量的突变大肠杆菌菌株 |
| EP2434015B1 (en) | 2004-09-09 | 2013-11-20 | Research Institute Of Innovative Technology For The Earth | DNA fragment having promoter function |
| EP1789569A2 (en) | 2004-09-17 | 2007-05-30 | Rice University | High succinate producing bacteria |
| EP1801227B1 (en) | 2004-10-14 | 2009-04-15 | Sumitomo Chemical Company, Limited | Method for producing 2-hydroxy-4-(methylthio)butanoic acid |
| US7569380B2 (en) | 2004-12-22 | 2009-08-04 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| DE102005002127A1 (de) * | 2005-01-17 | 2006-07-20 | Basf Ag | Verfahren zur Herstellung von Butadien aus n-Butan |
| JP2006204255A (ja) | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| EP1874334A4 (en) | 2005-04-15 | 2011-03-30 | Vascular Biogenics Ltd | COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES |
| KR100679638B1 (ko) | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100676160B1 (ko) | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| AU2006287257A1 (en) | 2005-09-09 | 2007-03-15 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| GB2433260A (en) | 2005-12-16 | 2007-06-20 | Mologic Ltd | A selectable decarboxylase marker |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| AU2008206403A1 (en) | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| CA2678946C (en) | 2007-03-16 | 2019-02-12 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| EP2147111A4 (en) | 2007-04-18 | 2010-06-23 | Gevo Inc | MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| CN101970673A (zh) | 2007-07-23 | 2011-02-09 | 帝斯曼知识产权资产管理有限公司 | 真核细胞中的丁醇生产 |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| AU2008310573A1 (en) | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| BRPI0823506A8 (pt) * | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| CN102015995B (zh) * | 2008-03-03 | 2014-10-22 | 焦耳无限科技公司 | 产生碳基目的产物的二氧化碳固定工程微生物 |
| SI2265709T1 (en) | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| JP2011518564A (ja) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| JP2011519561A (ja) | 2008-05-01 | 2011-07-14 | ジェノマティカ， インコーポレイテッド | メタクリル酸の産生のための微生物 |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| SG167485A1 (en) | 2008-06-30 | 2011-01-28 | Danisco Us Inc | Polymers of isoprene from renewable resources |
| EP2313491A4 (en) | 2008-07-08 | 2011-12-07 | Opx Biotechnologies Inc | METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL |
| WO2010022763A1 (en) | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| CA2735883C (en) * | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| WO2010031079A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| US8357826B2 (en) | 2008-10-16 | 2013-01-22 | Karl Kharas | Methods and apparatus for synthesis of alcohols from syngas |
| EP3260532A1 (en) | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| BRPI1013426A2 (pt) * | 2009-04-30 | 2016-11-08 | Genomatica Inc | organismos para produção de 1,3-butanodiol |
| SI3392340T1 (sl) | 2009-06-04 | 2022-05-31 | Genomatica, Inc. | Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoči postopki |
| US20120276606A1 (en) | 2009-10-30 | 2012-11-01 | Daicel Corporation | Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof |
| CN109136161A (zh) | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| MX336229B (es) | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| MX348334B (es) * | 2011-02-02 | 2017-06-07 | Genomatica Inc | Microorganismo y metodos para la biosintesis de butadieno. |
| US9169486B2 (en) * | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| BR112014008061A2 (pt) * | 2011-10-19 | 2017-04-11 | Scientist Of Fortune Sa | método para a produção enzimática de butadieno |
| US20150050708A1 (en) * | 2013-03-15 | 2015-02-19 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
| EP2971021A4 (en) * | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
-
2011
- 2011-05-04 MX MX2012012827A patent/MX336229B/es unknown
- 2011-05-04 JP JP2013509203A patent/JP5911847B2/ja active Active
- 2011-05-04 CN CN201180033199.2A patent/CN103080324B/zh active Active
- 2011-05-04 KR KR1020177037394A patent/KR20180005263A/ko not_active Ceased
- 2011-05-04 BR BR112012028049A patent/BR112012028049A2/pt not_active IP Right Cessation
- 2011-05-04 SG SG10201503501TA patent/SG10201503501TA/en unknown
- 2011-05-04 KR KR1020197001071A patent/KR20190006103A/ko not_active Ceased
- 2011-05-04 WO PCT/US2011/035105 patent/WO2011140171A2/en not_active Ceased
- 2011-05-04 KR KR1020127031134A patent/KR101814648B1/ko active Active
- 2011-05-04 SG SG2012081519A patent/SG185432A1/en unknown
- 2011-05-04 CA CA2797409A patent/CA2797409C/en not_active Expired - Fee Related
- 2011-05-04 CN CN201610340556.4A patent/CN106047782A/zh active Pending
- 2011-05-04 AU AU2011248182A patent/AU2011248182A1/en not_active Abandoned
- 2011-05-04 EP EP11778232.6A patent/EP2566969B1/en active Active
- 2011-05-04 US US13/101,046 patent/US8580543B2/en active Active
- 2011-05-05 TW TW100115805A patent/TWI575072B/zh not_active IP Right Cessation
- 2011-05-05 TW TW105130341A patent/TW201720931A/zh unknown
-
2012
- 2012-11-06 CO CO12199796A patent/CO6630182A2/es unknown
-
2013
- 2013-10-21 US US14/059,131 patent/US9732361B2/en not_active Expired - Fee Related
-
2016
- 2016-02-26 AU AU2016201231A patent/AU2016201231A1/en not_active Abandoned
- 2016-03-30 JP JP2016068884A patent/JP2016154551A/ja active Pending
-
2017
- 2017-07-10 US US15/645,880 patent/US10487343B2/en not_active Expired - Fee Related
-
2018
- 2018-08-16 JP JP2018153224A patent/JP2018196387A/ja active Pending
-
2019
- 2019-10-25 US US16/664,648 patent/US20200299736A1/en not_active Abandoned
-
2021
- 2021-03-05 US US17/193,914 patent/US20220025411A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013524853A5 (enExample) | ||
| JP2014504508A5 (enExample) | ||
| Sun et al. | Metabolic engineering of strains: from industrial-scale to lab-scale chemical production | |
| WO2013028519A4 (en) | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols | |
| JP6375227B2 (ja) | 組換え細胞、並びに、イソプレンの生産方法 | |
| JP2011519561A5 (enExample) | ||
| Yu et al. | Development and perspective of Rhodotorula toruloides as an efficient cell factory | |
| JP2012501678A5 (enExample) | ||
| JP2012525158A5 (enExample) | ||
| MY150715A (en) | Cells or plants having a producing ability of polylactate or its copolymers and method for preparing polylactate or its copolymers using the same | |
| Dykstra et al. | Metabolic engineering of Clostridium autoethanogenum for ethyl acetate production from CO | |
| NZ600540A (en) | Ethanol production in non-recombinant hosts | |
| WO2008126667A3 (en) | Method for producing lactic acid | |
| Mazumdar et al. | L-lactate production from seaweed hydrolysate of Laminaria japonica using metabolically engineered Escherichia coli | |
| JP2014513542A5 (enExample) | ||
| CN101631864A (zh) | 使用酵母菌通过丁酰-CoA作为中间体制备丁醇的方法 | |
| CN106957878A (zh) | 一种生物催化生产2‑苯乙醇的方法 | |
| CN102083977B (zh) | 产同型琥珀酸细菌突变体以及使用该微生物突变体制备琥珀酸的方法 | |
| Liu et al. | Biopolymer production in microbiology by application of metabolic engineering | |
| CN104762242B (zh) | 甲羟戊酸的生产菌以及生产甲羟戊酸的方法 | |
| WO2008126669A3 (en) | Method for producing pyruvic acid | |
| de Siqueira et al. | Polyhydroxyalkanoates and exopolysaccharides: An alternative for valuation of the co‐production of microbial biopolymers | |
| CN106148255B (zh) | 产有机酸途径缺失的工程菌及其在联产1,3-丙二醇、2,3-丁二醇和乙醇中的应用 | |
| CN101381696A (zh) | 构建基因工程菌增强1，3-丙二醇生产菌株抗逆性的方法 | |
| CN101668852A (zh) | 增强的产生丁醇的微生物和使用该微生物制备丁醇的方法 |