JP2013501037A - Ｃ−ｍｅｔチロシンキナーゼモジュレーターとしての３−ヘテロアリールメチル−イミダゾ［１，２−ｂ］ピリダジン−６−イル誘導体 - Google Patents

Ｃ−ｍｅｔチロシンキナーゼモジュレーターとしての３−ヘテロアリールメチル−イミダゾ［１，２−ｂ］ピリダジン−６−イル誘導体 Download PDF

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JP2013501037A
JP2013501037A JP2012523349A JP2012523349A JP2013501037A JP 2013501037 A JP2013501037 A JP 2013501037A JP 2012523349 A JP2012523349 A JP 2012523349A JP 2012523349 A JP2012523349 A JP 2012523349A JP 2013501037 A JP2013501037 A JP 2013501037A
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Prior art keywords
imidazo
pyridazin
difluoro
ethyl
quinolin
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Japanese (ja)
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パスカル・フュレ
クライブ・マッカーシー
ヨーゼフ・シェープファー
シュテファン・シュトゥッツ
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012523349A 2009-08-07 2010-08-06 Ｃ−ｍｅｔチロシンキナーゼモジュレーターとしての３−ヘテロアリールメチル−イミダゾ［１，２−ｂ］ピリダジン−６−イル誘導体 Pending JP2013501037A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27375609P 2009-08-07 2009-08-07
US61/273,756 2009-08-07
PCT/EP2010/061485 WO2011015652A1 (en) 2009-08-07 2010-08-06 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives as c-met tyrosine kinase modulators

Publications (1)

Publication Number Publication Date
JP2013501037A true JP2013501037A (ja) 2013-01-10

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Family Applications (1)

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JP2012523349A Pending JP2013501037A (ja) 2009-08-07 2010-08-06 Ｃ−ｍｅｔチロシンキナーゼモジュレーターとしての３−ヘテロアリールメチル−イミダゾ［１，２−ｂ］ピリダジン−６−イル誘導体

Country Status (15)

Country Link
US (1) US8389526B2 (Direct)
EP (1) EP2462143B1 (Direct)
JP (1) JP2013501037A (Direct)
KR (1) KR20120053030A (Direct)
CN (1) CN102482287B (Direct)
AR (1) AR077714A1 (Direct)
AU (1) AU2010280706A1 (Direct)
BR (1) BR112012002801A2 (Direct)
CA (1) CA2770248A1 (Direct)
ES (1) ES2426405T3 (Direct)
IN (1) IN2012DN00953A (Direct)
MX (1) MX2012001529A (Direct)
TW (1) TW201107332A (Direct)
UY (1) UY32829A (Direct)
WO (1) WO2011015652A1 (Direct)

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WO2011018454A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
MX2012002179A (es) 2009-08-20 2012-03-16 Novartis Ag Compuestos heterociclicos de oxima.
CN103958509B (zh) * 2011-09-15 2015-12-23 诺华股份有限公司 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
US9062045B2 (en) 2011-09-15 2015-06-23 Novartis Ag Triazolopyridine compounds
WO2014071832A1 (en) 2012-11-06 2014-05-15 Shanghai Fochon Pharmaceutical Co Ltd Alk kinase inhibitors
CN105431148A (zh) 2013-03-07 2016-03-23 加利菲亚生物公司 混合谱系激酶抑制剂及治疗方法
CN109771642B (zh) 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
CN111226956B (zh) * 2019-11-26 2021-10-26 贵州医科大学 3,6-二取代咪唑[1,2-b]哒嗪类衍生物在制备抑制植物病原真菌杀菌剂中的应用
WO2025248032A1 (en) 2024-05-31 2025-12-04 Syngenta Crop Protection Ag Pesticidally active indazole compounds

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WO2009091374A2 (en) * 2008-01-15 2009-07-23 Amgen Inc. Fused heterocyclic derivatives and methods of use

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