MX348334B - Microorganismo y metodos para la biosintesis de butadieno. - Google Patents

Microorganismo y metodos para la biosintesis de butadieno.

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Publication number
MX348334B
MX348334B MX2013008988A MX2013008988A MX348334B MX 348334 B MX348334 B MX 348334B MX 2013008988 A MX2013008988 A MX 2013008988A MX 2013008988 A MX2013008988 A MX 2013008988A MX 348334 B MX348334 B MX 348334B
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MX
Mexico
Prior art keywords
butadiene
naturally occurring
occurring microbial
methods
biosynthesis
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Application number
MX2013008988A
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English (en)
Other versions
MX2013008988A (es
Inventor
E Osterhout Robin
Pharkya Priti
J Burk Mark
P Burgard Anthony
Sun Jun
Original Assignee
Genomatica Inc
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Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of MX2013008988A publication Critical patent/MX2013008988A/es
Publication of MX348334B publication Critical patent/MX348334B/es

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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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    • C12Y103/08—Oxidoreductases acting on the CH-CH group of donors (1.3) with flavin as acceptor (1.3.8)
    • C12Y103/08006—Glutaryl-CoA dehydrogenase (1.3.8.6)
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    • C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
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    • C12Y401/01—Carboxy-lyases (4.1.1)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Genetics & Genomics (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la producción de butadieno, caracterizado porque comprende: (a) cultivar por fermentación en una cantidad suficiente de nutrientes y medio un organismo cicrobiano que no está presente en forma natural que produce alcohol crotílico produciendo así de manera biosintética alcohol crotílico, en donde dicho organismo microbiano comprende una ruta de alcohol crotílico que comprende al menos dos ácidos nucleicos exógenos que codifican para enzimas de la ruta alcohol crotílico expresadas en una cantidad suficiente para producir alcohol crotílico, en donde dicha ruta de alcohol crotílico comprende convertir crotonil-CoA a alcohol crotílico utilizando al menos un ácido nucleico exógeno de dichos dos ácidos nucleicos exógenos, en donde dichas enzimas de la ruta de alcohol crotílico se seleccionan del grupo que consisten en; (i) una crotonil-CoA reductasa (formada de aldehído), y una crotonaldehído reductasa (formadora de alcohol); (ii) na crotonil-CoA reductasa (formadora de alcohol); y (iii) una crotonil-CoA hidrolasa, sintetasa o transferasa, una crotonato reductasa, y una crotonaldehído reductasa (formadora de alcohol), y en donde dicha ruta de alcohol crotílico comprende adicionalmente al menos un ácido nucleico exógeno de dichos dos ácidos nucleicos exógenos que codifica para una enzima de la ruta de alcohol crotílico para convertir : (i) acetil-CoA a crotonilo-CoA utilizando una aceitil-CoA: acetil-CoA aciltransferasa, una acetoacetil-CoA reductasa y una 3-hidroxibutiril-CoA deshidratasa; (ii) gulutaconil-CoA a crotonil-CoA utilizando una glutaconil-CoA descarboxilasa; (iii) glutaril-CoA o crotonil-CoA utilizando una glutaril-CoA deshidrogenasa; (iv) 3-acminobutiril-CoA a crotoni-lCoA utilizando una 3- aminobutiril-CoA desaminasa; o (v) 4-hidroxibutiril-CoA a crotonil-CoA utilizando una 4-hidroxibutiril-CoA deshidratasa; y (b) convertir el alcohol crotílico producido al cultivar dicho microorganismo microbiano que no está presente en forma natural en el pasa (a) a butadieno utilizando un producto químico.
MX2013008988A 2011-02-02 2012-02-02 Microorganismo y metodos para la biosintesis de butadieno. MX348334B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161438947P 2011-02-02 2011-02-02
PCT/US2012/023632 WO2012106516A1 (en) 2011-02-02 2012-02-02 Microorganisms and methods for the biosynthesis of butadiene

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MX2013008988A MX2013008988A (es) 2014-03-21
MX348334B true MX348334B (es) 2017-06-07

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US (4) US9321701B2 (es)
EP (1) EP2670852A4 (es)
JP (3) JP5960729B2 (es)
KR (1) KR20140145935A (es)
CN (2) CN103459602B (es)
AU (1) AU2012212118B2 (es)
BR (1) BR112013019811A2 (es)
CA (1) CA2826293A1 (es)
MX (1) MX348334B (es)
MY (2) MY162964A (es)
PH (1) PH12013501630A1 (es)
SG (1) SG192614A1 (es)
WO (1) WO2012106516A1 (es)

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BR112012014062A2 (pt) 2009-12-10 2017-04-04 Genomatica Inc organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo
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