JP2012530713A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012530713A5 JP2012530713A5 JP2012516299A JP2012516299A JP2012530713A5 JP 2012530713 A5 JP2012530713 A5 JP 2012530713A5 JP 2012516299 A JP2012516299 A JP 2012516299A JP 2012516299 A JP2012516299 A JP 2012516299A JP 2012530713 A5 JP2012530713 A5 JP 2012530713A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- group
- optionally
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 1266
- 229910052736 halogen Inorganic materials 0.000 claims description 408
- 150000002367 halogens Chemical class 0.000 claims description 398
- -1 cyano, hydroxy Chemical group 0.000 claims description 346
- 125000001424 substituent group Chemical group 0.000 claims description 314
- 125000004043 oxo group Chemical group O=* 0.000 claims description 255
- 125000003545 alkoxy group Chemical group 0.000 claims description 166
- 150000001875 compounds Chemical class 0.000 claims description 155
- 125000003118 aryl group Chemical group 0.000 claims description 138
- 125000000623 heterocyclic group Chemical group 0.000 claims description 100
- 238000000034 method Methods 0.000 claims description 100
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 87
- 229910052799 carbon Inorganic materials 0.000 claims description 86
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 72
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 68
- 125000002837 carbocyclic group Chemical group 0.000 claims description 67
- 229910052739 hydrogen Inorganic materials 0.000 claims description 57
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims description 51
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims description 50
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 46
- 125000002431 aminoalkoxy group Chemical group 0.000 claims description 41
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 41
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 38
- 125000001072 heteroaryl group Chemical group 0.000 claims description 35
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 34
- 125000001931 aliphatic group Chemical group 0.000 claims description 32
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 27
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 26
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 23
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims description 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims description 21
- 125000004429 atom Chemical group 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 20
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 16
- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 12
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 12
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- 125000001188 haloalkyl group Chemical group 0.000 claims description 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 12
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
- QYSYONJOCHVMLX-UHFFFAOYSA-N N#COOC(NN=O)=O Chemical compound N#COOC(NN=O)=O QYSYONJOCHVMLX-UHFFFAOYSA-N 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 8
- 125000001246 bromo group Chemical group Br* 0.000 claims description 8
- 241000712461 unidentified influenza virus Species 0.000 claims description 7
- 230000010076 replication Effects 0.000 claims description 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 4
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 4
- 206010022000 influenza Diseases 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 229940126062 Compound A Drugs 0.000 claims description 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 27
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 24
- 150000001721 carbon Chemical group 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229960005222 phenazone Drugs 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 claims 1
- ZENKESXKWBIZCV-UHFFFAOYSA-N 2,2,4,4-tetrafluoro-1,3-benzodioxin-6-amine Chemical group O1C(F)(F)OC(F)(F)C2=CC(N)=CC=C21 ZENKESXKWBIZCV-UHFFFAOYSA-N 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 150000001717 carbocyclic compounds Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 0 CC(C*)(C1)NC1c(cccc1)c1NC(*)=O Chemical compound CC(C*)(C1)NC1c(cccc1)c1NC(*)=O 0.000 description 48
- 125000004966 cyanoalkyl group Chemical group 0.000 description 13
- 125000004103 aminoalkyl group Chemical group 0.000 description 12
- 125000004181 carboxyalkyl group Chemical group 0.000 description 7
- 239000003814 drug Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- MOCREHIQYHKRSW-UHFFFAOYSA-N CC(C)C(C)(C1)C1(C)C(C1)=CC=C1C(C)C Chemical compound CC(C)C(C)(C1)C1(C)C(C1)=CC=C1C(C)C MOCREHIQYHKRSW-UHFFFAOYSA-N 0.000 description 1
- SDOFCRMKKDREOD-PICGMCJFSA-M CCC(CC1)C[C@]1(N)NC(O[Re])=O Chemical compound CCC(CC1)C[C@]1(N)NC(O[Re])=O SDOFCRMKKDREOD-PICGMCJFSA-M 0.000 description 1
- NQFAQVJTYNEPAG-UHFFFAOYSA-N CCN(C)C(C)(C)C(C1)=CC=C1NS([Re])(=O)=O Chemical compound CCN(C)C(C)(C)C(C1)=CC=C1NS([Re])(=O)=O NQFAQVJTYNEPAG-UHFFFAOYSA-N 0.000 description 1
- CEZSVYMWEDJIIK-UHFFFAOYSA-N CCS(C)C(C)C#CC(CC1)CC1NC(C)=O Chemical compound CCS(C)C(C)C#CC(CC1)CC1NC(C)=O CEZSVYMWEDJIIK-UHFFFAOYSA-N 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18771309P | 2009-06-17 | 2009-06-17 | |
| US61/187,713 | 2009-06-17 | ||
| US28778109P | 2009-12-18 | 2009-12-18 | |
| US61/287,781 | 2009-12-18 | ||
| PCT/US2010/038988 WO2010148197A1 (en) | 2009-06-17 | 2010-06-17 | Inhibitors of influenza viruses replication |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230557A Division JP2015034177A (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
| JP2014230556A Division JP6030619B2 (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530713A JP2012530713A (ja) | 2012-12-06 |
| JP2012530713A5 true JP2012530713A5 (OSRAM) | 2013-07-25 |
| JP5721706B2 JP5721706B2 (ja) | 2015-05-20 |
Family
ID=42537408
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516299A Expired - Fee Related JP5721706B2 (ja) | 2009-06-17 | 2010-06-17 | インフルエンザウイルス複製の阻害剤 |
| JP2014230557A Withdrawn JP2015034177A (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
| JP2014230556A Expired - Fee Related JP6030619B2 (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
| JP2016173354A Expired - Fee Related JP6348939B2 (ja) | 2009-06-17 | 2016-09-06 | インフルエンザウイルス複製の阻害剤 |
| JP2017200914A Expired - Fee Related JP6620135B2 (ja) | 2009-06-17 | 2017-10-17 | インフルエンザウイルス複製の阻害剤 |
| JP2019181224A Withdrawn JP2020011990A (ja) | 2009-06-17 | 2019-10-01 | インフルエンザウイルス複製の阻害剤 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230557A Withdrawn JP2015034177A (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
| JP2014230556A Expired - Fee Related JP6030619B2 (ja) | 2009-06-17 | 2014-11-13 | インフルエンザウイルス複製の阻害剤 |
| JP2016173354A Expired - Fee Related JP6348939B2 (ja) | 2009-06-17 | 2016-09-06 | インフルエンザウイルス複製の阻害剤 |
| JP2017200914A Expired - Fee Related JP6620135B2 (ja) | 2009-06-17 | 2017-10-17 | インフルエンザウイルス複製の阻害剤 |
| JP2019181224A Withdrawn JP2020011990A (ja) | 2009-06-17 | 2019-10-01 | インフルエンザウイルス複製の阻害剤 |
Country Status (37)
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921376B2 (en) * | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| SG10201405826RA (en) | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| CA2822062A1 (en) * | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| KR20130128436A (ko) * | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| RU2013132681A (ru) * | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CN103702980B (zh) | 2011-07-04 | 2016-10-05 | 罗达制药生物技术有限责任公司 | 环胺衍生物作为ep4受体拮抗剂 |
| CN106432311A (zh) * | 2011-07-05 | 2017-02-22 | 沃泰克斯药物股份有限公司 | 生产氮杂吲哚类的方法和中间体 |
| UA118010C2 (uk) * | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| US10323012B2 (en) * | 2012-06-05 | 2019-06-18 | Hong Kong Baptist University | Miliusanes as antiviral agents |
| EP2858984A1 (en) * | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Inc. | Inhibitors of influenza viruses replication |
| DK2922828T3 (da) | 2012-11-21 | 2020-08-31 | Ptc Therapeutics Inc | 4,6-diamino-pyrimidin-derivater som bmi-1-inhibitorer til at behandle cancer |
| CA2922657C (en) | 2013-08-30 | 2022-04-12 | Ptc Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
| US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| CA2930105A1 (en) * | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Formulations of azaindole compounds |
| WO2015073481A1 (en) * | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
| RS58175B1 (sr) | 2014-04-04 | 2019-03-29 | Syros Pharmaceuticals Inc | Inhibitori ciklin-zavisne kinaze 7 (cdk7) |
| CN106573920B (zh) | 2014-08-08 | 2020-11-10 | 爱尔兰詹森科学公司 | 用于在流感病毒感染中使用的吲哚 |
| AU2015314394A1 (en) * | 2014-09-08 | 2017-03-02 | Janssen Sciences Ireland Uc | Pyrrolopyrimidines for use in influenza virus infection |
| MA40772A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
| MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
| JP6660393B2 (ja) * | 2015-01-16 | 2020-03-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ４−シアノピペリジン塩酸塩を調製する方法 |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| WO2016191079A1 (en) * | 2015-05-26 | 2016-12-01 | Boropharm, Inc. | Improved process for preparing boryl 7-azaindole compounds |
| KR20180087290A (ko) * | 2015-11-27 | 2018-08-01 | 얀센 사이언시즈 아일랜드 유씨 | 인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌 |
| AU2016368317B2 (en) * | 2015-12-09 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
| KR20180099839A (ko) * | 2016-01-07 | 2018-09-05 | 얀센 사이언시즈 아일랜드 유씨 | 인플루엔자 바이러스 감염에서 사용하기 위한 작용화된 펜탄산 |
| JP6989509B2 (ja) * | 2016-01-20 | 2022-01-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | インフルエンザウイルス感染における使用のためのアリール置換ピリミジン |
| WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
| WO2017198122A1 (zh) * | 2016-05-19 | 2017-11-23 | 四川大学 | 抗流感小分子化合物及其制备方法和用途 |
| CN107759571B (zh) * | 2016-08-16 | 2021-03-02 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| CN109641868B (zh) | 2016-08-30 | 2021-12-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| CA3035680C (en) * | 2016-09-05 | 2023-05-02 | Jian Xiong | Anti-influenza virus pyrimidine derivatives |
| CN110088100B (zh) * | 2016-11-08 | 2023-02-17 | 癌症研究科技有限公司 | 作为cdc7抑制剂的嘧啶酮衍生物 |
| US10987354B2 (en) | 2016-12-15 | 2021-04-27 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| JP7299837B2 (ja) * | 2016-12-23 | 2023-06-28 | アクイナ ファーマシューティカルズ， インコーポレイテッド | 化合物、組成物、および使用方法 |
| WO2018127096A1 (en) | 2017-01-05 | 2018-07-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| CN110446711B (zh) | 2017-03-02 | 2022-02-15 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| CA3059362A1 (en) | 2017-04-12 | 2018-10-18 | Vertex Pharmaceuticals Incorporated | Combination therapies for treating influenza virus infection |
| CA3059449A1 (en) * | 2017-04-24 | 2018-11-01 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
| CN108727369B (zh) * | 2017-04-25 | 2023-06-09 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| MA49858A (fr) | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| JP7382308B2 (ja) | 2017-09-01 | 2023-11-16 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物、及び、方法 |
| CN109745309B (zh) * | 2017-11-03 | 2022-01-28 | 香港浸会大学 | 作为抗病毒剂的密瘤杀 |
| CN110117285B (zh) * | 2018-02-07 | 2023-02-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| KR102484804B1 (ko) * | 2018-03-05 | 2023-01-04 | 광둥 레이노벤트 바이오테크 컴퍼니 리미티드 | 이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법 |
| CN111936497A (zh) * | 2018-04-06 | 2020-11-13 | 杨森制药公司 | 制备匹莫迪韦盐酸盐半水合物的结晶形式的等温反应性结晶方法 |
| CN110590768B (zh) * | 2018-06-13 | 2021-02-26 | 银杏树药业(苏州)有限公司 | 杂环化合物、其组合物及其作为抗流感病毒药物的应用 |
| KR102813547B1 (ko) * | 2018-07-27 | 2025-05-27 | 코크리스탈 파마, 아이엔씨. | 인플루엔자바이러스 복제 억제제로서의 피롤로[2,3-b]피리딘 유도체 |
| BR112021002630A2 (pt) | 2018-08-17 | 2021-05-11 | Ptc Therapeutics, Inc. | método para tratar câncer pancreático |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| US20220177456A1 (en) * | 2019-03-06 | 2022-06-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| WO2020212399A1 (en) | 2019-04-15 | 2020-10-22 | Janssen Pharmaceutica Nv | Method for preparing an alkyl trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid ester compound |
| WO2020256820A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Pharmaceuticals, Inc. | Formulations of azaindole compounds |
| JP7450017B2 (ja) * | 2019-07-22 | 2024-03-14 | 広東衆生睿創生物科技有限公司 | ピリミジン誘導体の優位な塩形およびその結晶形 |
| EP4023647B1 (en) * | 2019-08-30 | 2025-04-09 | TSD Life Sciences Co., Ltd. | Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient |
| CN114502150B (zh) * | 2019-09-10 | 2023-03-24 | 广东众生睿创生物科技有限公司 | 一种用于治疗病毒性感冒的药物组合物及其制剂 |
| RU2726119C1 (ru) * | 2019-11-22 | 2020-07-09 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые производные полиолов, их применение, фармацевтическая композиция на их основе |
| WO2022007966A1 (zh) | 2020-07-10 | 2022-01-13 | 四川海思科制药有限公司 | Pb2抑制剂及其制备方法和用途 |
| CN112979647B (zh) * | 2021-03-12 | 2022-05-20 | 浙江大学 | 含氮杂氨基酸的氮杂吲哚衍生物及制备和应用 |
Family Cites Families (174)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4349552A (en) | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
| NZ221717A (en) | 1986-09-10 | 1990-08-28 | Sandoz Ltd | Azaindole and indolizine derivatives and pharmaceutical compositions |
| WO1990007926A1 (en) | 1989-01-20 | 1990-07-26 | Pfizer Inc. | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| FR2687402B1 (fr) | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
| DE4304455A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| IL129871A (en) | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| US6075037A (en) | 1994-06-09 | 2000-06-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5821243A (en) | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
| US6187713B1 (en) | 1996-10-31 | 2001-02-13 | Corning Incorporated | Method of making activated carbon bodies having improved adsorption properties |
| GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| US6313126B1 (en) | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| WO2000040581A1 (en) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | 3,4-dihydro-2h-benzo[1,4]oxazine derivatives |
| EP1147083B1 (en) | 1999-01-07 | 2004-06-16 | Wyeth | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| AR028475A1 (es) | 1999-04-22 | 2003-05-14 | Wyeth Corp | Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion. |
| US20030153560A1 (en) | 1999-04-23 | 2003-08-14 | Salituro Francesco G. | Inhibitors of c-Jun N-terminal kinases (JNK) |
| JP2003503456A (ja) | 1999-07-02 | 2003-01-28 | スチュアート エイ． リプトン | 神経傷害またはアポトーシスを軽減する方法 |
| GB9919843D0 (en) | 1999-08-20 | 1999-10-27 | Smithkline Beecham Plc | Novel compounds |
| DE19948417A1 (de) | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
| US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| JP2003519143A (ja) | 1999-12-28 | 2003-06-17 | ファーマコピーア，インコーポレーティッド | ピリミジン及びトリアジン系キナーゼ阻害剤 |
| JP2003532635A (ja) | 2000-02-17 | 2003-11-05 | アムジエン・インコーポレーテツド | キナーゼ阻害薬 |
| US7041277B2 (en) | 2000-03-10 | 2006-05-09 | Cadbury Adams Usa Llc | Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same |
| CA2308994A1 (en) | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| ES2262674T3 (es) | 2000-08-14 | 2006-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Pirazoles sustituidos. |
| US6369032B1 (en) | 2000-09-06 | 2002-04-09 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating allergies |
| CA2421510A1 (en) | 2000-09-06 | 2002-03-14 | Hui Cai | A method for treating allergies using substituted pyrazoles |
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| CA2420210A1 (en) | 2000-09-22 | 2002-03-28 | Michael Edward Kobierski | Stereoselective process for preparing cyclohexyl amine derivatives |
| CA2432654A1 (en) | 2000-12-22 | 2002-07-04 | Wyeth | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
| WO2002070662A2 (en) | 2001-03-02 | 2002-09-12 | Gpc Biotech Ag | Three hybrid assay system |
| EP1392697B1 (en) | 2001-03-14 | 2004-11-03 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino 2,3-f]quinoline |
| US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
| AU2002258971A1 (en) | 2001-04-24 | 2002-11-05 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
| US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
| US6656947B2 (en) | 2001-04-26 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline |
| US6593350B2 (en) | 2001-04-26 | 2003-07-15 | Wyeth | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole |
| DK1381613T3 (da) | 2001-04-26 | 2005-01-24 | Wyeth Corp | Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner |
| AU2002256334A1 (en) | 2001-04-26 | 2002-11-11 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino(2,3-f)quinoxaline |
| JP2004527561A (ja) | 2001-04-26 | 2004-09-09 | ワイス | 抗うつ作用を有する７，８−ジヒドロ−３Ｈ−６，９−ジオキサ−１，３−ジアザシクロペンタ［ａ］ナフタレンのアザへテロシクリルメチル誘導体 |
| US6555560B2 (en) | 2001-04-30 | 2003-04-29 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
| TR200402753T4 (tr) | 2001-04-30 | 2004-11-22 | Wyeth | 7,8-Dihidro-1,6,9-trioksa-3-aza-siklopenta[a]naftalen'in antidepresan azaheterosiklmetil türevleri. |
| GB0111186D0 (en) | 2001-05-08 | 2001-06-27 | Smithkline Beecham Plc | Novel compounds |
| IL158879A0 (en) | 2001-05-17 | 2004-05-12 | Wyeth Corp | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE |
| ATE432929T1 (de) | 2001-06-15 | 2009-06-15 | Vertex Pharma | 5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| WO2003010169A1 (en) | 2001-07-25 | 2003-02-06 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene |
| BR0211900A (pt) | 2001-08-14 | 2004-08-24 | Toyama Chemical Co Ltd | Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste |
| US20040236110A1 (en) | 2001-09-26 | 2004-11-25 | Ladouceur Gaetan H | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
| WO2003031439A1 (en) | 2001-10-05 | 2003-04-17 | Wyeth | Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole |
| US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| WO2003091246A1 (en) | 2002-04-26 | 2003-11-06 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| WO2003091258A1 (en) | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
| AU2003241925A1 (en) | 2002-05-31 | 2003-12-19 | Eisai R&D Management Co., Ltd. | Pyrazole compound and medicinal composition containing the same |
| UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| JP4733388B2 (ja) | 2002-08-02 | 2011-07-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物 |
| WO2004014912A1 (en) | 2002-08-08 | 2004-02-19 | Ribapharm Inc. | Improved synthesis for hydroxyalkylated heterocyclic bases |
| SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| WO2004037814A1 (en) | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| HRP20050735B1 (hr) | 2003-02-26 | 2013-08-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Dihidropteridinoni, metoda za njihovu proizvodnju i upotrebu u obliku lijekova |
| US7432375B2 (en) | 2003-03-06 | 2008-10-07 | Eisai R & D Management Co., Ltd. | JNK inhibitors |
| EP1608628A2 (en) | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| WO2004106298A1 (en) | 2003-05-30 | 2004-12-09 | Janssen Pharmaceutica N.V. | Indole derivatives with an improved antipsychotic activity |
| WO2005000813A1 (en) | 2003-05-30 | 2005-01-06 | Imclone Systems Incorporated | Heteroarylamino-phenylketone derivatives and their use as kinase inhibitors |
| US7449465B2 (en) | 2003-07-16 | 2008-11-11 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
| TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
| CA2540828A1 (en) | 2003-09-30 | 2005-04-14 | Scios Inc. | Heterocyclic amides and sulfonamides |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| PT1696920E (pt) | 2003-12-19 | 2015-01-14 | Plexxikon Inc | Compostos e métodos para o desenvolvimento de moduladores de ret |
| GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| DE602005027825D1 (de) | 2004-03-30 | 2011-06-16 | Vertex Pharma | Als inhibitoren von jak und anderen proteinkinasen geeignete azaindole |
| MXPA06011328A (es) | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| ITMI20040874A1 (it) | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
| KR100476851B1 (ko) | 2004-05-18 | 2005-03-17 | (주)성신엔지니어링 | 중력식 섬유여과기 |
| WO2006009755A2 (en) | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US20060122213A1 (en) | 2004-06-30 | 2006-06-08 | Francoise Pierard | Azaindoles useful as inhibitors of protein kinases |
| MX2007001127A (es) | 2004-07-27 | 2007-07-11 | Sgx Pharmaceuticals Inc | Moduladores de pirrolo-piridina cinasa. |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2582235A1 (en) | 2004-10-04 | 2006-04-20 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| WO2006038001A1 (en) | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
| WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| MX337817B (es) | 2004-11-04 | 2011-11-04 | Vertex Pharma | Pirazolo [1,5-a] pirimidinas de utilidad como inhibidores de proteina quinasas. |
| CN101098872B (zh) | 2004-11-22 | 2012-09-05 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡咯并吡嗪和吡唑并吡嗪 |
| LT2522365T (lt) | 2004-11-24 | 2017-02-10 | Meda Pharmaceuticals Inc. | Kompozicijos, apimančios azelastiną, ir jų panaudojimo būdai |
| US20090233955A1 (en) | 2004-12-08 | 2009-09-17 | Frazee James S | 1H-Pyrrolo[2,3-B]Pyridnes |
| US8101770B2 (en) | 2004-12-16 | 2012-01-24 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
| US20060161001A1 (en) | 2004-12-20 | 2006-07-20 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| JP5227032B2 (ja) | 2005-02-03 | 2013-07-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なピロロピリミジン |
| US20080300267A1 (en) | 2005-05-16 | 2008-12-04 | Barun Okram | Compounds and Compositions as Protein Kinase Inhibitors |
| US8921376B2 (en) | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| PL1893612T3 (pl) * | 2005-06-22 | 2012-01-31 | Plexxikon Inc | Pochodne pirolo-[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| EP1749523A1 (en) | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
| GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
| KR20080063809A (ko) | 2005-09-30 | 2008-07-07 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나아제의 억제제로서 유용한 데아자퓨린 |
| US20130096302A1 (en) | 2005-11-22 | 2013-04-18 | Hayley Binch | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
| CN101374839A (zh) * | 2006-01-17 | 2009-02-25 | 沃泰克斯药物股份有限公司 | 适用作詹纳斯激酶抑制剂的吖吲哚类 |
| EP2537849A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of janus kinases |
| JP2009528991A (ja) | 2006-02-14 | 2009-08-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なピロロ（３，２−ｃ）ピリジン |
| NZ570530A (en) | 2006-02-14 | 2011-09-30 | Vertex Pharma | Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives |
| DE102006012617A1 (de) | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
| CA2648250A1 (en) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| BRPI0710866A2 (pt) * | 2006-04-26 | 2012-08-14 | Hoffmann La Roche | compostos farmacÊuticos |
| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| US20090017444A1 (en) | 2006-06-09 | 2009-01-15 | Wisconsin Alumni Research Foundation | Screening method for modulators of viral transcription or replication |
| US8778977B2 (en) | 2006-06-30 | 2014-07-15 | Sunesis Pharmaceuticals, Inc. | Pyridinonyl PDK1 inhibitors |
| TW200808325A (en) | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
| PT2050749T (pt) | 2006-08-08 | 2018-01-02 | Chugai Pharmaceutical Co Ltd | Derivado de pirimidina como inibidador de pi3k e sua utilização |
| WO2008023159A1 (en) * | 2006-08-24 | 2008-02-28 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| WO2008076392A2 (en) | 2006-12-14 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as protein kinase inhibitors |
| NZ577798A (en) | 2006-12-21 | 2012-04-27 | Vertex Pharma | 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| TW200840581A (en) | 2007-02-28 | 2008-10-16 | Astrazeneca Ab | Novel pyrimidine derivatives |
| MX2009009592A (es) | 2007-03-09 | 2009-11-10 | Vertex Pharma | Aminopiridinas utiles como inhibidores de proteinas cinasas. |
| WO2008112651A2 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| WO2008112642A1 (en) | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| SI2139892T1 (sl) | 2007-03-22 | 2011-12-30 | Takede Pharmaceutical Company Ltd | Substituirani pirimidodiazepini, uporabni kot PLK1 inhibitorji |
| KR20090130105A (ko) | 2007-04-05 | 2009-12-17 | 알라 캠, 엘엘씨 | 치환된 2,3,4,5-테트라히드로-1ｈ-피리도［4,3-ｂ］ 인돌, 그 제조방법 및 용도 |
| RU2339637C1 (ru) | 2007-04-05 | 2008-11-27 | Андрей Александрович Иващенко | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием |
| CN101952291A (zh) | 2007-08-15 | 2011-01-19 | 弗特克斯药品有限公司 | 用作人蛋白激酶plk1至plk4的抑制剂以治疗增殖疾病的4-(9-(3,3-二氟环戊基)-5,7,7-三甲基-6-氧代-6,7,8,9-四氢-5h-嘧啶并[4,5-b][1,4]二氮杂䓬-2-基氨基)-3-甲氧基苯甲酰胺衍生物 |
| EP2610256B1 (en) | 2007-09-28 | 2016-04-27 | Cyclacel Limited | Pyrimidine derivatives as protein kinase inhibitors |
| AU2008309939B2 (en) | 2007-10-09 | 2013-11-14 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus PB2 protein capable of binding RNA-cap |
| CN101903384A (zh) | 2007-11-02 | 2010-12-01 | 沃泰克斯药物股份有限公司 | 作为蛋白激酶Cθ抑制剂的[1H-吡唑并[3,4-B]吡啶-4-基]-苯基或-吡啶-2-基衍生物 |
| PT2207775E (pt) | 2007-11-05 | 2012-05-11 | Novartis Ag | Derivados de 4-benzilamino-1-carboxiacil-piperidina como inibidores de cetp úteis para o tratamento de doenças tais como hiperlipidemia ou arteriosclerose |
| MX2010008198A (es) | 2008-02-25 | 2010-08-23 | Hoffmann La Roche | Inhibidores de cinasa de pirrolopirazina. |
| JP2011513483A (ja) | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| WO2009125395A1 (en) | 2008-04-09 | 2009-10-15 | Technion Research & Development Foundation Ltd. | Anti influenza antibodies and uses thereof |
| AU2009271658B2 (en) | 2008-06-23 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| WO2010008459A1 (en) | 2008-06-23 | 2010-01-21 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| WO2010011768A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| CN102131808A (zh) | 2008-07-23 | 2011-07-20 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶激酶抑制剂 |
| MX2011000839A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa. |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| MX2011011653A (es) | 2009-05-06 | 2012-01-20 | Vertex Pharma | Pirazolopiridinas. |
| US20120093738A1 (en) | 2009-06-11 | 2012-04-19 | Rubicon Research Private Limited | Taste-masked oral formulations of influenza antivirals |
| SG10201405826RA (en) | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
| CN102471339A (zh) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| NZ602795A (en) | 2010-04-07 | 2015-01-30 | Vertex Pharma | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| PH12012502046A1 (en) | 2010-04-14 | 2017-07-26 | Array Biopharma Inc | 5,7-substituted~imidazo[1,2-c]pyrimidines as inhibitors of jak kinases |
| US20130040933A1 (en) | 2010-04-27 | 2013-02-14 | Brandon Cash | Azaindoles as janus kinase inhibitors |
| KR20130128436A (ko) | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CA2822062A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CN106432311A (zh) | 2011-07-05 | 2017-02-22 | 沃泰克斯药物股份有限公司 | 生产氮杂吲哚类的方法和中间体 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2776036A1 (en) | 2011-11-07 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
| EP2858984A1 (en) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Inc. | Inhibitors of influenza viruses replication |
| WO2014201332A1 (en) | 2013-06-14 | 2014-12-18 | Vertex Pharmaceuticals Incorporated | Pharmaceutical combinations useful for treating rheumatoid arthritis |
| RU2016110094A (ru) | 2013-08-22 | 2017-09-27 | Вертекс Фармасьютикалз Инкорпорейтед | Изотопно-обогащенные азаиндолы |
| PE20160661A1 (es) | 2013-09-12 | 2016-08-05 | Alios Biopharma Inc | Compuesto de azapiridona y sus usos de los mismos |
| US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
| WO2015073481A1 (en) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| CA2930105A1 (en) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Formulations of azaindole compounds |
| CN106573920B (zh) | 2014-08-08 | 2020-11-10 | 爱尔兰詹森科学公司 | 用于在流感病毒感染中使用的吲哚 |
| AU2015314394A1 (en) | 2014-09-08 | 2017-03-02 | Janssen Sciences Ireland Uc | Pyrrolopyrimidines for use in influenza virus infection |
| MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
| MA40772A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| KR20180087290A (ko) | 2015-11-27 | 2018-08-01 | 얀센 사이언시즈 아일랜드 유씨 | 인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌 |
| KR20180099839A (ko) | 2016-01-07 | 2018-09-05 | 얀센 사이언시즈 아일랜드 유씨 | 인플루엔자 바이러스 감염에서 사용하기 위한 작용화된 펜탄산 |
| JP6989509B2 (ja) | 2016-01-20 | 2022-01-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | インフルエンザウイルス感染における使用のためのアリール置換ピリミジン |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
| CA3059362A1 (en) | 2017-04-12 | 2018-10-18 | Vertex Pharmaceuticals Incorporated | Combination therapies for treating influenza virus infection |
-
2010
- 2010-06-17 SG SG10201405826RA patent/SG10201405826RA/en unknown
- 2010-06-17 TW TW107126935A patent/TWI666209B/zh not_active IP Right Cessation
- 2010-06-17 PH PH1/2015/501678A patent/PH12015501678B1/en unknown
- 2010-06-17 WO PCT/US2010/038988 patent/WO2010148197A1/en not_active Ceased
- 2010-06-17 EP EP16181549.3A patent/EP3141252B8/en active Active
- 2010-06-17 MX MX2011013475A patent/MX2011013475A/es active IP Right Grant
- 2010-06-17 RS RS20161032A patent/RS55341B1/sr unknown
- 2010-06-17 CN CN201510221329.5A patent/CN104940202B/zh not_active Expired - Fee Related
- 2010-06-17 PE PE2011002120A patent/PE20120508A1/es active IP Right Grant
- 2010-06-17 AP AP2012006067A patent/AP3631A/xx active
- 2010-06-17 DK DK16181549.3T patent/DK3141252T3/en active
- 2010-06-17 ME MEP-2016-272A patent/ME02558B/me unknown
- 2010-06-17 AR ARP100102150A patent/AR077130A1/es not_active Application Discontinuation
- 2010-06-17 GE GEAP201013375A patent/GEP20207129B/en unknown
- 2010-06-17 TW TW099119816A patent/TWI483941B/zh not_active IP Right Cessation
- 2010-06-17 PL PL10726760T patent/PL2442809T3/pl unknown
- 2010-06-17 EA EA201500871A patent/EA037529B1/ru not_active IP Right Cessation
- 2010-06-17 PT PT16181549T patent/PT3141252T/pt unknown
- 2010-06-17 TR TR2018/15272T patent/TR201815272T4/tr unknown
- 2010-06-17 SG SG10201405827PA patent/SG10201405827PA/en unknown
- 2010-06-17 PL PL16181549T patent/PL3141252T3/pl unknown
- 2010-06-17 JP JP2012516299A patent/JP5721706B2/ja not_active Expired - Fee Related
- 2010-06-17 MX MX2015000091A patent/MX348066B/es unknown
- 2010-06-17 CN CN201510221305.XA patent/CN104922128B/zh not_active Expired - Fee Related
- 2010-06-17 ES ES10726760.1T patent/ES2604667T3/es active Active
- 2010-06-17 EA EA201270032A patent/EA025276B1/ru unknown
- 2010-06-17 NZ NZ597059A patent/NZ597059A/en not_active IP Right Cessation
- 2010-06-17 CN CN201410195237.XA patent/CN104151312B/zh not_active Expired - Fee Related
- 2010-06-17 SI SI201031307A patent/SI2442809T1/sl unknown
- 2010-06-17 KR KR1020187027093A patent/KR102050712B1/ko not_active Expired - Fee Related
- 2010-06-17 SG SG2011090651A patent/SG176722A1/en unknown
- 2010-06-17 DK DK10726760.1T patent/DK2442809T3/en active
- 2010-06-17 HU HUE10726760A patent/HUE031048T2/en unknown
- 2010-06-17 NZ NZ619259A patent/NZ619259A/en not_active IP Right Cessation
- 2010-06-17 PT PT107267601T patent/PT2442809T/pt unknown
- 2010-06-17 LT LTEP10726760.1T patent/LT2442809T/lt unknown
- 2010-06-17 KR KR1020127001354A patent/KR101702609B1/ko not_active Expired - Fee Related
- 2010-06-17 BR BRPI1011993-0A patent/BRPI1011993A2/pt active Search and Examination
- 2010-06-17 UY UY0001032717A patent/UY32717A/es active IP Right Grant
- 2010-06-17 CA CA2764177A patent/CA2764177C/en not_active Expired - Fee Related
- 2010-06-17 KR KR1020177002581A patent/KR101903354B1/ko not_active Expired - Fee Related
- 2010-06-17 RS RS20181199A patent/RS57869B1/sr unknown
- 2010-06-17 GE GEAP201012538A patent/GEP20156325B/en unknown
- 2010-06-17 CN CN201910673938.2A patent/CN110540538A/zh active Pending
- 2010-06-17 LT LTEP16181549.3T patent/LT3141252T/lt unknown
- 2010-06-17 EA EA201500266A patent/EA030188B1/ru unknown
- 2010-06-17 GE GEAP201013376A patent/GEP20227397B/en unknown
- 2010-06-17 HR HRP20161577TT patent/HRP20161577T1/hr unknown
- 2010-06-17 AU AU2010262905A patent/AU2010262905B2/en not_active Ceased
- 2010-06-17 PE PE2015002683A patent/PE20160127A1/es unknown
- 2010-06-17 CN CN201080036505.3A patent/CN102458408B/zh not_active Expired - Fee Related
- 2010-06-17 ES ES16181549.3T patent/ES2692396T3/es active Active
- 2010-06-17 SI SI201031779T patent/SI3141252T1/sl unknown
- 2010-06-17 TW TW104103498A patent/TWI574963B/zh not_active IP Right Cessation
- 2010-06-17 MX MX2017006441A patent/MX375432B/es unknown
- 2010-06-17 EP EP18177481.1A patent/EP3427738B1/en not_active Not-in-force
- 2010-06-17 EP EP10726760.1A patent/EP2442809B1/en active Active
- 2010-06-17 TW TW105139121A patent/TWI639596B/zh not_active IP Right Cessation
-
2011
- 2011-12-12 ZA ZA2011/09127A patent/ZA201109127B/en unknown
- 2011-12-14 IL IL216980A patent/IL216980B/en active IP Right Grant
- 2011-12-15 US US13/327,206 patent/US20120171245A1/en not_active Abandoned
- 2011-12-16 CL CL2011003192A patent/CL2011003192A1/es unknown
-
2012
- 2012-01-17 CO CO12006237A patent/CO6491048A2/es active IP Right Grant
- 2012-01-17 EC EC2012011610A patent/ECSP12011610A/es unknown
-
2013
- 2013-12-06 US US14/098,867 patent/US8829007B2/en active Active
-
2014
- 2014-06-16 US US14/305,393 patent/US9345708B2/en active Active
- 2014-11-13 JP JP2014230557A patent/JP2015034177A/ja not_active Withdrawn
- 2014-11-13 JP JP2014230556A patent/JP6030619B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-04 ZA ZA2015/00820A patent/ZA201500820B/en unknown
- 2015-11-02 US US14/929,634 patent/US9518056B2/en active Active
-
2016
- 2016-09-06 JP JP2016173354A patent/JP6348939B2/ja not_active Expired - Fee Related
- 2016-10-21 US US15/299,757 patent/US9808459B2/en active Active
- 2016-11-21 CY CY20161101196T patent/CY1118246T1/el unknown
-
2017
- 2017-09-28 US US15/718,186 patent/US10039762B2/en active Active
- 2017-10-17 JP JP2017200914A patent/JP6620135B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-25 US US16/016,917 patent/US10874673B2/en active Active
- 2018-10-19 HR HRP20181715TT patent/HRP20181715T1/hr unknown
- 2018-10-31 CY CY181101086T patent/CY1120778T1/el unknown
- 2018-11-01 IL IL262734A patent/IL262734B/en active IP Right Grant
-
2019
- 2019-10-01 JP JP2019181224A patent/JP2020011990A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012530713A5 (OSRAM) | ||
| JP2013545817A5 (OSRAM) | ||
| JP2013545818A5 (OSRAM) | ||
| JP2013545816A5 (OSRAM) | ||
| JP6505013B2 (ja) | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 | |
| AR070522A1 (es) | Derivados de pirido 4,3-d-pirimidinona como inhibidores de cinasa, una composicion farmaceutica y un metodo para el tratamient0 de una enfermedad, un medicamento en base al compuesto y el uso de este para la fabricacion de un medicamento | |
| JP2014510774A5 (OSRAM) | ||
| JP2013504593A5 (OSRAM) | ||
| JP2010511626A5 (OSRAM) | ||
| JP2013056886A5 (OSRAM) | ||
| JP2010540508A5 (OSRAM) | ||
| JP2018526367A5 (OSRAM) | ||
| JP2011525171A5 (OSRAM) | ||
| CA2972014A1 (en) | Fused pyrimidine compounds for the treatment of hiv | |
| JP2013544261A5 (OSRAM) | ||
| JP2013508373A5 (OSRAM) | ||
| KR20150039832A (ko) | 디하이드록시피리미딘 탄산 유도체 및 바이러스성 질환의 치료, 개선 또는 예방에서의 이의 용도 | |
| TW201100083A (en) | Novel pyrimidine derivatives and their use in the treatment of disease | |
| JP2011523412A5 (OSRAM) | ||
| AR066120A1 (es) | Derivados de pirimidinona y sus metodos de uso | |
| JP2019500387A5 (OSRAM) | ||
| JP2013543883A5 (OSRAM) | ||
| JP2014521688A5 (OSRAM) | ||
| RU2018127728A (ru) | Слитые трициклические гетероциклические соединения в качестве ингибиторов интегразы вич | |
| JP2017519754A5 (OSRAM) |