JP2012519181A - ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 - Google Patents

ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 Download PDF

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JP2012519181A
JP2012519181A JP2011552194A JP2011552194A JP2012519181A JP 2012519181 A JP2012519181 A JP 2012519181A JP 2011552194 A JP2011552194 A JP 2011552194A JP 2011552194 A JP2011552194 A JP 2011552194A JP 2012519181 A JP2012519181 A JP 2012519181A
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compound
prodrug
pharmaceutically acceptable
acceptable salt
composition
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JP2012519181A5 (enExample
Inventor
ポーター，スティーブン，ビー．
ブラッドフォード，ウィリアムスン，ジーグラー
スミス，パトリック，エフ．
イェッツァー，エレン，エス．
ラ ロサ，アベル デ
ロジャース，マイケル，ディー．
サイモンズ，ウィリアム，ティー．
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Roche Palo Alto LLC
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Roche Palo Alto LLC
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Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of JP2012519181A publication Critical patent/JP2012519181A/ja
Publication of JP2012519181A5 publication Critical patent/JP2012519181A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2011552194A 2009-02-27 2010-02-26 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 Pending JP2012519181A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15641409P 2009-02-27 2009-02-27
US61/156,414 2009-02-27
US25736709P 2009-11-02 2009-11-02
US61/257,367 2009-11-02
PCT/US2010/025611 WO2010099458A1 (en) 2009-02-27 2010-02-26 Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function

Related Child Applications (1)

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JP2015041648A Division JP2015098501A (ja) 2009-02-27 2015-03-03 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用

Publications (2)

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JP2012519181A true JP2012519181A (ja) 2012-08-23
JP2012519181A5 JP2012519181A5 (enExample) 2013-03-28

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JP2011552194A Pending JP2012519181A (ja) 2009-02-27 2010-02-26 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用
JP2015041648A Withdrawn JP2015098501A (ja) 2009-02-27 2015-03-03 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用

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US (2) US8735345B2 (enExample)
EP (1) EP2400966A1 (enExample)
JP (2) JP2012519181A (enExample)
KR (1) KR20110135941A (enExample)
CN (1) CN102361641A (enExample)
AR (1) AR075584A1 (enExample)
AU (1) AU2010217818A1 (enExample)
BR (1) BRPI1009338A2 (enExample)
CA (1) CA2751220A1 (enExample)
CL (1) CL2011002082A1 (enExample)
CO (1) CO6410304A2 (enExample)
CR (1) CR20110453A (enExample)
EC (1) ECSP11011292A (enExample)
IL (1) IL214760A0 (enExample)
MA (1) MA33236B1 (enExample)
MX (1) MX2011008980A (enExample)
NZ (1) NZ594524A (enExample)
PE (1) PE20120777A1 (enExample)
RU (1) RU2011139180A (enExample)
SG (1) SG173774A1 (enExample)
TW (1) TWI473810B (enExample)
WO (1) WO2010099458A1 (enExample)

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MA33236B1 (fr) 2012-05-02
CA2751220A1 (en) 2010-09-02
CR20110453A (es) 2011-12-08
EP2400966A1 (en) 2012-01-04
JP2015098501A (ja) 2015-05-28
TWI473810B (zh) 2015-02-21
CO6410304A2 (es) 2012-03-30
AR075584A1 (es) 2011-04-20
ECSP11011292A (es) 2011-12-30
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MX2011008980A (es) 2011-11-18
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RU2011139180A (ru) 2013-04-10

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