SG183558A1 - Stabilized alpha-galactosidase and uses thereof - Google Patents
Stabilized alpha-galactosidase and uses thereof Download PDFInfo
- Publication number
- SG183558A1 SG183558A1 SG2012064580A SG2012064580A SG183558A1 SG 183558 A1 SG183558 A1 SG 183558A1 SG 2012064580 A SG2012064580 A SG 2012064580A SG 2012064580 A SG2012064580 A SG 2012064580A SG 183558 A1 SG183558 A1 SG 183558A1
- Authority
- SG
- Singapore
- Prior art keywords
- galactosidase
- gal
- protein structure
- activity
- multimeric protein
- Prior art date
Links
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| PCT/IL2010/000956 WO2011061736A1 (en) | 2009-11-17 | 2010-11-17 | Alkaline alpha galactosidase for the treatment of fabry disease |
| US201161434503P | 2011-01-20 | 2011-01-20 | |
| US201161434499P | 2011-01-20 | 2011-01-20 | |
| PCT/IL2011/000209 WO2011107990A1 (en) | 2010-03-02 | 2011-03-02 | Stabilized alpha-galactosidase and uses thereof |
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Families Citing this family (17)
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| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| PL2865751T3 (pl) * | 2010-03-02 | 2017-03-31 | Protalix Ltd | Stabilizowana alfa-galaktozydaza i jej zastosowania |
| WO2012098537A1 (en) * | 2011-01-20 | 2012-07-26 | Protalix Ltd. | Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells |
| TWI793159B (zh) * | 2013-10-23 | 2023-02-21 | 美商健臻公司 | 重組醣蛋白及其用途 |
| LT3237621T (lt) | 2014-12-22 | 2023-09-25 | Codexis, Inc. | Žmogaus alfa-galaktozidazės variantai |
| WO2016116966A1 (en) * | 2015-01-22 | 2016-07-28 | Jcr Pharmaceuticals Co., Ltd. | Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins |
| DK3271453T3 (da) | 2015-03-17 | 2021-11-15 | eleva GmbH | Glycosylerede lysosomale proteiner, fremgangsmåde til fremstilling og anvendelser |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| CN110381987A (zh) | 2017-01-05 | 2019-10-25 | 波塔力克斯有限公司 | 使用稳定化α-半乳糖苷酶治疗法布里病的治疗方法 |
| DK3636751T3 (da) * | 2017-06-07 | 2024-01-29 | Amano Enzyme Inc | Lactase-bulkpulver og lactasepræparat |
| EP3898960A4 (en) | 2018-12-20 | 2022-11-30 | Codexis, Inc. | VARIANTS OF HUMAN ALPHA GALACTOSIDASE |
| TW202146648A (zh) * | 2020-02-28 | 2021-12-16 | 美商克迪科思股份有限公司 | 人類α-半乳糖苷酶變異體 |
| KR20230110281A (ko) | 2020-11-03 | 2023-07-21 | 프로탈릭스 리미티드 | 변형된 유리카제(uricase) 및 이의 용도 |
| CN112176026A (zh) * | 2020-11-06 | 2021-01-05 | 诺道中科(北京)生物科技有限公司 | 一种α-半乳糖苷酶活性的检测试剂盒 |
| CN116254287B (zh) * | 2022-11-24 | 2024-06-04 | 西北农林科技大学 | 玉米ZmAGA3基因用于提高植物耐旱性的应用 |
| CN118243646B (zh) * | 2024-04-24 | 2025-01-24 | 武汉简为医疗科技有限公司 | 一种乳糖不耐受检测试剂盒及其使用方法 |
| JP7745040B1 (ja) * | 2024-06-21 | 2025-09-26 | デンカ株式会社 | 目的タンパク質の回収方法及び製造方法 |
Family Cites Families (18)
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| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| CA2052728A1 (en) | 1991-10-03 | 1993-04-04 | Guy Ampleman | Glycidyl azide polymer |
| US6329191B1 (en) * | 1993-08-30 | 2001-12-11 | Hawaii Biotechnology Group, Inc. | DNA encoding recombinant coffee bean alpha-galactosidase |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| AU8772498A (en) * | 1997-09-05 | 1999-03-29 | Altus Biologics Inc. | Carbohydrate crosslinked glycoprotein crystals |
| IL125423A (en) | 1998-07-20 | 2004-08-31 | Israel State | Alkaline alpha-galactosidase having broad substrate specificity |
| WO2000059926A1 (en) * | 1999-04-02 | 2000-10-12 | Ajinomoto Co., Inc. | Process for producing subunit peptide origintaing in polymer protein |
| AU2003235988A1 (en) | 2002-05-15 | 2003-12-02 | Agricultural Research Organization, The Volcani Center | Polynucleotide sequences encoding alkaline a-galactosidases and methods of using same |
| US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| PL1877099T3 (pl) * | 2005-04-06 | 2013-02-28 | Genzyme Corp | Terapeutyczne koniugaty zawierające enzym lizosomalny, kwas polisialowy i grupę kierującą |
| TWI500765B (zh) * | 2005-11-18 | 2015-09-21 | Tokyo Metropolitan Inst Medical Science | 轉換基質特異性之新穎高機能酵素 |
| US20100144008A1 (en) | 2006-12-21 | 2010-06-10 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Treatment of fabry disease |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| WO2009024977A2 (en) * | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| PL2865751T3 (pl) * | 2010-03-02 | 2017-03-31 | Protalix Ltd | Stabilizowana alfa-galaktozydaza i jej zastosowania |
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