JP2013517327A5 - - Google Patents
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- Publication number
- JP2013517327A5 JP2013517327A5 JP2012550067A JP2012550067A JP2013517327A5 JP 2013517327 A5 JP2013517327 A5 JP 2013517327A5 JP 2012550067 A JP2012550067 A JP 2012550067A JP 2012550067 A JP2012550067 A JP 2012550067A JP 2013517327 A5 JP2013517327 A5 JP 2013517327A5
- Authority
- JP
- Japan
- Prior art keywords
- opsonin
- recombinant
- recombinant opsonin
- domain
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108700022034 Opsonin Proteins Proteins 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 31
- 239000000758 substrate Substances 0.000 claims description 27
- 244000005700 microbiome Species 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 13
- 239000008280 blood Substances 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 108090001090 Lectins Proteins 0.000 claims description 9
- 102000004856 Lectins Human genes 0.000 claims description 9
- 239000002523 lectin Substances 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- 108010087870 Mannose-Binding Lectin Proteins 0.000 claims description 7
- 102000009112 Mannose-Binding Lectin Human genes 0.000 claims description 7
- 210000000056 organ Anatomy 0.000 claims description 7
- 210000001519 tissue Anatomy 0.000 claims description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000013060 biological fluid Substances 0.000 claims description 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 5
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- 210000000987 immune system Anatomy 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 230000005291 magnetic effect Effects 0.000 claims description 5
- 239000011325 microbead Substances 0.000 claims description 5
- 108090000909 Collectins Proteins 0.000 claims description 4
- 102000004405 Collectins Human genes 0.000 claims description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 229960000310 isoleucine Drugs 0.000 claims description 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- 206010040047 Sepsis Diseases 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 238000010382 chemical cross-linking Methods 0.000 claims description 2
- 238000011109 contamination Methods 0.000 claims description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 210000002744 extracellular matrix Anatomy 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000012510 hollow fiber Substances 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 239000006249 magnetic particle Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000012982 microporous membrane Substances 0.000 claims description 2
- 230000005298 paramagnetic effect Effects 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 210000001539 phagocyte Anatomy 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 210000001179 synovial fluid Anatomy 0.000 claims description 2
- 210000001138 tear Anatomy 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000001662 opsonic effect Effects 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 101001056128 Homo sapiens Mannose-binding protein C Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000014207 opsonization Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 description 8
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29622210P | 2010-01-19 | 2010-01-19 | |
| US61/296,222 | 2010-01-19 | ||
| PCT/US2011/021603 WO2011090954A2 (en) | 2010-01-19 | 2011-01-19 | Engineered opsonin for pathogen detection and treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016122230A Division JP6513604B2 (ja) | 2010-01-19 | 2016-06-21 | 病原体の検出および治療のための改変オプソニン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517327A JP2013517327A (ja) | 2013-05-16 |
| JP2013517327A5 true JP2013517327A5 (OSRAM) | 2014-03-06 |
| JP5959440B2 JP5959440B2 (ja) | 2016-08-02 |
Family
ID=44307537
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550067A Active JP5959440B2 (ja) | 2010-01-19 | 2011-01-19 | 病原体の検出および治療のための改変オプソニン |
| JP2016122230A Active JP6513604B2 (ja) | 2010-01-19 | 2016-06-21 | 病原体の検出および治療のための改変オプソニン |
| JP2019074496A Active JP6960957B2 (ja) | 2010-01-19 | 2019-04-10 | 病原体の検出および治療のための改変オプソニン |
| JP2020120294A Active JP7062723B2 (ja) | 2010-01-19 | 2020-07-14 | 病原体の検出および治療のための改変オプソニン |
| JP2022069222A Pending JP2022097536A (ja) | 2010-01-19 | 2022-04-20 | 病原体の検出および治療のための改変オプソニン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016122230A Active JP6513604B2 (ja) | 2010-01-19 | 2016-06-21 | 病原体の検出および治療のための改変オプソニン |
| JP2019074496A Active JP6960957B2 (ja) | 2010-01-19 | 2019-04-10 | 病原体の検出および治療のための改変オプソニン |
| JP2020120294A Active JP7062723B2 (ja) | 2010-01-19 | 2020-07-14 | 病原体の検出および治療のための改変オプソニン |
| JP2022069222A Pending JP2022097536A (ja) | 2010-01-19 | 2022-04-20 | 病原体の検出および治療のための改変オプソニン |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US9150631B2 (OSRAM) |
| EP (1) | EP2526119B1 (OSRAM) |
| JP (5) | JP5959440B2 (OSRAM) |
| CN (1) | CN102947341B (OSRAM) |
| AU (1) | AU2011207626B2 (OSRAM) |
| CA (1) | CA2787376A1 (OSRAM) |
| DK (1) | DK2526119T3 (OSRAM) |
| ES (1) | ES2678143T3 (OSRAM) |
| IN (1) | IN2012DN06589A (OSRAM) |
| SG (2) | SG182577A1 (OSRAM) |
| WO (1) | WO2011090954A2 (OSRAM) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9220831B2 (en) | 2005-10-06 | 2015-12-29 | Children's Medical Center Corporation | Device and method for combined microfluidic-micromagnetic separation of material in continuous flow |
| CA2632630C (en) | 2005-12-13 | 2016-12-06 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
| WO2010123594A2 (en) | 2009-01-15 | 2010-10-28 | Children's Medical Center Corporation | Device for filtration of fluids there through and accompanying method |
| DK2526119T3 (en) | 2010-01-19 | 2018-07-30 | Harvard College | Manipulated opsonin for pathogen detection and treatment |
| ES2773858T3 (es) | 2010-10-06 | 2020-07-15 | Harvard College | Hidrogeles formadores de poros inyectables para terapias celulares basadas en materiales |
| WO2012135042A1 (en) * | 2011-03-25 | 2012-10-04 | Receptors Llc | Filtration article with microbial removal, micro-biocidal, or static growth capability |
| RU2013148071A (ru) * | 2011-04-01 | 2015-05-10 | Президент Энд Феллоуз Ов Харвард Колледж | Аналогичное диализу терапевтическое (dlt) устройство |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| US9593160B2 (en) | 2011-07-18 | 2017-03-14 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
| US9632085B2 (en) * | 2012-02-29 | 2017-04-25 | President And Fellows Of Harvard College | Rapid antibiotic susceptibility testing |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| US20130334120A1 (en) * | 2012-06-15 | 2013-12-19 | President And Fellows Of Harvard College | Fluid cleansing devices and methods of use |
| EP3327090A1 (en) * | 2012-07-18 | 2018-05-30 | President and Fellows of Harvard College | Modification of surfaces for simulataneous repellency and targeted binding of desired moieties |
| EP2976642A4 (en) | 2013-03-15 | 2016-09-21 | Harvard College | METHOD AND COMPOSITIONS FOR IMPROVING THE DETECTION AND / OR RECORDING OF A TARGET UNIT |
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| DE102014206444A1 (de) * | 2014-04-03 | 2015-10-08 | Siemens Aktiengesellschaft | Verfahren für die Molekulardiagnostik zum Anreichern einer Nukleinsäure aus einer biologischen Probe |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
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| KR20190020668A (ko) | 2016-05-16 | 2019-03-04 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Co2-플라즈마-활성화된 표면 상에 수성 생분자 커플링 |
| CA3030427A1 (en) | 2016-07-13 | 2018-01-18 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| BR112019000748A2 (pt) | 2016-07-28 | 2019-04-24 | Medisieve Ltd | método e misturador magnético |
| JP7274214B2 (ja) | 2016-08-02 | 2023-05-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫応答を調節するための生体材料 |
| WO2019064463A1 (ja) * | 2017-09-28 | 2019-04-04 | 学校法人中部大学 | バイオアフィニティーを利用したウイルス又は細菌の濃縮方法及び装置 |
| KR102084688B1 (ko) * | 2018-06-18 | 2020-03-04 | 울산과학기술원 | 다중 프로브 혼성화를 이용한 미생물 검출 방법 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| CN110628624B (zh) * | 2019-02-01 | 2022-07-15 | 传鸣(宁波)化学科技有限公司 | 一种磁性微生物捕获材料及微生物捕获方法 |
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| CN111675825B (zh) * | 2020-06-09 | 2022-06-24 | 大连工业大学 | 一种附有胰蛋白酶的微孔膜的制备方法及其在蛋白水解中的应用 |
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| WO2022151333A1 (zh) * | 2021-01-15 | 2022-07-21 | 传鸣(宁波)化学科技有限公司 | 用于富集微生物的混合物、方法及应用 |
Family Cites Families (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5418198A (en) | 1977-07-09 | 1979-02-09 | Toshimitsu Niwa | Artificial intraretinal device |
| US4425330A (en) | 1981-05-20 | 1984-01-10 | Cornell Research Foundation, Inc. | Bovine mastitis vaccine and method for detecting efficacy thereof |
| JPS60500548A (ja) | 1982-12-03 | 1985-04-18 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 発色性支持体免疫測定法 |
| EP0126772A1 (en) | 1982-12-03 | 1984-12-05 | E.I. Du Pont De Nemours And Company | Chromogenic support immunoassay |
| JPH0718875B2 (ja) | 1987-06-19 | 1995-03-06 | ヤマサ醤油株式会社 | 血中または体液中の微量物質含有量の測定法 |
| US5270199A (en) | 1987-08-20 | 1993-12-14 | The Children's Medical Center Corporation | Human mannose-binding protein |
| EP0375736B1 (en) | 1987-08-20 | 1998-05-13 | Children's Medical Center Corporation | Nucleic acid fragments encoding mannose binding fragments of human mannose binding protein |
| ATE122568T1 (de) | 1989-01-25 | 1995-06-15 | Commw Scient Ind Res Org | Polypeptide, antigene oder vakzine gegen babesiosis. |
| US5137810A (en) * | 1989-04-26 | 1992-08-11 | The University Of North Carolina | Method of determining the gram sign of bacteria |
| DE4018583A1 (de) | 1990-06-09 | 1991-12-12 | Henkel Kgaa | Modifiziertes verfahren zur direkten herstellung von alkylglykosiden |
| DK0542833T3 (da) | 1990-07-30 | 2000-03-27 | Novartis Ag | Insekticide proteiner |
| GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
| JPH04130274A (ja) | 1990-09-20 | 1992-05-01 | Kyoto Ikagaku Kenkyusho:Kk | 糖蛋白の分析，検出方法 |
| US5783179A (en) | 1991-08-09 | 1998-07-21 | Syntex (U.S.A.) Inc. | C-reactive protein fragment with immunomodulatory activity |
| US5874238A (en) | 1993-02-26 | 1999-02-23 | Immtech International Inc. | Mutant protein and methods and materials for making and using it |
| US5405832A (en) | 1991-11-27 | 1995-04-11 | Immtech International Inc. | Method of treating non-streptococcal bacterial infections |
| EP0616535B1 (en) | 1991-11-27 | 2000-02-02 | Immtech International Incorporated | Method of treating viral infections |
| US5283238A (en) | 1992-04-24 | 1994-02-01 | Immtech International, Inc. | Methods of treating cancer using modified C-reactive protein |
| US6703219B1 (en) | 1993-02-26 | 2004-03-09 | Immtech International Inc. | Mutant protein and methods and materials for making and using it |
| IT1271486B (it) | 1993-10-12 | 1997-05-28 | Italfarmaco Spa | Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| AUPN214095A0 (en) * | 1995-04-03 | 1995-04-27 | Australian Water Technologies Pty Ltd | Method for detecting microorganisms using flow cytometry |
| WO1997035619A1 (en) | 1996-03-28 | 1997-10-02 | Genitrix, L.L.C. | Opsonin-enhanced cells, and methods of modulating an immune response to an antigen |
| ZA973051B (en) | 1996-04-24 | 1998-10-12 | Genentech Inc | Type c lectins |
| US6117977A (en) | 1996-04-24 | 2000-09-12 | Genentech, Inc. | Type C lectins |
| FR2751229B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
| US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| IL121191A0 (en) | 1997-06-29 | 1997-11-20 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| JPH11206378A (ja) | 1998-01-23 | 1999-08-03 | Fuso Pharmaceutical Industries Ltd | 組換えヒトマンナン結合タンパク質およびその製造方法 |
| US7049099B2 (en) | 1998-01-23 | 2006-05-23 | Fuso Pharmaceutical Industries, Ltd. | Recombinant human mannan-binding proteins and producing method of the same |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| JP4707231B2 (ja) | 1998-06-10 | 2011-06-22 | スタテンズ セーラム インスティテュート | マンナン結合レクチンを製造するための精製方法及びｍｂｌ医薬品 |
| JP5219057B2 (ja) | 1998-07-31 | 2013-06-26 | 旭化成株式会社 | 微生物検出用抗体 |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| RU2292217C2 (ru) | 1999-05-14 | 2007-01-27 | Стеффен ТИЭЛЬ | Рекомбинантный маннан-связывающий лектин человека |
| ES2317843T3 (es) * | 1999-07-13 | 2009-05-01 | Bolder Biotechnology, Inc. | Proteinas de fusion de eritropoyetina-inmunoglobulina. |
| US6503761B1 (en) | 1999-10-19 | 2003-01-07 | Kimberly-Clark Worldwide, Inc. | Selective removal of contaminants from a surface using articles having magnets |
| CN1406249B (zh) * | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
| US6471968B1 (en) | 2000-05-12 | 2002-10-29 | Regents Of The University Of Michigan | Multifunctional nanodevice platform |
| JP2002165591A (ja) | 2000-09-25 | 2002-06-11 | Jsr Corp | 磁性粒子およびその使用方法 |
| AU2002227184A1 (en) | 2000-10-18 | 2002-04-29 | The Board Of Trustess Of The Leland Stanford Junior University | Methods for development and use of diagnostic and therapeutic agents |
| GB0119274D0 (en) | 2001-08-08 | 2001-10-03 | Univ Durham | Fusion proteins for insect control |
| US6900292B2 (en) * | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| US7396662B2 (en) * | 2001-12-19 | 2008-07-08 | Immunex Corporation | C-type lectin polypeptides |
| EP1335003A3 (en) | 2002-02-06 | 2004-04-07 | Toyo Boseki Kabushiki Kaisha | Magnetic carrier capable of binding with protein and purification method of protein utilizing the magnetic carrier |
| AU2003219730A1 (en) | 2002-02-07 | 2003-09-02 | Massachusetts Institute Of Technology | Anti-pathogen treatements |
| WO2003077937A1 (en) | 2002-03-15 | 2003-09-25 | Natimmune A/S | Pharmaceutical compositions comprising mannose binding lectin |
| US20030180814A1 (en) | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
| US7211396B2 (en) | 2002-04-18 | 2007-05-01 | Antibodyshop A/S | Antibody pairs and kits for immunochemical determination of mannan-binding lectin |
| CA2483441A1 (en) | 2002-04-24 | 2003-11-06 | The Council Of The Queensland Institute Of Medical Research | Mannose binding lectin and uses thereof |
| US20040018611A1 (en) | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
| EP1573047B1 (en) * | 2002-08-20 | 2013-11-13 | OpSaniTx LLC | Lectin compositions and methods for modulating an immune response to an antigen |
| US7629440B2 (en) | 2002-08-20 | 2009-12-08 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
| EP1539964B1 (en) | 2002-09-10 | 2006-12-27 | Natlmmune A/S | Collectin-complement activating protein chimeras |
| GB2393728A (en) | 2002-10-04 | 2004-04-07 | Nanomagnetics Ltd | Magnetic nanoparticles |
| EP1417965A1 (en) | 2002-11-07 | 2004-05-12 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | C-type lectin binding molecules, identification and uses thereof |
| RU2353399C2 (ru) | 2003-01-17 | 2009-04-27 | Этлон Медикал, Инк. | Способ удаления вирусов из крови посредством лектин-аффинного гемодиализа |
| US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| DE10325752A1 (de) | 2003-06-06 | 2004-12-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Lektin-Konjugate |
| WO2005040194A2 (en) | 2003-10-24 | 2005-05-06 | Ludwig Institute For Cancer Research | Methods and compositions for pdgf-c activation and inhibition |
| KR20060124656A (ko) * | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
| SE0401033D0 (sv) | 2004-04-20 | 2004-04-20 | Amersham Biosciences Ab | Device and method for protein analysis |
| US8080245B2 (en) | 2004-08-04 | 2011-12-20 | University Of Massachusetts | Anti-pathogen immunoadhesins |
| US20090269843A1 (en) | 2004-08-20 | 2009-10-29 | Novo Nordisk A/S | Hemopexin fusion proteins |
| EP1800136B1 (en) | 2004-10-15 | 2011-12-07 | Danisco US Inc. | Competitive differential screening |
| DK1812459T3 (da) | 2004-10-28 | 2011-05-23 | Dobeel Co Ltd | Fremgangsmåde til masseproduktion af multimer mannosebindende lectin |
| US20060141547A1 (en) | 2004-11-16 | 2006-06-29 | Das Hasi R | Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis |
| US7172906B2 (en) | 2004-11-16 | 2007-02-06 | Dade Behring Inc. | Reduction of non-specific binding in assays |
| US8084275B2 (en) | 2005-02-08 | 2011-12-27 | Fujifilm Corporation | Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| CN101193651A (zh) | 2005-04-11 | 2008-06-04 | 内蒂穆恩公司 | 甘露聚糖结合凝集素(mbl)在治疗与癌症相关的免疫削弱的病症中的用途 |
| US20070031819A1 (en) | 2005-04-26 | 2007-02-08 | University Of Washington | Microfluidic systems for biological and molecular analysis and methods thereof |
| EP2484344B1 (en) | 2005-05-09 | 2016-02-10 | Biosphere Medical, S.A. | Compositions and methods of using microspheres and non-ionic contrast agents |
| US20070231833A1 (en) | 2005-05-23 | 2007-10-04 | Arcidiacono Steven M | Labeled antimicrobial peptides and method of using the same to detect microorganisms of interest |
| JP4423394B2 (ja) * | 2005-06-17 | 2010-03-03 | 独立行政法人産業技術総合研究所 | 新規糖鎖認識蛋白質及びその遺伝子 |
| US20070072247A1 (en) | 2005-08-31 | 2007-03-29 | Academia Sinica | Methods and reagents for the analysis and purification of polysaccharides |
| CN101273258A (zh) | 2005-09-30 | 2008-09-24 | 卡钳生命科学股份有限公司 | 利用磁性珠纯化生物学组分的微流体装置 |
| US9220831B2 (en) | 2005-10-06 | 2015-12-29 | Children's Medical Center Corporation | Device and method for combined microfluidic-micromagnetic separation of material in continuous flow |
| US8013120B2 (en) | 2005-10-26 | 2011-09-06 | Stc.Unm | C-reactive protein and its use to treat systemic lupus erythematosus and related conditions |
| WO2009148566A2 (en) | 2008-06-03 | 2009-12-10 | Stc.Unm | Development of a c-reactive protein mutant with improved therapeutic benefit in immune thrombocytopenia and lupus nephritis |
| US20070269818A1 (en) | 2005-12-28 | 2007-11-22 | Affymetrix, Inc. | Carbohydrate arrays |
| US20090181041A1 (en) | 2006-01-23 | 2009-07-16 | Jan Holgersson | Production of proteins carrying oligomannose or human-like glycans in yeast and methods of use thereof |
| JP5063616B2 (ja) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | マイクロ流体デバイス |
| US8821851B2 (en) | 2006-03-23 | 2014-09-02 | The General Hospital Corporation | Inflammation-inhibitory serum factors and uses thereof |
| WO2007111496A1 (en) * | 2006-03-28 | 2007-10-04 | Universiteit Utrecht Holding B.V. | Improved carbohydrate recognition domains |
| EP1862541A1 (en) | 2006-06-01 | 2007-12-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Polypeptides derived from the hemopexin-like domain of metalloproteinase MMP-2 |
| US8273310B2 (en) | 2006-09-05 | 2012-09-25 | Samsung Electronics Co., Ltd. | Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device |
| KR101343034B1 (ko) | 2006-09-05 | 2013-12-18 | 삼성전자 주식회사 | 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템 |
| US8088596B2 (en) * | 2006-10-10 | 2012-01-03 | Oakland University | Method of microorganism detection using carbohydrate and lectin recognition |
| WO2009008925A2 (en) | 2007-04-05 | 2009-01-15 | The Regents Of The University Of California | A particle-based microfluidic device for providing high magnetic field gradients |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| US8292083B2 (en) | 2007-04-19 | 2012-10-23 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for separating particles, cells, molecules and particulates |
| KR20100021601A (ko) | 2007-05-14 | 2010-02-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | 단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법 |
| ES2415604T3 (es) | 2007-05-30 | 2013-07-26 | Postech Academy-Industry- Foundation | Proteínas de fusión de inmunoglobulina |
| CA2704724A1 (en) | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | 5use of a peptide as a therapeutic agent |
| US8415118B2 (en) | 2007-10-29 | 2013-04-09 | Virginia Tech Intellectual Properties, Inc. | Porcine DC-SIGN, ICAM-3 and LSECtin and uses thereof |
| AU2008323678A1 (en) | 2007-11-09 | 2009-05-14 | Anaphore, Inc. | Fusion proteins of mannose binding lectins for treatment of disease |
| ES2326109B1 (es) | 2007-12-05 | 2010-06-25 | Consejo Superior De Investigaciones Cientificas | Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones. |
| US20100266558A1 (en) | 2007-12-18 | 2010-10-21 | Dov Zipori | Method and assay for glycosylation pattern detection related to cell state of stem cells |
| CN101952727A (zh) | 2007-12-31 | 2011-01-19 | 3M创新有限公司 | 微生物捕获用组合物和方法 |
| US20100331240A1 (en) | 2008-01-18 | 2010-12-30 | The General Hospital Corporation | Methods for prevention and treatment of infections with supraphysiological doses of mannan-binding lectin (mbl) and ficolin-mbl fusion proteins |
| KR101625979B1 (ko) | 2008-03-28 | 2016-05-31 | 국립대학법인 홋가이도 다이가쿠 | 항 ｈ5 아형 ａ형 인플루엔자 바이러스 헤마글루티닌 모노클로날 항체 |
| US20110053145A1 (en) | 2008-03-31 | 2011-03-03 | Japan Tobacco Inc. | Quantitation method of virus |
| AU2009232598A1 (en) | 2008-03-31 | 2009-10-08 | Japan Tobacco Inc. | Enrichment method of virus |
| US20100323429A1 (en) | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| US8865876B2 (en) | 2008-06-02 | 2014-10-21 | California Institute Of Technology | Engineered lectin oligomers with antiviral activity |
| JP2010122205A (ja) | 2008-08-29 | 2010-06-03 | Sysmex Corp | 麻疹ウイルス検出方法、メンブレンアッセイ用試験具およびメンブレンアッセイ用試験キット |
| WO2010028306A2 (en) | 2008-09-05 | 2010-03-11 | The Regents Of The University Of California Office Of The President | Antibodies with mannose binding lectin effector function for inhibiting pathologic inflammatory conditions |
| WO2010065765A2 (en) | 2008-12-04 | 2010-06-10 | Aethlon Medical, Inc. | Affinity capture of circulating biomarkers |
| ES2536198T3 (es) | 2008-12-22 | 2015-05-21 | National University Corporation Hokkaido University | Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma |
| WO2010078966A1 (en) * | 2009-01-09 | 2010-07-15 | Apogenix Gmbh | Fusion proteins forming trimers |
| CA2750533A1 (en) | 2009-01-23 | 2010-07-29 | Biogen Idec Ma Inc. | Stabilized fc polypeptides with reduced effector function and methods of use |
| JP2012516338A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 結合部位が修飾されたレクチンおよびその使用 |
| US20130012451A1 (en) | 2009-12-21 | 2013-01-10 | The Research Foundation Of State University Of New York | Compositions and methods for inhibiting mmp-9-mediated cell migration |
| US20130157283A1 (en) | 2010-01-19 | 2013-06-20 | President And Fellows Of Harvard College | Rapid pathogen diagnostic device and method |
| DK2526119T3 (en) | 2010-01-19 | 2018-07-30 | Harvard College | Manipulated opsonin for pathogen detection and treatment |
| JP6228012B2 (ja) | 2011-01-19 | 2017-11-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 高圧力安定性、光透過性、および自己修復特性を伴う易滑性表面 |
| RU2013148071A (ru) | 2011-04-01 | 2015-05-10 | Президент Энд Феллоуз Ов Харвард Колледж | Аналогичное диализу терапевтическое (dlt) устройство |
| US9593160B2 (en) | 2011-07-18 | 2017-03-14 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
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