JP2013517327A - 病原体の検出および治療のための改変オプソニン - Google Patents
病原体の検出および治療のための改変オプソニン Download PDFInfo
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Abstract
Description
本出願は、その内容が参照によりその全体として本明細書に完全に組み入れられる2010年1月19日に提出された米国仮出願第61/296,222号の恩典を主張するものである。
本発明は、分子免疫学、微生物病原体、ならびに血液等の体液を含む流体中の病原体を検出および/または除去するためのシステムに関する。より具体的には、例えば、本発明が提供する改変分子オプソニンは、生物学的病原体に結合させるのに用いられ得るか、または感染性疾患、血液媒介性感染症、もしくは敗血症を有する患者の治療および診断のためのデバイスおよびシステムにおける使用のためのサブクラスもしくは特定病原体種を同定するのに用いられ得る。
米国において、敗血症は、非冠動脈(non-coronary)ICU患者における死亡原因の第2位であり、死亡全体の10番目に多い原因である。敗血症は、全身の炎症状態(全身性炎症応答症候群と呼ばれる)および既知のまたは疑われる感染症の存在によって特徴付けされる重篤な医学的病態である。敗血症は、典型的には菌血症、ウイルス血症、または真菌血症の過程で発症し、かつ典型的な血液媒介性病原体ではない黄色ブドウ球菌(Staphylococcus aureus)等の病原体によって引き起こされる感染症により生じ得る。血液媒介性病原体は、血液または他の潜在的に感染した体液を介して感染した人から別の人へ伝達された場合に疾患を引き起こす微生物である。最も多い疾患には、B型肝炎、ヒト免疫不全ウイルス、マラリア、C型肝炎、および梅毒が含まれる。
本発明が提供する改変分子オプソニンは、生物学的病原体に結合させるのに用いられ得るか、または感染性疾患、血液媒介性感染症、もしくは敗血症を有する患者の治療および診断のためのデバイスおよびシステムにおける使用のためのサブクラスもしくは特定病原体種を同定するのに用いられ得るか、あるいは水もしくは食物媒介性病原体の同定において用いられ得る。本発明の局面は、自然免疫系の一部である豊富な天然血清タンパク質であるマンノース結合レクチン(MBL)を提供する。このタンパク質レクチンが事実上すべてのクラスの生物病原体(biopathogen)(ウイルス、細菌、真菌、原生動物)上の表面分子に結合する能力があることにより、MBLの改変型は感染性疾患および敗血症を診断および治療するのに極めて有用となる。
本発明は、本明細書に記載される特定の方法論、プロトコール、および試薬などに限定されるものではなく、そのため変化し得ることが理解されるべきである。本明細書で用いられる用語は、特定の態様を記載することのみを目的とするものであって、特許請求の範囲によってだけ規定される本発明の範囲を限定することを意図するものではない。
1.オプソニンの糖鎖認識ドメイン;
基質結合ドメイン;および
該認識ドメインを基質結合ドメインに連結させるペプチドドメイン
を含む、組換えオプソニン。
2.前記糖鎖認識ドメインがコレクチンもしくはフィコリン(ficollin)である、またはコレクチンもしくはフィコリンに由来する、項目1記載の組換えオプソニン。
3.前記糖鎖認識ドメインがレクチン、またはレクチンの一部分もしくはフラグメントである、項目1記載の組換えオプソニン。
4.前記レクチンがマンノース結合レクチン(MBL)である、項目3記載の組換えオプソニン。
5.レクチンがMBLのアミノ酸残基81(プロリン)〜228(イソロイシン)(SEQ ID NO:2)からなる、項目4記載の組換えオプソニン。
6.前記基質結合ドメインが、固体基質への化学的架橋を可能にする少なくとも1つのシステイン残基を含む、前記項目のいずれか一項記載の組換えオプソニン。
7.フレキシブルペプチドがグリシン+セリンセグメントまたはプロリン+アラニン+セリンセグメントを含む、前記項目のいずれか一項記載の組換えオプソニン。
8.フレキシブルペプチドが免疫グロブリンのFcの部分を含む、前記項目のいずれか一項記載の組換えオプソニン。
9.Fc部分がIgG FcドメインのCH2-CH3境界面を含む、項目8記載の組換えオプソニン。
10.前記基質が磁性マイクロビーズ、常磁性マイクロビーズ、微多孔膜、中空糸リアクター、または他の任意の流体濾過膜もしくはフローデバイスである、前記項目のいずれか一項記載の組換えオプソニン。
11.前記基質が生物学的組織または器官の生きた細胞または細胞外マトリックスである、前記項目のいずれか一項記載の組換えオプソニン。
12.前記基質が食細胞である、項目11記載の組換えオプソニン。
13.固体表面にコンジュゲートさせた組換えオプソニンと流体を接触させる工程であって、組換えオプソニンが、オプソニンの糖鎖認識ドメイン、固体基質結合ドメイン、および該認識ドメインを固体表面結合ドメインに連結させるフレキシブルペプチドドメインからなる、工程;
オプソニン結合微生物を該組換えオプソニン−固体表面コンジュゲートに結合させる工程;ならびに
該微生物が結合した組換えオプソニン−固体表面コンジュゲートから該流体を分離する工程
を含む、流体からオプソニン結合微生物を回収する方法。
14.固体表面が磁性粒子であり、かつオプソニン結合微生物が組換えオプソニン−固体表面コンジュゲートに結合した後に流体に磁力をかけることによって分離が達成される、項目13記載の方法。
15.微生物を同定する工程をさらに含む、項目13記載の方法。
16.流体が生物学的流体である、項目13記載の方法。
17.生物学的流体が、血液、脳脊髄液、滑液、尿、精液、唾液、涙液、および注射針、生検、または吸引の手順によって回収される流体からなる群より選択される、項目16記載の方法。
18.生物学的流体が血液である、項目17記載の方法。
19.血液をその供給源に戻す工程をさらに含む、項目18記載の方法。
20.供給源が対象である、項目19記載の方法。
21.対象が感染症または敗血症に罹患している、項目20記載の方法。
22.流体が水または食物サンプルに由来する、項目13記載の方法。
23.病原体の同定における、項目1〜10のいずれか一項記載の組換えオプソニンの使用。
24.疾患の診断における、項目1〜10のいずれか一項記載の組換えオプソニンの使用。
25.水または食物のコンタミネーションの同定における、項目1〜10のいずれか一項記載の組換えオプソニンの使用。
26.疾患の治療における、項目1〜12のいずれか一項記載の組換えオプソニンの使用。
27.追加の治療または療法とさらに組み合わせた、項目26記載の組換えオプソニンの使用。
28.対象の血液に組換えオプソニンを投与する工程であって、組換えオプソニンが、オプソニンの糖鎖認識ドメイン、基質結合ドメイン、および該認識ドメインを基質結合ドメインに連結させるフレキシブルペプチドドメインからなり、糖鎖認識ドメインがオプソニン結合微生物に結合し、かつ基質結合ドメインが免疫系の細胞、組織、または器官に結合する、工程;
組換えオプソニンをオプソニン結合微生物に結合させる工程;ならびに
微生物が結合した組換えオプソニンを、微生物を殺傷する免疫系の細胞、組織、または器官に結合させる工程
を含む、対象における血液感染症を治療する方法。
29.対象が動物である、項目28記載の方法。
30.対象がヒトである、項目28記載の方法。
診断および治療上の応用のための包括的オプソニンとして有用な改変した形態のMBLの態様を、MBLの「ネック」および「レクチン」ドメインを用いて構築した。プロリン81(構造バイオインフォマティクス研究共同体、タンパク質データバンクの構造ファイル1HUPにおいて定義されている)を、レクチン配列を開始するN末端のポイントとして選択した。レクチン分子のこの部分を、ヒトγ1のFc部分(Fcγ)の下流(C末端)に融合させた。改変オプソニン構築物の略図を図3に示す。クローンのFc部分の図式を図4に示す。この構築物のアミノ酸には、以下の残基が含まれる:
Fcタンパク質配列:
MBL.81タンパク質配列(これには、ヒトMBLのコイルドコイルのネック領域および糖鎖認識ドメイン(CRD)が含まれる):
Fc-MBL.81配列:
およそ550万個のカンジダ・アルビカンス酵母細胞に、野生型、全長MBL(三量体の六量体)、またはFc MBL.81のいずれかをコートした種々の数のMBLビーズを接種した。図9に図で表現されているように、1800万個の野生型、全長MBL、またはFc MBL.81のビーズは、550万個のすべての真菌細胞に結合した。この実施例は、C.アルビカンスへの結合において、Fc MBL.81のビーズが、野生型、全長MBLのビーズと同程度に活性があることを実証している。
Claims (30)
- オプソニンの糖鎖認識ドメイン;
基質結合ドメイン;および
該認識ドメインを基質結合ドメインに連結させるペプチドドメイン
を含む、組換えオプソニン。 - 前記糖鎖認識ドメインがコレクチンもしくはフィコリン(ficollin)である、またはコレクチンもしくはフィコリンに由来する、請求項1記載の組換えオプソニン。
- 前記糖鎖認識ドメインがレクチン、またはレクチンの一部分もしくはフラグメントである、請求項1記載の組換えオプソニン。
- 前記レクチンがマンノース結合レクチン(MBL)である、請求項3記載の組換えオプソニン。
- レクチンがMBLのアミノ酸残基81(プロリン)〜228(イソロイシン)(SEQ ID NO:2)からなる、請求項4記載の組換えオプソニン。
- 前記基質結合ドメインが、固体基質への化学的架橋を可能にする少なくとも1つのシステイン残基を含む、前記請求項のいずれか一項記載の組換えオプソニン。
- フレキシブルペプチドがグリシン+セリンセグメントまたはプロリン+アラニン+セリンセグメントを含む、前記請求項のいずれか一項記載の組換えオプソニン。
- フレキシブルペプチドが免疫グロブリンのFcの部分を含む、前記請求項のいずれか一項記載の組換えオプソニン。
- Fc部分がIgG FcドメインのCH2-CH3境界面を含む、請求項8記載の組換えオプソニン。
- 前記基質が磁性マイクロビーズ、常磁性マイクロビーズ、微多孔膜、中空糸リアクター、または他の任意の流体濾過膜もしくはフローデバイスである、前記請求項のいずれか一項記載の組換えオプソニン。
- 前記基質が生物学的組織または器官の生きた細胞または細胞外マトリックスである、前記請求項のいずれか一項記載の組換えオプソニン。
- 前記基質が食細胞である、請求項11記載の組換えオプソニン。
- 固体表面にコンジュゲートさせた組換えオプソニンと流体を接触させる工程であって、組換えオプソニンが、オプソニンの糖鎖認識ドメイン、固体基質結合ドメイン、および該認識ドメインを固体表面結合ドメインに連結させるフレキシブルペプチドドメインからなる、工程;
オプソニン結合微生物を該組換えオプソニン−固体表面コンジュゲートに結合させる工程;ならびに
該微生物が結合した組換えオプソニン−固体表面コンジュゲートから該流体を分離する工程
を含む、流体からオプソニン結合微生物を回収する方法。 - 固体表面が磁性粒子であり、かつオプソニン結合微生物が組換えオプソニン−固体表面コンジュゲートに結合した後に流体に磁力をかけることによって分離が達成される、請求項13記載の方法。
- 微生物を同定する工程をさらに含む、請求項13記載の方法。
- 流体が生物学的流体である、請求項13記載の方法。
- 生物学的流体が、血液、脳脊髄液、滑液、尿、精液、唾液、涙液、および注射針、生検、または吸引の手順によって回収される流体からなる群より選択される、請求項16記載の方法。
- 生物学的流体が血液である、請求項17記載の方法。
- 血液をその供給源に戻す工程をさらに含む、請求項18記載の方法。
- 供給源が対象である、請求項19記載の方法。
- 対象が感染症または敗血症に罹患している、請求項20記載の方法。
- 流体が水または食物サンプルに由来する、請求項13記載の方法。
- 病原体の同定における、請求項1〜10のいずれか一項記載の組換えオプソニンの使用。
- 疾患の診断における、請求項1〜10のいずれか一項記載の組換えオプソニンの使用。
- 水または食物のコンタミネーションの同定における、請求項1〜10のいずれか一項記載の組換えオプソニンの使用。
- 疾患の治療における、請求項1〜12のいずれか一項記載の組換えオプソニンの使用。
- 追加の治療または療法とさらに組み合わせた、請求項26記載の組換えオプソニンの使用。
- 対象の血液に組換えオプソニンを投与する工程であって、組換えオプソニンが、オプソニンの糖鎖認識ドメイン、基質結合ドメイン、および認識ドメインを基質結合ドメインに連結させるフレキシブルペプチドドメインからなり、糖鎖認識ドメインがオプソニン結合微生物に結合し、かつ基質結合ドメインが免疫系の細胞、組織、または器官に結合する、工程;
組換えオプソニンをオプソニン結合微生物に結合させる工程;ならびに
微生物が結合した組換えオプソニンを、微生物を殺傷する免疫系の細胞、組織、または器官に結合させる工程
を含む、対象における血液感染症を治療する方法。 - 対象が動物である、請求項28記載の方法。
- 対象がヒトである、請求項28記載の方法。
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KR20190142555A (ko) * | 2018-06-18 | 2019-12-27 | 울산과학기술원 | 다중 프로브 혼성화를 이용한 미생물 검출 방법 |
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