JP2014504508A5 - - Google Patents
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- Publication number
- JP2014504508A5 JP2014504508A5 JP2013552630A JP2013552630A JP2014504508A5 JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5 JP 2013552630 A JP2013552630 A JP 2013552630A JP 2013552630 A JP2013552630 A JP 2013552630A JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- crotonyl
- reductase
- alcohol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 33
- 102000004316 Oxidoreductases Human genes 0.000 claims 32
- 108090000854 Oxidoreductases Proteins 0.000 claims 32
- 108010011384 acyl-CoA dehydrogenase (NADP+) Proteins 0.000 claims 24
- WCASXYBKJHWFMY-NSCUHMNNSA-N 2-Buten-1-ol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 20
- MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 claims 20
- MLUCVPSAIODCQM-UHFFFAOYSA-N crotonaldehyde Natural products CC=CC=O MLUCVPSAIODCQM-UHFFFAOYSA-N 0.000 claims 20
- WCASXYBKJHWFMY-UHFFFAOYSA-N gamma-methylallyl alcohol Natural products CC=CCO WCASXYBKJHWFMY-UHFFFAOYSA-N 0.000 claims 20
- 244000005700 microbiome Species 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 230000037361 pathway Effects 0.000 claims 16
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical group O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 15
- 230000015572 biosynthetic process Effects 0.000 claims 15
- 102000003960 Ligases Human genes 0.000 claims 12
- 108090000364 Ligases Proteins 0.000 claims 12
- 102000004357 Transferases Human genes 0.000 claims 12
- 108090000992 Transferases Proteins 0.000 claims 12
- 150000001299 aldehydes Chemical class 0.000 claims 12
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 108010031139 3-aminobutyryl-CoA deaminase Proteins 0.000 claims 8
- 108030005660 3-hydroxybutyryl-CoA dehydratases Proteins 0.000 claims 8
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 claims 8
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 8
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 108010015451 Glutaryl-CoA Dehydrogenase Proteins 0.000 claims 8
- 102100028603 Glutaryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 8
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims 8
- 108010068207 Glutaconyl-CoA decarboxylase Proteins 0.000 claims 6
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 4
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 1
- KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438947P | 2011-02-02 | 2011-02-02 | |
| US61/438,947 | 2011-02-02 | ||
| PCT/US2012/023632 WO2012106516A1 (en) | 2011-02-02 | 2012-02-02 | Microorganisms and methods for the biosynthesis of butadiene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Division JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504508A JP2014504508A (ja) | 2014-02-24 |
| JP2014504508A5 true JP2014504508A5 (enExample) | 2015-03-26 |
| JP5960729B2 JP5960729B2 (ja) | 2016-08-02 |
Family
ID=46603080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552630A Active JP5960729B2 (ja) | 2011-02-02 | 2012-02-02 | ブタジエンの生合成のための微生物および方法 |
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9321701B2 (enExample) |
| EP (1) | EP2670852A4 (enExample) |
| JP (3) | JP5960729B2 (enExample) |
| KR (1) | KR20140145935A (enExample) |
| CN (2) | CN106191132A (enExample) |
| AU (1) | AU2012212118B2 (enExample) |
| BR (1) | BR112013019811A2 (enExample) |
| CA (1) | CA2826293A1 (enExample) |
| MX (1) | MX348334B (enExample) |
| MY (2) | MY162964A (enExample) |
| PH (1) | PH12013501630A1 (enExample) |
| SG (1) | SG192614A1 (enExample) |
| WO (1) | WO2012106516A1 (enExample) |
Families Citing this family (44)
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|---|---|---|---|---|
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ， インク． | Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| CN109136161A (zh) | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| MX336229B (es) * | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| MX348334B (es) * | 2011-02-02 | 2017-06-07 | Genomatica Inc | Microorganismo y metodos para la biosintesis de butadieno. |
| US9663801B2 (en) | 2011-06-17 | 2017-05-30 | Invista North America S.A.R.L. | Methods of producing four carbon molecules |
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| BR112014008061A2 (pt) | 2011-10-19 | 2017-04-11 | Scientist Of Fortune Sa | método para a produção enzimática de butadieno |
| WO2013071074A1 (en) * | 2011-11-11 | 2013-05-16 | Invista North America S.A. R.L. | Methods of producing butadiene |
| CN104903455A (zh) | 2012-11-28 | 2015-09-09 | 英威达技术有限责任公司 | 用于异丁烯生物合成的方法 |
| WO2014086781A1 (en) | 2012-12-07 | 2014-06-12 | Global Bioenergies | Fermentative production of a hydrocarbon |
| EP2929037B1 (en) | 2012-12-07 | 2020-09-09 | Global Bioenergies | Improved fermentation method |
| JP2014161252A (ja) * | 2013-02-22 | 2014-09-08 | Sekisui Chem Co Ltd | 組換え細胞 |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| CN105683385A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异戊二烯的方法 |
| EP3030668A1 (en) | 2013-08-05 | 2016-06-15 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| WO2015100338A2 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| CN106795519A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生成戊二酸和戊二酸甲酯的方法 |
| WO2016004334A1 (en) | 2014-07-03 | 2016-01-07 | Genomatica, Inc. | Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto |
| WO2016007196A1 (en) * | 2014-07-07 | 2016-01-14 | Cobalt Technologies, Inc. | Biomass conversion to butadiene |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| CN104298866B (zh) * | 2014-09-30 | 2017-06-06 | 杭州电子科技大学 | 一种克劳斯硫磺回收过程中反应炉动态建模方法 |
| WO2016066869A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Catalizador microporoso con encapsulación selectiva de óxidos metálicos útil para producir precursores de butadieno |
| WO2016066873A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Óxidos mixtos que comprenden magnesio y boro, y su uso como catalizadores para producir precursores de butadieno |
| US10196326B2 (en) * | 2015-02-23 | 2019-02-05 | Versalis S.P.A. | Process for the production of dienes |
| KR20170134682A (ko) | 2015-04-09 | 2017-12-06 | 게노마티카 인코포레이티드 | 향상된 크로틸 알코올 생성을 위한 유전자조작 미생물 및 방법 |
| CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
| US20190218578A1 (en) * | 2015-08-24 | 2019-07-18 | White Dog Labs, Inc. | Microbial organisms for converting acetyl-coa into crotyl alcohol and methods for producing crotyl alcohol |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| KR101929631B1 (ko) | 2016-12-20 | 2018-12-14 | 서강대학교산학협력단 | 미생물 발효를 이용한 1,3-부타디엔의 제조 방법 |
| EA201891926A1 (ru) * | 2017-02-03 | 2019-04-30 | Киверди, Инк. | Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1 |
| WO2019006257A1 (en) | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11142778B2 (en) | 2017-07-24 | 2021-10-12 | Riken | Decarboxylase and method for producing unsaturated hydrocarbon compound using same |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
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| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| US20220282265A1 (en) * | 2019-08-12 | 2022-09-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of 3-amino-4-hydroxybenzoic acid by fermentation |
| EP4050068B1 (en) | 2019-10-24 | 2025-01-29 | Shin-Etsu Chemical Co., Ltd. | Thermally conductive silicone composition and production method therefor |
| BR112023019832A2 (pt) | 2021-04-01 | 2023-11-07 | Synthos Dwory 7 Spolka Z Ograniczona Odpowiedzialnoscia | Processo adiabaticamente conduzido para a produção de 1,3-butadieno a partir de misturas de etanol e acetaldeído |
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| GB525198A (en) | 1938-03-21 | 1940-08-23 | Melle Usines Sa | Improvements in or relating to the preparation of di-olefines |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| WO2000046405A2 (en) | 1999-02-02 | 2000-08-10 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| CA2434224C (en) | 2001-01-10 | 2013-04-02 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| US20030059792A1 (en) | 2001-03-01 | 2003-03-27 | Palsson Bernhard O. | Models and methods for determining systemic properties of regulated reaction networks |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
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| EP1532516A4 (en) | 2002-07-10 | 2007-05-23 | Penn State Res Found | Method for determining gene knockout strategies |
| AU2003222214B2 (en) | 2002-10-15 | 2010-08-12 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| CA2678946C (en) | 2007-03-16 | 2019-02-12 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CN102015995B (zh) * | 2008-03-03 | 2014-10-22 | 焦耳无限科技公司 | 产生碳基目的产物的二氧化碳固定工程微生物 |
| JP2011518564A (ja) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| EP2313491A4 (en) * | 2008-07-08 | 2011-12-07 | Opx Biotechnologies Inc | METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL |
| WO2010031079A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| BRPI1013426A2 (pt) * | 2009-04-30 | 2016-11-08 | Genomatica Inc | organismos para produção de 1,3-butanodiol |
| US20120276606A1 (en) | 2009-10-30 | 2012-11-01 | Daicel Corporation | Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof |
| MX336229B (es) * | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| WO2012081723A1 (ja) * | 2010-12-17 | 2012-06-21 | 三菱化学株式会社 | 合成経路作成装置、合成経路作成方法及び合成経路作成プログラムならびに３－ヒドロキシプロピオン酸、クロトニルアルコールおよびブタジエンの製造方法 |
| MX348334B (es) * | 2011-02-02 | 2017-06-07 | Genomatica Inc | Microorganismo y metodos para la biosintesis de butadieno. |
| US9169486B2 (en) * | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
-
2012
- 2012-02-02 MX MX2013008988A patent/MX348334B/es active IP Right Grant
- 2012-02-02 PH PH1/2013/501630A patent/PH12013501630A1/en unknown
- 2012-02-02 US US13/365,132 patent/US9321701B2/en active Active
- 2012-02-02 CA CA2826293A patent/CA2826293A1/en not_active Abandoned
- 2012-02-02 EP EP12742132.9A patent/EP2670852A4/en not_active Withdrawn
- 2012-02-02 WO PCT/US2012/023632 patent/WO2012106516A1/en not_active Ceased
- 2012-02-02 KR KR1020137023026A patent/KR20140145935A/ko not_active Ceased
- 2012-02-02 MY MYPI2013701358A patent/MY162964A/en unknown
- 2012-02-02 AU AU2012212118A patent/AU2012212118B2/en not_active Ceased
- 2012-02-02 CN CN201610552260.9A patent/CN106191132A/zh active Pending
- 2012-02-02 JP JP2013552630A patent/JP5960729B2/ja active Active
- 2012-02-02 SG SG2013059167A patent/SG192614A1/en unknown
- 2012-02-02 BR BR112013019811A patent/BR112013019811A2/pt not_active Application Discontinuation
- 2012-02-02 CN CN201280016837.4A patent/CN103459602B/zh not_active Expired - Fee Related
-
2013
- 2013-08-01 MY MYPI2017702592A patent/MY179664A/en unknown
-
2016
- 2016-03-23 US US15/078,437 patent/US20170044572A1/en not_active Abandoned
- 2016-06-23 JP JP2016124920A patent/JP2016192974A/ja active Pending
-
2018
- 2018-03-09 US US15/917,411 patent/US20190048366A1/en not_active Abandoned
- 2018-06-27 JP JP2018122381A patent/JP2018166514A/ja active Pending
-
2020
- 2020-06-25 US US16/912,409 patent/US20210147881A1/en not_active Abandoned
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