|
ES2364495T3
(es)
|
2005-02-03 |
2011-09-05 |
The General Hospital Corporation |
Método para tratar cáncer resistente a gefitinib.
|
|
JP2009514870A
(ja)
|
2005-11-04 |
2009-04-09 |
ワイス |
mTORインヒビター、ハーセプチン、および/またはHKI−272の抗悪性腫瘍性組み合わせ
|
|
CA2833706C
(en)
|
2005-11-11 |
2014-10-21 |
Boehringer Ingelheim International Gmbh |
Quinazoline derivatives for the treatment of cancer diseases
|
|
US8022216B2
(en)
|
2007-10-17 |
2011-09-20 |
Wyeth Llc |
Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
|
|
PT2300013T
(pt)
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Derivados de fósforo como inibidores de cinases
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
ES2692769T3
(es)
|
2008-06-17 |
2018-12-05 |
Wyeth Llc |
Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
|
|
TWI546290B
(zh)
|
2008-06-27 |
2016-08-21 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
CN105147713A
(zh)
|
2008-08-04 |
2015-12-16 |
惠氏有限责任公司 |
4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
|
|
AR074209A1
(es)
*
|
2008-11-24 |
2010-12-29 |
Boehringer Ingelheim Int |
Derivados de pirimidina utiles para el tratamiento del cancer
|
|
TWI491605B
(zh)
|
2008-11-24 |
2015-07-11 |
Boehringer Ingelheim Int |
新穎化合物
|
|
SG174382A1
(en)
|
2009-04-06 |
2011-11-28 |
Wyeth Llc |
Treatment regimen utilizing neratinib for breast cancer
|
|
KR101705158B1
(ko)
|
2009-05-05 |
2017-02-09 |
다나-파버 캔서 인스티튜트 인크. |
Egfr 억제제 및 질환 치료방법
|
|
PL2451445T3
(pl)
|
2009-07-06 |
2019-09-30 |
Boehringer Ingelheim International Gmbh |
Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną
|
|
US8466155B2
(en)
|
2009-10-02 |
2013-06-18 |
Boehringer Ingelheim International Gmbh |
Pyrimidines
|
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
|
US20130137709A1
(en)
*
|
2010-05-05 |
2013-05-30 |
Nathanael S. Gray |
Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith
|
|
PT2576541T
(pt)
*
|
2010-06-04 |
2016-07-08 |
Hoffmann La Roche |
Derivados de aminopirimidina como moduladores de lrrk2
|
|
PT2585470T
(pt)
|
2010-06-23 |
2017-03-06 |
Hanmi Science Co Ltd |
Novos derivados fundidos de pirimidina para inibição da actividade da tirosina cinase
|
|
UA112517C2
(uk)
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
Тетрагідропіридопіримідинові похідні
|
|
CN105566229A
(zh)
|
2010-08-10 |
2016-05-11 |
西建阿维拉米斯研究公司 |
Btk抑制剂的苯磺酸盐及其用途和制备方法
|
|
EP2635285B1
(en)
*
|
2010-11-01 |
2017-05-03 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
MX382354B
(es)
|
2010-11-01 |
2025-03-13 |
Celgene Car Llc |
Compuestos heterocíclicos y usos de los mismos.
|
|
JP5957003B2
(ja)
*
|
2010-11-10 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
変異体選択的egfr阻害剤およびその使用
|
|
HRP20172006T1
(hr)
|
2010-11-10 |
2018-02-09 |
Genentech, Inc. |
Derivati pirazol-aminopiridina kao lrrk2-modulatori
|
|
CN103348243A
(zh)
*
|
2010-11-30 |
2013-10-09 |
基因泰克公司 |
Lrrk2的分析方法和生物标记物
|
|
PL2678332T3
(pl)
*
|
2011-02-25 |
2016-12-30 |
|
Pochodne diaminopirymidyny i sposoby ich wytwarzania
|
|
EP2694486B1
(en)
*
|
2011-04-01 |
2018-01-10 |
University of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
MX363696B
(es)
|
2011-04-21 |
2019-03-28 |
Origenis Gmbh |
Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas.
|
|
US9834518B2
(en)
|
2011-05-04 |
2017-12-05 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
US8828391B2
(en)
*
|
2011-05-17 |
2014-09-09 |
Boehringer Ingelheim International Gmbh |
Method for EGFR directed combination treatment of non-small cell lung cancer
|
|
MX340536B
(es)
|
2011-07-06 |
2016-07-13 |
Sykehuset Sorlandet Hf |
Terapia direccionada al receptor del factor de crecimiento epidermico (egfr).
|
|
KR20140058543A
(ko)
|
2011-07-08 |
2014-05-14 |
노파르티스 아게 |
신규 피롤로 피리미딘 유도체
|
|
CN103702990B
(zh)
|
2011-07-27 |
2015-09-09 |
阿斯利康(瑞典)有限公司 |
2-(2,4,5-取代苯胺)嘧啶衍生物作为egfr调谐子用于治疗癌症
|
|
WO2013041605A1
(en)
|
2011-09-20 |
2013-03-28 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors
|
|
KR20140059246A
(ko)
|
2011-09-22 |
2014-05-15 |
화이자 인코포레이티드 |
피롤로피리미딘 및 퓨린 유도체
|
|
AR088570A1
(es)
|
2011-10-28 |
2014-06-18 |
Celgene Avilomics Res Inc |
Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton
|
|
CN103086982A
(zh)
*
|
2011-10-31 |
2013-05-08 |
上海壹志医药科技有限公司 |
嘧啶衍生物的盐
|
|
CA2856291C
(en)
|
2011-11-17 |
2020-08-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
AR089182A1
(es)
*
|
2011-11-29 |
2014-08-06 |
Hoffmann La Roche |
Derivados de aminopirimidina como moduladores de lrrk2
|
|
CN103958482B
(zh)
*
|
2011-11-29 |
2017-06-09 |
健泰科生物技术公司 |
作为lrrk2调节剂的氨基嘧啶衍生物
|
|
CN103958498B
(zh)
*
|
2011-11-29 |
2016-09-07 |
霍夫曼-拉罗奇有限公司 |
作为lrrk2调节剂的氨基嘧啶衍生物
|
|
KR20130076046A
(ko)
*
|
2011-12-28 |
2013-07-08 |
한미약품 주식회사 |
타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
|
|
US9034885B2
(en)
|
2012-01-13 |
2015-05-19 |
Acea Biosciences Inc. |
EGFR modulators and uses thereof
|
|
US9464089B2
(en)
|
2012-01-13 |
2016-10-11 |
Acea Biosciences Inc. |
Heterocyclic compounds and uses thereof
|
|
CA2861010A1
(en)
|
2012-01-13 |
2013-07-18 |
Xiao Xu |
Heterocyclic compounds and uses as anticancer agents
|
|
US9586965B2
(en)
|
2012-01-13 |
2017-03-07 |
Acea Biosciences Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
|
|
PL2805940T3
(pl)
*
|
2012-01-17 |
2017-06-30 |
Astellas Pharma Inc. |
Związek pirazynokarboksyamidowy
|
|
KR102081042B1
(ko)
*
|
2012-03-15 |
2020-02-26 |
셀젠 카르 엘엘씨 |
상피 성장 인자 수용체 키나제 억제제의 고체 형태
|
|
PL2825042T3
(pl)
*
|
2012-03-15 |
2019-02-28 |
Celgene Car Llc |
Sole inhibitora kinazy receptora czynnika wzrostu naskórka
|
|
PT2840080T
(pt)
*
|
2012-04-17 |
2018-02-06 |
Fujifilm Corp |
Composto heterocíclico que contém azoto ou sal do mesmo
|
|
CN106279202A
(zh)
*
|
2012-05-03 |
2017-01-04 |
霍夫曼-拉罗奇有限公司 |
作为lrrk2调节剂用于治疗帕金森病的吡唑氨基嘧啶衍生物
|
|
US20150166591A1
(en)
|
2012-05-05 |
2015-06-18 |
Ariad Pharmaceuticals, Inc. |
Methods and compositions for raf kinase mediated diseases
|
|
WO2014001973A1
(en)
|
2012-06-29 |
2014-01-03 |
Pfizer Inc. |
NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
|
|
US9505765B2
(en)
|
2012-07-26 |
2016-11-29 |
Confluence Life Sciences Inc. |
4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment
|
|
BR112015002709B1
(pt)
*
|
2012-08-06 |
2022-09-20 |
Acea Biosciences Inc |
Compostos, composição farmacêutica, uso dos mesmos e uso de uma combinação de composto ou composição farmacêutica e um segundo agente profilático ou agente terapêutico
|
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
|
US9296703B2
(en)
|
2012-10-04 |
2016-03-29 |
University Of Utah Research Foundation |
Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
|
|
WO2014055928A2
(en)
*
|
2012-10-04 |
2014-04-10 |
University Of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
WO2014060112A1
(en)
|
2012-10-19 |
2014-04-24 |
Origenis Gmbh |
Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
EP2935333A1
(en)
*
|
2012-12-21 |
2015-10-28 |
Sykehuset Sorlandet HF |
Egfr targeted therapy of neurological disorders and pain
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
AU2014214846A1
(en)
|
2013-02-08 |
2015-07-23 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
AU2014223396A1
(en)
*
|
2013-03-01 |
2015-08-27 |
Amgen Inc. |
Substituted 7-oxo-pyrido [2, 3-d] pyrimidines and methods of use
|
|
US9346801B2
(en)
|
2013-03-01 |
2016-05-24 |
Amgen Inc. |
Substituted 7-oxo-pyrido[2,3-d]pyrimidines and methods of use
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
WO2014175370A1
(ja)
*
|
2013-04-25 |
2014-10-30 |
塩野義製薬株式会社 |
ピロリジン誘導体およびそれらを含有する医薬組成物
|
|
US20160074399A1
(en)
*
|
2013-05-06 |
2016-03-17 |
Clovis Oncology, Inc. |
Salts of an Epidermal Growth Factor Receptor Kinase Inhibitor
|
|
EP3019491A4
(en)
|
2013-07-09 |
2016-12-21 |
Dana Farber Cancer Inst Inc |
KINASEHEMMER FOR THE TREATMENT OF DISEASES
|
|
NZ715687A
(en)
*
|
2013-07-11 |
2019-04-26 |
Acea Biosciences Inc |
Pyrimidine derivatives as kinase inhibitors
|
|
EP4105208A1
(en)
|
2013-07-31 |
2022-12-21 |
Novartis AG |
1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions
|
|
ES2792979T3
(es)
|
2013-08-22 |
2020-11-12 |
Jubilant Biosys Ltd |
Compuestos de pirimidina sustituidos, composiciones y aplicaciones médicas de los mismos
|
|
AU2014308616B2
(en)
|
2013-08-23 |
2018-12-06 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
KR101879422B1
(ko)
*
|
2013-09-18 |
2018-07-17 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
|
|
EP3055301B1
(en)
|
2013-10-07 |
2019-11-20 |
Kadmon Corporation, LLC |
(2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases
|
|
CN105683167B
(zh)
*
|
2013-10-16 |
2018-10-23 |
富士胶片株式会社 |
含氮杂环化合物的盐或其结晶、药品组合物及flt3抑制剂
|
|
US10047070B2
(en)
|
2013-10-18 |
2018-08-14 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
EP3057955B1
(en)
|
2013-10-18 |
2018-04-11 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
|
UA115388C2
(uk)
*
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
|
MX368464B
(es)
*
|
2013-12-05 |
2019-10-02 |
Pfizer |
Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo.
|
|
JP6487921B2
(ja)
|
2013-12-17 |
2019-03-20 |
ファイザー・インク |
LRRK2阻害薬としての新規の3,4−二置換−1H−ピロロ[2,3−b]ピリジンおよび4,5−二置換−7H−ピロロ[2,3−c]ピリダジン
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
US9242965B2
(en)
|
2013-12-31 |
2016-01-26 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
|
|
HRP20201384T1
(hr)
|
2014-01-01 |
2020-11-27 |
Medivation Technologies Llc |
Spojevi i postupci njihove upotrebe
|
|
ES2717757T3
(es)
*
|
2014-01-29 |
2019-06-25 |
Glaxosmithkline Ip Dev Ltd |
Compuestos
|
|
KR20160106622A
(ko)
|
2014-01-29 |
2016-09-12 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
화합물
|
|
NO2718543T3
(https=)
*
|
2014-02-04 |
2018-01-06 |
|
|
|
CN104860891B
(zh)
*
|
2014-02-25 |
2017-06-30 |
上海海雁医药科技有限公司 |
芳氨基嘧啶类化合物及其应用以及由其制备的药物组合物和药用组合物
|
|
MX2016012574A
(es)
|
2014-03-28 |
2017-09-26 |
Calitor Sciences Llc |
Compuestos heteroarilo sustituidos y metodos de uso.
|
|
US10017477B2
(en)
|
2014-04-23 |
2018-07-10 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
EP3143015B1
(en)
*
|
2014-05-13 |
2019-02-20 |
ARIAD Pharmaceuticals, Inc. |
Heteroaryl compounds for kinase inhibition
|
|
CN104825455B
(zh)
*
|
2014-06-11 |
2017-08-15 |
中国科学院合肥物质科学研究院 |
依鲁替尼的用途
|
|
CN110526912B
(zh)
*
|
2014-06-19 |
2023-02-14 |
武田药品工业株式会社 |
用于激酶抑制的杂芳基化合物
|
|
CA2958643A1
(en)
*
|
2014-07-07 |
2016-01-14 |
Dana Farber Cancer Institute, Inc. |
Methods of treating cancer
|
|
CN105315285B
(zh)
*
|
2014-07-25 |
2017-12-08 |
上海海雁医药科技有限公司 |
2,4‑二取代7H‑吡咯并[2,3‑d]嘧啶衍生物、其制法与医药上的用途
|
|
CN105315259B
(zh)
|
2014-07-29 |
2018-03-09 |
上海艾力斯医药科技有限公司 |
吡啶胺基嘧啶衍生物、其制备方法及应用
|
|
HRP20220522T1
(hr)
|
2014-08-04 |
2022-06-10 |
Nuevolution A/S |
Proizvoljno kondenzirani heterociklil-supstituirani derivati pirimidina koji su korisni za liječenje upalnih, metaboličkih, onkoloških i autoimunih bolesti
|
|
US10005760B2
(en)
|
2014-08-13 |
2018-06-26 |
Celgene Car Llc |
Forms and compositions of an ERK inhibitor
|
|
CN105384694B
(zh)
*
|
2014-08-22 |
2020-09-04 |
四川海思科制药有限公司 |
一种取代的氨基嘧啶衍生物及其制备方法和药物用途
|
|
WO2016027904A1
(ja)
|
2014-08-22 |
2016-02-25 |
富士フイルム株式会社 |
Flt3変異陽性癌を処置するための医薬組成物、変異型flt3阻害剤およびそれらの応用
|
|
CN105384695B
(zh)
*
|
2014-08-22 |
2019-12-20 |
四川海思科制药有限公司 |
嘧啶衍生物及其制备方法和在医药上的应用
|
|
CN105461694B
(zh)
*
|
2014-09-27 |
2019-05-24 |
广东东阳光药业有限公司 |
取代的杂芳基化合物及其组合物和用途
|
|
CN105524068B
(zh)
*
|
2014-09-30 |
2017-11-24 |
上海海雁医药科技有限公司 |
氮杂双环衍生物、其制法与医药上的用途
|
|
CN105503827B
(zh)
*
|
2014-10-11 |
2019-09-24 |
上海翰森生物医药科技有限公司 |
Egfr抑制剂及其制备方法和用途
|
|
CN117069700B
(zh)
*
|
2014-10-11 |
2026-01-30 |
上海翰森生物医药科技有限公司 |
Egfr抑制剂及其制备和应用
|
|
EP3929190B1
(en)
|
2014-10-13 |
2024-12-25 |
Yuhan Corporation |
Compounds and compositions for modulating egfr mutant kinase activities
|
|
EP3206691B1
(en)
|
2014-10-14 |
2018-09-19 |
Sunshine Lake Pharma Co., Ltd. |
Substituted heteroaryl compounds and methods of use
|
|
CN111170998B
(zh)
|
2014-11-05 |
2023-04-11 |
益方生物科技(上海)股份有限公司 |
嘧啶或吡啶类化合物、其制备方法和医药用途
|
|
CN108024993B
(zh)
*
|
2014-12-11 |
2020-11-06 |
贝达医药公司 |
取代的2-苯胺基嘧啶衍生物及其作为表皮生长因子受体调节剂
|
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
CN113563332B
(zh)
|
2014-12-23 |
2024-12-17 |
达纳-法伯癌症研究所公司 |
作为egfr抑制剂的新的嘧啶和治疗病症的方法
|
|
CA2973597A1
(en)
|
2015-01-23 |
2016-07-28 |
Confluence Life Sciences, Inc. |
Heterocyclic itk inhibitors for treating inflammation and cancer
|
|
AU2016219102B2
(en)
*
|
2015-02-13 |
2020-10-15 |
Dana-Farber Cancer Institute, Inc. |
LRRK2 inhibitors and methods of making and using the same
|
|
CN107613769A
(zh)
*
|
2015-02-17 |
2018-01-19 |
润新生物公司 |
某些化学实体、组合物和方法
|
|
HK1246645A1
(zh)
*
|
2015-03-27 |
2018-09-14 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
CN106146478B
(zh)
*
|
2015-04-10 |
2019-07-16 |
海南轩竹医药科技有限公司 |
三嗪衍生物类间变性淋巴瘤激酶抑制剂
|
|
WO2016175264A1
(ja)
*
|
2015-04-28 |
2016-11-03 |
カルナバイオサイエンス株式会社 |
抗マラリア活性を有する新規ヘテロアリール誘導体
|
|
CN106188029B
(zh)
*
|
2015-05-05 |
2018-09-18 |
山东轩竹医药科技有限公司 |
二并环类间变性淋巴瘤激酶抑制剂
|
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
JP6412471B2
(ja)
|
2015-07-15 |
2018-10-24 |
富士フイルム株式会社 |
含窒素複素環化合物の製造方法およびその中間体
|
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
|
EP3347018B1
(en)
|
2015-09-09 |
2021-09-01 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
WO2017044434A1
(en)
|
2015-09-11 |
2017-03-16 |
Sunshine Lake Pharma Co., Ltd. |
Substituted heteroaryl compounds and methods of use
|
|
KR102161364B1
(ko)
|
2015-09-14 |
2020-09-29 |
화이자 인코포레이티드 |
LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체
|
|
BR112018005833B1
(pt)
*
|
2015-09-25 |
2023-10-10 |
Dizal (Jiangsu) Pharmaceutical Co., Limited |
Composto, sal farmaceuticamente aceitável, composição farmacêutica e uso do composto
|
|
KR20180067584A
(ko)
|
2015-10-09 |
2018-06-20 |
아세아 테라퓨틱스 인코포레이티드 |
피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법
|
|
CN108137544B
(zh)
*
|
2015-12-10 |
2022-01-04 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物
|
|
CN106905245B
(zh)
*
|
2015-12-23 |
2021-06-25 |
正大天晴药业集团股份有限公司 |
2,4-二取代的嘧啶类化合物
|
|
CN107098887B
(zh)
*
|
2016-02-22 |
2019-08-09 |
复旦大学 |
嘧啶类化合物
|
|
US20190119284A1
(en)
*
|
2016-04-19 |
2019-04-25 |
The Regents Of The University Of California |
ErbB Inhibitors and Uses Thereof
|
|
KR20190003805A
(ko)
*
|
2016-05-27 |
2019-01-09 |
한미약품 주식회사 |
암 세포 성장을 저해하는 아민 유도체 또는 이의 약학적으로 허용가능한 염 및 저융점을 갖는 안정화제를 포함하는 약학적 조성물
|
|
AU2017275657B2
(en)
|
2016-06-02 |
2021-08-19 |
Novartis Ag |
Potassium channel modulators
|
|
RU2714206C1
(ru)
|
2016-06-30 |
2020-02-13 |
Даевунг Фармасьютикал Ко., Лтд. |
Пиразолопиримидиновые производные в качестве ингибитора киназы
|
|
US11168068B2
(en)
|
2016-07-18 |
2021-11-09 |
Janssen Pharmaceutica Nv |
Tau PET imaging ligands
|
|
JP6740452B2
(ja)
*
|
2016-07-26 |
2020-08-12 |
深▲セン▼市塔吉瑞生物医▲薬▼有限公司Shenzhen TargetRx,Inc. |
プロテインチロシンキナーゼの活性を阻害するためのアミノピリミジン系化合物
|
|
CN109843858B
(zh)
|
2016-08-15 |
2023-05-05 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
CN114149432B
(zh)
*
|
2016-09-30 |
2024-07-05 |
斯坦福国际研究院 |
用于癌症治疗的双重clk/cdk1抑制剂
|
|
KR102686957B1
(ko)
*
|
2016-11-08 |
2024-07-22 |
주식회사 대웅제약 |
신규한 피롤로피리미딘 유도체 및 이를 포함하는 약학적 조성물
|
|
CA3045224A1
(en)
|
2016-12-16 |
2018-06-21 |
Basf Se |
Pesticidal compounds
|
|
PL3571193T3
(pl)
|
2017-01-23 |
2022-04-25 |
Cadent Therapeutics, Inc. |
Modulatory kanału potasowego
|
|
WO2018139883A1
(ko)
*
|
2017-01-26 |
2018-08-02 |
부광약품 주식회사 |
다중 표적 키나아제 저해제로서 융합피리미딘 유도체
|
|
CN110072865B
(zh)
*
|
2017-02-08 |
2022-02-11 |
中国医药研究开发中心有限公司 |
吡咯并芳杂环类化合物及其制备方法和医药用途
|
|
CN106916112B
(zh)
*
|
2017-03-02 |
2019-12-20 |
四川海思科制药有限公司 |
嘧啶衍生物及其制备方法和在医药上的应用
|
|
CN110506038B
(zh)
|
2017-03-28 |
2023-11-24 |
巴斯夫欧洲公司 |
杀害虫化合物
|
|
AU2017408099A1
(en)
|
2017-04-07 |
2019-11-07 |
ACEA Therapeutics, Inc. |
Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
|
|
KR102032418B1
(ko)
*
|
2017-06-15 |
2019-10-16 |
한국화학연구원 |
접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
|
|
CN110799191B
(zh)
|
2017-06-16 |
2023-05-26 |
贝塔制药有限公司 |
N-(2-(2-(二甲氨基)乙氧基)-4-甲氧基-5-((4-(1-甲基-1h-吲哚-3-基)嘧啶-2-基)氨基)苯基)丙烯酰胺及其盐的药物制剂
|
|
EP3675860B1
(en)
*
|
2017-08-28 |
2023-03-08 |
Zhihong, Chen |
Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
|
|
JP2019062834A
(ja)
*
|
2017-10-03 |
2019-04-25 |
アークレイ株式会社 |
ヒトegfrのc797s(g2390c)変異検出用プローブ、ヒトegfrのc797s(g2390c)変異検出用キット、及びヒトegfrのc797s(g2390c)変異の検出方法
|
|
AR113451A1
(es)
*
|
2017-10-18 |
2020-05-06 |
Spectrum Pharmaceuticals Inc |
Inhibidores de tirosina quinasas de la familia de los egfr mutantes
|
|
US10683297B2
(en)
|
2017-11-19 |
2020-06-16 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
CA3086083A1
(en)
|
2017-12-21 |
2019-06-27 |
Basf Se |
Pesticidal compounds
|
|
KR102577241B1
(ko)
*
|
2017-12-28 |
2023-09-11 |
주식회사 대웅제약 |
카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체
|
|
IL275207B
(en)
|
2017-12-28 |
2022-09-01 |
Daewoong Pharmaceutical Co Ltd |
An oxy-fluoropiperidine derivative as a kinase inhibitor
|
|
KR102577242B1
(ko)
*
|
2017-12-28 |
2023-09-11 |
주식회사 대웅제약 |
카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체
|
|
WO2019161224A1
(en)
|
2018-02-15 |
2019-08-22 |
GiraFpharma LLC |
Heterocyclic compounds as kinase inhibitors
|
|
KR20190114910A
(ko)
*
|
2018-03-30 |
2019-10-10 |
한미약품 주식회사 |
상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 설폰아마이드 유도체
|
|
CN108530450B
(zh)
*
|
2018-05-03 |
2021-03-30 |
赖建智 |
具有egfr抑制活性的化合物、制备方法及其在疾病治疗中的应用
|
|
US12084431B2
(en)
*
|
2018-05-14 |
2024-09-10 |
Takeda Pharmaceutical Company Limited |
Pharmaceutical salts of pyrimidine derivatives and method of treating disorders
|
|
US12187701B2
(en)
|
2018-06-25 |
2025-01-07 |
Dana-Farber Cancer Institute, Inc. |
Taire family kinase inhibitors and uses thereof
|
|
JP2021530470A
(ja)
*
|
2018-06-30 |
2021-11-11 |
ナショナル インスティテュート オブ バイオロジカル サイエンシズ, ベイジンNational Institute Of Biological Sciences, Beijing |
カテプシンc阻害剤
|
|
EP3613738A1
(en)
*
|
2018-08-23 |
2020-02-26 |
Lead Discovery Center GmbH |
4-substituted pyrrolo[2,3-b]pyridine as erbb modulators useful for treating cancer
|
|
KR102328682B1
(ko)
*
|
2018-08-27 |
2021-11-18 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
|
CA3112043A1
(en)
|
2018-09-10 |
2020-03-19 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
JP7542538B2
(ja)
|
2018-09-18 |
2024-08-30 |
ニカング セラピューティクス, インコーポレイテッド |
Srcホモロジー-2ホスファターゼ阻害剤としての縮合三環式環誘導体
|
|
WO2020068873A1
(en)
*
|
2018-09-25 |
2020-04-02 |
Black Diamond Therapeutics, Inc. |
Tyrosine kinase inhibitor compositions, methods of making and methods of use
|
|
TWI767148B
(zh)
|
2018-10-10 |
2022-06-11 |
美商弗瑪治療公司 |
抑制脂肪酸合成酶(fasn)
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
WO2020081572A1
(en)
*
|
2018-10-15 |
2020-04-23 |
Dana-Farber Cancer Institute, Inc. |
Transcriptional enhanced associate domain (tead) transcription factor inhibitors and uses thereof
|
|
EP3870291A1
(en)
|
2018-10-22 |
2021-09-01 |
Cadent Therapeutics, Inc. |
Crystalline forms of potassium channel modulators
|
|
EP3643705A1
(en)
|
2018-10-24 |
2020-04-29 |
Basf Se |
Pesticidal compounds
|
|
CN109265469A
(zh)
*
|
2018-11-12 |
2019-01-25 |
大连医科大学附属第医院 |
嘧啶并噻唑类杂环化合物,组合物及其治疗淋巴细胞白血病的用途
|
|
JP7660063B2
(ja)
|
2018-12-28 |
2025-04-10 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
サイクリン依存性キナーゼ7のインヒビターおよびそれらの使用
|
|
CN111393377B
(zh)
*
|
2019-01-02 |
2022-04-05 |
四川大学华西医院 |
具有抗癌作用的氘代嘧啶衍生物
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
WO2020180959A1
(en)
|
2019-03-05 |
2020-09-10 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
US20220143049A1
(en)
|
2019-03-21 |
2022-05-12 |
Onxeo |
A dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
|
KR20210144844A
(ko)
|
2019-03-29 |
2021-11-30 |
아스트라제네카 아베 |
비-소세포 폐암의 치료에 사용하기 위한 오시머티닙
|
|
CN111747950B
(zh)
*
|
2019-03-29 |
2024-01-23 |
深圳福沃药业有限公司 |
用于治疗癌症的嘧啶衍生物
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
MX2021013531A
(es)
|
2019-05-05 |
2022-02-11 |
Qilu Regor Therapeutics Inc |
Inhibidores de cdk.
|
|
WO2020245208A1
(en)
|
2019-06-04 |
2020-12-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
|
|
AU2020296620B2
(en)
*
|
2019-06-20 |
2023-07-13 |
Oncobix Co.Ltd. |
Pyrimidine derivative inhibiting growth of cancer cell and medicinal use thereof
|
|
CA3139969A1
(en)
*
|
2019-06-20 |
2020-12-24 |
Dana-Farber Cancer Institute, Inc. |
Small molecule inhibitors of src tyrosine kinase
|
|
JP2022539208A
(ja)
|
2019-07-03 |
2022-09-07 |
スミトモ ファーマ オンコロジー, インコーポレイテッド |
チロシンキナーゼ非受容体1(tnk1)阻害剤およびその使用
|
|
EP3766879A1
(en)
|
2019-07-19 |
2021-01-20 |
Basf Se |
Pesticidal pyrazole derivatives
|
|
KR102470980B1
(ko)
*
|
2019-07-26 |
2022-11-25 |
차이나 리소시즈 파마수티컬 홀딩스 컴퍼니 리미티드 |
Egfr 및 erbb2에 작용하는 피리미딘계 화합물
|
|
TW202115024A
(zh)
|
2019-08-14 |
2021-04-16 |
美商英塞特公司 |
作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
|
|
AU2020364007A1
(en)
|
2019-10-11 |
2022-04-28 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
EP4054579A1
(en)
|
2019-11-08 |
2022-09-14 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
|
CN111057021B
(zh)
*
|
2019-12-11 |
2023-05-23 |
中国药科大学 |
均三嗪类化合物及其制备方法和用途
|
|
US11685727B2
(en)
|
2019-12-20 |
2023-06-27 |
Nuevolution A/S |
Compounds active towards nuclear receptors
|
|
MX2022007265A
(es)
|
2019-12-20 |
2022-09-09 |
Nuevolution As |
Compuestos activos frente a receptores nucleares.
|
|
CN120271565A
(zh)
|
2019-12-23 |
2025-07-08 |
缆图药品公司 |
Egfr突变形式的抑制剂
|
|
WO2021138391A1
(en)
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
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|
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|
|
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*
|
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|
|
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(pt)
*
|
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|
|
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(en)
*
|
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|
|
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|
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|
|
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*
|
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|
|
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|
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|
|
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*
|
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|
|
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(en)
*
|
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|
|
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|
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|
|
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(en)
|
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|
|
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*
|
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|
|
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*
|
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|
|
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|
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|
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|
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|
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|
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