|
JP5004390B2
(ja)
*
|
1999-08-23 |
2012-08-22 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
新規b7−4分子およびその用途
|
|
EP1210428B1
(en)
*
|
1999-08-23 |
2015-03-18 |
Dana-Farber Cancer Institute, Inc. |
Pd-1, a receptor for b7-4, and uses therefor
|
|
PT1234031T
(pt)
|
1999-11-30 |
2017-06-26 |
Mayo Foundation |
B7-h1, uma nova molécula imunoregulatória
|
|
US7030219B2
(en)
|
2000-04-28 |
2006-04-18 |
Johns Hopkins University |
B7-DC, Dendritic cell co-stimulatory molecules
|
|
US7432351B1
(en)
|
2002-10-04 |
2008-10-07 |
Mayo Foundation For Medical Education And Research |
B7-H1 variants
|
|
PT3428191T
(pt)
*
|
2004-10-06 |
2024-12-30 |
Mayo Found Medical Education & Res |
B7-h1 e tratamento do carcinona de células renais
|
|
EP3130350A1
(en)
|
2005-06-08 |
2017-02-15 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway
|
|
CA2630483C
(en)
|
2005-12-08 |
2015-05-19 |
Medarex, Inc. |
Human monoclonal antibodies to o8e
|
|
US20090215084A1
(en)
*
|
2006-01-05 |
2009-08-27 |
Mayo Foundation For Medical Education And Research |
B7-h1 and b7-h4 in cancer
|
|
US20100015642A1
(en)
*
|
2006-01-05 |
2010-01-21 |
Kwon Eugene D |
B7-h1 and survivin in cancer
|
|
WO2007124361A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Mayo Foundation For Medical Education And Research |
Soluble b7-h1
|
|
MY150756A
(en)
*
|
2006-08-21 |
2014-02-28 |
Hoffmann La Roche |
Tumor theraphy with an anti-vegf antibody
|
|
CA2668800A1
(en)
*
|
2006-11-08 |
2008-06-05 |
Macrogenics West, Inc. |
Tes7 and antibodies that bind thereto
|
|
AU2014268176B2
(en)
*
|
2006-12-27 |
2016-03-31 |
Dana-Farber Cancer Institute, Inc |
Compositions and methods for the treatment of infections and tumors
|
|
US7989173B2
(en)
|
2006-12-27 |
2011-08-02 |
The Johns Hopkins University |
Detection and diagnosis of inflammatory disorders
|
|
AU2013200388B2
(en)
*
|
2006-12-27 |
2014-10-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for the treatment of infections and tumors
|
|
NZ720288A
(en)
*
|
2006-12-27 |
2020-02-28 |
Harvard College |
Compositions and methods for the treatment of infections and tumors
|
|
CA2673659A1
(en)
*
|
2006-12-27 |
2008-07-10 |
The Johns Hopkins University |
Methods of detecting and diagnosing inflamatory responses and disorders by determining the level of soluble b7-h4
|
|
JP2010528591A
(ja)
*
|
2007-05-23 |
2010-08-26 |
マンカインド コーポレイション |
マルチシストロン性ベクター及びそれらの設計方法
|
|
NZ600758A
(en)
|
2007-06-18 |
2013-09-27 |
Merck Sharp & Dohme |
Antibodies to human programmed death receptor pd-1
|
|
EP2514762B1
(en)
|
2007-07-13 |
2015-04-08 |
The Johns Hopkins University |
B7-DC variants
|
|
US8062852B2
(en)
*
|
2007-10-01 |
2011-11-22 |
The Children's Hospital And Regional Medical Center |
Detection and treatment of autoimmune disorders
|
|
WO2009111315A2
(en)
*
|
2008-02-29 |
2009-09-11 |
Mayo Foundation For Medical Education And Research |
Methods for reducing granulomatous inflammation
|
|
EP2262837A4
(en)
*
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
WO2010011845A2
(en)
*
|
2008-07-24 |
2010-01-28 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Methods of preventing or treating viral infection or reactivation after latency in a host using inhibitors of the lsd1 protein
|
|
AR072999A1
(es)
*
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
CA2735006A1
(en)
*
|
2008-08-25 |
2010-03-11 |
Amplimmune, Inc. |
Pd-1 antagonists and methods of use thereof
|
|
EP2927240A1
(en)
*
|
2008-08-25 |
2015-10-07 |
Amplimmune, Inc. |
Compositions of pd-1 antagonists and methods of use
|
|
EP2342228B1
(en)
|
2008-09-12 |
2017-09-06 |
Oxford University Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
|
ES2592216T3
(es)
|
2008-09-26 |
2016-11-28 |
Dana-Farber Cancer Institute, Inc. |
Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
|
|
HRP20180045T1
(hr)
|
2008-10-02 |
2018-03-23 |
Aptevo Research And Development Llc |
Proteini antagonisti cd86 koji se vežu na više meta
|
|
US11542328B2
(en)
|
2008-11-14 |
2023-01-03 |
The Brigham And Women's Hospital, Inc. |
Therapeutic and diagnostic methods relating to cancer stem cells
|
|
ES2796111T3
(es)
|
2008-11-14 |
2020-11-25 |
Brigham & Womens Hospital Inc |
Métodos terapéuticos relacionados con células madre cancerosas
|
|
CN102282265B
(zh)
*
|
2008-11-28 |
2020-07-24 |
埃默里大学 |
用于治疗传染病和肿瘤的方法
|
|
WO2010077634A1
(en)
|
2008-12-09 |
2010-07-08 |
Genentech, Inc. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
EP2404997B1
(en)
*
|
2009-03-06 |
2017-10-18 |
Mie University |
Method for enhancing t cell function
|
|
EP3002296B1
(en)
*
|
2009-03-17 |
2020-04-29 |
Université d'Aix-Marseille |
Btla antibodies and uses thereof
|
|
EP2408449A4
(en)
|
2009-03-18 |
2012-08-08 |
Univ Leland Stanford Junior |
METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS
|
|
US9005616B2
(en)
|
2009-08-31 |
2015-04-14 |
Amplimmune, Inc. |
Methods and compositions for the inhibition of transplant rejection
|
|
CA2775761C
(en)
|
2009-09-30 |
2018-08-28 |
Memorial Sloan-Kettering Cancer Center |
Combination immunotherapy for the treatment of cancer
|
|
NZ599405A
(en)
*
|
2009-11-24 |
2014-09-26 |
Medimmune Ltd |
Targeted binding agents against b7-h1
|
|
EP2531855A4
(en)
*
|
2010-02-04 |
2013-08-07 |
Virostatics Srl |
KI-67 ASSAY FOR DETERMINING THE STATUS OF A PATIENT'S IMMUNE SYSTEM
|
|
WO2011100841A1
(en)
*
|
2010-02-16 |
2011-08-25 |
Valorisation-Recherche, Limited Partnership |
Pd-1 modulation and uses thereof for modulating hiv replication
|
|
TW201134488A
(en)
*
|
2010-03-11 |
2011-10-16 |
Ucb Pharma Sa |
PD-1 antibodies
|
|
EP2545078A1
(en)
|
2010-03-11 |
2013-01-16 |
UCB Pharma, S.A. |
Pd-1 antibody
|
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
|
CA2794483C
(en)
|
2010-03-26 |
2020-07-07 |
Trustees Of Dartmouth College |
Vista regulatory t cell mediator protein, vista binding agents and use thereof
|
|
US9163087B2
(en)
|
2010-06-18 |
2015-10-20 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
|
|
US8907053B2
(en)
*
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
EP2595613B1
(en)
|
2010-07-22 |
2019-01-09 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Compounds for use in a method of preventing or treating viral infection
|
|
PL2699264T3
(pl)
|
2011-04-20 |
2018-08-31 |
Medimmune, Llc |
Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1
|
|
PE20141520A1
(es)
|
2011-07-29 |
2014-11-17 |
Univ Pennsylvania |
Receptores coestimuladores de cambio
|
|
CA2845536A1
(en)
|
2011-08-15 |
2013-02-21 |
Amplimmune, Inc. |
Anti-b7-h4 antibodies and their uses
|
|
EP3210625B1
(en)
|
2011-09-30 |
2019-08-28 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides comprising antibodies binding to mhc class 1 polypeptide related sequence a (mica)
|
|
BR112014013649A2
(pt)
|
2011-12-06 |
2020-10-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
métodos e agentes para o tratamento de doenças virais e usos dos referidos agentes
|
|
WO2013090552A1
(en)
*
|
2011-12-13 |
2013-06-20 |
Yale University |
Compositions and methods for reducing ctl exhaustion
|
|
AU2013221187B9
(en)
|
2012-02-16 |
2018-01-04 |
Vlp Therapeutics, Inc. |
Virus like particle composition
|
|
EP3939572B1
(en)
|
2012-04-12 |
2024-03-27 |
Yale University |
Vehicles for controlled delivery of different pharmaceutical agents
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
WO2013177102A2
(en)
*
|
2012-05-21 |
2013-11-28 |
Felder Mitchell S |
Treatment of cancer by manipulating the immune system
|
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
|
TWI677507B
(zh)
|
2012-06-22 |
2019-11-21 |
達特茅斯學院基金會 |
新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途
|
|
US9845356B2
(en)
*
|
2012-08-03 |
2017-12-19 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
|
|
EP2892558B1
(en)
|
2012-09-07 |
2019-04-10 |
The Trustees Of Dartmouth College |
Vista modulators for diagnosis and treatment of cancer
|
|
BR112015012644A2
(pt)
|
2012-11-30 |
2017-12-19 |
Hoffmann La Roche |
método para determinar a necessidade de um paciente com câncer, método de tratamento do câncer, composição farmacêutica, uso de um ácido nucleico ou anticorpo e kit;
|
|
EP2934575A2
(en)
|
2012-12-19 |
2015-10-28 |
Amplimmune, Inc. |
B7-h4 specific antibodies, and compositions and methods of use thereof
|
|
WO2014122271A1
(en)
|
2013-02-07 |
2014-08-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the survival time of patients suffering from diffuse large b-cell lymphomas
|
|
DK3292873T3
(da)
|
2013-02-22 |
2019-06-03 |
Curevac Ag |
Kombination af vaccination og hæmning af PD-1-vejen
|
|
US9974845B2
(en)
|
2013-02-22 |
2018-05-22 |
Curevac Ag |
Combination of vaccination and inhibition of the PD-1 pathway
|
|
US9302005B2
(en)
|
2013-03-14 |
2016-04-05 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
|
WO2014144791A2
(en)
|
2013-03-15 |
2014-09-18 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
JP6483082B2
(ja)
*
|
2013-03-15 |
2019-03-13 |
ジェネンテック, インコーポレイテッド |
Pd−1及びpd−l1に関連する状態を治療するためのバイオマーカー及び方法
|
|
HRP20210122T1
(hr)
|
2013-05-02 |
2021-04-16 |
Anaptysbio, Inc. |
Protutijela usmjerena protiv programirane smrti-1 (pd-1)
|
|
WO2014194293A1
(en)
|
2013-05-30 |
2014-12-04 |
Amplimmune, Inc. |
Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
|
|
CN111423511B
(zh)
|
2013-05-31 |
2024-02-23 |
索伦托药业有限公司 |
与pd-1结合的抗原结合蛋白
|
|
US9637532B2
(en)
*
|
2013-07-12 |
2017-05-02 |
Vlp Therapeutics, Llc |
Virus like particle comprising PD-1 antigen or PD-1 ligand antigen
|
|
WO2015038538A1
(en)
*
|
2013-09-10 |
2015-03-19 |
Medimmune, Llc |
Compositions and methods for treating sepsis
|
|
AR097584A1
(es)
|
2013-09-12 |
2016-03-23 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
|
|
ES2792183T3
(es)
|
2013-09-13 |
2020-11-10 |
Beigene Switzerland Gmbh |
Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico
|
|
EP3757130A1
(en)
|
2013-09-26 |
2020-12-30 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
US10259875B2
(en)
|
2013-10-01 |
2019-04-16 |
Mayo Foundation For Medical Education And Research |
Methods for treating cancer in patients with elevated levels of BIM
|
|
CN105848649B
(zh)
|
2013-11-01 |
2019-08-02 |
耶鲁大学 |
用于免疫疗法的模块化粒子
|
|
WO2015085210A1
(en)
*
|
2013-12-06 |
2015-06-11 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic peptides
|
|
PE20160953A1
(es)
|
2013-12-12 |
2016-09-26 |
Shanghai hengrui pharmaceutical co ltd |
Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este
|
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
|
CN119775416A
(zh)
|
2013-12-24 |
2025-04-08 |
杨森制药公司 |
抗vista抗体及片段
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
GB201403775D0
(en)
|
2014-03-04 |
2014-04-16 |
Kymab Ltd |
Antibodies, uses & methods
|
|
ES2754239T3
(es)
|
2014-03-12 |
2020-04-16 |
Curevac Ag |
Combinación de vacunación y agonistas de OX40
|
|
WO2015139020A2
(en)
|
2014-03-14 |
2015-09-17 |
Dana-Farber Cancer Institute, Inc. |
Vaccine compositions and methods for restoring nkg2d pathway function against cancers
|
|
ME03558B
(me)
|
2014-03-14 |
2020-07-20 |
Novartis Ag |
Molekuli anti-lag-3 antiтela i njihove upotrebe
|
|
US11230719B2
(en)
*
|
2014-03-26 |
2022-01-25 |
Denovo Biopharma Llc |
Retroviral vector having immune-stimulating activity
|
|
WO2015179654A1
(en)
|
2014-05-22 |
2015-11-26 |
Mayo Foundation For Medical Education And Research |
Distinguishing antagonistic and agonistic anti b7-h1 antibodies
|
|
JP6997619B2
(ja)
|
2014-06-11 |
2022-01-17 |
キャシー・エイ・グリーン |
液性免疫の抑制または増進のための、vistaアゴニスト及びvistaアンタゴニストの使用
|
|
DK3157956T3
(da)
|
2014-06-19 |
2020-04-27 |
Regeneron Pharma |
Ikke-humane dyr med et humaniseret gen med programmeret celledød 1
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
CN106604742B
(zh)
|
2014-07-03 |
2019-01-11 |
百济神州有限公司 |
抗pd-l1抗体及其作为治疗剂及诊断剂的用途
|
|
EP3309174B1
(en)
|
2014-07-11 |
2022-05-11 |
Ventana Medical Systems, Inc. |
Anti-pd-l1 antibodies and diagnostic uses thereof
|
|
JP6843736B2
(ja)
|
2014-07-16 |
2021-03-17 |
トランジェーヌTransgene |
腫瘍溶解性ウイルスと免疫チェックポイントモジュレーターとの組合せ
|
|
JP6895374B2
(ja)
|
2014-07-16 |
2021-06-30 |
トランジェーヌTransgene |
免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス
|
|
US10517875B2
(en)
|
2014-07-23 |
2019-12-31 |
Mayo Foundation for Medical Engineering and Research |
Targeting DNA-PKcs and B7-H1 to treat cancer
|
|
US9982052B2
(en)
|
2014-08-05 |
2018-05-29 |
MabQuest, SA |
Immunological reagents
|
|
CA2957258C
(en)
|
2014-08-05 |
2023-11-07 |
MabQuest SA |
Immunological reagents
|
|
US10385101B2
(en)
|
2014-08-08 |
2019-08-20 |
Vlp Therapeutics, Llc |
Virus like particle comprising modified envelope protein E3
|
|
WO2016020538A1
(en)
*
|
2014-08-08 |
2016-02-11 |
Transgene Sa |
Hbv vaccine and antibody combination therapy to treat hbv infections
|
|
JP6824154B2
(ja)
|
2014-08-08 |
2021-02-03 |
ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC |
修飾エンベロープタンパク質e3を含むウイルス様粒子
|
|
AU2015301753B2
(en)
*
|
2014-08-12 |
2021-04-08 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with IL-2 and integrin-binding-Fc-fusion protein
|
|
WO2016038895A1
(en)
|
2014-09-11 |
2016-03-17 |
Vlp Therapeutics, Llc |
Flavivirus virus like particle
|
|
KR20170060042A
(ko)
|
2014-09-13 |
2017-05-31 |
노파르티스 아게 |
Alk 억제제의 조합 요법
|
|
MX391478B
(es)
|
2014-10-10 |
2025-03-21 |
Idera Pharmaceuticals Inc |
Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
|
|
MX389663B
(es)
|
2014-10-14 |
2025-03-20 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
|
|
WO2016061456A2
(en)
*
|
2014-10-17 |
2016-04-21 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of t-cell exhaustion using cd39 biomarkers and modulators
|
|
AU2015357463B2
(en)
|
2014-12-05 |
2021-10-07 |
Immunext, Inc. |
Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
|
|
GB201500319D0
(en)
|
2015-01-09 |
2015-02-25 |
Agency Science Tech & Res |
Anti-PD-L1 antibodies
|
|
JP6737185B2
(ja)
*
|
2015-01-29 |
2020-08-05 |
コニカミノルタ株式会社 |
相互作用する分子を有する血中細胞の同時検出方法
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
WO2016128542A1
(en)
|
2015-02-13 |
2016-08-18 |
Transgene Sa |
Immunotherapeutic vaccine and antibody combination therapy
|
|
MX2017011644A
(es)
|
2015-03-13 |
2017-12-04 |
Cytomx Therapeutics Inc |
Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos.
|
|
RS60614B1
(sr)
|
2015-03-23 |
2020-08-31 |
Jounce Therapeutics Inc |
Antitela za icos
|
|
WO2016162867A1
(en)
*
|
2015-04-08 |
2016-10-13 |
Efranat Ltd. |
Combination therapy of macrophage activating factor and pd-1 signaling inhibitors
|
|
HUE045866T2
(hu)
|
2015-05-04 |
2020-01-28 |
Affimed Gmbh |
CD30XCD16A antitest kombinálása anti-PD-1-antagonista antitesttel terápiához
|
|
EP3090751A1
(en)
*
|
2015-05-06 |
2016-11-09 |
Université de Lausanne |
Molecular profiling of cd8 t-cells in autochthonous melanoma identifies maf as driver of exhaustion
|
|
EP3303619B1
(en)
*
|
2015-05-29 |
2020-06-10 |
H. Hoffnabb-La Roche Ag |
Pd-l1 promoter methylation in cancer
|
|
CN107849144B
(zh)
|
2015-05-29 |
2021-09-17 |
艾吉纳斯公司 |
抗-ctla-4抗体及其使用方法
|
|
TWI773646B
(zh)
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
EP3722314A1
(en)
|
2015-06-24 |
2020-10-14 |
Janssen Pharmaceutica NV |
Anti-vista antibodies and fragments
|
|
PL3322731T3
(pl)
*
|
2015-07-14 |
2021-05-31 |
Bristol-Myers Squibb Company |
Sposób leczenia raka inhibitorem immunologicznych punktów kontrolnych; przeciwciałem, które wiąże się z receptorem programowanej śmierci-1 (pd-1) lub ligandem receptora programowanej śmierci 1 (pd-l1)
|
|
CN116333138A
(zh)
|
2015-07-30 |
2023-06-27 |
宏观基因有限公司 |
Pd-1结合分子和其使用方法
|
|
EP3331901A1
(en)
|
2015-08-07 |
2018-06-13 |
Pieris Pharmaceuticals GmbH |
Novel fusion polypeptide specific for lag-3 and pd-1
|
|
WO2017024465A1
(en)
|
2015-08-10 |
2017-02-16 |
Innovent Biologics (Suzhou) Co., Ltd. |
Pd-1 antibodies
|
|
FI3334763T3
(fi)
|
2015-08-11 |
2024-10-30 |
Wuxi Biologics Ireland Ltd |
Uusia pd-l1-vasta-aineita
|
|
WO2017031760A1
(zh)
*
|
2015-08-27 |
2017-03-02 |
杨光华 |
干涉片段及其应用
|
|
WO2017031761A1
(zh)
*
|
2015-08-27 |
2017-03-02 |
杨光华 |
干涉片段及其应用
|
|
HK1257840A1
(zh)
|
2015-09-01 |
2019-11-01 |
Agenus Inc. |
抗-pd-1抗体及其使用方法
|
|
AU2016332725A1
(en)
|
2015-09-29 |
2018-03-22 |
Celgene Corporation |
PD-1 binding proteins and methods of use thereof
|
|
PE20180773A1
(es)
|
2015-10-02 |
2018-05-07 |
Hoffmann La Roche |
Anticuerpos biespecificos para pd1 y tim3
|
|
CA2997799A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-pd1 antibodies and methods of use
|
|
IL258521B2
(en)
*
|
2015-10-08 |
2024-01-01 |
Macrogenics Inc |
Combination therapy for the treatment of cancer
|
|
US10968277B2
(en)
|
2015-10-22 |
2021-04-06 |
Jounce Therapeutics, Inc. |
Gene signatures for determining ICOS expression
|
|
US10875923B2
(en)
|
2015-10-30 |
2020-12-29 |
Mayo Foundation For Medical Education And Research |
Antibodies to B7-H1
|
|
SI3370768T1
(sl)
|
2015-11-03 |
2022-04-29 |
Janssen Biotech, Inc. |
Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe
|
|
TW202208440A
(zh)
|
2015-12-14 |
2022-03-01 |
美商宏觀基因股份有限公司 |
對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法
|
|
US11214617B2
(en)
|
2016-01-22 |
2022-01-04 |
MabQuest SA |
Immunological reagents
|
|
CA3012075A1
(en)
|
2016-01-22 |
2017-07-27 |
MabQuest SA |
Immunological reagents
|
|
CN116769054A
(zh)
*
|
2016-02-05 |
2023-09-19 |
奥里尼斯生物科学私人有限公司 |
双特异性信号传导剂及其用途
|
|
MX2018009800A
(es)
|
2016-02-12 |
2018-11-09 |
Janssen Pharmaceutica Nv |
Anticuerpos y fragmentos anti-vista, usos de los mismos y procedimientos de identificacion de los mismos.
|
|
WO2017155981A1
(en)
|
2016-03-07 |
2017-09-14 |
Massachusetts Institute Of Technology |
Protein-chaperoned t-cell vaccines
|
|
AR108038A1
(es)
*
|
2016-03-14 |
2018-07-11 |
Roche Innovation Ct Copenhagen As |
Oligonucleótidos para reducir la expresión de pd-l1 (ligando de muerte programada-1)
|
|
CA3016474A1
(en)
|
2016-03-15 |
2017-09-21 |
Mersana Therapeutics, Inc. |
Napi2b-targeted antibody-drug conjugates and methods of use thereof
|
|
US11185555B2
(en)
|
2016-04-11 |
2021-11-30 |
Noah James Harrison |
Method to kill pathogenic microbes in a patient
|
|
EP3448412A4
(en)
|
2016-04-15 |
2020-03-25 |
Immunext Inc. |
ANTI-HUMAN-VISTA ANTIBODIES AND USE THEREOF
|
|
EP3243832A1
(en)
|
2016-05-13 |
2017-11-15 |
F. Hoffmann-La Roche AG |
Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
|
|
BR112018076260A2
(pt)
|
2016-06-20 |
2019-03-26 |
Kymab Limited |
anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
|
|
US9567399B1
(en)
|
2016-06-20 |
2017-02-14 |
Kymab Limited |
Antibodies and immunocytokines
|
|
EP3478321A4
(en)
|
2016-06-30 |
2020-04-22 |
Oncorus, Inc. |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
CN109475536B
(zh)
|
2016-07-05 |
2022-05-27 |
百济神州有限公司 |
用于治疗癌症的PD-l拮抗剂和RAF抑制剂的组合
|
|
CA3032826A1
(en)
|
2016-08-03 |
2018-02-08 |
Nextcure, Inc. |
Compositions and methods for modulating lair signal transduction
|
|
CN116640214A
(zh)
|
2016-08-09 |
2023-08-25 |
科马布有限公司 |
分离抗体及其应用
|
|
PT3500299T
(pt)
|
2016-08-19 |
2024-02-21 |
Beigene Switzerland Gmbh |
Combinação de zanubrutinib com um anticorpo anti-cd20 ou anti-pd-1 para utilização no tratamento do cancro
|
|
WO2018036852A1
(en)
|
2016-08-25 |
2018-03-01 |
F. Hoffmann-La Roche Ag |
Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent
|
|
EP3512563A1
(en)
|
2016-09-16 |
2019-07-24 |
The Johns Hopkins University |
Protein nanocages with enhanced mucus penetration for targeted tissue and intracellular delivery
|
|
US10751414B2
(en)
|
2016-09-19 |
2020-08-25 |
Celgene Corporation |
Methods of treating psoriasis using PD-1 binding antibodies
|
|
JP2019534859A
(ja)
|
2016-09-19 |
2019-12-05 |
セルジーン コーポレイション |
Pd−1結合タンパク質を使用して白斑を治療する方法
|
|
CN106480027A
(zh)
*
|
2016-09-30 |
2017-03-08 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9 靶向敲除人PD‑1基因及其特异性gRNA
|
|
JP7288854B2
(ja)
*
|
2016-10-07 |
2023-06-08 |
セカルナ・ファーマシューティカルズ・ゲーエムベーハー・ウント・コ・カーゲー |
がんを治療するための新規アプローチ
|
|
EP3666794A1
(en)
|
2016-11-01 |
2020-06-17 |
AnaptysBio, Inc. |
Antibodies directed against programmed death- 1 (pd-1)
|
|
US11779604B2
(en)
|
2016-11-03 |
2023-10-10 |
Kymab Limited |
Antibodies, combinations comprising antibodies, biomarkers, uses and methods
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
EP3551225A1
(en)
|
2016-12-07 |
2019-10-16 |
Agenus Inc. |
Antibodies and methods of use thereof
|
|
FI3551660T3
(fi)
|
2016-12-07 |
2023-12-11 |
Agenus Inc |
Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
|
|
JP7304287B2
(ja)
|
2016-12-22 |
2023-07-06 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
抗pd-l1/pd1治療の不成功後の、抗pd-l1抗体との組み合わせでの抗csf-1r抗体を用いた腫瘍の治療
|
|
CN110382545A
(zh)
|
2017-01-09 |
2019-10-25 |
泰萨罗公司 |
用抗pd-1抗体治疗癌症的方法
|
|
JP2020505438A
(ja)
*
|
2017-01-10 |
2020-02-20 |
ノダス・セラピューティクスNodus Therapeutics |
インテグリン結合性ポリペプチド−Fc融合タンパク質および免疫調節物質を用いる併用がん治療法
|
|
WO2018134279A1
(en)
|
2017-01-18 |
2018-07-26 |
Pieris Pharmaceuticals Gmbh |
Novel fusion polypeptides specific for lag-3 and pd-1
|
|
CN110461847B
(zh)
|
2017-01-25 |
2022-06-07 |
百济神州有限公司 |
(S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途
|
|
KR102089371B1
(ko)
*
|
2017-01-26 |
2020-03-16 |
사회복지법인 삼성생명공익재단 |
혈관면역아세포성 t 세포 림프종 진단용 마커 및 이의 용도
|
|
US20180271996A1
(en)
|
2017-02-28 |
2018-09-27 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
PT3606946T
(pt)
|
2017-04-03 |
2022-10-17 |
Hoffmann La Roche |
Imunoconjugados de um anticorpo anti-pd-1 com uma il-2 mutante ou com il-15
|
|
CN116375876A
(zh)
|
2017-04-05 |
2023-07-04 |
豪夫迈·罗氏有限公司 |
特异性结合pd1和lag3的双特异性抗体
|
|
BR112019021847A2
(pt)
|
2017-05-30 |
2020-06-02 |
Bristol-Myers Squibb Company |
Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1
|
|
HUE065242T2
(hu)
|
2017-05-30 |
2024-05-28 |
Bristol Myers Squibb Co |
LAG-3-pozitív tumorok kezelése
|
|
EP3630838A1
(en)
|
2017-06-01 |
2020-04-08 |
CytomX Therapeutics, Inc. |
Activatable anti-pdl1 antibodies, and methods of use thereof
|
|
GB201709808D0
(en)
|
2017-06-20 |
2017-08-02 |
Kymab Ltd |
Antibodies
|
|
TW202515616A
(zh)
|
2017-06-26 |
2025-04-16 |
英屬開曼群島商百濟神州有限公司 |
抗pd-1抗體或其抗原結合片段在製備治療用於患有肝細胞癌(hcc)之藥物的用途
|
|
CN107253988B
(zh)
*
|
2017-07-19 |
2021-01-29 |
福州大学 |
一种人源程序性死亡因子配体pd-l2蛋白的制备方法
|
|
UA128472C2
(uk)
|
2017-08-25 |
2024-07-24 |
Файв Прайм Терапеутікс Інк. |
B7-h4 антитіла і методи їх використання
|
|
CN107596374B
(zh)
*
|
2017-09-01 |
2020-06-30 |
广东医科大学 |
B12蛋白表达抑制剂及其在结核病免疫和治疗中应用
|
|
WO2019083971A1
(en)
*
|
2017-10-23 |
2019-05-02 |
Children's Medical Center Corporation |
METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
|
|
EP3717021A1
(en)
|
2017-11-27 |
2020-10-07 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
WO2019108795A1
(en)
|
2017-11-29 |
2019-06-06 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
|
|
US11946094B2
(en)
|
2017-12-10 |
2024-04-02 |
Augusta University Research Institute, Inc. |
Combination therapies and methods of use thereof
|
|
GB201721338D0
(en)
|
2017-12-19 |
2018-01-31 |
Kymab Ltd |
Anti-icos Antibodies
|
|
EP3728314A1
(en)
|
2017-12-19 |
2020-10-28 |
Kymab Limited |
Bispecific antibody for icos and pd-l1
|
|
EP3728611A4
(en)
|
2017-12-20 |
2021-09-08 |
VLP Therapeutics, Inc. |
ALPHAVIRUS REPLICON PARTICLE
|
|
EP3727463A1
(en)
|
2017-12-21 |
2020-10-28 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
EP3731850A4
(en)
|
2017-12-29 |
2021-12-01 |
Oncorus, Inc. |
ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
KR20200112913A
(ko)
|
2018-01-23 |
2020-10-05 |
넥스트큐어 인코포레이티드 |
B7-h4 항체 및 그 사용 방법
|
|
EP3746480A1
(en)
|
2018-01-31 |
2020-12-09 |
F. Hoffmann-La Roche AG |
Bispecific antibodies comprising an antigen-binding site binding to lag3
|
|
BR112020016986A2
(pt)
|
2018-02-21 |
2021-03-02 |
Five Prime Therapeutics, Inc. |
formulações de anticorpo contra b7-h4
|
|
CA3091801A1
(en)
|
2018-03-02 |
2019-09-06 |
Five Prime Therapeutics, Inc. |
B7-h4 antibodies and methods of use thereof
|
|
CN108530537B
(zh)
*
|
2018-03-29 |
2019-07-02 |
中国人民解放军军事科学院军事医学研究院 |
Pd-1/pd-l1信号通路抑制剂
|
|
JP6630026B1
(ja)
*
|
2018-04-27 |
2020-01-15 |
隆代 大田 |
免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー
|
|
TW202017569A
(zh)
|
2018-05-31 |
2020-05-16 |
美商佩樂敦治療公司 |
用於抑制cd73之組合物及方法
|
|
CA3104467A1
(en)
|
2018-06-20 |
2019-12-26 |
Incyte Corporation |
Anti-pd-1 antibodies and uses thereof
|
|
WO2020021061A1
(en)
|
2018-07-26 |
2020-01-30 |
Pieris Pharmaceuticals Gmbh |
Humanized anti-pd-1 antibodies and uses thereof
|
|
AU2019328632A1
(en)
|
2018-08-27 |
2021-03-25 |
Pieris Pharmaceuticals Gmbh |
Combination therapies comprising CD137/HER2 bispecific agents and PD-1 axis inhibitors and uses thereof
|
|
US20210340279A1
(en)
|
2018-08-31 |
2021-11-04 |
Yale University |
Compositions and methods of using cell-penetrating antibodies in combination with immune checkpoint modulators
|
|
CN112672759B
(zh)
*
|
2018-09-29 |
2023-05-30 |
四川科伦博泰生物医药股份有限公司 |
抗程序性死亡配体-1(pd-l1)抗体的抗肿瘤用途
|
|
AU2019369340A1
(en)
|
2018-10-29 |
2021-05-20 |
Mersana Therapeutics, Inc. |
Cysteine engineered antibody-drug conjugates with peptide-containing linkers
|
|
WO2020092839A1
(en)
|
2018-10-31 |
2020-05-07 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
|
EP3873540A4
(en)
|
2018-10-31 |
2022-07-27 |
Mayo Foundation for Medical Education and Research |
METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
|
|
CN113195467A
(zh)
|
2018-12-11 |
2021-07-30 |
施万生物制药研发Ip有限责任公司 |
适用作alk5抑制剂的萘啶和喹啉衍生物
|
|
CN110092826B
(zh)
*
|
2019-02-28 |
2022-04-15 |
天津大学 |
CTLA-4类似物CFN13及CFN13-Fc基因和蛋白
|
|
CN110452870A
(zh)
*
|
2019-05-20 |
2019-11-15 |
河南省肿瘤医院 |
一种肿瘤特异性t细胞的分离培养方法及由其获得的产品
|
|
WO2020255011A1
(en)
|
2019-06-18 |
2020-12-24 |
Janssen Sciences Ireland Unlimited Company |
Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody
|
|
JP2022537324A
(ja)
|
2019-06-18 |
2022-08-25 |
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー |
B型肝炎ウイルス(hbv)ワクチンおよび抗pd-1抗体の組合せ
|
|
JP2023502662A
(ja)
|
2019-11-22 |
2023-01-25 |
セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー |
Alk5阻害剤としての置換1,5-ナフチリジンまたはキノリン
|
|
US20210154281A1
(en)
|
2019-11-26 |
2021-05-27 |
Massachusetts Institute Of Technology |
Cell-based cancer vaccines and cancer therapies
|
|
JP2023519673A
(ja)
|
2020-03-31 |
2023-05-12 |
セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー |
置換ピリミジンおよび使用方法
|
|
JP7644993B2
(ja)
|
2020-04-17 |
2025-03-13 |
ブイエルピー・セラピューティクス・インコーポレイテッド |
コロナウイルスワクチン
|
|
IL297564A
(en)
|
2020-04-30 |
2022-12-01 |
Vlp Therapeutics Inc |
Cytokine immunotherapy
|
|
CN115835856A
(zh)
|
2020-05-13 |
2023-03-21 |
麻省理工学院 |
聚合物微装置的组合物以及其在癌症免疫疗法中的用途
|
|
US11767353B2
(en)
|
2020-06-05 |
2023-09-26 |
Theraly Fibrosis, Inc. |
Trail compositions with reduced immunogenicity
|
|
EP4165041A1
(en)
|
2020-06-10 |
2023-04-19 |
Theravance Biopharma R&D IP, LLC |
Naphthyridine derivatives useful as alk5 inhibitors
|
|
WO2022165403A1
(en)
|
2021-02-01 |
2022-08-04 |
Yale University |
Chemotherapeutic bioadhesive particles with immunostimulatory molecules for cancer treatment
|
|
WO2022251359A1
(en)
|
2021-05-26 |
2022-12-01 |
Theravance Biopharma R&D Ip, Llc |
Bicyclic inhibitors of alk5 and methods of use
|
|
CN117794953A
(zh)
|
2021-08-03 |
2024-03-29 |
豪夫迈·罗氏有限公司 |
双特异性抗体及使用方法
|
|
CA3232968A1
(en)
|
2021-10-14 |
2023-04-20 |
Jasper Williams |
Immune cells having co-expressed shrnas and logic gate systems
|
|
EP4197525A1
(en)
|
2021-12-20 |
2023-06-21 |
Scandion Oncology A/S |
Combination of drugs for the treatment of cancer
|
|
CN114181310B
(zh)
*
|
2022-02-14 |
2022-07-05 |
中山康方生物医药有限公司 |
抗tigit抗体、其药物组合物及用途
|
|
WO2023194656A1
(en)
|
2022-04-08 |
2023-10-12 |
Tilt Biotherapeutics Oy |
Monoclonal pd-l1 antibodies
|
|
CN114588258B
(zh)
*
|
2022-05-10 |
2023-04-25 |
中山大学 |
Bmp9联合nk细胞和pd-l1抗体在制备肝癌药物方面的应用
|
|
WO2023242235A1
(en)
|
2022-06-14 |
2023-12-21 |
Scandion Oncology A/S |
Abcg2 inhibitor and nae inhibitor for the treatment of cancer
|
|
WO2024040264A1
(en)
|
2022-08-19 |
2024-02-22 |
Massachusetts Institute Of Technology |
Compositions and methods for targeting dendritic cell lectins
|
|
EP4602078A2
(en)
|
2022-10-11 |
2025-08-20 |
Yale University |
Compositions and methods of using cell-penetrating antibodies
|
|
CN120569191A
(zh)
|
2022-11-23 |
2025-08-29 |
乔治亚大学研究基金公司 |
用于增加免疫应答的组合物及其使用方法
|
|
WO2025029625A1
(en)
*
|
2023-07-28 |
2025-02-06 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for programmed death ligand receptor (pd-l1) expression
|