JP2013510154A5 - - Google Patents
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- JP2013510154A5 JP2013510154A5 JP2012537924A JP2012537924A JP2013510154A5 JP 2013510154 A5 JP2013510154 A5 JP 2013510154A5 JP 2012537924 A JP2012537924 A JP 2012537924A JP 2012537924 A JP2012537924 A JP 2012537924A JP 2013510154 A5 JP2013510154 A5 JP 2013510154A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- alkyl
- formula
- tert
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 125000004452 carbocyclyl group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 6
- -1 1-adamantyl Chemical group 0.000 claims 5
- 150000004696 coordination complex Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- CAVTUIDTRDJLGP-HKDRDPIHSA-N (2s,3s)-3-tert-butyl-2-[(2s,3s)-3-tert-butyl-2h-1,3-benzoxaphosphol-2-yl]-2h-1,3-benzoxaphosphole Chemical compound O1C2=CC=CC=C2[P@](C(C)(C)C)[C@H]1[C@@H]1[P@@](C(C)(C)C)C2=CC=CC=C2O1 CAVTUIDTRDJLGP-HKDRDPIHSA-N 0.000 claims 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- IYGMJRCUQOOENU-UHFFFAOYSA-N oxaphosphole Chemical compound C1=COP=C1 IYGMJRCUQOOENU-UHFFFAOYSA-N 0.000 claims 2
- 229910052723 transition metal Inorganic materials 0.000 claims 2
- 150000003624 transition metals Chemical class 0.000 claims 2
- KVPCVNGTJXEQKH-OBMDHMNCSA-N (2s,3s)-3-tert-butyl-2-[(2s,3s)-3-tert-butyl-4-methoxy-2h-1,3-benzoxaphosphol-2-yl]-4-methoxy-2h-1,3-benzoxaphosphole Chemical compound O1C2=CC=CC(OC)=C2[P@](C(C)(C)C)[C@H]1[C@H]1OC(C=CC=C2OC)=C2[P@@]1C(C)(C)C KVPCVNGTJXEQKH-OBMDHMNCSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 150000001993 dienes Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052741 iridium Inorganic materials 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000005023 xylyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25841709P | 2009-11-05 | 2009-11-05 | |
| US61/258,417 | 2009-11-05 | ||
| PCT/US2010/054912 WO2011056737A1 (en) | 2009-11-05 | 2010-11-01 | Novel chiral phosphorus ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510154A JP2013510154A (ja) | 2013-03-21 |
| JP2013510154A5 true JP2013510154A5 (enExample) | 2013-12-19 |
| JP5750449B2 JP5750449B2 (ja) | 2015-07-22 |
Family
ID=43587465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537924A Expired - Fee Related JP5750449B2 (ja) | 2009-11-05 | 2010-11-01 | 新規キラルリンリガンド |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8552212B2 (enExample) |
| EP (1) | EP2496589B1 (enExample) |
| JP (1) | JP5750449B2 (enExample) |
| WO (1) | WO2011056737A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CA2715290A1 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8138178B2 (en) | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2323994A1 (en) | 2008-07-25 | 2011-05-25 | Boehringer Ingelheim International GmbH | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| KR20110050459A (ko) | 2008-07-25 | 2011-05-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| JP5750449B2 (ja) | 2009-11-05 | 2015-07-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
| EP2556077B1 (en) * | 2010-04-05 | 2014-03-19 | Boehringer Ingelheim International GmbH | Monophosphorus ligands and their use in cross-coupling reactions |
| JP2013531636A (ja) | 2010-05-26 | 2013-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体 |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| US8816112B2 (en) | 2012-11-15 | 2014-08-26 | Boehringer Ingelheim International Gmbh | Process for making novel chiral phosphorus ligands |
| CN103087105B (zh) * | 2013-01-18 | 2015-08-05 | 中国科学院上海有机化学研究所 | 手性膦配体以及包含该配体的金属催化剂和它们的应用 |
| WO2015002769A1 (en) * | 2013-07-01 | 2015-01-08 | Boehringer Ingelheim International Gmbh | Novel ruthenium catalysts and their use for asymmetric reduction of ketones |
| US8946418B1 (en) * | 2013-07-10 | 2015-02-03 | Boehringer Ingelheim International Gmbh | Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes |
| CN104558038B (zh) * | 2013-10-23 | 2017-03-22 | 中国科学院上海有机化学研究所 | 一种取代的2，3‑二氢苯并[d][1，3]氧杂磷杂茂配体的制备方法 |
| US20150141651A1 (en) | 2013-11-20 | 2015-05-21 | Boehringer Ingelheim International Gmbh | Hexahydroindenopyridine derivatives |
| CN104650145A (zh) * | 2015-02-06 | 2015-05-27 | 中国科学院上海有机化学研究所 | 手性膦配体以及包含该配体的金属催化剂和它们的应用 |
| CN105732249B (zh) * | 2016-01-27 | 2019-03-15 | 中国科学院上海有机化学研究所 | 芳基醇类化合物及艾司西酞普兰合成方法 |
| JP7069202B2 (ja) * | 2016-12-06 | 2022-05-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルジヒドロベンゾアザホスホール配位子及びその合成 |
| EP3551638A2 (en) | 2016-12-06 | 2019-10-16 | Boehringer Ingelheim International GmbH | Novel chiral dihydrobenzooxaphosphole ligands and synthesis thereof |
| CN107445999B (zh) * | 2017-08-15 | 2020-11-13 | 中国科学院上海有机化学研究所 | 金属络合物、制备方法和应用及其中间体 |
| CN107827929B (zh) * | 2017-11-17 | 2020-03-10 | 中国科学院上海有机化学研究所 | 一种联芳基双膦配体、其制备方法及应用 |
| CN109096338B (zh) * | 2018-09-10 | 2020-05-12 | 中国科学院上海有机化学研究所 | 苯并氮杂磷杂茂膦氧配体及含其络合物、制备方法和应用 |
| CN111018918B (zh) * | 2018-10-10 | 2022-10-04 | 中国科学院上海有机化学研究所 | 一种金属配合物、中间体、其制备方法及应用 |
| CN111848680B (zh) * | 2019-04-30 | 2021-12-14 | 中国科学院上海有机化学研究所 | 双齿膦-膦氧配体及其中间体、制备方法和应用 |
| CN112574234B (zh) * | 2019-09-27 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | 一种海鞘素衍生物的制备方法 |
| CN111647020A (zh) * | 2020-04-09 | 2020-09-11 | 宁波赜军医药科技有限公司 | 一种膦氧双齿配体的合成方法 |
| CN113636950B (zh) | 2020-05-11 | 2023-01-17 | 浙江医药股份有限公司新昌制药厂 | 一种手性4-芳基-β-氨基酸衍生物的制备方法 |
| WO2025103462A1 (en) * | 2023-11-17 | 2025-05-22 | Shenzhen Catalys Technology Co., Ltd | Substituted 2, 3-dihydrobenzo [d] [1, 3] oxaphosphole ligand, preparation method and use thereof |
| CN118619995A (zh) * | 2024-04-16 | 2024-09-10 | 凯特立斯（深圳）科技有限公司 | 一种富电子双膦配体、制备及其应用 |
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| JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤 |
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| US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
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| JP5451646B2 (ja) | 2008-02-27 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
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| US8138178B2 (en) | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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| WO2009134392A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
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| KR20110050459A (ko) | 2008-07-25 | 2011-05-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| EP2323994A1 (en) | 2008-07-25 | 2011-05-25 | Boehringer Ingelheim International GmbH | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5589003B2 (ja) | 2009-02-04 | 2014-09-10 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体 |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| EP2405913A1 (en) | 2009-03-09 | 2012-01-18 | Bristol-Myers Squibb Company | Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| US20100331320A1 (en) | 2009-04-30 | 2010-12-30 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR076936A1 (es) | 2009-06-02 | 2011-07-20 | Vitae Pharmaceuticals Inc | Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
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| CN102625803A (zh) | 2009-09-11 | 2012-08-01 | 赛林药物股份有限公司 | 药学上有用的杂环-取代的内酰胺 |
| JP5750449B2 (ja) | 2009-11-05 | 2015-07-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
-
2010
- 2010-11-01 JP JP2012537924A patent/JP5750449B2/ja not_active Expired - Fee Related
- 2010-11-01 WO PCT/US2010/054912 patent/WO2011056737A1/en not_active Ceased
- 2010-11-01 US US13/504,146 patent/US8552212B2/en not_active Expired - Fee Related
- 2010-11-01 EP EP10774398.1A patent/EP2496589B1/en not_active Not-in-force
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