JP5960729B2 - ブタジエンの生合成のための微生物および方法 - Google Patents
ブタジエンの生合成のための微生物および方法 Download PDFInfo
- Publication number
- JP5960729B2 JP5960729B2 JP2013552630A JP2013552630A JP5960729B2 JP 5960729 B2 JP5960729 B2 JP 5960729B2 JP 2013552630 A JP2013552630 A JP 2013552630A JP 2013552630 A JP2013552630 A JP 2013552630A JP 5960729 B2 JP5960729 B2 JP 5960729B2
- Authority
- JP
- Japan
- Prior art keywords
- coa
- butadiene
- reductase
- pathway
- crotonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *CC(***C1)C1O Chemical compound *CC(***C1)C1O 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/20—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms
- C07C1/24—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as heteroatoms by elimination of water
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01036—Acetoacetyl-CoA reductase (1.1.1.36)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01008—Acyl-CoA dehydrogenase (NADP+) (1.3.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/08—Oxidoreductases acting on the CH-CH group of donors (1.3) with flavin as acceptor (1.3.8)
- C12Y103/08006—Glutaryl-CoA dehydrogenase (1.3.8.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
- C12Y103/99032—Glutaryl-CoA dehydrogenase (non-decarboxylating) (1.3.99.32)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/0107—Glutaconyl-CoA decarboxylase (4.1.1.70)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01055—3-Hydroxybutyryl-CoA dehydratase (4.2.1.55)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/0112—4-Hydroxybutanoyl-CoA dehydratase (4.2.1.120)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01014—3-Aminobutyryl-CoA ammonia-lyase (4.3.1.14)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2521/00—Catalysts comprising the elements, oxides or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium or hafnium
- C07C2521/02—Boron or aluminium; Oxides or hydroxides thereof
- C07C2521/04—Alumina
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2521/00—Catalysts comprising the elements, oxides or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium or hafnium
- C07C2521/12—Silica and alumina
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2521/00—Catalysts comprising the elements, oxides or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium or hafnium
- C07C2521/16—Clays or other mineral silicates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
- C07C2523/10—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of rare earths
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
- C07C2523/16—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- C07C2523/24—Chromium, molybdenum or tungsten
- C07C2523/28—Molybdenum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
- C07C2523/16—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- C07C2523/24—Chromium, molybdenum or tungsten
- C07C2523/31—Chromium, molybdenum or tungsten combined with bismuth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
- C07C2523/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of the iron group metals or copper
- C07C2523/74—Iron group metals
- C07C2523/745—Iron
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2527/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- C07C2527/14—Phosphorus; Compounds thereof
- C07C2527/16—Phosphorus; Compounds thereof containing oxygen
- C07C2527/167—Phosphates or other compounds comprising the anion (PnO3n+1)(n+2)-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2527/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- C07C2527/14—Phosphorus; Compounds thereof
- C07C2527/16—Phosphorus; Compounds thereof containing oxygen
- C07C2527/167—Phosphates or other compounds comprising the anion (PnO3n+1)(n+2)-
- C07C2527/173—Phosphoric acid or other acids with the formula Hn+2PnO3n+1
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438947P | 2011-02-02 | 2011-02-02 | |
| US61/438,947 | 2011-02-02 | ||
| PCT/US2012/023632 WO2012106516A1 (en) | 2011-02-02 | 2012-02-02 | Microorganisms and methods for the biosynthesis of butadiene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Division JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504508A JP2014504508A (ja) | 2014-02-24 |
| JP2014504508A5 JP2014504508A5 (enExample) | 2015-03-26 |
| JP5960729B2 true JP5960729B2 (ja) | 2016-08-02 |
Family
ID=46603080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552630A Expired - Fee Related JP5960729B2 (ja) | 2011-02-02 | 2012-02-02 | ブタジエンの生合成のための微生物および方法 |
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9321701B2 (enExample) |
| EP (1) | EP2670852A4 (enExample) |
| JP (3) | JP5960729B2 (enExample) |
| KR (1) | KR20140145935A (enExample) |
| CN (2) | CN103459602B (enExample) |
| AU (1) | AU2012212118B2 (enExample) |
| BR (1) | BR112013019811A2 (enExample) |
| CA (1) | CA2826293A1 (enExample) |
| MX (1) | MX348334B (enExample) |
| MY (2) | MY162964A (enExample) |
| PH (1) | PH12013501630A1 (enExample) |
| SG (1) | SG192614A1 (enExample) |
| WO (1) | WO2012106516A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024257686A1 (ja) | 2023-06-15 | 2024-12-19 | 株式会社Co2資源化研究所 | クロチルアルコールを生成するヒドロゲノフィラス属細菌形質転換体 |
| WO2025142753A1 (ja) | 2023-12-27 | 2025-07-03 | 株式会社Co2資源化研究所 | クロトンアルデヒド-クロチルアルコールデヒドロゲナーゼ変異体 |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2304039B1 (en) | 2008-06-17 | 2019-08-21 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| CA2783096A1 (en) | 2009-12-10 | 2011-06-16 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
| JP5911847B2 (ja) | 2010-05-05 | 2016-04-27 | ジェノマティカ, インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| WO2012106516A1 (en) * | 2011-02-02 | 2012-08-09 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| BR112013032516A2 (pt) | 2011-06-17 | 2017-03-01 | Invista Tech Sarl | método de biosintetizar butadieno e método para produzir butadieno |
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| AU2012324935B2 (en) * | 2011-10-19 | 2016-01-14 | Scientist Of Fortune S.A. | Process for the enzymatic production of butadiene from crotyl alcohol |
| WO2013071074A1 (en) * | 2011-11-11 | 2013-05-16 | Invista North America S.A. R.L. | Methods of producing butadiene |
| US9777295B2 (en) | 2012-11-28 | 2017-10-03 | Invista North America S.A.R.L. | Methods for biosynthesis of isobutene |
| AU2013354180B2 (en) | 2012-12-07 | 2017-05-11 | Global Bioenergies | Fermentative production of a hydrocarbon |
| WO2014086780A2 (en) | 2012-12-07 | 2014-06-12 | Global Bioenergies | Improved fermentation method |
| JP2014161252A (ja) * | 2013-02-22 | 2014-09-08 | Sekisui Chem Co Ltd | 組換え細胞 |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| EP3030668A1 (en) | 2013-08-05 | 2016-06-15 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
| CN105683385A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异戊二烯的方法 |
| WO2015084633A1 (en) | 2013-12-03 | 2015-06-11 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CN118879602A (zh) | 2013-12-27 | 2024-11-01 | 基因组股份公司 | 具有增加的碳通量效率的方法和生物 |
| US20170152531A1 (en) | 2014-06-16 | 2017-06-01 | North America S.A.R.L. | Process for producing glutarate and glutaric acid methyl ester |
| WO2016004334A1 (en) | 2014-07-03 | 2016-01-07 | Genomatica, Inc. | Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto |
| WO2016007196A1 (en) * | 2014-07-07 | 2016-01-14 | Cobalt Technologies, Inc. | Biomass conversion to butadiene |
| BR112017005665A2 (pt) | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
| CN104298866B (zh) * | 2014-09-30 | 2017-06-06 | 杭州电子科技大学 | 一种克劳斯硫磺回收过程中反应炉动态建模方法 |
| WO2016066869A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Catalizador microporoso con encapsulación selectiva de óxidos metálicos útil para producir precursores de butadieno |
| WO2016066873A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Óxidos mixtos que comprenden magnesio y boro, y su uso como catalizadores para producir precursores de butadieno |
| CN107108397B (zh) * | 2015-02-23 | 2021-07-27 | 维尔萨利斯股份公司 | 用于生产二烯烃的方法 |
| BR112017021667A2 (pt) | 2015-04-09 | 2018-07-24 | Genomatica Inc | microorganismos modificados & métodos para produção aperfeiçoada de álcool de crotila |
| CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
| EP3341471A4 (en) * | 2015-08-24 | 2020-07-22 | White Dog Labs, Inc. | MICROBIAL ORGANISMS FOR CONVERTING ACETYL-COA IN CROTYL ALCOHOL AND METHOD FOR PRODUCING CROTYL ALCOHOL |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| KR101929631B1 (ko) | 2016-12-20 | 2018-12-14 | 서강대학교산학협력단 | 미생물 발효를 이용한 1,3-부타디엔의 제조 방법 |
| EA201891926A1 (ru) * | 2017-02-03 | 2019-04-30 | Киверди, Инк. | Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1 |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| WO2019022083A1 (ja) * | 2017-07-24 | 2019-01-31 | 国立研究開発法人理化学研究所 | デカルボキシラーゼ、及びそれを用いた不飽和炭化水素化合物の製造方法 |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| CN113166784A (zh) | 2018-06-26 | 2021-07-23 | 基因组股份公司 | 包括具有合成或增强的甲基营养的那些工程微生物的、具有g3p→3pg酶和/或果糖-1,6-二磷酸酶的工程微生物 |
| US20220282265A1 (en) * | 2019-08-12 | 2022-09-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of 3-amino-4-hydroxybenzoic acid by fermentation |
| EP4050068B1 (en) | 2019-10-24 | 2025-01-29 | Shin-Etsu Chemical Co., Ltd. | Thermally conductive silicone composition and production method therefor |
| MX2023011547A (es) | 2021-04-01 | 2023-10-30 | Synthos Dwory 7 Spolka Z Ograniczona Odpowiedzialnoscia | Procedimiento conducido adiabaticamente para la produccion de 1,3-butadieno a partir de mezclas de etanol y acetaldehido. |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB525198A (en) | 1938-03-21 | 1940-08-23 | Melle Usines Sa | Improvements in or relating to the preparation of di-olefines |
| EP0633319B1 (en) | 1988-04-27 | 1999-03-17 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| EP1147229A2 (en) | 1999-02-02 | 2001-10-24 | Bernhard O. Palsson | Methods for identifying drug targets based on genomic sequence data |
| US7711490B2 (en) | 2001-01-10 | 2010-05-04 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| EP1381860A4 (en) | 2001-03-01 | 2008-10-15 | Univ California | MODELS AND METHOD FOR DETERMINING SYSTEMIC PROPERTIES OF REGULATED RESPONSE NETWORKS |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| JP2005521929A (ja) | 2002-03-29 | 2005-07-21 | ジェノマティカ・インコーポレイテッド | ヒト代謝モデルおよび方法 |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| JP4418793B2 (ja) | 2002-07-10 | 2010-02-24 | ザ ペン ステート リサーチ ファウンデーション | 遺伝子ノックアウト戦略を決定する方法 |
| JP5064656B2 (ja) | 2002-10-15 | 2012-10-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 実施反応経路を同定するための方法およびシステム |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| TWI568847B (zh) | 2007-03-16 | 2017-02-01 | 奇諾麥提卡公司 | 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法 |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| US7981647B2 (en) * | 2008-03-03 | 2011-07-19 | Joule Unlimited, Inc. | Engineered CO2 fixing microorganisms producing carbon-based products of interest |
| WO2009132220A2 (en) | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| US20110190513A1 (en) * | 2008-07-08 | 2011-08-04 | Lynch Michael D | Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol |
| BRPI0918453A2 (pt) | 2008-09-15 | 2019-12-17 | Danisco Us Inc | sistemas usando cultura de células para a produção de isopreno |
| KR102115497B1 (ko) * | 2009-04-30 | 2020-05-26 | 게노마티카 인코포레이티드 | 1,3-부탄다이올 생산 유기체 |
| JP5787360B2 (ja) | 2009-10-30 | 2015-09-30 | 株式会社ダイセル | 1,3−ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用 |
| JP5911847B2 (ja) * | 2010-05-05 | 2016-04-27 | ジェノマティカ, インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| JP5907072B2 (ja) * | 2010-12-17 | 2016-04-20 | 三菱化学株式会社 | 合成経路作成装置、合成経路作成方法及び合成経路作成プログラム |
| WO2012106516A1 (en) * | 2011-02-02 | 2012-08-09 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| US9169486B2 (en) * | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
-
2012
- 2012-02-02 WO PCT/US2012/023632 patent/WO2012106516A1/en not_active Ceased
- 2012-02-02 MY MYPI2013701358A patent/MY162964A/en unknown
- 2012-02-02 PH PH1/2013/501630A patent/PH12013501630A1/en unknown
- 2012-02-02 EP EP12742132.9A patent/EP2670852A4/en not_active Withdrawn
- 2012-02-02 SG SG2013059167A patent/SG192614A1/en unknown
- 2012-02-02 CA CA2826293A patent/CA2826293A1/en not_active Abandoned
- 2012-02-02 US US13/365,132 patent/US9321701B2/en active Active
- 2012-02-02 AU AU2012212118A patent/AU2012212118B2/en not_active Ceased
- 2012-02-02 KR KR1020137023026A patent/KR20140145935A/ko not_active Ceased
- 2012-02-02 JP JP2013552630A patent/JP5960729B2/ja not_active Expired - Fee Related
- 2012-02-02 CN CN201280016837.4A patent/CN103459602B/zh not_active Expired - Fee Related
- 2012-02-02 MX MX2013008988A patent/MX348334B/es active IP Right Grant
- 2012-02-02 CN CN201610552260.9A patent/CN106191132A/zh active Pending
- 2012-02-02 BR BR112013019811A patent/BR112013019811A2/pt not_active Application Discontinuation
-
2013
- 2013-08-01 MY MYPI2017702592A patent/MY179664A/en unknown
-
2016
- 2016-03-23 US US15/078,437 patent/US20170044572A1/en not_active Abandoned
- 2016-06-23 JP JP2016124920A patent/JP2016192974A/ja active Pending
-
2018
- 2018-03-09 US US15/917,411 patent/US20190048366A1/en not_active Abandoned
- 2018-06-27 JP JP2018122381A patent/JP2018166514A/ja active Pending
-
2020
- 2020-06-25 US US16/912,409 patent/US20210147881A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024257686A1 (ja) | 2023-06-15 | 2024-12-19 | 株式会社Co2資源化研究所 | クロチルアルコールを生成するヒドロゲノフィラス属細菌形質転換体 |
| WO2025142753A1 (ja) | 2023-12-27 | 2025-07-03 | 株式会社Co2資源化研究所 | クロトンアルデヒド-クロチルアルコールデヒドロゲナーゼ変異体 |
Also Published As
| Publication number | Publication date |
|---|---|
| MY162964A (en) | 2017-07-31 |
| CA2826293A1 (en) | 2012-08-09 |
| JP2016192974A (ja) | 2016-11-17 |
| US20120225466A1 (en) | 2012-09-06 |
| KR20140145935A (ko) | 2014-12-24 |
| JP2018166514A (ja) | 2018-11-01 |
| EP2670852A4 (en) | 2017-04-26 |
| US20170044572A1 (en) | 2017-02-16 |
| CN103459602A (zh) | 2013-12-18 |
| MX348334B (es) | 2017-06-07 |
| MY179664A (en) | 2020-11-11 |
| PH12013501630A1 (en) | 2014-01-06 |
| AU2012212118A1 (en) | 2013-05-02 |
| US20210147881A1 (en) | 2021-05-20 |
| MX2013008988A (es) | 2014-03-21 |
| WO2012106516A1 (en) | 2012-08-09 |
| US20190048366A1 (en) | 2019-02-14 |
| CN103459602B (zh) | 2016-08-10 |
| BR112013019811A2 (pt) | 2017-02-21 |
| JP2014504508A (ja) | 2014-02-24 |
| US9321701B2 (en) | 2016-04-26 |
| SG192614A1 (en) | 2013-09-30 |
| CN106191132A (zh) | 2016-12-07 |
| EP2670852A1 (en) | 2013-12-11 |
| AU2012212118B2 (en) | 2015-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5911847B2 (ja) | ブタジエンの生合成のための微生物および方法 | |
| US20210147881A1 (en) | Microorganisms and methods for the biosynthesis of butadiene | |
| US20160244786A1 (en) | Microorganisms for producing butadiene and methods related thereto | |
| AU2013203173B2 (en) | Microorganisms and methods for the biosynthesis of butadiene | |
| AU2019204872A1 (en) | Microorganisms and methods for the biosynthesis of butadiene | |
| AU2013202446A1 (en) | Microorganisms and methods for the biosynthesis of butadiene |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150202 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150202 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160126 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160426 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160524 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160623 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5960729 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |