KR20180005263A - 부타디엔을 생합성하기 위한 미생물 및 방법 - Google Patents

부타디엔을 생합성하기 위한 미생물 및 방법 Download PDF

Info

Publication number
KR20180005263A
KR20180005263A KR1020177037394A KR20177037394A KR20180005263A KR 20180005263 A KR20180005263 A KR 20180005263A KR 1020177037394 A KR1020177037394 A KR 1020177037394A KR 20177037394 A KR20177037394 A KR 20177037394A KR 20180005263 A KR20180005263 A KR 20180005263A
Authority
KR
South Korea
Prior art keywords
coa
butadiene
reductase
kinase
crotyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020177037394A
Other languages
English (en)
Korean (ko)
Inventor
마크 제이. 버크
안소니 피. 버르가드
준 순
로빈 이. 오스터후트
프리티 파르크야
Original Assignee
게노마티카 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게노마티카 인코포레이티드 filed Critical 게노마티카 인코포레이티드
Publication of KR20180005263A publication Critical patent/KR20180005263A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/12—Alkadienes
    • C07C11/16—Alkadienes with four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F136/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
    • C08F136/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
    • C08F136/04—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
    • C08F136/06—Butadiene
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020177037394A 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법 Ceased KR20180005263A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33181210P 2010-05-05 2010-05-05
US61/331,812 2010-05-05
PCT/US2011/035105 WO2011140171A2 (en) 2010-05-05 2011-05-04 Microorganisms and methods for the biosynthesis of butadiene

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020127031134A Division KR101814648B1 (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197001071A Division KR20190006103A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Publications (1)

Publication Number Publication Date
KR20180005263A true KR20180005263A (ko) 2018-01-15

Family

ID=45064763

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020177037394A Ceased KR20180005263A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020197001071A Ceased KR20190006103A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020127031134A Active KR101814648B1 (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020197001071A Ceased KR20190006103A (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법
KR1020127031134A Active KR101814648B1 (ko) 2010-05-05 2011-05-04 부타디엔을 생합성하기 위한 미생물 및 방법

Country Status (13)

Country Link
US (5) US8580543B2 (enExample)
EP (1) EP2566969B1 (enExample)
JP (3) JP5911847B2 (enExample)
KR (3) KR20180005263A (enExample)
CN (2) CN103080324B (enExample)
AU (2) AU2011248182A1 (enExample)
BR (1) BR112012028049A2 (enExample)
CA (1) CA2797409C (enExample)
CO (1) CO6630182A2 (enExample)
MX (1) MX336229B (enExample)
SG (2) SG10201503501TA (enExample)
TW (2) TWI575072B (enExample)
WO (1) WO2011140171A2 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
JP2012529889A (ja) 2009-06-10 2012-11-29 ゲノマチカ， インク． Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法
CN109136161A (zh) 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
MX336229B (es) * 2010-05-05 2016-01-08 Genomatica Inc Microorganismos y metodos para la biosintesis de butadieno.
JP2013535203A (ja) 2010-07-26 2013-09-12 ジェノマティカ・インコーポレイテッド 芳香族、２，４−ペンタジエノエートおよび１，３−ブタジエンを生合成するための微生物および方法
MX348334B (es) * 2011-02-02 2017-06-07 Genomatica Inc Microorganismo y metodos para la biosintesis de butadieno.
WO2013188546A2 (en) * 2012-06-15 2013-12-19 Invista Technologies S.À.R.L. Methods for biosynthesizing 1,3 butadiene
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
US9663801B2 (en) 2011-06-17 2017-05-30 Invista North America S.A.R.L. Methods of producing four carbon molecules
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
SG11201400113XA (en) * 2011-08-19 2014-08-28 Genomatica Inc Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols
BR112014008061A2 (pt) * 2011-10-19 2017-04-11 Scientist Of Fortune Sa método para a produção enzimática de butadieno
DK2776571T3 (en) 2011-11-09 2017-06-26 Amyris Inc PREPARATION OF ACETYL-COENZYM A-DERIVED ISOPRENOIDS
CN104321434A (zh) * 2011-12-02 2015-01-28 英威达技术有限责任公司 生物合成1,3丁二烯的方法
EP2791342B1 (en) * 2011-12-16 2020-04-29 Braskem S.A. Modified microorganisms and methods of making butadiene using same
EP2794891A2 (en) * 2011-12-20 2014-10-29 Scientist of Fortune S.A. Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates
US20150017698A1 (en) * 2012-03-02 2015-01-15 Codexis, Inc. a corporation Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
WO2013130481A1 (en) * 2012-03-02 2013-09-06 Codexis, Inc. Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
US20150152440A1 (en) * 2012-06-18 2015-06-04 Braskem S.A. Modified microorganisms and methods of co-producing butadiene with 1-propanol and/or 1,2-propanediol
BR112015004488A2 (pt) * 2012-08-28 2018-11-21 Braskem Sa método de coprodução de um terpeno e pelo menos um coproduto a partir de uma fonte de carbono fermentável
WO2014052630A1 (en) 2012-09-27 2014-04-03 Novozymes, Inc. Bacterial mutants with improved transformation efficiency
WO2014055649A1 (en) * 2012-10-02 2014-04-10 Braskem S/A Ap 09 Modified microorganisms and methods of using same for producing butadiene and succinate
WO2014063156A2 (en) * 2012-10-19 2014-04-24 Braskem S/A Ap 09 Modified microorganisms and methods of using same for producing butadiene and one or more of 1,3-butanediol, 1,4-butanediol, and/or 1,3-propanediol
US11535874B2 (en) * 2012-10-22 2022-12-27 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
EP2920314A1 (en) * 2012-11-13 2015-09-23 Global Bioenergies Process for the enzymatic preparation of isoprene from isoprenol
WO2014081973A1 (en) * 2012-11-21 2014-05-30 The Regents Of The University Of California Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic archaea
CN104903455A (zh) 2012-11-28 2015-09-09 英威达技术有限责任公司 用于异丁烯生物合成的方法
JP6304924B2 (ja) * 2012-11-29 2018-04-04 住友ゴム工業株式会社 サイドウォール用ゴム組成物、及び空気入りタイヤ
WO2014089025A1 (en) * 2012-12-04 2014-06-12 Genomatica, Inc. Increased yields of biosynthesized products
WO2014106122A1 (en) * 2012-12-31 2014-07-03 Genomatica, Inc. Compositions and methods for bio-butadiene production screening
JP2014155455A (ja) * 2013-02-15 2014-08-28 Sekisui Chem Co Ltd 組換え細胞、並びに、クロトニルＣｏＡ又はクロチルアルコールの生産方法
JP2014161252A (ja) * 2013-02-22 2014-09-08 Sekisui Chem Co Ltd 組換え細胞
EP2971021A4 (en) 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION
ES2728307T3 (es) 2013-06-21 2019-10-23 Danisco Us Inc Composiciones y métodos para la transformación clostridial
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
EP3030668A1 (en) 2013-08-05 2016-06-15 Invista Technologies S.A R.L. Methods for biosynthesis of isobutene
CN105683385A (zh) 2013-08-05 2016-06-15 英威达技术有限责任公司 用于生物合成异戊二烯的方法
PL3077501T3 (pl) 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa
WO2015100338A2 (en) 2013-12-27 2015-07-02 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
WO2015147644A1 (en) * 2014-03-27 2015-10-01 Photanol B.V. Erythritol production in cyanobacteria
CN106795519A (zh) 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生成戊二酸和戊二酸甲酯的方法
US10487342B2 (en) 2014-07-11 2019-11-26 Genomatica, Inc. Microorganisms and methods for the production of butadiene using acetyl-CoA
EP3741865B1 (en) 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
CN104298866B (zh) * 2014-09-30 2017-06-06 杭州电子科技大学 一种克劳斯硫磺回收过程中反应炉动态建模方法
JP6432774B2 (ja) * 2014-12-25 2018-12-05 江南化工株式会社 細胞賦活剤
MX387737B (es) 2015-02-27 2025-03-18 White Dog Labs Inc Método de fermentación mixotrófica para producir acetona, isopropanol, acido butírico y otros bioproductos, y mezclas de los mismos.
WO2016160812A1 (en) * 2015-03-31 2016-10-06 White Dog Labs, Inc. Method of producing bioproducts
KR20170134682A (ko) * 2015-04-09 2017-12-06 게노마티카 인코포레이티드 향상된 크로틸 알코올 생성을 위한 유전자조작 미생물 및 방법
CN108026214B (zh) 2015-05-30 2021-03-02 基因组股份公司 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用
WO2017064606A1 (en) * 2015-10-12 2017-04-20 Reliance Industries Limited Process for preparation of 1,3-butadiene
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
GB201605354D0 (en) 2016-03-30 2016-05-11 Zuvasyntha Ltd Modified enzyme
US10919030B2 (en) 2016-09-30 2021-02-16 Regents Of The University Of Minnesota Forming dienes from cyclic ethers and diols, including tetrahydrofuran and 2-methyl-1,4-butanediol
JP6317497B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 トレッド用ゴム組成物、及び空気入りタイヤ
JP6317498B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 スタッドレスタイヤ用トレッド用ゴム組成物、及びスタッドレスタイヤ
JP2020512351A (ja) * 2017-03-31 2020-04-23 ジェノマティカ， インコーポレイテッド 発酵ブロスから１，３−ブタンジオールを取得するためのプロセスおよびシステム
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
WO2019006257A1 (en) 2017-06-30 2019-01-03 Invista North America .S.A.R.L. METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3814515A2 (en) 2018-06-26 2021-05-05 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
US20220258100A1 (en) * 2019-07-16 2022-08-18 San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation Products of manufacture and methods for methane capturing using biofiltration

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076948A (en) 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
US3513209A (en) 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
GB1230276A (enExample) 1968-12-09 1971-04-28
US3965182A (en) 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (enExample) 1972-06-28 1980-11-07
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
ES2036188T3 (es) 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
US5143834A (en) 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
US5182199A (en) 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
JPH01195596A (ja) 1988-01-30 1989-08-07 Casio Comput Co Ltd 値札システム
US5219757A (en) 1988-04-27 1993-06-15 Daicel Chemical Industries, Ltd. Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone
CA2062753C (en) 1989-04-27 2005-04-26 N. Robert Ward, Jr. Precipitate test for microorganisms
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
EP0769557B1 (en) 1990-10-15 2000-11-15 Daicel Chemical Industries, Ltd. Process for producing optically active 1,3-butanediol
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) * 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
FR2736927B1 (fr) 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
JP2000506012A (ja) 1996-02-27 2000-05-23 ミシガン ステイト ユニヴァーシティー サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
JP4101295B2 (ja) 1996-07-01 2008-06-18 バイオエンジニアリング・リソーシズ・インコーポレーテツド 廃ガスからの酢酸の生物学的生産
KR100459818B1 (ko) 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
US6117658A (en) 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE19820652A1 (de) 1998-05-08 1999-11-11 Basf Ag Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
WO2000004163A1 (en) 1998-07-15 2000-01-27 E.I. Du Pont De Nemours And Company Tetrahydrofolate metabolism enzymes
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
WO2000046405A2 (en) 1999-02-02 2000-08-10 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
US6448473B1 (en) 1999-03-05 2002-09-10 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
CA2374482C (en) 1999-05-21 2012-09-18 Cargill Dow Llc Methods and materials for the synthesis of organic products
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
NZ523484A (en) 2000-07-25 2005-01-28 Emmaus Foundation Inc Methods for increasing the production of ethanol from microbial fermentation
JP4490628B2 (ja) 2000-11-20 2010-06-30 カーギル インコーポレイテッド ３−ヒドロキシプロピオン酸および他の有機化合物
US7109010B2 (en) 2000-11-22 2006-09-19 Nature Works Llc Methods and materials for the synthesis of organic products
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
US7501268B2 (en) 2000-12-28 2009-03-10 Toyota Jidosha Kabushiki Kaisha Methods of producing prenyl alcohols
CA2434224C (en) 2001-01-10 2013-04-02 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
US20030059792A1 (en) 2001-03-01 2003-03-27 Palsson Bernhard O. Models and methods for determining systemic properties of regulated reaction networks
US6743610B2 (en) 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
JP4630486B2 (ja) 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
CA2466133A1 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
WO2003066863A1 (fr) 2002-02-06 2003-08-14 Showa Denko K.K. Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
US20050287655A1 (en) 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
AU2003222214B2 (en) 2002-10-15 2010-08-12 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
AU2003287625A1 (en) 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
CN1802341A (zh) 2003-01-13 2006-07-12 卡吉尔公司 制备工业化学品的方法
US7432091B2 (en) 2003-02-24 2008-10-07 Research Institute Of Innovative Technology For The Earth Highly efficient hydrogen production method using microorganism
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
WO2005010182A1 (ja) 2003-07-29 2005-02-03 Research Institute Of Innovative Technology For The Earth コリネ型細菌形質転換体及びそれを用いるジカルボン酸の製造方法
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026349A1 (ja) 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
US7244610B2 (en) 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
CN1926240B (zh) 2004-01-19 2010-06-02 帝斯曼知识产权资产管理有限公司 6-氨基己酸的生物化学合成
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
US7262046B2 (en) 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
JP2008510485A (ja) * 2004-08-26 2008-04-10 ザ ペン ステイト リサーチ ファウンデーション 微生物産生系の再設計法
CN101044245B (zh) 2004-08-27 2012-05-02 莱斯大学 具有增加的琥珀酸产量的突变大肠杆菌菌株
EP2434015B1 (en) 2004-09-09 2013-11-20 Research Institute Of Innovative Technology For The Earth DNA fragment having promoter function
EP1789569A2 (en) 2004-09-17 2007-05-30 Rice University High succinate producing bacteria
EP1801227B1 (en) 2004-10-14 2009-04-15 Sumitomo Chemical Company, Limited Method for producing 2-hydroxy-4-(methylthio)butanoic acid
US7569380B2 (en) 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
DE102005002127A1 (de) * 2005-01-17 2006-07-20 Basf Ag Verfahren zur Herstellung von Butadien aus n-Butan
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
EP1874334A4 (en) 2005-04-15 2011-03-30 Vascular Biogenics Ltd COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
GB2433260A (en) 2005-12-16 2007-06-20 Mologic Ltd A selectable decarboxylase marker
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
AU2008206403A1 (en) 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
CA2678946C (en) 2007-03-16 2019-02-12 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
EP2147111A4 (en) 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US20080274522A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
CN101970673A (zh) 2007-07-23 2011-02-09 帝斯曼知识产权资产管理有限公司 真核细胞中的丁醇生产
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
AU2008310573A1 (en) 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
BRPI0823506A8 (pt) * 2007-12-13 2018-05-15 Danisco Us Inc Genencor Div composições e métodos para a produção de isoprene
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CN102015995B (zh) * 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
SI2265709T1 (en) 2008-03-27 2018-03-30 Genomatica, Inc. MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
JP2011519561A (ja) 2008-05-01 2011-07-14 ジェノマティカ， インコーポレイテッド メタクリル酸の産生のための微生物
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
SG167485A1 (en) 2008-06-30 2011-01-28 Danisco Us Inc Polymers of isoprene from renewable resources
EP2313491A4 (en) 2008-07-08 2011-12-07 Opx Biotechnologies Inc METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL
WO2010022763A1 (en) 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CA2737082A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
WO2010031079A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Systems using cell culture for production of isoprene
US8357826B2 (en) 2008-10-16 2013-01-22 Karl Kharas Methods and apparatus for synthesis of alcohols from syngas
EP3260532A1 (en) 2008-12-12 2017-12-27 CJ Research Center LLC Green process and compositions for producing poly(5hv) and 5 carbon chemicals
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
BRPI1013426A2 (pt) * 2009-04-30 2016-11-08 Genomatica Inc organismos para produção de 1,3-butanodiol
SI3392340T1 (sl) 2009-06-04 2022-05-31 Genomatica, Inc. Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoči postopki
US20120276606A1 (en) 2009-10-30 2012-11-01 Daicel Corporation Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof
CN109136161A (zh) 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
MX336229B (es) 2010-05-05 2016-01-08 Genomatica Inc Microorganismos y metodos para la biosintesis de butadieno.
MX348334B (es) * 2011-02-02 2017-06-07 Genomatica Inc Microorganismo y metodos para la biosintesis de butadieno.
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
BR112014008061A2 (pt) * 2011-10-19 2017-04-11 Scientist Of Fortune Sa método para a produção enzimática de butadieno
US20150050708A1 (en) * 2013-03-15 2015-02-19 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
EP2971021A4 (en) * 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION

Also Published As

Publication number Publication date
US20110300597A1 (en) 2011-12-08
EP2566969B1 (en) 2019-09-04
CA2797409A1 (en) 2011-11-10
CO6630182A2 (es) 2013-03-01
US10487343B2 (en) 2019-11-26
US9732361B2 (en) 2017-08-15
JP2013524853A (ja) 2013-06-20
MX2012012827A (es) 2013-01-24
EP2566969A2 (en) 2013-03-13
AU2016201231A1 (en) 2016-03-17
US8580543B2 (en) 2013-11-12
WO2011140171A3 (en) 2012-04-26
US20140155567A1 (en) 2014-06-05
JP2018196387A (ja) 2018-12-13
TW201720931A (zh) 2017-06-16
US20200299736A1 (en) 2020-09-24
CA2797409C (en) 2019-12-24
TWI575072B (zh) 2017-03-21
BR112012028049A2 (pt) 2015-11-24
SG185432A1 (en) 2012-12-28
WO2011140171A2 (en) 2011-11-10
JP2016154551A (ja) 2016-09-01
KR101814648B1 (ko) 2018-01-04
CN106047782A (zh) 2016-10-26
KR20130062939A (ko) 2013-06-13
JP5911847B2 (ja) 2016-04-27
MX336229B (es) 2016-01-08
EP2566969A4 (en) 2014-01-15
AU2011248182A1 (en) 2012-11-15
TW201139683A (en) 2011-11-16
KR20190006103A (ko) 2019-01-16
CN103080324A (zh) 2013-05-01
SG10201503501TA (en) 2015-06-29
CN103080324B (zh) 2019-03-08
US20180155742A1 (en) 2018-06-07
US20220025411A1 (en) 2022-01-27

Similar Documents

Publication Publication Date Title
KR101814648B1 (ko) 부타디엔을 생합성하기 위한 미생물 및 방법
US20210147881A1 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2013203173B2 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2019204872A1 (en) Microorganisms and methods for the biosynthesis of butadiene
AU2013202445A1 (en) Microorganisms and methods for the biosynthesis of butadiene

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20171227

Application number text: 1020127031134

Filing date: 20121128

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20180126

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180409

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20181012

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180409

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190111

Application number text: 1020127031134

Filing date: 20121128