JP5750449B2 - 新規キラルリンリガンド - Google Patents

新規キラルリンリガンド Download PDF

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JP5750449B2
JP5750449B2 JP2012537924A JP2012537924A JP5750449B2 JP 5750449 B2 JP5750449 B2 JP 5750449B2 JP 2012537924 A JP2012537924 A JP 2012537924A JP 2012537924 A JP2012537924 A JP 2012537924A JP 5750449 B2 JP5750449 B2 JP 5750449B2
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membered
alkyl
formula
tert
mixture
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JP2013510154A5 (enExample
JP2013510154A (ja
Inventor
チュ，ボ
セナナヤケ，クリス・ヒュー
タン，ウェンジュン
ウェイ，シュードン
イー，ネイサン・ケイ
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
    • C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2012537924A 2009-11-05 2010-11-01 新規キラルリンリガンド Expired - Fee Related JP5750449B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25841709P 2009-11-05 2009-11-05
US61/258,417 2009-11-05
PCT/US2010/054912 WO2011056737A1 (en) 2009-11-05 2010-11-01 Novel chiral phosphorus ligands

Publications (3)

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JP2013510154A JP2013510154A (ja) 2013-03-21
JP2013510154A5 JP2013510154A5 (enExample) 2013-12-19
JP5750449B2 true JP5750449B2 (ja) 2015-07-22

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US (1) US8552212B2 (enExample)
EP (1) EP2496589B1 (enExample)
JP (1) JP5750449B2 (enExample)
WO (1) WO2011056737A1 (enExample)

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JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
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US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
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UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
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CN103087105B (zh) * 2013-01-18 2015-08-05 中国科学院上海有机化学研究所 手性膦配体以及包含该配体的金属催化剂和它们的应用
US9029540B2 (en) * 2013-07-01 2015-05-12 Boehringer Ingelheim International Gmbh Ruthenium catalysts and their use for asymmetric reduction of ketones
US8946418B1 (en) * 2013-07-10 2015-02-03 Boehringer Ingelheim International Gmbh Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes
CN104558038B (zh) * 2013-10-23 2017-03-22 中国科学院上海有机化学研究所 一种取代的2，3‑二氢苯并[d][1，3]氧杂磷杂茂配体的制备方法
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CN104650145A (zh) * 2015-02-06 2015-05-27 中国科学院上海有机化学研究所 手性膦配体以及包含该配体的金属催化剂和它们的应用
CN105732249B (zh) * 2016-01-27 2019-03-15 中国科学院上海有机化学研究所 芳基醇类化合物及艾司西酞普兰合成方法
JP2020500937A (ja) 2016-12-06 2020-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルジヒドロベンゾオキサホスホール配位子及びその合成
JP7069202B2 (ja) * 2016-12-06 2022-05-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルジヒドロベンゾアザホスホール配位子及びその合成
CN107445999B (zh) * 2017-08-15 2020-11-13 中国科学院上海有机化学研究所 金属络合物、制备方法和应用及其中间体
CN107827929B (zh) * 2017-11-17 2020-03-10 中国科学院上海有机化学研究所 一种联芳基双膦配体、其制备方法及应用
CN109096338B (zh) * 2018-09-10 2020-05-12 中国科学院上海有机化学研究所 苯并氮杂磷杂茂膦氧配体及含其络合物、制备方法和应用
CN111018918B (zh) * 2018-10-10 2022-10-04 中国科学院上海有机化学研究所 一种金属配合物、中间体、其制备方法及应用
CN111848680B (zh) * 2019-04-30 2021-12-14 中国科学院上海有机化学研究所 双齿膦-膦氧配体及其中间体、制备方法和应用
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
CN111647020A (zh) * 2020-04-09 2020-09-11 宁波赜军医药科技有限公司 一种膦氧双齿配体的合成方法
CN113636950B (zh) 2020-05-11 2023-01-17 浙江医药股份有限公司新昌制药厂 一种手性4-芳基-β-氨基酸衍生物的制备方法
CN122249450A (zh) * 2023-11-17 2026-06-19 凯特立斯（深圳）科技有限公司 取代的2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯配体、其制备方法及应用
CN118619995B (zh) * 2024-04-16 2026-07-31 凯特立斯（深圳）科技有限公司 一种富电子双膦配体、制备及其应用
CN119504577A (zh) * 2024-11-27 2025-02-25 浙江永太科技股份有限公司 一种4-取代-1,2-二氢喹啉的选择性不对称氢化方法及其应用

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WO2011056737A1 (en) 2011-05-12
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