ES2536198T3 - Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma - Google Patents

Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma Download PDF

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Publication number
ES2536198T3
ES2536198T3 ES09834882.4T ES09834882T ES2536198T3 ES 2536198 T3 ES2536198 T3 ES 2536198T3 ES 09834882 T ES09834882 T ES 09834882T ES 2536198 T3 ES2536198 T3 ES 2536198T3
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Spain
Prior art keywords
human
triple helix
helix structure
domain gene
production method
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Active
Application number
ES09834882.4T
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English (en)
Inventor
Yusuke Suzuki
Hiroshi Tahara
Keiichi Yamamoto
Yuzuru Kitahara
Yasuhiko Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Fuso Pharmaceutical Industries Ltd
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Hokkaido University NUC
Fuso Pharmaceutical Industries Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

Una proteína recombinante que tiene una estructura de hélice triple, que comprende una proteína codificada por un polinucleótido que comprende (i) a (v) a continuación en orden desde el terminal amino: (i) un gen de dominio de péptido de señalización de colectina humana; (ii) un gen de domino rico en cisteína de colectina humana; (iii) un gen de dominio de colágeno de colágeno humano; (iv) un gen de dominio de cuello de colectina humana; y (v) un gen de dominio de reconocimiento de carbohidratos de colectina humana.

Description

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Claims (1)

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ES09834882.4T 2008-12-22 2009-12-22 Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma Active ES2536198T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008325691 2008-12-22
JP2008325691 2008-12-22
PCT/JP2009/071327 WO2010074081A1 (ja) 2008-12-22 2009-12-22 三重螺旋構造を有するタンパク質、およびその製造方法

Publications (1)

Publication Number Publication Date
ES2536198T3 true ES2536198T3 (es) 2015-05-21

Family

ID=42287689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09834882.4T Active ES2536198T3 (es) 2008-12-22 2009-12-22 Sustancia proteínica que tiene estructura de hélice triple y método de producción de la misma

Country Status (12)

Country Link
US (1) US8470555B2 (es)
EP (1) EP2380979B1 (es)
JP (1) JP5645187B2 (es)
KR (1) KR101686688B1 (es)
CN (2) CN102325882A (es)
AU (1) AU2009331327B2 (es)
CA (1) CA2748015C (es)
DK (1) DK2380979T3 (es)
ES (1) ES2536198T3 (es)
HK (1) HK1163153A1 (es)
PT (1) PT2380979E (es)
WO (1) WO2010074081A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2552325T3 (es) 2008-12-22 2015-11-27 National University Corporation Hokkaido University Vector de expresión para producción a gran escala de proteína derivada de genes foráneos usando células animales, y uso del mismo
DK2526119T3 (en) 2010-01-19 2018-07-30 Harvard College Manipulated opsonin for pathogen detection and treatment
WO2013012924A2 (en) 2011-07-18 2013-01-24 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
CN102351954B (zh) * 2011-10-26 2013-12-18 陕西巨子生物技术有限公司 重组胶原蛋白
AU2014268603B2 (en) 2013-05-21 2018-03-22 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
CN108289928A (zh) * 2015-08-06 2018-07-17 哈佛大学校长及研究员协会 改进的微生物-结合分子和其用途
CA3012006A1 (en) * 2017-07-31 2019-01-31 Modern Meadow, Inc. Yeast strains and methods for controlling hydroxylation of recombinant collagen
US20220112267A1 (en) * 2020-10-08 2022-04-14 Jellatech, Inc. Produce and isolate and/or extract collagen and/or gelatin from animal cell lines and/or tissue explants

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GB8708009D0 (en) 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
AU680606B2 (en) 1991-10-23 1997-08-07 Academy Of Finland Synthesis of human procollagens and collagens in recombinant DNA systems
US5428022A (en) 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
JPH0823979A (ja) 1994-07-15 1996-01-30 Terumo Corp ヒト・コラーゲン発現ベクターおよびヒト・コラーゲンの製造方法
CA2400143C (en) 1995-08-17 2009-05-12 Fuso Pharmaceutical Industries, Ltd. Recombinant conglutinin and producing method thereof
WO2000011161A1 (fr) 1998-08-24 2000-03-02 Fuso Pharmaceutical Industries, Ltd. Nouvelle collectine
JP2001316282A (ja) 2000-05-11 2001-11-13 Yoshihiko Shimizu 生理活性ペプチド含有コラーゲン成形体及びその製法
JP3603103B2 (ja) 2000-11-15 2004-12-22 独立行政法人農業・生物系特定産業技術研究機構 動物（但し、ヒトを除く。）の受精卵の共培養担体及びこの担体を用いる動物（但し、ヒトを除く。）の受精卵の培養方法
AU2002218154A1 (en) * 2000-11-27 2002-06-03 Jens Christian Jensenius Collectins as adjuvants
JP2002325584A (ja) 2000-11-30 2002-11-12 Japan Science & Technology Corp 組換えヒトｉｖ型コラーゲンペプチドとその製造方法
JP4701336B2 (ja) 2001-04-18 2011-06-15 独立行政法人農業生物資源研究所 ヒト・コラーゲンを産生する形質転換カイコ
US20060188963A1 (en) 2002-09-10 2006-08-24 Natlmmune A/S Collectin-complement activating protein chimeras
JP4681214B2 (ja) 2003-06-10 2011-05-11 グンゼ株式会社 コラーゲンスポンジの製造方法及び人工皮膚の製造方法
JP2005014774A (ja) 2003-06-26 2005-01-20 Kubota Corp 作業車の車軸ケース支持構造
CA2602611C (en) * 2005-03-31 2015-09-29 Fuso Pharmaceutical Industries, Ltd. Methods of producing proteins having triple-helix structure
GB2433029A (en) 2005-12-09 2007-06-13 Ethicon Inc Wound dressings comprising oxidized cellulose and human recombinant collagen
JP4677559B2 (ja) 2006-02-02 2011-04-27 財団法人ヒューマンサイエンス振興財団 任意の形状のビトリゲルと、当該ビトリゲルの製造方法
WO2007102200A1 (ja) * 2006-03-07 2007-09-13 Osaka University 抗ｃｄ２０モノクローナル抗体
CN102016025B (zh) 2008-02-27 2015-09-16 国立大学法人北海道大学 用于用动物细胞大量生产源自外源基因的蛋白质的表达载体及其应用

Also Published As

Publication number Publication date
DK2380979T3 (da) 2015-06-22
KR101686688B1 (ko) 2016-12-14
EP2380979A1 (en) 2011-10-26
CA2748015A1 (en) 2010-07-01
EP2380979A4 (en) 2012-07-25
JP5645187B2 (ja) 2014-12-24
PT2380979E (pt) 2015-06-26
AU2009331327A1 (en) 2011-07-14
CN106243229A (zh) 2016-12-21
CN106243229B (zh) 2019-09-06
HK1163153A1 (en) 2012-09-07
JPWO2010074081A1 (ja) 2012-06-21
AU2009331327B2 (en) 2014-04-24
US8470555B2 (en) 2013-06-25
EP2380979B1 (en) 2015-04-15
CA2748015C (en) 2017-02-28
WO2010074081A1 (ja) 2010-07-01
KR20110119650A (ko) 2011-11-02
AU2009331327A8 (en) 2011-07-28
US20120059152A1 (en) 2012-03-08
CN102325882A (zh) 2012-01-18

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