JP2013520986A5 - - Google Patents
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- Publication number
- JP2013520986A5 JP2013520986A5 JP2012555542A JP2012555542A JP2013520986A5 JP 2013520986 A5 JP2013520986 A5 JP 2013520986A5 JP 2012555542 A JP2012555542 A JP 2012555542A JP 2012555542 A JP2012555542 A JP 2012555542A JP 2013520986 A5 JP2013520986 A5 JP 2013520986A5
- Authority
- JP
- Japan
- Prior art keywords
- galactosidase
- multimeric protein
- protein structure
- activity
- exposed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 57
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 57
- 102000004169 proteins and genes Human genes 0.000 claims 45
- 108090000623 proteins and genes Proteins 0.000 claims 45
- 230000000694 effects Effects 0.000 claims 30
- 230000002132 lysosomal effect Effects 0.000 claims 14
- 230000007423 decrease Effects 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000004971 Cross linker Substances 0.000 claims 1
- 208000024720 Fabry Disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- -1 poly (alkylene glycol Chemical compound 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30948710P | 2010-03-02 | 2010-03-02 | |
| US61/309,487 | 2010-03-02 | ||
| PCT/IL2010/000956 WO2011061736A1 (en) | 2009-11-17 | 2010-11-17 | Alkaline alpha galactosidase for the treatment of fabry disease |
| ILPCT/IL2010/000956 | 2010-11-17 | ||
| US201161434499P | 2011-01-20 | 2011-01-20 | |
| US201161434503P | 2011-01-20 | 2011-01-20 | |
| US61/434,503 | 2011-01-20 | ||
| US61/434,499 | 2011-01-20 | ||
| PCT/IL2011/000209 WO2011107990A1 (en) | 2010-03-02 | 2011-03-02 | Stabilized alpha-galactosidase and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014160449A Division JP5871999B2 (ja) | 2010-03-02 | 2014-08-06 | 安定化α−ガラクトシダーゼおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013520986A JP2013520986A (ja) | 2013-06-10 |
| JP2013520986A5 true JP2013520986A5 (enExample) | 2014-04-17 |
| JP5758920B2 JP5758920B2 (ja) | 2015-08-05 |
Family
ID=44121635
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555542A Active JP5758920B2 (ja) | 2010-03-02 | 2011-03-02 | 安定化α−ガラクトシダーゼおよびその使用 |
| JP2014160449A Active JP5871999B2 (ja) | 2010-03-02 | 2014-08-06 | 安定化α−ガラクトシダーゼおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014160449A Active JP5871999B2 (ja) | 2010-03-02 | 2014-08-06 | 安定化α−ガラクトシダーゼおよびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| EP (3) | EP2542675B1 (enExample) |
| JP (2) | JP5758920B2 (enExample) |
| KR (1) | KR101928403B1 (enExample) |
| CN (1) | CN102933707B (enExample) |
| AU (1) | AU2011222452B2 (enExample) |
| BR (2) | BR112012022029B1 (enExample) |
| CA (1) | CA2791461C (enExample) |
| DK (1) | DK2865751T3 (enExample) |
| ES (2) | ES2708843T3 (enExample) |
| FI (1) | FIC20230032I1 (enExample) |
| FR (1) | FR23C1041I2 (enExample) |
| HR (1) | HRP20200428T1 (enExample) |
| HU (2) | HUE030959T2 (enExample) |
| IL (2) | IL221741A (enExample) |
| IN (1) | IN2012MN02262A (enExample) |
| NL (1) | NL301249I2 (enExample) |
| NO (1) | NO2023041I1 (enExample) |
| NZ (2) | NZ602317A (enExample) |
| PL (1) | PL2865751T3 (enExample) |
| SG (2) | SG183558A1 (enExample) |
| SI (1) | SI2865751T1 (enExample) |
| WO (1) | WO2011107990A1 (enExample) |
| ZA (1) | ZA201206725B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| BR112012022029B1 (pt) * | 2010-03-02 | 2022-10-11 | Protalix Ltd | Estrutura de proteina multimérica, seu uso e processo para preparação da estrutura de proteína multimérica |
| BR112013018516B1 (pt) * | 2011-01-20 | 2023-11-07 | Protalix Ltd | Construto de expressão de ácido nucleico, método de produção de uma proteína alfa-galactosidase humana recombinante, proteína alfagalactosidase humana, composição farmacêutica, e, uso de uma proteína alfagalactosidase humana ou de uma composição |
| TWI642782B (zh) * | 2013-10-23 | 2018-12-01 | 健臻公司 | 重組醣蛋白及其用途 |
| US20170360900A1 (en) * | 2014-12-22 | 2017-12-21 | Codexis, Inc. | Human alpha-galactosidase variants |
| WO2016116966A1 (en) * | 2015-01-22 | 2016-07-28 | Jcr Pharmaceuticals Co., Ltd. | Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins |
| PT3271453T (pt) | 2015-03-17 | 2021-11-29 | eleva GmbH | Proteínas lisossomais glicosiladas, método de produção e usos |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| MX2019008076A (es) * | 2017-01-05 | 2019-08-29 | Protalix Ltd | Regimen terapeutico para el tratamiento de fabry usando alfa-galactosidasa estabilizada. |
| WO2018225623A1 (ja) * | 2017-06-07 | 2018-12-13 | 天野エンザイム株式会社 | ラクターゼ原末及びラクターゼ製剤 |
| US11427813B2 (en) | 2018-12-20 | 2022-08-30 | Codexis, Inc. | Human alpha-galactosidase variants |
| JP2023516301A (ja) * | 2020-02-28 | 2023-04-19 | コデクシス， インコーポレイテッド | ヒトアルファ－ガラクトシダーゼ変異体 |
| KR20230110281A (ko) | 2020-11-03 | 2023-07-21 | 프로탈릭스 리미티드 | 변형된 유리카제(uricase) 및 이의 용도 |
| CN112176026A (zh) * | 2020-11-06 | 2021-01-05 | 诺道中科(北京)生物科技有限公司 | 一种α-半乳糖苷酶活性的检测试剂盒 |
| CN116254287B (zh) * | 2022-11-24 | 2024-06-04 | 西北农林科技大学 | 玉米ZmAGA3基因用于提高植物耐旱性的应用 |
| CN118243646B (zh) * | 2024-04-24 | 2025-01-24 | 武汉简为医疗科技有限公司 | 一种乳糖不耐受检测试剂盒及其使用方法 |
| JP7745040B1 (ja) * | 2024-06-21 | 2025-09-26 | デンカ株式会社 | 目的タンパク質の回収方法及び製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| CA2052728A1 (en) | 1991-10-03 | 1993-04-04 | Guy Ampleman | Glycidyl azide polymer |
| US6329191B1 (en) * | 1993-08-30 | 2001-12-11 | Hawaii Biotechnology Group, Inc. | DNA encoding recombinant coffee bean alpha-galactosidase |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| EP1956085A2 (en) * | 1997-09-05 | 2008-08-13 | Altus Pharmaceuticals Inc. | Carbohydrate crosslinked glycoprotein crystals |
| IL125423A (en) | 1998-07-20 | 2004-08-31 | Israel State | Alkaline alpha-galactosidase having broad substrate specificity |
| ATE303400T1 (de) * | 1999-04-02 | 2005-09-15 | Ajinomoto Kk | Vefahren zur herstellung von peptiduntereinheiten aus polymer-proteinen |
| EP1523548B1 (en) | 2002-05-15 | 2009-12-30 | Agricultural Research Organization | Polynucleotide sequences encoding alkaline a-galactosidases and methods of using same |
| US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| WO2006108052A2 (en) * | 2005-04-06 | 2006-10-12 | Genzyme Corporation | Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting |
| ES2547726T3 (es) * | 2005-11-18 | 2015-10-08 | Tokyo Metropolitan Institute Of Medical Science | Nueva enzima altamente funcional que tiene especificidad de sustrato modificada |
| US20100144008A1 (en) | 2006-12-21 | 2010-06-10 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Treatment of fabry disease |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| AU2008290217B2 (en) | 2007-08-20 | 2013-09-05 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| BR112012022029B1 (pt) * | 2010-03-02 | 2022-10-11 | Protalix Ltd | Estrutura de proteina multimérica, seu uso e processo para preparação da estrutura de proteína multimérica |
-
2011
- 2011-03-02 BR BR112012022029-2A patent/BR112012022029B1/pt active IP Right Grant
- 2011-03-02 SI SI201131048A patent/SI2865751T1/sl unknown
- 2011-03-02 EP EP11712340.6A patent/EP2542675B1/en active Active
- 2011-03-02 WO PCT/IL2011/000209 patent/WO2011107990A1/en not_active Ceased
- 2011-03-02 CN CN201180022145.6A patent/CN102933707B/zh active Active
- 2011-03-02 NZ NZ602317A patent/NZ602317A/en unknown
- 2011-03-02 NZ NZ623294A patent/NZ623294A/en unknown
- 2011-03-02 KR KR1020127025725A patent/KR101928403B1/ko active Active
- 2011-03-02 DK DK14195875.1T patent/DK2865751T3/en active
- 2011-03-02 ES ES16173953T patent/ES2708843T3/es active Active
- 2011-03-02 HU HUE14195875A patent/HUE030959T2/en unknown
- 2011-03-02 PL PL14195875T patent/PL2865751T3/pl unknown
- 2011-03-02 JP JP2012555542A patent/JP5758920B2/ja active Active
- 2011-03-02 BR BR122014021216-0A patent/BR122014021216A2/pt not_active Application Discontinuation
- 2011-03-02 EP EP14195875.1A patent/EP2865751B1/en active Active
- 2011-03-02 SG SG2012064580A patent/SG183558A1/en unknown
- 2011-03-02 SG SG10201502609QA patent/SG10201502609QA/en unknown
- 2011-03-02 CA CA2791461A patent/CA2791461C/en active Active
- 2011-03-02 IN IN2262MUN2012 patent/IN2012MN02262A/en unknown
- 2011-03-02 ES ES14195875.1T patent/ES2606532T3/es active Active
- 2011-03-02 EP EP16173953.7A patent/EP3088514B1/en active Active
- 2011-03-02 AU AU2011222452A patent/AU2011222452B2/en active Active
-
2012
- 2012-09-02 IL IL221741A patent/IL221741A/en active IP Right Grant
- 2012-09-07 ZA ZA2012/06725A patent/ZA201206725B/en unknown
-
2014
- 2014-08-06 JP JP2014160449A patent/JP5871999B2/ja active Active
-
2017
- 2017-06-29 IL IL253249A patent/IL253249B/en active IP Right Grant
-
2020
- 2020-03-16 HR HRP20200428TT patent/HRP20200428T1/hr unknown
-
2023
- 2023-10-31 HU HUS2300038C patent/HUS2300038I1/hu unknown
- 2023-11-01 NL NL301249C patent/NL301249I2/nl unknown
- 2023-11-01 NO NO2023041C patent/NO2023041I1/no unknown
- 2023-11-02 FI FIC20230032C patent/FIC20230032I1/fi unknown
- 2023-11-02 FR FR23C1041C patent/FR23C1041I2/fr active Active
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