CA2791461C - Stabilized alpha-galactosidase and uses thereof - Google Patents
Stabilized alpha-galactosidase and uses thereof Download PDFInfo
- Publication number
- CA2791461C CA2791461C CA2791461A CA2791461A CA2791461C CA 2791461 C CA2791461 C CA 2791461C CA 2791461 A CA2791461 A CA 2791461A CA 2791461 A CA2791461 A CA 2791461A CA 2791461 C CA2791461 C CA 2791461C
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- CA
- Canada
- Prior art keywords
- galactosidase
- alpha
- protein structure
- multimeric protein
- gal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30948710P | 2010-03-02 | 2010-03-02 | |
| US61/309,487 | 2010-03-02 | ||
| PCT/IL2010/000956 WO2011061736A1 (en) | 2009-11-17 | 2010-11-17 | Alkaline alpha galactosidase for the treatment of fabry disease |
| ILPCT/IL2010/000956 | 2010-11-17 | ||
| US201161434499P | 2011-01-20 | 2011-01-20 | |
| US201161434503P | 2011-01-20 | 2011-01-20 | |
| US61/434,499 | 2011-01-20 | ||
| US61/434,503 | 2011-01-20 | ||
| PCT/IL2011/000209 WO2011107990A1 (en) | 2010-03-02 | 2011-03-02 | Stabilized alpha-galactosidase and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2791461A1 CA2791461A1 (en) | 2011-09-09 |
| CA2791461C true CA2791461C (en) | 2019-10-22 |
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| CA2791461A Active CA2791461C (en) | 2010-03-02 | 2011-03-02 | Stabilized alpha-galactosidase and uses thereof |
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| JP (2) | JP5758920B2 (enExample) |
| KR (1) | KR101928403B1 (enExample) |
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| IN (1) | IN2012MN02262A (enExample) |
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| NO (1) | NO2023041I1 (enExample) |
| NZ (2) | NZ602317A (enExample) |
| PL (1) | PL2865751T3 (enExample) |
| SG (2) | SG10201502609QA (enExample) |
| SI (1) | SI2865751T1 (enExample) |
| WO (1) | WO2011107990A1 (enExample) |
| ZA (1) | ZA201206725B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| JP5758920B2 (ja) * | 2010-03-02 | 2015-08-05 | プロタリクス リミテッド | 安定化α−ガラクトシダーゼおよびその使用 |
| JP5913372B2 (ja) * | 2011-01-20 | 2016-04-27 | プロタリクス リミテッド | 植物および植物細胞におけるα−ガラクトシダーゼの発現のための核酸発現構築物 |
| TWI793159B (zh) * | 2013-10-23 | 2023-02-21 | 美商健臻公司 | 重組醣蛋白及其用途 |
| KR102702200B1 (ko) | 2014-12-22 | 2024-09-02 | 코덱시스, 인코포레이티드 | 인간 알파-갈락토시다제 변이체 |
| WO2016116966A1 (en) * | 2015-01-22 | 2016-07-28 | Jcr Pharmaceuticals Co., Ltd. | Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins |
| PL3271453T3 (pl) | 2015-03-17 | 2022-01-17 | eleva GmbH | Glikozylowane białka lizosomowe, sposób wytwarzania i zastosowania |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| NZ755725A (en) * | 2017-01-05 | 2023-06-30 | Protalix Ltd | Therapeutic regimen for the treatment of fabry using stabilized alpha-galactosidase |
| US11517613B2 (en) * | 2017-06-07 | 2022-12-06 | Amano Enzyme Inc. | Lactase bulk powder and lactase preparation |
| MX2021007552A (es) | 2018-12-20 | 2021-08-11 | Codexis Inc | Variantes de alfa-galactosidasa humana. |
| AR121457A1 (es) * | 2020-02-28 | 2022-06-08 | Codexis Inc | VARIANTES DE a-GALACTOSIDASA HUMANA |
| JP2023548496A (ja) | 2020-11-03 | 2023-11-17 | プロタリクス リミテッド | 修飾ウリカーゼ及びその使用 |
| CN112176026A (zh) * | 2020-11-06 | 2021-01-05 | 诺道中科(北京)生物科技有限公司 | 一种α-半乳糖苷酶活性的检测试剂盒 |
| CN116254287B (zh) * | 2022-11-24 | 2024-06-04 | 西北农林科技大学 | 玉米ZmAGA3基因用于提高植物耐旱性的应用 |
| CN118243646B (zh) * | 2024-04-24 | 2025-01-24 | 武汉简为医疗科技有限公司 | 一种乳糖不耐受检测试剂盒及其使用方法 |
| JP7745040B1 (ja) * | 2024-06-21 | 2025-09-26 | デンカ株式会社 | 目的タンパク質の回収方法及び製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| CA2052728A1 (en) | 1991-10-03 | 1993-04-04 | Guy Ampleman | Glycidyl azide polymer |
| US6329191B1 (en) * | 1993-08-30 | 2001-12-11 | Hawaii Biotechnology Group, Inc. | DNA encoding recombinant coffee bean alpha-galactosidase |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| DE69839563D1 (de) * | 1997-09-05 | 2008-07-10 | Altus Pharmaceuticals Inc | Kohlenhydrat-vernetzte glykoproteinkristalle |
| IL125423A (en) | 1998-07-20 | 2004-08-31 | Israel State | Alkaline alpha-galactosidase having broad substrate specificity |
| DE60022336T2 (de) | 1999-04-02 | 2006-06-22 | Ajinomoto Co., Inc. | Vefahren zur herstellung von peptiduntereinheiten aus polymer-proteinen |
| EP1523548B1 (en) | 2002-05-15 | 2009-12-30 | Agricultural Research Organization | Polynucleotide sequences encoding alkaline a-galactosidases and methods of using same |
| US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| PL1877099T3 (pl) * | 2005-04-06 | 2013-02-28 | Genzyme Corp | Terapeutyczne koniugaty zawierające enzym lizosomalny, kwas polisialowy i grupę kierującą |
| AU2006316122A1 (en) * | 2005-11-18 | 2007-05-24 | Altif Laboratories Inc. | Novel highly functional enzyme having modified substrate-specificity |
| WO2008075957A1 (en) | 2006-12-21 | 2008-06-26 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Treatment of fabry disease |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| CA2696699A1 (en) | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| JP5758920B2 (ja) * | 2010-03-02 | 2015-08-05 | プロタリクス リミテッド | 安定化α−ガラクトシダーゼおよびその使用 |
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- 2011-03-02 KR KR1020127025725A patent/KR101928403B1/ko active Active
- 2011-03-02 IN IN2262MUN2012 patent/IN2012MN02262A/en unknown
- 2011-03-02 WO PCT/IL2011/000209 patent/WO2011107990A1/en not_active Ceased
- 2011-03-02 AU AU2011222452A patent/AU2011222452B2/en active Active
- 2011-03-02 PL PL14195875T patent/PL2865751T3/pl unknown
- 2011-03-02 EP EP16173953.7A patent/EP3088514B1/en active Active
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